LOCUS       NM_006811               4396 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens serine incorporator 3 (SERINC3), transcript variant 1,
            mRNA.
ACCESSION   NM_006811
VERSION     NM_006811.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4396)
  AUTHORS   Leonhardt,S.A., Purdy,M.D., Grover,J.R., Yang,Z., Poulos,S.,
            McIntire,W.E., Tatham,E.A., Erramilli,S.K., Nosol,K., Lai,K.K.,
            Ding,S., Lu,M., Uchil,P.D., Finzi,A., Rein,A., Kossiakoff,A.A.,
            Mothes,W. and Yeager,M.
  TITLE     Antiviral HIV-1 SERINC restriction factors disrupt virus membrane
            asymmetry
  JOURNAL   Nat Commun 14 (1), 4368 (2023)
   PUBMED   37474505
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4396)
  AUTHORS   Ward,A.E., Kiessling,V., Pornillos,O., White,J.M.,
            Ganser-Pornillos,B.K. and Tamm,L.K.
  TITLE     HIV-cell membrane fusion intermediates are restricted by Serincs as
            revealed by cryo-electron and TIRF microscopy
  JOURNAL   J Biol Chem 295 (45), 15183-15195 (2020)
   PUBMED   32788212
  REMARK    GeneRIF: HIV-cell membrane fusion intermediates are restricted by
            Serincs as revealed by cryo-electron and TIRF microscopy.
REFERENCE   3  (bases 1 to 4396)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4396)
  AUTHORS   Wu,Y., Olety,B., Weiss,E.R., Popova,E., Yamanaka,H. and
            Gottlinger,H.
  TITLE     Potent Enhancement of HIV-1 Replication by Nef in the Absence of
            SERINC3 and SERINC5
  JOURNAL   mBio 10 (3), e01071-19 (2019)
   PUBMED   31186327
  REMARK    GeneRIF: In MOLT-3 cells, Nef remained crucial for HIV-1
            replication even in the absence of SERINC3 and SERINC5.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4396)
  AUTHORS   Rosa,A., Chande,A., Ziglio,S., De Sanctis,V., Bertorelli,R.,
            Goh,S.L., McCauley,S.M., Nowosielska,A., Antonarakis,S.E.,
            Luban,J., Santoni,F.A. and Pizzato,M.
  TITLE     HIV-1 Nef promotes infection by excluding SERINC5 from virion
            incorporation
  JOURNAL   Nature 526 (7572), 212-217 (2015)
   PUBMED   26416734
REFERENCE   6  (bases 1 to 4396)
  AUTHORS   Anderson,C.A., Boucher,G., Lees,C.W., Franke,A., D'Amato,M.,
            Taylor,K.D., Lee,J.C., Goyette,P., Imielinski,M., Latiano,A.,
            Lagace,C., Scott,R., Amininejad,L., Bumpstead,S., Baidoo,L.,
            Baldassano,R.N., Barclay,M., Bayless,T.M., Brand,S., Buning,C.,
            Colombel,J.F., Denson,L.A., De Vos,M., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Fehrmann,R.S., Floyd,J.A., Florin,T.,
            Franchimont,D., Franke,L., Georges,M., Glas,J., Glazer,N.L.,
            Guthery,S.L., Haritunians,T., Hayward,N.K., Hugot,J.P., Jobin,G.,
            Laukens,D., Lawrance,I., Lemann,M., Levine,A., Libioulle,C.,
            Louis,E., McGovern,D.P., Milla,M., Montgomery,G.W., Morley,K.I.,
            Mowat,C., Ng,A., Newman,W., Ophoff,R.A., Papi,L., Palmieri,O.,
            Peyrin-Biroulet,L., Panes,J., Phillips,A., Prescott,N.J.,
            Proctor,D.D., Roberts,R., Russell,R., Rutgeerts,P., Sanderson,J.,
            Sans,M., Schumm,P., Seibold,F., Sharma,Y., Simms,L.A.,
            Seielstad,M., Steinhart,A.H., Targan,S.R., van den Berg,L.H.,
            Vatn,M., Verspaget,H., Walters,T., Wijmenga,C., Wilson,D.C.,
            Westra,H.J., Xavier,R.J., Zhao,Z.Z., Ponsioen,C.Y., Andersen,V.,
            Torkvist,L., Gazouli,M., Anagnou,N.P., Karlsen,T.H., Kupcinskas,L.,
            Sventoraityte,J., Mansfield,J.C., Kugathasan,S., Silverberg,M.S.,
            Halfvarson,J., Rotter,J.I., Mathew,C.G., Griffiths,A.M., Gearry,R.,
            Ahmad,T., Brant,S.R., Chamaillard,M., Satsangi,J., Cho,J.H.,
            Schreiber,S., Daly,M.J., Barrett,J.C., Parkes,M., Annese,V.,
            Hakonarson,H., Radford-Smith,G., Duerr,R.H., Vermeire,S.,
            Weersma,R.K. and Rioux,J.D.
