LOCUS       NM_012139               1451 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens secretion regulating guanine nucleotide exchange
            factor (SERGEF), transcript variant 1, mRNA.
ACCESSION   NM_012139
VERSION     NM_012139.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1451)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1451)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1451)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1451)
  AUTHORS   Weimann,M., Grossmann,A., Woodsmith,J., Ozkan,Z., Birth,P.,
            Meierhofer,D., Benlasfer,N., Valovka,T., Timmermann,B.,
            Wanker,E.E., Sauer,S. and Stelzl,U.
  TITLE     A Y2H-seq approach defines the human protein methyltransferase
            interactome
  JOURNAL   Nat Methods 10 (4), 339-342 (2013)
   PUBMED   23455924
REFERENCE   5  (bases 1 to 1451)
  AUTHORS   Sjolinder,M., Uhlmann,J. and Ponstingl,H.
  TITLE     Characterisation of an evolutionary conserved protein interacting
            with the putative guanine nucleotide exchange factor DelGEF and
            modulating secretion
  JOURNAL   Exp Cell Res 294 (1), 68-76 (2004)
   PUBMED   14980502
REFERENCE   6  (bases 1 to 1451)
  AUTHORS   Sjolinder,M., Uhlmann,J. and Ponstingl,H.
  TITLE     DelGEF, a homologue of the Ran guanine nucleotide exchange factor
            RanGEF, binds to the exocyst component Sec5 and modulates secretion
  JOURNAL   FEBS Lett 532 (1-2), 211-215 (2002)
   PUBMED   12459492
  REMARK    GeneRIF: DelGEF binds to the human homologue of Sec5 and modulates
            secretion.
REFERENCE   7  (bases 1 to 1451)
  AUTHORS   Uhlmann,J., Wiemann,S. and Ponstingl,H.
  TITLE     DelGEF, an RCC1-related protein encoded by a gene on chromosome
            11p14 critical for two forms of hereditary deafness
  JOURNAL   FEBS Lett 460 (1), 153-160 (1999)
   PUBMED   10571079
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK292286.1 and BC065375.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012139.3.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065375.1, AK292286.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265965.10/ ENSP00000265965.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1017              AK292286.1         116-1132
            1018-1451           BC065375.1         1113-1546
FEATURES             Location/Qualifiers
     source          1..1451
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..1451
                     /gene="SERGEF"
                     /gene_synonym="DELGEF; Gnefr"
                     /note="secretion regulating guanine nucleotide exchange
                     factor"
                     /db_xref="GeneID:26297"
                     /db_xref="HGNC:HGNC:17499"
                     /db_xref="MIM:606051"
     exon            1..97
                     /gene="SERGEF"
                     /gene_synonym="DELGEF; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1414
                     /gene="SERGEF"
                     /gene_synonym="DELGEF; Gnefr"
                     /note="deafness locus associated putative guanine
                     nucleotide exchange factor; guanine nucleotide exchange
                     factor-related protein"
                     /codon_start=1
                     /product="secretion-regulating guanine nucleotide exchange
                     factor"
                     /protein_id="NP_036271.1"
                     /db_xref="CCDS:CCDS7828.1"
                     /db_xref="GeneID:26297"
                     /db_xref="HGNC:HGNC:17499"
                     /db_xref="MIM:606051"
                     /translation="MEREPSASEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLND
                     FCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCP
                     IQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAA
                     GLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVL
                     AGSDHSASLTDAGEVYVWGSNKHGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTH
                     LVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG
                     ATEVSCGSEHNLAIIGGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCG
                     AGHSLALCQLPAHPALVQDPKVTYLSPDAIEDTESQKAMDKERNWKERQSETSTQSQS
                     DWSRNGGL"
     exon            98..233
                     /gene="SERGEF"
                     /gene_synonym="DELGEF; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            234..389
                     /gene="SERGEF"
                     /gene_synonym="DELGEF; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            390..484
                     /gene="SERGEF"
                     /gene_synonym="DELGEF; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            485..545
                     /gene="SERGEF"
                     /gene_synonym="DELGEF; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            546..659
                     /gene="SERGEF"
                     /gene_synonym="DELGEF; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            660..722
                     /gene="SERGEF"
                     /gene_synonym="DELGEF; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            723..881
                     /gene="SERGEF"
                     /gene_synonym="DELGEF; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1048
                     /gene="SERGEF"
                     /gene_synonym="DELGEF; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1085
                     /gene="SERGEF"
                     /gene_synonym="DELGEF; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1451
                     /gene="SERGEF"
                     /gene_synonym="DELGEF; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1427..1432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERGEF"
                     /gene_synonym="DELGEF; Gnefr"
                     /note="hexamer: AATAAA"
     polyA_site      1451
                     /gene="SERGEF"
                     /gene_synonym="DELGEF; Gnefr"
                     /note="major polyA site"
ORIGIN      
        1 gccgtccctc ccggaagcgc cggcggagcg tcctcgcatg gagcgcgagc ccagcgcctc
       61 ggaggccgcc cccgcggcgg ccgcgctctt cgcctggggt gcaaatagct atgggcaact
      121 tggcctcggc cataaggaag atgtgctgtt gccccagcaa ctgaatgact tctgtaaacc
      181 caggagtgtc aggaggatca caggaggagg gggccactct gcagttgtca cagatggagg
      241 agacctcttt gtttgtggcc tgaacaaaga tgggcaactg gggcttggtc acacagagga
      301 tatcccatat tttaccccct gcaaatccct ctttggctgt cccatccaac aggtggcctg
      361 tggctgggat tttacgatta tgctcacaga aaatggtcaa gttctatcat gtggatccaa
      421 ctcctttggc cagttaggag ttcctcatgg acctcgaaga tgtgtggttc cccaggccat
      481 tgagctccat aaagagaagg ttgtttgtat tgctgctgga ctgaggcatg cagtagctgc
      541 tacagcgagt ggcatcgtgt tccagtgggg gactggtttg gcatcatgtg gacgacggtt
      601 gtgccctggg cagactcttc cattgttttt cacagcaaag gaaccaagca gagtgacagg
      661 tctagagaat tctaaagcaa tgtgtgttct tgctggctca gaccactcag cttcattaac
      721 agatgcagga gaggtgtatg tttggggaag caacaagcat gggcaactgg ctaatgaggc
      781 tgctttcctt cctgtgcccc agaaaataga agcacattgt ttccagaatg aaaaggtcac
      841 tgccatctgg agtggatgga cacacctggt tgctcagaca gaaactggca agatgtttac
      901 ctggggccga gcagactatg gtcagctagg gaggaagttg gagacttatg aaggctggaa
      961 actagaaaag caagattcat ttctcccctg ttcaagacca ccgaacagca tgccttcgtc
     1021 tccgcattgc ttaactggag caactgaggt ctcttgtggc tcagagcata atttggcaat
     1081 aattggtgga gtgtgttact cttggggctg gaatgagcat ggcatgtgcg gagatggcac
     1141 tgaagccaac gtctgggccc caaagccggt gcaggctctg ctgtcatcgt caggactcct
     1201 tgtgggctgt ggggctggcc actccttggc cctctgccag ctgccagctc accctgcatt
     1261 ggtccaggac cccaaggtca cctacctttc cccagatgcc atcgaggaca ctgaatctca
     1321 gaaagccatg gacaaagaga gaaactggaa ggaaagacaa tcagaaactt caacccaaag
     1381 ccaatctgac tggtccagaa atgggggact gtgatagaga atctttaata aagtggcttt
     1441 tcccaccaaa a
//
