LOCUS       NM_014445               3022 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens stress associated endoplasmic reticulum protein 1
            (SERP1), mRNA.
ACCESSION   NM_014445
VERSION     NM_014445.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3022)
  AUTHORS   You,T. and Zhang,B.
  TITLE     CircWDR33 alleviates human pulmonary microvascular endothelial cell
            injury in sepsis-associated acute lung injury by targeting
            miR-217-5p/SERP1 axis
  JOURNAL   Int Immunopharmacol 113 (Pt B), 109440 (2022)
   PUBMED   36417821
  REMARK    GeneRIF: CircWDR33 alleviates human pulmonary microvascular
            endothelial cell injury in sepsis-associated acute lung injury by
            targeting miR-217-5p/SERP1 axis.
REFERENCE   2  (bases 1 to 3022)
  AUTHORS   Fan,Y., Liang,X. and Yu,D.
  TITLE     Low expression of endoplasmic reticulum stress-related gene SERP1
            is associated with poor prognosis and immune infiltration in skin
            cutaneous melanoma
  JOURNAL   Aging (Albany NY) 13 (19), 23036-23071 (2021)
   PUBMED   34613934
  REMARK    GeneRIF: Low expression of endoplasmic reticulum stress-related
            gene SERP1 is associated with poor prognosis and immune
            infiltration in skin cutaneous melanoma.
REFERENCE   3  (bases 1 to 3022)
  AUTHORS   Liu,T.W., Liu,F. and Kang,J.
  TITLE     Let-7b-5p is involved in the response of endoplasmic reticulum
            stress in acute pulmonary embolism through upregulating the
            expression of stress-associated endoplasmic reticulum protein 1
  JOURNAL   IUBMB Life 72 (8), 1725-1736 (2020)
   PUBMED   32534478
  REMARK    GeneRIF: Let-7b-5p is involved in the response of endoplasmic
            reticulum stress in acute pulmonary embolism through upregulating
            the expression of stress-associated endoplasmic reticulum protein
            1.
REFERENCE   4  (bases 1 to 3022)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3022)
  AUTHORS   Jung,S., Hyun,J., Nah,J., Han,J., Kim,S.H., Park,J., Oh,Y.,
            Gwon,Y., Moon,S., Jo,D.G. and Jung,Y.K.
  TITLE     SERP1 is an assembly regulator of gamma-secretase in metabolic
            stress conditions
  JOURNAL   Sci Signal 13 (623) (2020)
   PUBMED   32184288
  REMARK    GeneRIF: SERP1 is an assembly regulator of gamma-secretase in
            metabolic stress conditions.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3022)
  AUTHORS   Atschekzei,F., Hennenlotter,J., Janisch,S., Grosshennig,A.,
            Trankenschuh,W., Waalkes,S., Peters,I., Dork,T., Merseburger,A.S.,
            Stenzl,A., Kuczyk,M.A. and Serth,J.
  TITLE     SFRP1 CpG island methylation locus is associated with renal cell
            cancer susceptibility and disease recurrence
  JOURNAL   Epigenetics 7 (5), 447-457 (2012)
   PUBMED   22419128
  REMARK    GeneRIF: SFRP1 DNA methylation, accumulates with age in
            normal-appearing kidney tissues and is associated with increased
            renal cancer risk.
REFERENCE   7  (bases 1 to 3022)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 3022)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3022)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   10 (bases 1 to 3022)
  AUTHORS   Yamaguchi,A., Hori,O., Stern,D.M., Hartmann,E., Ogawa,S. and
            Tohyama,M.
