LOCUS       NM_020755               3125 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens serine incorporator 1 (SERINC1), mRNA.
ACCESSION   NM_020755
VERSION     NM_020755.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3125)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3125)
  AUTHORS   Miyamoto-Sato,E., Fujimori,S., Ishizaka,M., Hirai,N., Masuoka,K.,
            Saito,R., Ozawa,Y., Hino,K., Washio,T., Tomita,M., Yamashita,T.,
            Oshikubo,T., Akasaka,H., Sugiyama,J., Matsumoto,Y. and Yanagawa,H.
  TITLE     A comprehensive resource of interacting protein regions for
            refining human transcription factor networks
  JOURNAL   PLoS One 5 (2), e9289 (2010)
   PUBMED   20195357
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3125)
  AUTHORS   Vieira,A.R., McHenry,T.G., Daack-Hirsch,S., Murray,J.C. and
            Marazita,M.L.
  TITLE     Candidate gene/loci studies in cleft lip/palate and dental
            anomalies finds novel susceptibility genes for clefts
  JOURNAL   Genet Med 10 (9), 668-674 (2008)
   PUBMED   18978678
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3125)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   5  (bases 1 to 3125)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   6  (bases 1 to 3125)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   7  (bases 1 to 3125)
  AUTHORS   Grossman,T.R., Luque,J.M. and Nelson,N.
  TITLE     Identification of a ubiquitous family of membrane proteins and
            their expression in mouse brain
  JOURNAL   J Exp Biol 203 (Pt 3), 447-457 (2000)
   PUBMED   10637174
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC033029.2, AY358429.1 and AF087902.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020755.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033029.2, AF087902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467147 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339697.5/ ENSP00000342962.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1672              BC033029.2         1-1672
            1673-1803           AY358429.1         1690-1820
            1804-2594           BC033029.2         1804-2594
            2595-2595           AF087902.1         2669-2669
            2596-3125           BC033029.2         2596-3125
FEATURES             Location/Qualifiers
     source          1..3125
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.31"
     gene            1..3125
                     /gene="SERINC1"
                     /gene_synonym="TDE1L; TDE2; TMS-2; TMS2"
                     /note="serine incorporator 1"
                     /db_xref="GeneID:57515"
                     /db_xref="HGNC:HGNC:13464"
                     /db_xref="MIM:614548"
     exon            1..109
                     /gene="SERINC1"
                     /gene_synonym="TDE1L; TDE2; TMS-2; TMS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1432
                     /gene="SERINC1"
                     /gene_synonym="TDE1L; TDE2; TMS-2; TMS2"
                     /note="tumor differentially expressed protein 2"
                     /codon_start=1
                     /product="serine incorporator 1"
                     /protein_id="NP_065806.1"
                     /db_xref="CCDS:CCDS5125.1"
                     /db_xref="GeneID:57515"
                     /db_xref="HGNC:HGNC:13464"
                     /db_xref="MIM:614548"
                     /translation="MGSVLGLCSMASWIPCLCGSAPCLLCRCCPSGNNSTVTRLIYAL
                     FLLVGVCVACVMLIPGMEEQLNKIPGFCENEKGVVPCNILVGYKAVYRLCFGLAMFYL
                     LLSLLMIKVKSSSDPRAAVHNGFWFFKFAAAIAIIIGAFFIPEGTFTTVWFYVGMAGA
                     FCFILIQLVLLIDFAHSWNESWVEKMEEGNSRCWYAALLSATALNYLLSLVAIVLFFV
                     YYTHPASCSENKAFISVNMLLCVGASVMSILPKIQESQPRSGLLQSSVITVYTMYLTW
                     SAMTNEPETNCNPSLLSIIGYNTTSTVPKEGQSVQWWHAQGIIGLILFLLCVFYSSIR
                     TSNNSQVNKLTLTSDESTLIEDGGARSDGSLEDGDDVHRAVDNERDGVTYSYSFFHFM
                     LFLASLYIMMTLTNWYRYEPSREMKSQWTAVWVKISSSWIGIVLYVWTLVAPLVLTNR
                     DFD"
     exon            110..271
                     /gene="SERINC1"
                     /gene_synonym="TDE1L; TDE2; TMS-2; TMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            272..441
                     /gene="SERINC1"
                     /gene_synonym="TDE1L; TDE2; TMS-2; TMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            442..521
                     /gene="SERINC1"
                     /gene_synonym="TDE1L; TDE2; TMS-2; TMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..659
                     /gene="SERINC1"
                     /gene_synonym="TDE1L; TDE2; TMS-2; TMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            660..829
                     /gene="SERINC1"
                     /gene_synonym="TDE1L; TDE2; TMS-2; TMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            830..920
