LOCUS       NM_178865               1900 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens serine incorporator 2 (SERINC2), transcript variant 1,
            mRNA.
ACCESSION   NM_178865
VERSION     NM_178865.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1900)
  AUTHORS   Wang,X., Jiang,C. and Li,Q.
  TITLE     Serinc2 Drives the Progression of Cervical Cancer Through
            Regulating Myc Pathway
  JOURNAL   Cancer Med 13 (19), e70296 (2024)
   PUBMED   39417376
  REMARK    GeneRIF: Serinc2 Drives the Progression of Cervical Cancer Through
            Regulating Myc Pathway.
REFERENCE   2  (bases 1 to 1900)
  AUTHORS   Leonhardt,S.A., Purdy,M.D., Grover,J.R., Yang,Z., Poulos,S.,
            McIntire,W.E., Tatham,E.A., Erramilli,S.K., Nosol,K., Lai,K.K.,
            Ding,S., Lu,M., Uchil,P.D., Finzi,A., Rein,A., Kossiakoff,A.A.,
            Mothes,W. and Yeager,M.
  TITLE     Antiviral HIV-1 SERINC restriction factors disrupt virus membrane
            asymmetry
  JOURNAL   Nat Commun 14 (1), 4368 (2023)
   PUBMED   37474505
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1900)
  AUTHORS   Yang,D., Chen,J., Cheng,X., Cao,B., Chang,H., Li,X., Yang,C.,
            Wu,Q., Sun,J., Manry,D., Pan,Y., Dong,Y., Li,J., Xu,T. and Cao,L.
  TITLE     SERINC2 increases the risk of bipolar disorder in the Chinese
            population
  JOURNAL   Depress Anxiety 38 (9), 985-995 (2021)
   PUBMED   34288243
  REMARK    GeneRIF: SERINC2 increases the risk of bipolar disorder in the
            Chinese population.
REFERENCE   4  (bases 1 to 1900)
  AUTHORS   Schulte,B., Selyutina,A., Opp,S., Herschhorn,A., Sodroski,J.G.,
            Pizzato,M. and Diaz-Griffero,F.
  TITLE     Localization to detergent-resistant membranes and HIV-1 core entry
            inhibition correlate with HIV-1 restriction by SERINC5
  JOURNAL   Virology 515, 52-65 (2018)
   PUBMED   29268082
  REMARK    GeneRIF: In contrast to human SERINC5(S5), we observed that human
            SERINC2(S2) did not restrict HIV-1, and was inefficiently
            incorporated into HIV-1 virions when compared to S5.
REFERENCE   5  (bases 1 to 1900)
  AUTHORS   Hnoonual,A., Thammachote,W., Tim-Aroon,T., Rojnueangnit,K.,
            Hansakunachai,T., Sombuntham,T., Roongpraiwan,R.,
            Worachotekamjorn,J., Chuthapisith,J., Fucharoen,S.,
            Wattanasirichaigoon,D., Ruangdaraganon,N., Limprasert,P. and
            Jinawath,N.
  TITLE     Chromosomal microarray analysis in a cohort of underrepresented
            population identifies SERINC2 as a novel candidate gene for autism
            spectrum disorder
  JOURNAL   Sci Rep 7 (1), 12096 (2017)
   PUBMED   28935972
  REMARK    GeneRIF: Results suggest that the serine incorporator 2 (SERINC2)
            gene is a novel autism spectrum disorder (ASD) candidate gene.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1900)
  AUTHORS   Zuo,L., Wang,K., Zhang,X.Y., Krystal,J.H., Li,C.S., Zhang,F.,
            Zhang,H. and Luo,X.
  TITLE     NKAIN1-SERINC2 is a functional, replicable and genome-wide
            significant risk gene region specific for alcohol dependence in
            subjects of European descent
  JOURNAL   Drug Alcohol Depend 129 (3), 254-264 (2013)
   PUBMED   23455491
  REMARK    GeneRIF: In subjects of European descent, SERINC2-NKAIN1 expression
            of genes is associated with alcohol dependence.
REFERENCE   7  (bases 1 to 1900)
  AUTHORS   Palmieri,M., Impey,S., Kang,H., di Ronza,A., Pelz,C., Sardiello,M.
            and Ballabio,A.
