LOCUS       NM_022978               1907 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens small EDRK-rich factor 1B (SERF1B), transcript variant
            2, mRNA.
ACCESSION   NM_022978 XM_001133833
VERSION     NM_022978.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1907)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1907)
  AUTHORS   Merle,D.A., Witternigg,A., Tam-Amersdorfer,C., Hartlmuller,C.,
            Spreitzer,E., Schrank,E., Wagner-Lichtenegger,S., Werzer,O.,
            Zangger,K., Kungl,A.J., Madl,T., Meyer,N.H. and Falsone,S.F.
  TITLE     Increased Aggregation Tendency of Alpha-Synuclein in a Fully
            Disordered Protein Complex
  JOURNAL   J Mol Biol 431 (14), 2581-2598 (2019)
   PUBMED   31034892
REFERENCE   3  (bases 1 to 1907)
  AUTHORS   Falsone,S.F., Meyer,N.H., Schrank,E., Leitinger,G., Pham,C.L.,
            Fodero-Tavoletti,M.T., Holmberg,M., Dulle,M., Scicluna,B.,
            Gesslbauer,B., Ruckert,H.M., Wagner,G.E., Merle,D.A., Nollen,E.A.,
            Kungl,A.J., Hill,A.F., Cappai,R. and Zangger,K.
  TITLE     SERF protein is a direct modifier of amyloid fiber assembly
  JOURNAL   Cell Rep 2 (2), 358-371 (2012)
   PUBMED   22854022
REFERENCE   4  (bases 1 to 1907)
  AUTHORS   van Ham,T.J., Holmberg,M.A., van der Goot,A.T., Teuling,E.,
            Garcia-Arencibia,M., Kim,H.E., Du,D., Thijssen,K.L., Wiersma,M.,
            Burggraaff,R., van Bergeijk,P., van Rheenen,J., Jerre van Veluw,G.,
            Hofstra,R.M., Rubinsztein,D.C. and Nollen,E.A.
  TITLE     Identification of MOAG-4/SERF as a regulator of age-related
            proteotoxicity
  JOURNAL   Cell 142 (4), 601-612 (2010)
   PUBMED   20723760
REFERENCE   5  (bases 1 to 1907)
  AUTHORS   Tomarev,S.I., Wistow,G., Raymond,V., Dubois,S. and Malyukova,I.
  TITLE     Gene expression profile of the human trabecular meshwork: NEIBank
            sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 44 (6), 2588-2596 (2003)
   PUBMED   12766061
REFERENCE   6  (bases 1 to 1907)
  AUTHORS   Endrizzi,M., Huang,S., Scharf,J.M., Kelter,A.R., Wirth,B.,
            Kunkel,L.M., Miller,W. and Dietrich,W.F.
  TITLE     Comparative sequence analysis of the mouse and human Lgn1/SMA
            interval
  JOURNAL   Genomics 60 (2), 137-151 (1999)
   PUBMED   10486205
REFERENCE   7  (bases 1 to 1907)
  AUTHORS   Scharf,J.M., Endrizzi,M.G., Wetter,A., Huang,S., Thompson,T.G.,
            Zerres,K., Dietrich,W.F., Wirth,B. and Kunkel,L.M.
  TITLE     Identification of a candidate modifying gene for spinal muscular
            atrophy by comparative genomics
  JOURNAL   Nat Genet 20 (1), 83-86 (1998)
   PUBMED   9731538
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB454907.1, AC139277.2,
            BC103687.1, BC104738.1 and BM686659.1.
            
            On Sep 3, 2019 this sequence version replaced NM_022978.2.
            
            Summary: This gene is part of a 500 kb inverted duplication on
            chromosome 5q13. This duplicated region contains at least four
            genes and repetitive elements which make it prone to rearrangements
            and deletions. The repetitiveness and complexity of the sequence
            have also caused difficulty in determining the organization of this
            genomic region. This gene is the centromeric copy which is
            identical to the telomeric copy. Alternatively spliced transcripts
            have been documented but it is unclear whether alternative splicing
            occurs for both the centromeric and telomeric copies of the gene.
