LOCUS       NM_001018108            2543 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens small EDRK-rich factor 2 (SERF2), transcript variant
            3, mRNA.
ACCESSION   NM_001018108
VERSION     NM_001018108.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2543)
  AUTHORS   Sahoo,B.R., Subramanian,V. and Bardwell,J.C.A.
  TITLE     Backbone 1H, 13C, and 15N chemical shift assignments for human
            SERF2
  JOURNAL   Biomol NMR Assign 18 (1), 51-57 (2024)
   PUBMED   38466543
  REMARK    GeneRIF: Backbone 1H, 13C, and 15N chemical shift assignments for
            human SERF2.
REFERENCE   2  (bases 1 to 2543)
  AUTHORS   Morimoto,E., Tsuboyama,K. and Tomari,Y.
  TITLE     Fusion with heat-resistant obscure (Hero) proteins have the
            potential to improve the molecular property of recombinant proteins
  JOURNAL   PLoS One 17 (6), e0270097 (2022)
   PUBMED   35714106
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2543)
  AUTHORS   Pras,A., Houben,B., Aprile,F.A., Seinstra,R., Gallardo,R.,
            Janssen,L., Hogewerf,W., Gallrein,C., De Vleeschouwer,M.,
            Mata-Cabana,A., Koopman,M., Stroo,E., de Vries,M., Louise
            Edwards,S., Kirstein,J., Vendruscolo,M., Falsone,S.F., Rousseau,F.,
            Schymkowitz,J. and Nollen,E.A.A.
  TITLE     The cellular modifier MOAG-4/SERF drives amyloid formation through
            charge complementation
  JOURNAL   EMBO J 40 (21), e107568 (2021)
   PUBMED   34617299
  REMARK    GeneRIF: The cellular modifier MOAG-4/SERF drives amyloid formation
            through charge complementation.
REFERENCE   4  (bases 1 to 2543)
  AUTHORS   Balasubramaniam,M., Ayyadevara,S. and Shmookler Reis,R.J.
  TITLE     Structural insights into pro-aggregation effects of C. elegans
            CRAM-1 and its human ortholog SERF2
  JOURNAL   Sci Rep 8 (1), 14891 (2018)
   PUBMED   30291272
  REMARK    GeneRIF: Atomistic molecular-dynamic simulations predict
            spontaneous unfolding of SERF2, and computational large-scale
            protein-protein interactions predict its stable binding to
            ubiquitins. SERF2 is also predicted to bind to most proteins
            screened at random, although with lower average stability than to
            ubiquitins, suggesting roles in aggregation initiation and/or
            progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2543)
  AUTHORS   van Ham,T.J., Holmberg,M.A., van der Goot,A.T., Teuling,E.,
            Garcia-Arencibia,M., Kim,H.E., Du,D., Thijssen,K.L., Wiersma,M.,
            Burggraaff,R., van Bergeijk,P., van Rheenen,J., Jerre van Veluw,G.,
            Hofstra,R.M., Rubinsztein,D.C. and Nollen,E.A.
  TITLE     Identification of MOAG-4/SERF as a regulator of age-related
            proteotoxicity
  JOURNAL   Cell 142 (4), 601-612 (2010)
   PUBMED   20723760
  REMARK    GeneRIF: The human orthologs of MOAG-4, SERF2 and SERF1A, are
            ubiquitously expressed, consistent with a role in a general
            cellular pathway.
REFERENCE   6  (bases 1 to 2543)
  AUTHORS   Wen,T., Bao,K. and Li,H.
  TITLE     Blocking BE301622 gene expression by RNAi initiates differentiation
            of neural stem cells in rat
  JOURNAL   Cell Biochem Funct 25 (6), 775-779 (2007)
   PUBMED   16927404
REFERENCE   7  (bases 1 to 2543)
  AUTHORS   Washietl,S., Pedersen,J.S., Korbel,J.O., Stocsits,C., Gruber,A.R.,
            Hackermuller,J., Hertel,J., Lindemeyer,M., Reiche,K., Tanzer,A.,
            Ucla,C., Wyss,C., Antonarakis,S.E., Denoeud,F., Lagarde,J.,
            Drenkow,J., Kapranov,P., Gingeras,T.R., Guigo,R., Snyder,M.,
            Gerstein,M.B., Reymond,A., Hofacker,I.L. and Stadler,P.F.
  TITLE     Structured RNAs in the ENCODE selected regions of the human genome
  JOURNAL   Genome Res 17 (6), 852-864 (2007)
   PUBMED   17568003
REFERENCE   8  (bases 1 to 2543)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   9  (bases 1 to 2543)
  AUTHORS   Scharf,J.M., Endrizzi,M.G., Wetter,A., Huang,S., Thompson,T.G.,
            Zerres,K., Dietrich,W.F., Wirth,B. and Kunkel,L.M.