  TITLE     Characterization of the CLEAR network reveals an integrated control
            of cellular clearance pathways
  JOURNAL   Hum Mol Genet 20 (19), 3852-3866 (2011)
   PUBMED   21752829
  REMARK    GeneRIF: SERINC2 protein localizes in lysosomes in HeLa cells
REFERENCE   8  (bases 1 to 1900)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 1900)
  AUTHORS   Player,A., Gillespie,J., Fujii,T., Fukuoka,J., Dracheva,T.,
            Meerzaman,D., Hong,K.M., Curran,J., Attoh,G., Travis,W. and Jen,J.
  TITLE     Identification of TDE2 gene and its expression in non-small cell
            lung cancer
  JOURNAL   Int J Cancer 107 (2), 238-243 (2003)
   PUBMED   12949800
REFERENCE   10 (bases 1 to 1900)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY094595.1, BC084580.1, AK127659.1, BM924335.1 and BC007375.2.
            
            On Nov 22, 2018 this sequence version replaced NM_178865.4.
            
            Transcript Variant: This variant (1) is a predominant transcript
            and encodes isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY094595.1, SRR3476690.744633.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373709.8/ ENSP00000362813.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-439               AY094595.1         98-536
            440-1157            BC084580.1         425-1142
            1158-1476           AK127659.1         1395-1713
            1477-1896           BM924335.1         179-598
            1897-1900           BC007375.2         863-866
FEATURES             Location/Qualifiers
     source          1..1900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..1900
                     /gene="SERINC2"
                     /gene_synonym="FKSG84; PRO0899; TDE2; TDE2L"
                     /note="serine incorporator 2"
                     /db_xref="GeneID:347735"
                     /db_xref="HGNC:HGNC:23231"
                     /db_xref="MIM:614549"
     exon            1..92
                     /gene="SERINC2"
                     /gene_synonym="FKSG84; PRO0899; TDE2; TDE2L"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1421
                     /gene="SERINC2"
                     /gene_synonym="FKSG84; PRO0899; TDE2; TDE2L"
                     /note="isoform 1 is encoded by transcript variant 1; tumor
                     differentially expressed protein 2"
                     /codon_start=1
                     /product="serine incorporator 2 isoform 1"
                     /protein_id="NP_849196.2"
                     /db_xref="CCDS:CCDS30662.1"
                     /db_xref="GeneID:347735"
                     /db_xref="HGNC:HGNC:23231"
                     /db_xref="MIM:614549"
                     /translation="MGACLGACSLLSCASCLCGSAPCILCSCCPASRNSTVSRLIFTF
                     FLFLGVLVSIIMLSPGVESQLYKLPWVCEEGAGIPTVLQGHIDCGSLLGYRAVYRMCF
                     ATAAFFFFFTLLMLCVSSSRDPRAAIQNGFWFFKFLILVGLTVGAFYIPDGSFTNIWF
                     YFGVVGSFLFILIQLVLLIDFAHSWNQRWLGKAEECDSRAWYAGLFFFTLLFYLLSIA
                     AVALMFMYYTEPSGCHEGKVFISLNLTFCVCVSIAAVLPKVQDAQPNSGLLQASVITL
                     YTMFVTWSALSSIPEQKCNPHLPTQLGNETVVAGPEGYETQWWDAPSIVGLIIFLLCT
                     LFISLRSSDHRQVNSLMQTEECPPMLDATQQQQQVAACEGRAFDNEQDGVTYSYSFFH
                     FCLVLASLHVMMTLTNWYKPGETRKMISTWTAVWVKICASWAGLLLYLWTLVAPLLLR
                     NRDFS"
     exon            93..254
                     /gene="SERINC2"
                     /gene_synonym="FKSG84; PRO0899; TDE2; TDE2L"
                     /inference="alignment:Splign:2.1.0"
     exon            255..445
                     /gene="SERINC2"
                     /gene_synonym="FKSG84; PRO0899; TDE2; TDE2L"
                     /inference="alignment:Splign:2.1.0"
     exon            446..525
                     /gene="SERINC2"
                     /gene_synonym="FKSG84; PRO0899; TDE2; TDE2L"