  TITLE     Stress-associated endoplasmic reticulum protein 1
            (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes
            membrane proteins during stress and facilitates subsequent
            glycosylation
  JOURNAL   J Cell Biol 147 (6), 1195-1204 (1999)
   PUBMED   10601334
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB022941.1, BC108314.1, AC107426.13 and AA890577.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014445.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.51653.1,
                                           SRR1660803.94250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239944.7/ ENSP00000239944.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DB022941.1         147-153
            8-1248              BC108314.1         1-1241
            1249-2865           AC107426.13        47119-48735
            2866-3022           AA890577.1         15-171              c
FEATURES             Location/Qualifiers
     source          1..3022
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.1"
     gene            1..3022
                     /gene="SERP1"
                     /gene_synonym="RAMP4"
                     /note="stress associated endoplasmic reticulum protein 1"
                     /db_xref="GeneID:27230"
                     /db_xref="HGNC:HGNC:10759"
                     /db_xref="MIM:617674"
     exon            1..445
                     /gene="SERP1"
                     /gene_synonym="RAMP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..562
                     /gene="SERP1"
                     /gene_synonym="RAMP4"
                     /note="ribosome associated membrane protein 4;
                     ribosome-attached membrane protein 4"
                     /codon_start=1
                     /product="stress-associated endoplasmic reticulum protein
                     1"
                     /protein_id="NP_055260.1"
                     /db_xref="CCDS:CCDS3150.1"
                     /db_xref="GeneID:27230"
                     /db_xref="HGNC:HGNC:10759"
                     /db_xref="MIM:617674"
                     /translation="MVAKQRIRMANEKHSKNITQRGNVAKTSRNAPEEKASVGPWLLA
                     LFIFVVCGSAIFQIIQSIRMGM"
     exon            446..521
                     /gene="SERP1"
                     /gene_synonym="RAMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            522..3022
                     /gene="SERP1"
                     /gene_synonym="RAMP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      782..787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERP1"
                     /gene_synonym="RAMP4"
                     /note="hexamer: AATAAA"
     polyA_site      802
                     /gene="SERP1"
                     /gene_synonym="RAMP4"
                     /note="major polyA site"
     regulatory      2488..2493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERP1"
                     /gene_synonym="RAMP4"
                     /note="hexamer: AATAAA"
     polyA_site      2510
                     /gene="SERP1"
                     /gene_synonym="RAMP4"
                     /note="major polyA site"
     regulatory      2817..2822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERP1"
                     /gene_synonym="RAMP4"
                     /note="hexamer: AATAAA"
     polyA_site      2842
                     /gene="SERP1"
                     /gene_synonym="RAMP4"
     regulatory      3004..3009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERP1"
                     /gene_synonym="RAMP4"
                     /note="hexamer: AAGAAA"
     polyA_site      3022
                     /gene="SERP1"
                     /gene_synonym="RAMP4"
                     /note="major polyA site"
ORIGIN      
