LOCUS       NM_001258031            2629 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens serine incorporator 4 (SERINC4), transcript variant 1,
            mRNA.
ACCESSION   NM_001258031
VERSION     NM_001258031.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2629)
  AUTHORS   Inuzuka,M., Hayakawa,M. and Ingi,T.
  TITLE     Serinc, an activity-regulated protein family, incorporates serine
            into membrane lipid synthesis
  JOURNAL   J Biol Chem 280 (42), 35776-35783 (2005)
   PUBMED   16120614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018512.6.
            
            On Sep 23, 2020 this sequence version replaced NM_001258031.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319327.7/ ENSP00000319796.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-336               AC018512.6         115083-115418       c
            337-513             AC018512.6         114508-114684       c
            514-692             AC018512.6         114157-114335       c
            693-772             AC018512.6         113623-113702       c
            773-866             AC018512.6         113118-113211       c
            867-1078            AC018512.6         112343-112554       c
            1079-1174           AC018512.6         112043-112138       c
            1175-1301           AC018512.6         111814-111940       c
            1302-1374           AC018512.6         111353-111425       c
            1375-1423           AC018512.6         110886-110934       c
            1424-1577           AC018512.6         110586-110739       c
            1578-2629           AC018512.6         109360-110411       c
FEATURES             Location/Qualifiers
     source          1..2629
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.3"
     gene            1..2629
                     /gene="SERINC4"
                     /note="serine incorporator 4"
                     /db_xref="GeneID:619189"
                     /db_xref="HGNC:HGNC:32237"
                     /db_xref="MIM:614550"
     exon            1..336
                     /gene="SERINC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..1791
                     /gene="SERINC4"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="serine incorporator 4 isoform 1"
                     /protein_id="NP_001244960.1"
                     /db_xref="CCDS:CCDS58360.1"
                     /db_xref="GeneID:619189"
                     /db_xref="HGNC:HGNC:32237"
                     /db_xref="MIM:614550"
                     /translation="MVGAKAGPSPGTSLGLAQQHSGGSSVLVKSPFCQVCCCGPAPCA
                     SCCHSRWPSLTASTCSRLFYILLHVGASAICCLLLSRTVVERVWGKTHRIQMPSGLCA
                     HLFGLSDCPVLSGSGAVYRVCAGTATFHLLQAVLLVHLHSPTSPRAQLHNSFWLLKLL
                     FLLGLCAIAFCIPDEHLFPAWHYIGICGGFAFILLQLVLITAFAHSWNKNWQTGAAQD
                     CSWFLAVLLATLGFYSMAGVGAVLLFHYYTHPAGCLLNKMLLSLHLCFCGLISFLSIA
                     PCIRLKQPRSGLLQASVISCYIMYLTFSALSSRPPERVILQGQNHTLCLPGLSKMEPQ
                     TPDISLAMLSASIMYACVLFACNEASYLAEVFGPLWIVKVYSYEFQKPSLCFCCPETV
                     EADKGQRGGAARPADQETPPAPPVQVQHLSYNYSAFHFVFFLASLYVMVTLTNWFSYE
                     GAELEKTFIKGSWATFWVKVASCWACVLLYLGLLLAPLCWPPTQKPQPLILRRRRHRI
                     ISPDNKYPPV"
     exon            337..513
                     /gene="SERINC4"
                     /inference="alignment:Splign:2.1.0"
     exon            514..692
                     /gene="SERINC4"
                     /inference="alignment:Splign:2.1.0"
     exon            693..772
                     /gene="SERINC4"
                     /inference="alignment:Splign:2.1.0"
     exon            773..866
                     /gene="SERINC4"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1078
                     /gene="SERINC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1174
                     /gene="SERINC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1301