                     /gene="SERINC1"
                     /gene_synonym="TDE1L; TDE2; TMS-2; TMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1065
                     /gene="SERINC1"
                     /gene_synonym="TDE1L; TDE2; TMS-2; TMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1296
                     /gene="SERINC1"
                     /gene_synonym="TDE1L; TDE2; TMS-2; TMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..3125
                     /gene="SERINC1"
                     /gene_synonym="TDE1L; TDE2; TMS-2; TMS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3106..3111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERINC1"
                     /gene_synonym="TDE1L; TDE2; TMS-2; TMS2"
                     /note="hexamer: AATAAA"
     polyA_site      3125
                     /gene="SERINC1"
                     /gene_synonym="TDE1L; TDE2; TMS-2; TMS2"
                     /note="major polyA site"
ORIGIN      
        1 aatctcggaa aggcgagaaa gaagctgtct ccatcttgtc tgtatccgct gctcttgtga
       61 cgttgtggag atggggagcg tcctggggct gtgctccatg gcgagctgga taccatgttt
      121 gtgtggaagt gccccgtgtt tgctatgccg atgctgtcct agtggaaaca actccactgt
      181 aactagattg atctatgcac ttttcttgct tgttggagta tgtgtagctt gtgtaatgtt
      241 gataccagga atggaagaac aactgaataa gattcctgga ttttgtgaga atgagaaagg
      301 tgttgtccct tgtaacattt tggttggcta taaagctgta tatcgtttgt gctttggttt
      361 ggctatgttc tatcttcttc tctctttact aatgatcaaa gtgaagagta gcagtgatcc
      421 tagagctgca gtgcacaatg gattttggtt ctttaaattt gctgcagcaa ttgcaattat
      481 tattggggca ttcttcattc cagaaggaac ttttacaact gtgtggtttt atgtaggcat
      541 ggcaggtgcc ttttgtttca tcctcataca actagtctta cttattgatt ttgcacattc
      601 atggaatgaa tcgtgggttg aaaaaatgga agaagggaac tcgagatgtt ggtatgcagc
      661 cttgttatca gctacagctc tgaattatct gctgtcttta gttgctatcg tcctgttctt
      721 tgtctactac actcatccag ccagttgttc agaaaacaag gcgttcatca gtgtcaacat
      781 gctcctctgc gttggtgctt ctgtaatgtc tatactgcca aaaatccaag aatcacaacc
      841 aagatctggt ttgttacagt cttcagtaat tacagtctac acaatgtatt tgacatggtc
      901 agctatgacc aatgaaccag aaacaaattg caacccaagt ctactaagca taattggcta
      961 caatacaaca agcactgtcc caaaggaagg gcagtcagtc cagtggtggc atgctcaagg
     1021 aattatagga ctaattctct ttttgttgtg tgtattttat tccagcatcc gtacttcaaa
     1081 caatagtcag gttaataaac tgactctaac aagtgatgaa tctacattaa tagaagatgg
     1141 tggagctaga agtgatggat cactggagga tggggacgat gttcaccgag ctgtagataa
     1201 tgaaagggat ggtgtcactt acagttattc cttctttcac ttcatgcttt tcctggcttc
     1261 actttatatc atgatgaccc ttaccaactg gtacaggtat gaaccctctc gtgagatgaa
     1321 aagtcagtgg acagctgtct gggtgaaaat ctcttccagt tggattggca tcgtgctgta
     1381 tgtttggaca ctcgtggcac cacttgttct tacaaatcgt gattttgact gagtgagact
     1441 tctagcatga aagtcccact ttgattattg cttatttgaa aacagtattc ccaacttttg
     1501 taaagttgtg tatgtttttg cttcccatgt aacttctcca gtgttctggc atgaattaga
     1561 ttttactgct tgtcattttg ttattttctt accaagtgca ttgatatgtg aagtagaatg
     1621 aattgcagag gaaagtttta tgaatatggt gatgagttag taaaagtggc cattattggg
     1681 cttattctct gctctatagt tgtgaaatga agagtaaaaa caaatttgtt tgactatttt
     1741 aaaattatat tagaccttaa gctgttttag caagcattaa agcaaatgta tggctgcctt
     1801 ttgaaatatt tgatgtgttg cctggcagga tactgcaaag aacatggttt attttaaaat
     1861 ttataaacaa gtcacttaaa tgccagttgt ctgaaaaatc ttataaggtt ttacccttga
     1921 tacggaattt acacaggtag ggagtgttta gtggacaata gtgtaggtta tggatggagg
     1981 tgtcggtact aaattgaata acgagtaaat aatcttactt gggtagagat ggcctttgcc
     2041 aacaaagtga actgttttgg ttgttttaaa ctcatgaagt atgggttcag tggaaatgtt
     2101 tggaactctg aaggatttag acaaggtttt gaaaaggata atcatgggtt agaaggaagt
     2161 gtttgaaagt cactttgaaa gttagttttg ggccagcacg gtagctcacc cttgtaatcc
     2221 cagcactttg ggaggctgag gtgggtagat tacttgagcc caggaattca agaccagcct
     2281 gggcaacatg gtgaaaccct gtttctataa aaaataatct gggctttgta gcatatgcct
     2341 gtggtcccag ctactgagga ggctgaggtg ggaggattgc ttgagcccag gaggcagagg
     2401 ttgcagtgag ccaaggtcac gtcactgcac tctagcctgg gcaacagagt aagacaaaaa
     2461 aatatatata tattgaaaat caaaggaggc aaaattttga cagggaagga agtaactgca
     2521 aaacactagg ctttagtagg tacttatata aaatctagtc cagttctctc atttaaaaaa
     2581 atgaagacac tgaaatacag acttaaatag ctcagatagc taattaggaa atttcaagtt
     2641 ggccaataat agcattctct ctgacattta aaaataattt ctattcaaaa tacatgcata
     2701 attgatttta cacctcatta ctggtggata atttatgtga tgtggattgc tggtgtccag
     2761 catgacccat aaacaggtca gaagaatgat ggaatgtttt agaataaact cctgcttata
     2821 gtatactaca cagttcaaaa gatgtttaaa atgcttttgt atttactgcc atgtaattga
     2881 aatatataga ttattgtaac ctttcaacct gaaaatcaag cagtatgaga gtttagttat
     2941 ttgtatgtgt cactagtgtc taatgaagct tttaaaatct acaatttctt ctttaaaaat
     3001 atttattaat gtgaatggaa tataacaatt cagcttaatt ccccaacctt attctgtgtg
     3061 tagacattgt attccacaat tttgaatggc tgtgttttac ctctaaataa atgaattcag
     3121 agaaa
//