        1 agatcgaggc ggcgggctgc acattcccgt tgttgcgttg cgtttccttc ctctttcact
       61 ccgcgctcac ggcggcggcc aaagcggcgg cgacggcggc gcgagaacga cccggcggcc
      121 agttctcttc ctcctgcgca cctgccccgc tcggtcagtc agtcggcggc cggcgcccgg
      181 cttgtgctca gacctcgcgc ttgcggcgcc caggcccagc ggccgtagct agcgtctggc
      241 ctgagaacct cggcgctccg gcggcgcggg caccacgagc cgagcctcgc agcggctcca
      301 gaggaggcag gcgagtgagc gagtccgagg ggtggccggg gcaggtggtg gcgccgcgaa
      361 gatggtcgcc aagcaaagga tccgtatggc caacgagaag cacagcaaga acatcaccca
      421 gcgcggcaac gtcgccaaga cctcgagaaa tgcccccgaa gagaaggcgt ctgtaggacc
      481 ctggttattg gctctcttca tttttgttgt ctgtggttct gcaattttcc agattattca
      541 aagtatcagg atgggcatgt gaagtgactg accttaagat gtttccattc tcctgtgaat
      601 tttaacttga actcattcct gatgtttgat accctggttg aaaacaattc agtaaagcat
      661 cctgcctcag aatgactttc ctatcatgct tcatgtgtca ttccaaggtt tcttcatgag
      721 tcattccaag ttttctagtc cataccacag tgccttgcaa aaaacaccac atgaataaag
      781 caataaaatt tgattgttaa gatacagtag tggaccctac ttattcagtc aattaagagt
      841 aagttttttt atgtggttat taaaacagta tgaacaatta gtctaactct gcatagacag
      901 ggtctagatt ttgttaaccc aaatgtataa ctgcagttag cttaaattac aatttgaagt
      961 cttgtggttt ttatatagct aggcacttta ttactctttt gaactgaaag cacactccct
     1021 tataggttca tgtaactgtc ctgtaataag gtgcttataa atggaacaac tacacagcct
     1081 agttttgcca caacctttag catctaaaaa gttttaaaag cttctaaatg tctaatataa
     1141 agggagatgc ttatagccac aacatctatt ttaccaatat tgtttccatt acactacctt
     1201 ggattttgca tgagtgagta tagtaaccca agatgccata aaaaaaaaac ttgatcgttt
     1261 tctgacttaa tcagttactg tggtttcact aaaagctacc gtggtggagt gaagtcagtc
     1321 agggaaggtt tgtttatgtt acatttattt caccagaact attttaatat atcaaagggg
     1381 tttactatgc caaacaaaat tctagggaaa aatactgcta aaaatggatg cctcatcaga
     1441 acatgctgtt gagtccaatg tgccataaga cattttagca tgttaaatag cacttttaat
     1501 agcaaaaaaa ggcacatcaa ctgcgaagtt atccttagtt tgcaaatgct ttttctagat
     1561 taatgatttt tcaatcatta gggtactaga cacatcagcc taaagtggca tctggaattg
     1621 aatggattta ctgataatga tcagtcttta gtcttccctt tgttatatga ctttataggt
     1681 tatgattgat caaatttacg ttttactaat ggtaagggtg agggtcatag ggcaggtttt
     1741 gggttttcta gtactgttga aaactgcaag tattggctat ttgtatactt agccataact
     1801 tggtgaaaaa aaacctgagc agtgtctatg tattaatgcg ttggaaagaa agctgcttgt
     1861 gtttgctttg ttaattgcct caggatattt cttttaaaat aagctgtttt aagaggaaca
     1921 gaagggaaat ctgctaccta gtctatacac agcgtgaacc tcacaggggg cttctgatac
     1981 cctcaaacat ggagaacagt aagggagcag agtggttaag gactttcagg aacttaacta
     2041 ttctggaata aggaatgaat caactgacct tgggccagca ggtttttaac taaattgtta
     2101 cttgcctttc tcacccagtt aatcagtctc tgtacttgtt tccctttttg aaacaagtgt
     2161 cttggttaac taattctgtt ttatggttgt gctaaattca tagcaggtgc cttattcttt
     2221 gcttttagtc aaaccattcc atatcagaat tttccttggt ttactataga tatttggctt
     2281 taagttgttg tttgtgtttt ttaatgtaca atgttctgat aaatttgact gttaaattgc
     2341 tatagctagc aatcatttta catatgtaaa attgcattcc ctttgtattt catgtgtaat
     2401 tcaccaatta agtgcagttt atattcaggt tggattatgc atgtttaggt aaacgaaagc
     2461 tgtgtcttac ttgatttatt ctttaaaaat aaagttccct gaatatttga tgcttttctt
     2521 ctaaacggaa atgattttac agttatctga gtgtaccttt tatagttagt agaaaatgat
     2581 tttaaagaat gtttagtatt gtacttaaat ggtatgcaga ggcacagatg taaggtttat
     2641 aactggaaat aggtggtaag aaaaatatat agaaagcaca atgatttgaa tatttttcca
     2701 cttaggattt cctaatctcc ttgtcatcca attcaagctc aagatgaagc acaattcttt
     2761 gatctccctt tgccagttga attttataga tcatctaatg ttgagcacag tatgagaata
     2821 aatattgggg ttgtcaacat tactcagtta ctctttgtgg tttaactcta acatttcaac
     2881 aagttgtcaa ttaattgtat ctgttgggtt gtatataatg ttgctcaaaa taattaagtg
     2941 gacttccaaa aataagattt ccattgtaac aggatgcatt gtgatgggct ttgacttaca
     3001 ttaaagaaat gtggatagtc aa
//