                     /gene="SERINC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1374
                     /gene="SERINC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1423
                     /gene="SERINC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1577
                     /gene="SERINC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..2629
                     /gene="SERINC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2599..2604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERINC4"
                     /note="hexamer: AATAAA"
     polyA_site      2629
                     /gene="SERINC4"
                     /note="major polyA site"
ORIGIN      
        1 agagaacagc ctgagtggcc gcagtgttga ggccctaagg acaaagctcc ttcacagggc
       61 atttgcattt accgcaacct ggaggtcagt gttctcttcc ggacgtctcc attctgcccg
      121 ggaccgggtg ctcagcccca acacagtggc agtccaatgg gctgaggaca gaagcaactg
      181 ctgctctcat ctgccttcca tctggtggac ctaagcctaa tccctgggac aaggatggtg
      241 ggtgccaagg ccggccccag ccccggcacc tccctgggcc tggcacagca gcacagcgga
      301 ggcagcagtg tcctagtgaa aagtcccttc tgtcaggtgt gctgctgtgg gcctgctcct
      361 tgtgccagct gctgccactc taggtggccc tctctcaccg catccacttg cagccgcctg
      421 ttctacatcc tcctccatgt gggggcctca gcaatctgct gcctcctgct gtcaaggaca
      481 gtagtggaaa gggtgtgggg caagacacac aggatccaga tgccctcggg gttgtgtgcc
      541 cacctgtttg gcctctctga ctgtccagtg ctcagtggct ctggggctgt gtaccgagta
      601 tgtgcaggaa ccgccacctt ccacctgctg caggctgtgt tgctggtcca cctccactcc
      661 cccaccagcc cgcgggcaca gctgcataat agcttctggc tcctcaagct gctgttcctg
      721 ttaggtctct gtgctattgc cttctgcatt cctgatgagc atctcttccc agcatggcat
      781 tacattggca tctgtggagg ctttgcattc atcctactgc agttggtgct tattacagct
      841 tttgcccatt cctggaacaa gaactggcag acaggtgcag ctcaagactg tagctggttc
      901 ctggctgtcc tgctggccac cctaggattc tacagcatgg caggtgtggg agctgtgctc
      961 ctattccact attatacaca cccagctggc tgcctgctta acaagatgct cctcagtctg
     1021 cacctttgct tctgtggcct catctccttc ctctccatcg ctccttgcat ccgcctcaag
     1081 caaccccgct ctggcctcct acaagcttct gtcatcagct gctatatcat gtatctgact
     1141 ttctctgcac tgtccagccg tcctccagag agagtaatcc ttcaaggaca gaatcacacc
     1201 ctgtgcctgc ctggcctgag taaaatggaa ccccaaacac cagatatctc tctagcaatg
     1261 ctgagtgcta gcatcatgta tgcttgtgtg ctttttgctt gcaatgaggc ctcctacctg
     1321 gctgaggtat ttggacccct gtggattgtc aaggtttaca gctatgagtt tcagaagccc
     1381 tcactgtgtt tctgctgccc tgaaacagtg gaggcagaca aagggcaaag gggtggggct
     1441 gcgaggccag ctgaccaaga aacccctcca gctcctccag tccaagtcca gcatctttcc
     1501 tacaactatt ctgccttcca cttcgtcttc ttccttgcct cactctatgt catggttacc
     1561 cttaccaact ggttcagcta tgagggagca gaactggaaa agaccttcat caagggtagc
     1621 tgggccacct tctgggtcaa ggttgcctca tgctgggcct gcgtactcct ctatctgggg
     1681 ctgttactgg caccactctg ttggcccccc acccagaaac cccagcccct tatcttgagg
     1741 cgccgccgcc accgcatcat atccccagat aacaaatatc ctccagtcta agtccttttc
     1801 acaaactggg gttcccctga cattgtactc ctagagttgg ctcaagggga gctgtccagc
     1861 ccagctcaat acctcaagga cacacaggga gttatctccg tttgggctga agtcaatact
     1921 atgaactgga agaagtggtc aaacacagtc taatgtgctg ggcagagtgt ctgactcact
     1981 ggagctactg ttacatctgc atcccagctc aagagcctaa cacccaaatc agcagctcaa
     2041 agaaccaccg ctgatcccag cagacagtgt ggcaccagcc ctttcctggc tcttgggctg
     2101 gaagtggggg tggggaaaga ccaacaggga ctgaagactc ggctctgccc ttggagaaag
     2161 gaaaataagg agttcagccc tgggcacacg gatataagaa gcccagaacc acagaacaaa
     2221 ccagggcata gaagaaagga gcacagaggc taccccaggt tttaatcctg attttgaggt
     2281 caagggaagc gggaagacaa aaccaccctc attccatgag gaatgacaga agagaaagtg
     2341 aacgcttgac agcagctgac cacgggaagt cggtgagcag caggattttt tggccaactt
     2401 tcaagcagac gaacaaactg aggaagaatg aggaaaagag gcataaacac agatcttgca
     2461 gcattcactc ttaggccaac tccatcctag agatggtgtt caagggtggg gaacaaaaat
     2521 cacagaaaag aagtctctat ggttcttaga ggattcctct actgcatatc cggagtactt
     2581 gtttggttgt cattgtataa taaaggcttc ttctgtgatg tttcactta
//