                     /inference="alignment:Splign:2.1.0"
     exon            526..663
                     /gene="SERINC2"
                     /gene_synonym="FKSG84; PRO0899; TDE2; TDE2L"
                     /inference="alignment:Splign:2.1.0"
     exon            664..833
                     /gene="SERINC2"
                     /gene_synonym="FKSG84; PRO0899; TDE2; TDE2L"
                     /inference="alignment:Splign:2.1.0"
     exon            834..924
                     /gene="SERINC2"
                     /gene_synonym="FKSG84; PRO0899; TDE2; TDE2L"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1066
                     /gene="SERINC2"
                     /gene_synonym="FKSG84; PRO0899; TDE2; TDE2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1285
                     /gene="SERINC2"
                     /gene_synonym="FKSG84; PRO0899; TDE2; TDE2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1900
                     /gene="SERINC2"
                     /gene_synonym="FKSG84; PRO0899; TDE2; TDE2L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1876..1881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERINC2"
                     /gene_synonym="FKSG84; PRO0899; TDE2; TDE2L"
                     /note="hexamer: AATAAA"
     polyA_site      1900
                     /gene="SERINC2"
                     /gene_synonym="FKSG84; PRO0899; TDE2; TDE2L"
                     /note="major polyA site"
ORIGIN      
        1 gaggtccgcg ccccgcgccc ggcgccgggc gcccgaagcc gggagccgcc gccatggggg
       61 cctgcctggg agcctgctcc ctgctcagct gcgcgtcctg cctctgcggc tctgccccct
      121 gcatcctgtg cagctgctgc cccgccagcc gcaactccac cgtgagccgc ctcatcttca
      181 cgttcttcct cttcctgggg gtgctggtgt ccatcattat gctgagcccg ggcgtggaga
      241 gtcagctcta caagctgccc tgggtgtgtg aggagggggc cgggatcccc accgtcctgc
      301 agggccacat cgactgtggc tccctgcttg gctaccgcgc tgtctaccgc atgtgcttcg
      361 ccacggcggc cttcttcttc tttttcaccc tgctcatgct ctgcgtgagc agcagccggg
      421 acccccgggc tgccatccag aatgggtttt ggttctttaa gttcctgatc ctggtgggcc
      481 tcaccgtggg tgccttctac attcctgacg gctccttcac caacatctgg ttctacttcg
      541 gcgtcgtggg ctccttcctc ttcatcctca tccagctggt gctgctcatc gactttgcgc
      601 actcctggaa ccagcggtgg ctgggcaagg ccgaggagtg cgattcccgt gcctggtacg
      661 caggcctctt cttcttcact ctcctcttct acttgctgtc gatcgcggcc gtggcgctga
      721 tgttcatgta ctacactgag cccagcggct gccacgaggg caaggtcttc atcagcctca
      781 acctcacctt ctgtgtctgc gtgtccatcg ctgctgtcct gcccaaggtc caggacgccc
      841 agcccaactc gggtctgctg caggcctcgg tcatcaccct ctacaccatg tttgtcacct
      901 ggtcagccct atccagtatc cctgaacaga aatgcaaccc ccatttgcca acccagctgg
      961 gcaacgagac agttgtggca ggccccgagg gctatgagac ccagtggtgg gatgccccga
     1021 gcattgtggg cctcatcatc ttcctcctgt gcaccctctt catcagtctg cgctcctcag
     1081 accaccggca ggtgaacagc ctgatgcaga ccgaggagtg cccacctatg ctagacgcca
     1141 cacagcagca gcagcaggtg gcagcctgtg agggccgggc ctttgacaac gagcaggacg
     1201 gcgtcaccta cagctactcc ttcttccact tctgcctggt gctggcctca ctgcacgtca
     1261 tgatgacgct caccaactgg tacaagcccg gtgagacccg gaagatgatc agcacgtgga
     1321 ccgccgtgtg ggtgaagatc tgtgccagct gggcagggct gctcctctac ctgtggaccc
     1381 tggtagcccc actcctcctg cgcaaccgcg acttcagctg aggcagcctc acagcctgcc
     1441 atctggtgcc tcctgccacc tggtgcctct cggctcagtg acagccaacc tgccccctcc
     1501 ccacaccaat cagccaggct gagcccccac ccctgcccca gctccaggac ctgcccctga
     1561 gccgggcctt ctagtcgtag tgccttcagg gtccgaggag catcaggctc ctgcagagcc
     1621 ccatcccccc gccacaccca cacggtggag ctgcctcttc cttcccctcc tccctgttgc
     1681 ccatactcag catctcggat gaaagggctc ccttgtcctc aggctccacg ggagcggggc
     1741 tgctggagag agcggggaac tcccaccaca gtggggcatc cggcactgaa gccctggtgt
     1801 tcctggtcac gtcccccagg ggaccctgcc cacttcctgg acttcgtgcc ttactgagtc
     1861 tctaagactt tttctaataa acaagccagt gcgtgtacca
//