  TITLE     Meta-analysis identifies 29 additional ulcerative colitis risk
            loci, increasing the number of confirmed associations to 47
  JOURNAL   Nat Genet 43 (3), 246-252 (2011)
   PUBMED   21297633
  REMARK    Erratum:[Nat Genet. 2011 Sep;43(9):919]
REFERENCE   7  (bases 1 to 4396)
  AUTHORS   Bossolasco,M., Veillette,F., Bertrand,R. and Mes-Masson,A.M.
  TITLE     Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro
            and stimulates in vivo tumorigenesis
  JOURNAL   Oncogene 25 (33), 4549-4558 (2006)
   PUBMED   16547497
  REMARK    GeneRIF: TDE1 inhibits apoptosis and stimulates tumorigenesis
REFERENCE   8  (bases 1 to 4396)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   9  (bases 1 to 4396)
  AUTHORS   Bossolasco,M., Lebel,M., Lemieux,N. and Mes-Masson,A.M.
  TITLE     The human TDE gene homologue: localization to 20q13.1-13.3 and
            variable expression in human tumor cell lines and tissue
  JOURNAL   Mol Carcinog 26 (3), 189-200 (1999)
   PUBMED   10559794
REFERENCE   10 (bases 1 to 4396)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA294859.1, CB956722.1, AF112227.1, CA950523.1, DA978982.1,
            CN369494.1, Z97053.2, BI599912.1 and AA772607.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006811.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.193324.1,
                                           SRR1803615.6034.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146, SAMEA2467148
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342374.5/ ENSP00000340243.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AA294859.1         16-65
            51-702              CB956722.1         62-713
            703-1934            AF112227.1         661-1892
            1935-2475           CA950523.1         36-576
            2476-2949           DA978982.1         34-507
            2950-3128           CN369494.1         476-654
            3129-3521           Z97053.2           15222-15614         c
            3522-4055           BI599912.1         4-537
            4056-4396           AA772607.1         13-353              c
FEATURES             Location/Qualifiers
     source          1..4396
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..4396
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /note="serine incorporator 3"
                     /db_xref="GeneID:10955"
                     /db_xref="HGNC:HGNC:11699"
                     /db_xref="MIM:607165"
     exon            1..158
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1541
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /note="tumor differentially expressed protein 1"
                     /codon_start=1
                     /product="serine incorporator 3"
                     /protein_id="NP_006802.1"
                     /db_xref="CCDS:CCDS13333.1"
                     /db_xref="GeneID:10955"
                     /db_xref="HGNC:HGNC:11699"
                     /db_xref="MIM:607165"
                     /translation="MGAVLGVFSLASWVPCLCSGASCLLCSCCPNSKNSTVTRLIYAF
                     ILLLSTVVSYIMQRKEMETYLKKIPGFCEGGFKIHEADINADKDCDVLVGYKAVYRIS
                     FAMAIFFFVFSLLMFKVKTSKDLRAAVHNGFWFFKIAALIGIMVGSFYIPGGYFSSVW
                     FVVGMIGAALFILIQLVLLVDFAHSWNESWVNRMEEGNPRLWYAALLSFTSAFYILSI
                     ICVGLLYTYYTKPDGCTENKFFISINLILCVVASIISIHPKIQEHQPRSGLLQSSLIT
                     LYTMYLTWSAMSNEPDRSCNPNLMSFITRITAPTLAPGNSTAVVPTPTPPSKSGSLLD
                     SDNFIGLFVFVLCLLYSSIRTSTNSQVDKLTLSGSDSVILGDTTTSGASDEEDGQPRR
