LOCUS       NM_001018069            6681 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens SERPINE1 mRNA binding protein 1 (SERBP1), transcript
            variant 3, mRNA.
ACCESSION   NM_001018069
VERSION     NM_001018069.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6681)
  AUTHORS   Shilenok,I., Kobzeva,K., Stetskaya,T., Freidin,M., Soldatova,M.,
            Deykin,A., Soldatov,V., Churnosov,M., Polonikov,A. and Bushueva,O.
  TITLE     SERPINE1 mRNA Binding Protein 1 Is Associated with Ischemic Stroke
            Risk: A Comprehensive Molecular-Genetic and Bioinformatics Analysis
            of SERBP1 SNPs
  JOURNAL   Int J Mol Sci 24 (10), 8716 (2023)
   PUBMED   37240062
  REMARK    GeneRIF: SERPINE1 mRNA Binding Protein 1 Is Associated with
            Ischemic Stroke Risk: A Comprehensive Molecular-Genetic and
            Bioinformatics Analysis of SERBP1 SNPs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6681)
  AUTHORS   Shetty,S., Hofstetter,J., Battaglioni,S., Ritz,D. and Hall,M.N.
  TITLE     TORC1 phosphorylates and inhibits the ribosome preservation factor
            Stm1 to activate dormant ribosomes
  JOURNAL   EMBO J 42 (5), e112344 (2023)
   PUBMED   36691768
REFERENCE   3  (bases 1 to 6681)
  AUTHORS   Shan,B., Qu,S., Lv,S., Fan,D. and Wang,S.
  TITLE     YY1-induced long non-coding RNA small nucleolar RNA host gene 8
            promotes the tumorigenesis of melanoma via the
            microRNA-656-3p/SERPINE1 mRNA binding protein 1 axis
  JOURNAL   Bioengineered 13 (3), 4832-4843 (2022)
   PUBMED   35156513
  REMARK    GeneRIF: YY1-induced long non-coding RNA small nucleolar RNA host
            gene 8 promotes the tumorigenesis of melanoma via the
            microRNA-656-3p/SERPINE1 mRNA binding protein 1 axis.
REFERENCE   4  (bases 1 to 6681)
  AUTHORS   Zhang,D., Zhang,Y., Zhang,X., Zhai,H., Sun,X. and Li,Y.
  TITLE     Circ_0046600 promotes hepatocellular carcinoma progression via
            up-regulating SERBP1 through sequestering miR-1258
  JOURNAL   Pathol Res Pract 228, 153681 (2021)
   PUBMED   34784519
  REMARK    GeneRIF: Circ_0046600 promotes hepatocellular carcinoma progression
            via up-regulating SERBP1 through sequestering miR-1258.
REFERENCE   5  (bases 1 to 6681)
  AUTHORS   Martini,S., Davis,K., Faraway,R., Elze,L., Lockwood,N., Jones,A.,
            Xie,X., McDonald,N.Q., Mann,D.J., Armstrong,A., Ule,J. and
            Parker,P.J.
  TITLE     A genetically-encoded crosslinker screen identifies SERBP1 as a
            PKCepsilon substrate influencing translation and cell division
  JOURNAL   Nat Commun 12 (1), 6934 (2021)
   PUBMED   34836941
  REMARK    GeneRIF: A genetically-encoded crosslinker screen identifies SERBP1
            as a PKCepsilon substrate influencing translation and cell
            division.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6681)
  AUTHORS   Lemos,T.A. and Kobarg,J.
  TITLE     CGI-55 interacts with nuclear proteins and co-localizes to
            p80-coilin positive-coiled bodies in the nucleus
  JOURNAL   Cell Biochem Biophys 44 (3), 463-474 (2006)
   PUBMED   16679534
  REMARK    GeneRIF: We observed that CGI-55 localizes to the nucleolus and
            co-localizes with p80-coilin positive nuclear-coiled bodies.
REFERENCE   7  (bases 1 to 6681)
  AUTHORS   Lemos,T.A., Passos,D.O., Nery,F.C. and Kobarg,J.