            The gene encodes a protein of unknown function which bears
            low-level homology with the RNA-binding domain of
            matrin-cyclophilin, a protein which colocalizes with small nuclear
            ribonucleoproteins (snRNPs) and the SMN1 gene product. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) has an alternate 3' exon, as
            compared to variant 1. The resulting isoform (2) has a shorter and
            distinct C-terminus, as compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104738.1, SRR14038192.346494.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380750.8/ ENSP00000370126.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                DB454907.1         1-69
            70-70               AC139277.2         181325-181325
            71-316              DB454907.1         71-316
            317-776             BC103687.1         137-596
            777-1416            BC104738.1         595-1234
            1417-1866           BM686659.1         86-535
            1867-1907           AC139277.2         199078-199118
FEATURES             Location/Qualifiers
     source          1..1907
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..1907
                     /gene="SERF1B"
                     /gene_synonym="FAM2B; h4F5; H4F5C"
                     /note="small EDRK-rich factor 1B"
                     /db_xref="GeneID:728492"
                     /db_xref="HGNC:HGNC:10756"
     exon            1..208
                     /gene="SERF1B"
                     /gene_synonym="FAM2B; h4F5; H4F5C"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..534
                     /gene="SERF1B"
                     /gene_synonym="FAM2B; h4F5; H4F5C"
                     /note="isoform 2 is encoded by transcript variant 2; small
                     EDRK-rich factor 1; protein 4F5; SMA modifier 1; small
                     EDRK-rich factor 1B (centromeric)"
                     /codon_start=1
                     /product="small EDRK-rich factor 1 isoform 2"
                     /protein_id="NP_075267.1"
                     /db_xref="CCDS:CCDS43326.1"
                     /db_xref="GeneID:728492"
                     /db_xref="HGNC:HGNC:10756"
                     /translation="MARGNQRELARQKNMKKTQEISKGKRKEDSLTASQRKQSSGGQK
                     SESKMSAGPHLPLKAPRENPCFPLPAAGGSRYYLAYGSITPISAFVFVVFFSVFFPSF
                     YEDFCCWI"
     exon            209..317
                     /gene="SERF1B"
                     /gene_synonym="FAM2B; h4F5; H4F5C"
                     /inference="alignment:Splign:2.1.0"
     exon            318..1907
                     /gene="SERF1B"
                     /gene_synonym="FAM2B; h4F5; H4F5C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgacgcgc cggccatgcc ggcggctgtt gtcgggcctc cagcgggcgg ggccgttggc
       61 ggagcagagg ggaggcgcag ccgggcggag ggcccacgag ggctcagcct tcccggtcag
      121 cggtggtgac ggtatcccag agtgccagag aaccgttgct tttccgagtt gctcttcttc
      181 caggctccgt tggtggtcgg catggcccgt ggaaatcaac gagaacttgc ccgccagaaa
      241 aacatgaaga aaacccagga aattagcaag ggaaagagga aagaggatag cttgactgcc
      301 tctcagagaa agcagagttc tggaggccag aaatctgaga gcaagatgtc agctgggcca
      361 cacctccctc tgaaggctcc aagggagaat ccttgctttc ctcttccagc tgctggtggc
      421 tccaggtatt acttggctta tggcagcata actcctatct ctgcctttgt ctttgtggtc
      481 ttcttttctg tcttcttccc ttctttttat gaggactttt gctgttggat ttaggttcca
      541 ttctaaccta ggatgatctc atttggaaat ccttaatttc atctacaaaa actgttttcc
      601 caaataggtc acattcacgc atatcagatg gacagatgta tcattttggg gtccaccatt
      661 caacccacta caaggagttt tttaaacaaa aataggaaac ttagatgtaa cttagcactt
      721 tttttttttt tttttgagat ggagtctcac tctgtcacca gactggagtg cagtggcgcc
      781 atctcagctc catgcaacct ctgcctcctg ggttcaagca gttctcttgc ctcagcctcc
      841 tgggtagctg ggattacagg cacgcgctgc cacacccagg taatttattt attttttttt
      901 tgagacagag tctcgcactg ttgcccaggc tggactgcag tggcgtgatc tctgctcact
      961 gcaacctccg cctcccgggt tcaagcgatt ctccagcctc agcttcctga gtagatggga
     1021 ttacaggcgc ctgccaccac gcccagctaa ttttttgtat tcttagtaga gatggggttt
     1081 caccatgttg gccaggctgg tctccatctc ctgacctcgt gattcacccg cctcggcctc
     1141 ccaaagtgct gggattacag gcgtgagtca cagcccccgg ccataattta gcactttaaa
     1201 aaataatagc catgttgggc caggcgtggt ggctcatgcc tgtaatctga gcactttggg
     1261 agaccaaggc gggtagatcc cttgtgccca ggagttcaag accagcctgg gcaacatggc
     1321 gaaaccccat ttctactaaa aatacaaaaa ttagctgggg cgaggggata ggccgagttc
     1381 cgggtgtaag ggggccatta gggagagcag agcgaggcag ctgatcttcc ggattggggg
     1441 ccttgcccgg aagctggacc tcacggagat gaaacggaag atgcacgagg atatgatctc
     1501 catacagaac tttctcatct acgtggccct gctgcgagtc actccattta tcttaaagaa
     1561 attggacagc atatgaagat tggacatcac atgtgaatgc atgatatgaa gagcctggtt
     1621 acagtttcta ctgttctctg caagtaaata ggcccagaaa ggtataagag actctttgaa
     1681 tggacataaa aattctgctt gttaagaaca agttgagctc tggtaactga tcttaatagc
     1741 taaaatataa aaatatttgg gaagtctgaa atgaggtctc ctggccctgg tgtgccctta
     1801 atgcctgtga cagttggcct ctgtgaatat tggtataatt gtaaataatg tcaaactcca
     1861 ttttctagca agtattaata attaagggaa gtatgtctga aatggca
//
