LOCUS       NP_849196                455 aa            linear   PRI 20-FEB-2025
DEFINITION  serine incorporator 2 isoform 1 [Homo sapiens].
ACCESSION   NP_849196
VERSION     NP_849196.2
DBSOURCE    REFSEQ: accession NM_178865.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 455)
  AUTHORS   Wang,X., Jiang,C. and Li,Q.
  TITLE     Serinc2 Drives the Progression of Cervical Cancer Through
            Regulating Myc Pathway
  JOURNAL   Cancer Med 13 (19), e70296 (2024)
   PUBMED   39417376
  REMARK    GeneRIF: Serinc2 Drives the Progression of Cervical Cancer Through
            Regulating Myc Pathway.
REFERENCE   2  (residues 1 to 455)
  AUTHORS   Leonhardt,S.A., Purdy,M.D., Grover,J.R., Yang,Z., Poulos,S.,
            McIntire,W.E., Tatham,E.A., Erramilli,S.K., Nosol,K., Lai,K.K.,
            Ding,S., Lu,M., Uchil,P.D., Finzi,A., Rein,A., Kossiakoff,A.A.,
            Mothes,W. and Yeager,M.
  TITLE     Antiviral HIV-1 SERINC restriction factors disrupt virus membrane
            asymmetry
  JOURNAL   Nat Commun 14 (1), 4368 (2023)
   PUBMED   37474505
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 455)
  AUTHORS   Yang,D., Chen,J., Cheng,X., Cao,B., Chang,H., Li,X., Yang,C.,
            Wu,Q., Sun,J., Manry,D., Pan,Y., Dong,Y., Li,J., Xu,T. and Cao,L.
  TITLE     SERINC2 increases the risk of bipolar disorder in the Chinese
            population
  JOURNAL   Depress Anxiety 38 (9), 985-995 (2021)
   PUBMED   34288243
  REMARK    GeneRIF: SERINC2 increases the risk of bipolar disorder in the
            Chinese population.
REFERENCE   4  (residues 1 to 455)
  AUTHORS   Schulte,B., Selyutina,A., Opp,S., Herschhorn,A., Sodroski,J.G.,
            Pizzato,M. and Diaz-Griffero,F.
  TITLE     Localization to detergent-resistant membranes and HIV-1 core entry
            inhibition correlate with HIV-1 restriction by SERINC5
  JOURNAL   Virology 515, 52-65 (2018)
   PUBMED   29268082
  REMARK    GeneRIF: In contrast to human SERINC5(S5), we observed that human
            SERINC2(S2) did not restrict HIV-1, and was inefficiently
            incorporated into HIV-1 virions when compared to S5.
REFERENCE   5  (residues 1 to 455)
  AUTHORS   Hnoonual,A., Thammachote,W., Tim-Aroon,T., Rojnueangnit,K.,
            Hansakunachai,T., Sombuntham,T., Roongpraiwan,R.,
            Worachotekamjorn,J., Chuthapisith,J., Fucharoen,S.,
            Wattanasirichaigoon,D., Ruangdaraganon,N., Limprasert,P. and
            Jinawath,N.
  TITLE     Chromosomal microarray analysis in a cohort of underrepresented
            population identifies SERINC2 as a novel candidate gene for autism
            spectrum disorder
  JOURNAL   Sci Rep 7 (1), 12096 (2017)
   PUBMED   28935972
  REMARK    GeneRIF: Results suggest that the serine incorporator 2 (SERINC2)
            gene is a novel autism spectrum disorder (ASD) candidate gene.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 455)
  AUTHORS   Zuo,L., Wang,K., Zhang,X.Y., Krystal,J.H., Li,C.S., Zhang,F.,
            Zhang,H. and Luo,X.
  TITLE     NKAIN1-SERINC2 is a functional, replicable and genome-wide
            significant risk gene region specific for alcohol dependence in
            subjects of European descent
  JOURNAL   Drug Alcohol Depend 129 (3), 254-264 (2013)
   PUBMED   23455491
  REMARK    GeneRIF: In subjects of European descent, SERINC2-NKAIN1 expression
            of genes is associated with alcohol dependence.
REFERENCE   7  (residues 1 to 455)
  AUTHORS   Palmieri,M., Impey,S., Kang,H., di Ronza,A., Pelz,C., Sardiello,M.
            and Ballabio,A.
  TITLE     Characterization of the CLEAR network reveals an integrated control
            of cellular clearance pathways
  JOURNAL   Hum Mol Genet 20 (19), 3852-3866 (2011)
   PUBMED   21752829
  REMARK    GeneRIF: SERINC2 protein localizes in lysosomes in HeLa cells
REFERENCE   8  (residues 1 to 455)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (residues 1 to 455)
  AUTHORS   Player,A., Gillespie,J., Fujii,T., Fukuoka,J., Dracheva,T.,
            Meerzaman,D., Hong,K.M., Curran,J., Attoh,G., Travis,W. and Jen,J.
  TITLE     Identification of TDE2 gene and its expression in non-small cell
            lung cancer
  JOURNAL   Int J Cancer 107 (2), 238-243 (2003)
   PUBMED   12949800
REFERENCE   10 (residues 1 to 455)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY094595.1, BC084580.1, AK127659.1, BM924335.1 and BC007375.2.
            
            On Aug 5, 2005 this sequence version replaced NP_849196.1.
            
            Transcript Variant: This variant (1) is a predominant transcript
            and encodes isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY094595.1, SRR3476690.744633.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373709.8/ ENSP00000362813.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     Protein         1..455
                     /product="serine incorporator 2 isoform 1"
                     /note="tumor differentially expressed protein 2"
                     /calculated_mol_wt=50612
     Site            5..27
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96SA4.3)"
     Region          15..452
                     /region_name="Serinc"
                     /note="Serine incorporator (Serinc); pfam03348"
                     /db_xref="CDD:460891"
     Site            40..57
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96SA4.3)"
     Site            96..118
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96SA4.3)"
     Site            131..150
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96SA4.3)"
     Site            160..182
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96SA4.3)"
     Site            202..224
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96SA4.3)"
     Site            239..256
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96SA4.3)"
     Site            268..290
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96SA4.3)"
     Site            317..339
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96SA4.3)"
     Site            385..407
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96SA4.3)"
     Site            422..444
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96SA4.3)"
     CDS             1..455
                     /gene="SERINC2"
                     /gene_synonym="FKSG84; PRO0899; TDE2; TDE2L"
                     /coded_by="NM_178865.5:54..1421"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS30662.1"
                     /db_xref="GeneID:347735"
                     /db_xref="HGNC:HGNC:23231"
                     /db_xref="MIM:614549"
ORIGIN      
        1 mgaclgacsl lscasclcgs apcilcsccp asrnstvsrl iftfflflgv lvsiimlspg
       61 vesqlyklpw vceegagipt vlqghidcgs llgyravyrm cfataaffff ftllmlcvss
      121 srdpraaiqn gfwffkflil vgltvgafyi pdgsftniwf yfgvvgsflf iliqlvllid
      181 fahswnqrwl gkaeecdsra wyaglffftl lfyllsiaav almfmyytep sgchegkvfi
      241 slnltfcvcv siaavlpkvq daqpnsgllq asvitlytmf vtwsalssip eqkcnphlpt
      301 qlgnetvvag pegyetqwwd apsivgliif llctlfislr ssdhrqvnsl mqteecppml
      361 datqqqqqva acegrafdne qdgvtysysf fhfclvlasl hvmmtltnwy kpgetrkmis
      421 twtavwvkic aswaglllyl wtlvaplllr nrdfs
//