                     AVDNEKEGVQYSYSLFHLMLCLASLYIMMTLTSWYSPDAKFQSMTSKWPAVWVKISSS
                     WVCLLLYVWTLVAPLVLTSRDFS"
     exon            159..320
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            321..514
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            515..594
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            595..732
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            733..902
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..993
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1174
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1402
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..4396
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2221..2226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /note="hexamer: AATGAA"
     polyA_site      2244
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /note="major polyA site"
     regulatory      2610..2615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /note="hexamer: AATAAA"
     polyA_site      2632
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /note="major polyA site"
     regulatory      4351..4356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /note="hexamer: AATAAA"
     regulatory      4370..4375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
                     /note="hexamer: AATAAA"
     polyA_site      4371
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
     polyA_site      4396
                     /gene="SERINC3"
                     /gene_synonym="AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1"
ORIGIN      
        1 ggaaggctgc gtttccggcc tgagaaaccg tcatgtttct ggggagtcac ctcagctggc
       61 agttaccacc gtgttagaaa gcagcctcag gaccggccac ctccatcact ggcgtcacca
      121 tgggggctgt gctgggtgtc ttctccctcg ccagctgggt tccatgcctc tgcagcggtg
      181 cctcatgttt gctgtgtagt tgctgtccta acagtaagaa ttccacggtg actcgcctca
      241 tttatgcttt cattctcctc ctgagcactg tcgtatccta tatcatgcag agaaaagaga
      301 tggaaactta cttgaagaag attcctggat tttgtgaagg gggatttaaa atccatgagg
      361 ctgatataaa tgcagataaa gattgtgatg tgctggttgg ttataaagct gtgtatcgga
      421 tcagctttgc catggccatc tttttctttg tcttttctct gctcatgttc aaagtaaaaa
      481 caagtaaaga tctccgagcg gcagtacaca atgggttttg gttcttcaaa attgctgccc
      541 ttattggaat catggttggc tctttctaca tccctggggg ctatttcagc tcagtctggt
      601 ttgttgttgg catgataggg gccgccctct tcatcctcat tcagctggtg ctgctggtag
      661 attttgctca ttcttggaat gaatcatggg taaatcgaat ggaagaagga aacccaaggt
      721 tgtggtatgc tgctttactg tctttcacaa gcgcctttta tatcctgtca atcatctgtg
      781 tcgggctgct ctatacatat tacaccaaac cagatggctg cacagaaaac aagttcttca
      841 tcagtattaa cctgatcctt tgcgttgtgg cttctattat atcgatccac ccaaaaattc
      901 aggaacacca gcctcgctcc ggcctcttgc agtcctccct catcaccctc tacactatgt
      961 acctcacctg gtcagccatg tccaatgaac ctgatcgttc ctgcaatccc aacctgatga
     1021 gctttattac acgcataact gcaccaaccc tggctcctgg aaattcaact gctgtggtcc
     1081 ctacccctac tccaccatca aagagtgggt ctttactgga ttcagataat tttattggac
     1141 tgtttgtctt tgttctctgc ctcttgtatt ctagcatccg cacttccact aatagccaag
     1201 tagacaagct gaccctgtca gggagtgaca gcgtcatcct tggtgataca actaccagtg
     1261 gtgccagtga tgaagaagat ggacagcctc ggcgggctgt ggacaacgag aaagagggag
     1321 tgcagtatag ctactcctta ttccacctca tgctctgctt ggcttccttg tacatcatga
     1381 tgaccctgac cagctggtac agccctgatg caaagtttca gagcatgacc agcaagtggc
     1441 cagctgtgtg ggtcaagatc agctccagct gggtctgcct cctgctttac gtctggaccc
     1501 ttgtggctcc acttgtcctc accagtcggg acttcagctg aacctctgag tgccaaggac