  TITLE     Identification of a candidate modifying gene for spinal muscular
            atrophy by comparative genomics
  JOURNAL   Nat Genet 20 (1), 83-86 (1998)
   PUBMED   9731538
REFERENCE   10 (bases 1 to 2543)
  AUTHORS   Faber,P.W., Barnes,G.T., Srinidhi,J., Chen,J., Gusella,J.F. and
            MacDonald,M.E.
  TITLE     Huntingtin interacts with a family of WW domain proteins
  JOURNAL   Hum Mol Genet 7 (9), 1463-1474 (1998)
   PUBMED   9700202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC008214.1, AC018512.6 and BM970646.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001018108.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, and
            uses an alternate splice site that causes a frameshift in the 3'
            coding region, compared to variant 1. The encoded isoform (c) has a
            distinct and shorter C-terminus, compared to isoform a. Both
            variants 3 and 4 encode isoform c.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.105912.1,
                                           SRR1803615.193126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249786.9/ ENSP00000249786.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-510               BC008214.1         479-988
            511-2069            AC018512.6         109245-110803
            2070-2543           BM970646.1         28-501              c
FEATURES             Location/Qualifiers
     source          1..2543
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.3"
     gene            1..2543
                     /gene="SERF2"
                     /gene_synonym="4F5REL; FAM2C; H4F5REL; Hero7; HsT17089"
                     /note="small EDRK-rich factor 2"
                     /db_xref="GeneID:10169"
                     /db_xref="HGNC:HGNC:10757"
                     /db_xref="MIM:605054"
     exon            1..64
                     /gene="SERF2"
                     /gene_synonym="4F5REL; FAM2C; H4F5REL; Hero7; HsT17089"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..237
                     /gene="SERF2"
                     /gene_synonym="4F5REL; FAM2C; H4F5REL; Hero7; HsT17089"
                     /note="isoform c is encoded by transcript variant 3;
                     protein 4F5-related; gastric cancer-related protein
                     VRG107"
                     /codon_start=1
                     /product="small EDRK-rich factor 2 isoform c"
                     /protein_id="NP_001018118.1"
                     /db_xref="CCDS:CCDS32218.1"
                     /db_xref="GeneID:10169"
                     /db_xref="HGNC:HGNC:10757"
                     /db_xref="MIM:605054"
                     /translation="MTRGNQRELARQKNMKKQSDSVKGKRRDDGLSAAARKQRDSEIM
                     QQKQKKANEKKEEPK"
     exon            65..173
                     /gene="SERF2"
                     /gene_synonym="4F5REL; FAM2C; H4F5REL; Hero7; HsT17089"
                     /inference="alignment:Splign:2.1.0"
     exon            174..2543
                     /gene="SERF2"
                     /gene_synonym="4F5REL; FAM2C; H4F5REL; Hero7; HsT17089"
                     /inference="alignment:Splign:2.1.0"
     regulatory      489..494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERF2"
                     /gene_synonym="4F5REL; FAM2C; H4F5REL; Hero7; HsT17089"
                     /note="hexamer: ATTAAA"
     polyA_site      511
                     /gene="SERF2"
                     /gene_synonym="4F5REL; FAM2C; H4F5REL; Hero7; HsT17089"
                     /note="major polyA site"
     regulatory      989..994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERF2"
                     /gene_synonym="4F5REL; FAM2C; H4F5REL; Hero7; HsT17089"
                     /note="hexamer: ATTAAA"
     polyA_site      1026
                     /gene="SERF2"
                     /gene_synonym="4F5REL; FAM2C; H4F5REL; Hero7; HsT17089"
