LOCUS       NM_014509               1337 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens serine hydrolase like 2 (SERHL2), transcript variant
            1, mRNA.
ACCESSION   NM_014509
VERSION     NM_014509.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1337)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1337)
  AUTHORS   Sadusky,T.J., Kemp,T.J., Simon,M., Carey,N. and Coulton,G.R.
  TITLE     Identification of Serhl, a new member of the serine hydrolase
            family induced by passive stretch of skeletal muscle in vivo
  JOURNAL   Genomics 73 (1), 38-49 (2001)
   PUBMED   11352564
  REMARK    Erratum:[Genomics 2001 Jun 1;74(2):251]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450314.1 and AW134760.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014509.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL450314.1, HM005629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327678.10/ ENSP00000331376.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1003              AL450314.1         38-1040
            1004-1337           AW134760.1         17-350              c
FEATURES             Location/Qualifiers
     source          1..1337
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..1337
                     /gene="SERHL2"
                     /gene_synonym="dJ222E13.1"
                     /note="serine hydrolase like 2"
                     /db_xref="GeneID:253190"
                     /db_xref="HGNC:HGNC:29446"
                     /db_xref="MIM:619045"
     exon            1..87
                     /gene="SERHL2"
                     /gene_synonym="dJ222E13.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1010
                     /gene="SERHL2"
                     /gene_synonym="dJ222E13.1"
                     /note="isoform a is encoded by transcript variant 1;
                     serine hydrolase-like protein 2; testis secretory
                     sperm-binding protein Li 216e"
                     /codon_start=1
                     /product="serine hydrolase-like protein 2 isoform a"
                     /protein_id="NP_055324.2"
                     /db_xref="CCDS:CCDS14037.1"
                     /db_xref="GeneID:253190"
                     /db_xref="HGNC:HGNC:29446"
                     /db_xref="MIM:619045"
                     /translation="MSENAAPGLISELKLAVPWGHIAAKAWGSLQGPPVLCLHGWLDN
                     ASSFDRLIPLLPQDFYYVAMDFGGHGLSSHYSPGVPYYLQTFVSEIRRVVAALKWNRF
                     SILGHSFGGVVGGMFFCTFPEMVDKLILLDTPLFLLESDEMENLLTYKRRAIEHVLQV
                     EASQEPSHVFSLKQLLQRLLKSNSHLSEECGELLLQRGTTKVATGLVLNRDQRLAWAE
                     NSIDFISRELCAHSIRKLQAHVLLIKAVHGYFDSRQNYSEKESLSFMIDTMKSTLKEQ
                     FQFVEVPGNHCVHMSEPQHVASIISSFLQCTHMLPAQL"
     exon            88..237
                     /gene="SERHL2"
                     /gene_synonym="dJ222E13.1"
                     /inference="alignment:Splign:2.1.0"
     exon            238..351
                     /gene="SERHL2"
                     /gene_synonym="dJ222E13.1"
                     /inference="alignment:Splign:2.1.0"
     exon            352..393
                     /gene="SERHL2"
                     /gene_synonym="dJ222E13.1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..413
                     /gene="SERHL2"
                     /gene_synonym="dJ222E13.1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..488
                     /gene="SERHL2"
                     /gene_synonym="dJ222E13.1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..598
                     /gene="SERHL2"
                     /gene_synonym="dJ222E13.1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..678
                     /gene="SERHL2"
                     /gene_synonym="dJ222E13.1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..713
                     /gene="SERHL2"
                     /gene_synonym="dJ222E13.1"
                     /inference="alignment:Splign:2.1.0"
     exon            714..796
                     /gene="SERHL2"
                     /gene_synonym="dJ222E13.1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..890
                     /gene="SERHL2"
                     /gene_synonym="dJ222E13.1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1337
                     /gene="SERHL2"
                     /gene_synonym="dJ222E13.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1315..1320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERHL2"
                     /gene_synonym="dJ222E13.1"
                     /note="hexamer: AATAAA"
     polyA_site      1337
                     /gene="SERHL2"
                     /gene_synonym="dJ222E13.1"
                     /note="major polyA site"
ORIGIN      
        1 actctgctcc tgcgacctag ccaggcgtga gggagtgaca gcagcgcatt cgcgggacga
       61 gagcgatgag tgagaacgcc gcaccaggtc tgatctcaga gctgaagctg gctgtgccct
      121 ggggccacat cgcagccaaa gcctggggct ccctgcaggg ccctccagtt ctctgcctgc
      181 acggctggct ggacaatgcc agctccttcg acagactcat ccctcttctc ccgcaagact
      241 tttattacgt tgccatggat ttcggaggtc atgggctctc gtcccattac agcccaggtg
      301 tcccatatta cctccagact tttgtgagtg agatccgaag agttgtggca gccttgaaat
      361 ggaatcgatt ctccattctg ggccacagct tcggtggcgt cgtgggcgga atgtttttct
      421 gtaccttccc cgagatggtg gataaactta tcttgctgga cacgccgctc tttctcctgg
      481 aatcagatga aatggagaac ttgctgacct acaagcggag agccatagag cacgtgctgc
      541 aggtagaggc ctcccaggag ccctcgcacg tgttcagcct gaagcagctg ctgcagaggt
      601 tactgaagag caatagccac ttgagtgagg agtgcgggga gcttctcctg caaagaggaa
      661 ccacgaaggt ggccacaggt ctggttctga acagagacca gaggctcgcc tgggcagaga
      721 acagcattga cttcatcagc agggagctgt gtgcgcattc catcaggaag ctgcaggccc
      781 atgtcctgtt gatcaaagca gtccacggat attttgattc aagacagaat tactctgaga
      841 aggagtccct gtcgttcatg atagacacga tgaaatccac cctcaaagag cagttccagt
      901 ttgtggaagt cccaggcaat cactgtgtcc acatgagcga accccagcac gtggccagta
      961 tcatcagctc cttcttacag tgcacacaca tgctcccagc ccagctgtag ctctgggcct
     1021 ggaactatga agacctagtg ctcccagact caacactggg actctgagtt cctgagcccc
     1081 acaacaaggc cagggatggt ggggacaggc ctcactagtc ttgaggccca gcctaggatg
     1141 gtagtcaggg gaaggagcga gattccaact tcaacatctg tgacctcaag ggggagacag
     1201 agtctgggtt ccagggctgc tttctcctgg ctaataataa atatccagcc agctggagga
     1261 aggaagggca ggctgggccc acctagcctt tccctgctgc ccaactggat ggaaaataaa
     1321 aggttcttgt attctca
//