     1561 accactggaa ctcacaaagg tctccttcac cgaaaaccca tatacctttt aagtttgttt
     1621 caactaaaat attaagtgaa tgctttgcaa gtttgactgt atgcaggttt atatcagaag
     1681 gtgagattga ataatgcttg atgcagaatc gaaacttctc atttatctgt atattatgtt
     1741 tacttctaag gatatagcac aaagggaaca ttttttgttt aaagtgaact acagctgtgc
     1801 tgtgaagaga gttctttata aagcctgtag gttcttttaa ctttggttta aaatgtaaga
     1861 taggaaaatg ttggatattt gaggccatgc ttaatatatt tatattgcag tatcctttaa
     1921 aagcaaaaaa aaaaaaatgc atttatatta cagttttcct ctatgaaagt ccttacttat
     1981 atgatacaag cactgtgttt tgtgcttaaa ctcttcagcg gggtagcatc aaagttcttg
     2041 gggaaggatc gtatatgtgg gtcccttccc tagaagaatg gttgctgata tggctactgc
     2101 ttctacatct tgagtttttt aatttacttt ttttacactg tagcattgag actgcttgat
     2161 tcaagtctgg tgctttgcca gatgtattaa tttccataaa tgctttgtga gtttggttaa
     2221 aatgaagatt cacttgggaa aacactgcag ctttagtctg tgttactatc ttgttatgag
     2281 tatgtaaaag taaaatgcat gtgaatttat catatttgca ctatgaaggt atttggttaa
     2341 aatacaaaga cttttaagat tttaaggccc tttcttccaa cagcttttat agttagcagc
     2401 cattctttat tttctggata gccaggtttt atcacgcttc tagtcaggat gctcctattc
     2461 cttctaaaaa ttacggtctg actagtgagc aaagtcttga atttattcaa aagtcctaaa
     2521 taccttctct aggtaagaca cttggtagat gagagacgga aggcattgtc aagaaccatt
     2581 ttcatgagag gtggtgtgca aaaaggtaga ataaaagagt tctttcaaca aagatttact
     2641 gtctattctg tactagaccc tgtaggtttt ggggtacagt gttaaacatg atagaggctc
     2701 tgccgtcttg gactttaata gcttagagaa gagagcaaat gagctgacag gtggttataa
     2761 tgtgaattag tgctgtggtt taggaattgg agagaactca aaggagaggt atttggtgta
     2821 atggtaggct ttctggagaa aatgatattt aagccaagaa ctcttagaag ttagctaaga
     2881 gagagatggg aaaatgagac gacattgctg gagtagataa aactgcatgt taaaggcagg
     2941 aagatgggga aaaaaagttc agtaaagctg gaatggggaa atgtagtcag ggactgaatt
     3001 ttaaagggct ttatcaacct cagtaaagag tttggacctt atgttgaggg tggctgaaaa
     3061 catattcata gtgtcatgaa caaattttat cttcagtcac ttgggctgat atatagagaa
     3121 tggatttaga gagatgagac caggtgcagt ccatatgaga tgtgaaatag agaagtggaa
     3181 tcgtagggac ggggagaaat tgacaggtga gggctactta gcaattagaa tttttttttt
     3241 tcaattttaa tttttttttt tgagacggag tcttgctctg tcgcccaggc tggagtgcaa
     3301 tggtgcgatc tccgctcact gcaggctccg cctcccgggt tcacgccatt ctcccgcctc
     3361 agcctcccta gtagctggga ctacaggcac ccaccaccac gcctggctaa ttttttttgt
     3421 atttttagta gagacagggt ttcaccatgt tagccaggat ggtctcgatc tcctgacctc
     3481 gtgatccacc tgccgcggcc tcccaaagtt ctaggattac tggcatgagc caccgtgcct
     3541 ggccagcaat tagaatttta acactggcag ttatgaataa tatgaaggag aggtagattt
     3601 ctgagtgatt ctggtttaac cagctgggtg gatggtggtt ccacgtattc aggtggcaaa
     3661 caggaaaaac atgtgttcga agaagaatgg aggtaggtgg tctcttaaga atggttaaga
     3721 ggcttgggag tcagactgct tgggtttgca tcccagcttt gccgttttct ggctatcaaa
     3781 cttgtcagct attatttgtt gagtacgtac tatttgattt atgaccacag gcagctgagc
     3841 ctcagtgttg gtgcctagtg tacaagattg ttaaagaata aagttatttt gcaaagtgta
     3901 acccattttt agcactgaca tagcactgac agtagctgct gatctcatta tgggctaaaa
     3961 taagacaata ttcaaaggtc agagatatct agccagaatc tgatggaggc tggatttcag
     4021 attttgttac agaattagac agaggaacac agaggggaca ggctcagtta gggtggaggt
     4081 gtggggtagg gaagcaggac ttgatataaa ttattggaat cattgtcttt taaaccagtg
     4141 gtttatgtca gggtatagcg tttcaaggga tttgagggtc agatggggaa atgtagcccc
     4201 ttattttgcc agtgtgaagc agataccctg cttttcttta cagtagcgga gtcagcttaa
     4261 gagctttaaa ggtcctaaac ttcaaaaaca ttacagtgcc ccatcctccg ccttaatgta
     4321 attcaaaata caaacaatac taaactgtaa aataaatgta acaaagtcca ataaagtttt
     4381 tatttttttc tcatga
//