     regulatory      2445..2450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERF2"
                     /gene_synonym="4F5REL; FAM2C; H4F5REL; Hero7; HsT17089"
                     /note="hexamer: ATTAAA"
     polyA_site      2468
                     /gene="SERF2"
                     /gene_synonym="4F5REL; FAM2C; H4F5REL; Hero7; HsT17089"
     regulatory      2503..2508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERF2"
                     /gene_synonym="4F5REL; FAM2C; H4F5REL; Hero7; HsT17089"
                     /note="hexamer: AATAAA"
     polyA_site      2543
                     /gene="SERF2"
                     /gene_synonym="4F5REL; FAM2C; H4F5REL; Hero7; HsT17089"
ORIGIN      
        1 aacgtccgac agaacgaggg gacgtaacgg aggcaggttg gagccgctgc cgtcgccatg
       61 acccgcggta accagcgtga gctcgcccgc cagaagaata tgaaaaagca gagcgactcg
      121 gttaagggaa agcgccgaga tgacgggctt tctgctgccg cccgcaagca gagggactcg
      181 gagatcatgc agcagaagca gaaaaaggca aacgagaaga aggaggaacc caagtagctt
      241 tgtggcttcg tgtccaaccc tcttgccctt cgcctgtgtg cctggagcca gtcccaccac
      301 gctcgcgttt cctcctgtag tgctcacagg tcccagcacc gatggcattc cctttgccct
      361 gagtctgcag cgggtccctt ttgtgcttcc ttcccctcag gtagcctctc tccccctggg
      421 ccactcccgg gggtgagggg gttacccctt cccagtgttt tttattcctg tggggctcac
      481 cccaaagtat taaaagtagc tttgtaattc cttgagcgcc tggtttgact ggggacttgg
      541 ggggatgggg ttggaagaat gactgccctt tcccaccaaa aaagggagaa ctctttagat
      601 tcagattgtg ggtatgtaga cttaataagt gaaacatcac agaagaagcc tttattatac
      661 aatgacaacc aaacaagtac tccggatatg cagtagagga atcctctaag aaccatagag
      721 acttcttttc tgtgattttt gttccccacc cttgaacacc atctctagga tggagttggc
      781 ctaagagtga atgctgcaag atctgtgttt atgcctcttt tcctcattct tcctcagttt
      841 gttcgtctgc ttgaaagttg gccaaaaaat cctgctgctc accgacttcc cgtggtcagc
      901 tgctgtcaag cgttcacttt ctcttctgtc attcctcatg gaatgagggt ggttttgtct
      961 tcccgcttcc cttgacctca aaatcaggat taaaacctgg ggtagcctct gtgctccttt
     1021 cttctatgcc ctggtttgtt ctgtggttct gggcttctta tatccgtgtg cccagggctg
     1081 aactccttat tttcctttct ccaagggcag agccgagtct tcagtccctg ttggtctttc
     1141 cccaccccca cttccagccc aagagccagg aaagggctgg tgccacactg tctgctggga
     1201 tcagcggtgg ttctttgagc tgctgatttg ggtgttaggc tcttgagctg ggatgcagat
     1261 gtaacagtag ctccagtgag tcagacactc tgcccagcac attagactgt gtttgaccac
     1321 ttcttccagt tcatagtatt gacttcagcc caaacggaga taactccctg tgtgtccttg
     1381 aggtattgag ctgggctgga cagctcccct tgagccaact ctaggagtac aatgtcaggg
     1441 gaaccccagt ttgtgaaaag gacttagact ggaggatatt tgttatctgg ggatatgatg
     1501 cggtggcggc ggcgcctcaa gataaggggc tggggtttct gggtgggggg ccaacagagt
     1561 ggtgccagta acagccccag atagaggagt acgcaggccc agcatgaggc aaccttgacc
     1621 cagaaggtgg cccagctacc cttgatgaag gtcttttcca gttctgctcc ctcatagctg
     1681 tgtaaccaaa ggctctggtt agagaatatg aagggcctta gcttttagac ctgttctacc
     1741 tcctcaccaa atataatggc agacccatgt gtgtctggaa tggccttgaa ttgctctttc
     1801 cttaaaatag ctagctcttc aggagagtat ctaaggccca ctccatctta cctgaaccag
     1861 ttggtaaggg taaccatgac atagagtgag gcaaggaaga agacgaagtg gaaggcagaa
     1921 tagttgtagg aaagatgctg gacttggact ggaggagctg gaggggtttc ttggtcagct
     1981 ggcctcgcag ccccacccct ttgccctgga gagaggaaat ggctgctggg agcagagctg
     2041 ctgaaacacc tcttcccctc tcccccaact acctttgtta aggctcttga gggttcttat
     2101 ggcactccac agagatctac cacttcttat ggttcctcac ttggcactca cctttgtctg
     2161 cctccactgt ttcagggcag cagaaacaca gtgagggctt ctgcaaaaca gaacgcaggt
     2221 tttggaatgg tcttaaaaga tgtgagggtg ttaatctagg aaacttcccc cgtgaaaaga
     2281 ttggtctagt attaaaaagt ggaggcacac ctgggttcaa attctagctc cagcatataa
     2341 gtggctgtgc agactttggt aagatgttta atcttttgtg cctcgatttc tccatttgta
     2401 aaatggagca aatacctacc tcacagggtt gttgtgaggg ttaaattaaa tgagattatg
     2461 taaaagtatc tagcacagtt gcctagcaca ttgtgggtac tcaataaaag gtaacagcag
     2521 ctataatctg agcattctgg gta
//