  TITLE     Characterization of a new family of proteins that interact with the
            C-terminal region of the chromatin-remodeling factor CHD-3
  JOURNAL   FEBS Lett 533 (1-3), 14-20 (2003)
   PUBMED   12505151
  REMARK    GeneRIF: interacts with the C-terminal region of the human
            chromatin-remodeling factor CHD-3
REFERENCE   8  (bases 1 to 6681)
  AUTHORS   Jones,K., Powell,J., Brown,L., Greenhalgh,R., Jormsjo,S. and
            Eriksson,P.
  TITLE     The influence of 4G/5G polymorphism in the plasminogen activator
            inhibitor-1 gene promoter on the incidence, growth and operative
            risk of abdominal aortic aneurysm
  JOURNAL   Eur J Vasc Endovasc Surg 23 (5), 421-425 (2002)
   PUBMED   12027469
  REMARK    GeneRIF: Polymorphism of the PAI-1 gene promoter does not influence
            the development of AAA. However, the effect of PAI-1 genotype
            (5G5G) appears protective on survival following open aneurysm
            repair.
REFERENCE   9  (bases 1 to 6681)
  AUTHORS   Buckova,D., Izakovicova Holla,L. and Vacha,J.
  TITLE     Polymorphism 4G/5G in the plasminogen activator inhibitor-1 (PAI-1)
            gene is associated with IgE-mediated allergic diseases and asthma
            in the Czech population
  JOURNAL   Allergy 57 (5), 446-448 (2002)
   PUBMED   11972486
  REMARK    GeneRIF: The 4G allele of the 4G/5G polymorphism in the PAI-1 gene
            may be a risk factor for IgE-mediated asthma and allergic diseases.
REFERENCE   10 (bases 1 to 6681)
  AUTHORS   Heaton,J.H., Dlakic,W.M., Dlakic,M. and Gelehrter,T.D.
  TITLE     Identification and cDNA cloning of a novel RNA-binding protein that
            interacts with the cyclic nucleotide-responsive sequence in the
            Type-1 plasminogen activator inhibitor mRNA
  JOURNAL   J Biol Chem 276 (5), 3341-3347 (2001)
   PUBMED   11001948
  REMARK    GeneRIF: This gene encodes a protein, PAI-RBP1, that binds to an
            RNA sequence (cyclic nucleotide responsive sequence, CRS) in the
            plasminogen activator-inhibitor (PAI-1) mRNA that confers cAMP
            regulation of mRNA stability.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590559.3, AF151813.1 and AL358512.9.
            
            On Jun 2, 2019 this sequence version replaced NM_001018069.1.
            
            Transcript Variant: This variant (3) uses an alternate, in-frame
            splice site in the coding region, compared to variant 1. It encodes
            isoform 3, which is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.887364.1,
                                           SRR18074969.1314723.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361219.11/ ENSP00000354591.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-415               AL590559.3         19147-19561         c
            416-1867            AF151813.1         413-1864
            1868-1923           AF151813.1         1866-1921
            1924-6681           AL358512.9         40531-45288         c
FEATURES             Location/Qualifiers
     source          1..6681
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..6681
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /note="SERPINE1 mRNA binding protein 1"
                     /db_xref="GeneID:26135"
                     /db_xref="HGNC:HGNC:17860"
                     /db_xref="MIM:607378"
     exon            1..415
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1284
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     chromodomain helicase DNA binding protein 3 interacting
                     protein; PAI-1 mRNA binding protein; plasminogen activator
                     inhibitor 1 RNA-binding protein; PAI1 RNA-binding protein
                     1"
                     /codon_start=1
                     /product="SERPINE1 mRNA-binding protein 1 isoform 3"
                     /protein_id="NP_001018079.1"
                     /db_xref="CCDS:CCDS30747.1"
                     /db_xref="GeneID:26135"
                     /db_xref="HGNC:HGNC:17860"
                     /db_xref="MIM:607378"
                     /translation="MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGG
                     GVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALK
                     KEGIRRVGRRPDQQLQGEGKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDR
                     PIRGRGGLGRGRGGRGRGMGRGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGG
                     SGSHNWGTVKDELTDLDQSNVTEETPEGEEHHPVADTENKENEVEEVKEEGPKEMTLD
                     EWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPAN
                     DITSQLEINFGDLGRPGRGGRGGRGGRGRGGRPNRGSRTDKSSASAPDVDDPEAFPAL
                     A"
     exon            416..566
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..707
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..797
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            798..875
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1053
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1227
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..6681
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3415..3420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /note="hexamer: AATAAA"
     polyA_site      3438
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /note="major polyA site"
     regulatory      3451..3456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /note="hexamer: CATAAA"
     polyA_site      3471
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /note="major polyA site"
     regulatory      6201..6206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /note="hexamer: TATAAA"
     polyA_site      6222
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /note="major polyA site"
     regulatory      6656..6661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /note="hexamer: AGTAAA"
     polyA_site      6681
                     /gene="SERBP1"
                     /gene_synonym="CGI-55; CHD3IP; HABP4L; Hero45; PAI-RBP1;
                     PAIRBP1"
                     /note="major polyA site"
ORIGIN      
        1 ctctctcggc ccggccatct tgtgggaaga gctgaagcag gcgctcttgg ctcggcgcgg
       61 cccgctgcaa tccgtggagg aacgcgccgc cgagccacca tcatgcctgg gcacttacag
      121 gaaggcttcg gctgcgtggt caccaaccga ttcgaccagt tatttgacga cgaatcggac
      181 cccttcgagg tgctgaaggc agcagagaac aagaaaaaag aagccggcgg gggcggcgtt
      241 gggggccctg gggccaagag cgcagctcag gccgcggccc agaccaactc caacgcggca
      301 ggcaaacagc tgcgcaagga gtcccagaaa gaccgcaaga acccgctgcc ccccagcgtt
      361 ggcgtggttg acaagaaaga ggagacgcag ccgcccgtgg cgcttaagaa agaaggaata
      421 agacgagttg gaagaagacc tgatcaacaa cttcagggtg aagggaaaat aattgataga
      481 agaccagaaa ggcgaccacc tcgtgaacga agattcgaaa agccacttga agaaaagggt
      541 gaaggaggcg aattttcagt tgatagaccg attattgacc gacctattcg aggtcgtggt
      601 ggtcttggaa gaggtcgagg gggccgtgga cgtggaatgg gccgaggaga tggatttgat
      661 tctcgtggca aacgtgaatt tgataggcat agtggaagtg atagatcttc tttttcacat
      721 tacagtggcc tgaagcacga ggacaaacgt ggaggtagcg gatctcacaa ctggggaact
      781 gtcaaagacg aattaactga cttggatcaa tcaaatgtga ctgaggaaac acctgaaggt
      841 gaagaacatc atccagtggc agacactgaa aataaggaga atgaagttga agaggtaaaa
      901 gaggagggtc caaaagagat gactttggat gagtggaagg ctattcaaaa taaggaccgg
      961 gcaaaagtag aatttaatat ccgaaaacca aatgaaggtg ctgatgggca gtggaagaag
     1021 ggatttgttc ttcataaatc aaagagtgaa gaggctcatg ctgaagattc ggttatggac
     1081 catcatttcc ggaagccagc aaatgatata acgtctcagc tggagatcaa ttttggagac
     1141 cttggccgcc caggacgtgg cggcagggga ggacgaggtg gacgtgggcg tggtgggcgc
     1201 ccaaaccgtg gcagcaggac cgacaagtca agtgcttctg ctcctgatgt ggatgaccca
     1261 gaggcattcc cagctctggc ttaactggat gccataagac aaccctggtt cctttgtgaa
     1321 cccttctgtt caaagctttt gcatgcttaa ggattccaaa cgactaagaa attaaaaaaa
     1381 aaaagactgt cattcatacc attcacacct aaagactgaa ttttatctgt tttaaaaatg
     1441 aacttctccc gctacacaga agtaacaaat atggtagtca gttttgtatt tagaaatgta
     1501 ttggtagcag ggatgttttc ataattttca gagattatgc attcttcatg aatacttttg
     1561 tattgctgct tgcaaatatg catttccaaa cttgaaatat aggtgtgaac agtgtgtacc
     1621 agtttaaagc tttcacttca tttgtgtttt ttaattaagg atttagaagt tcccccaatt
     1681 acaaactggt tttaaatatt ggacatactg gttttaatac ctgctttgca tattcacaca
     1741 tggtcaactg ggacatgtta aactttgatt tgtcaaattt tatgctgtgt ggaatactaa
     1801 ctatatgtat tttaacttag ttttaatatt ttcatttttg gggaaaaatc ttttttcact
     1861 tctcatgata gctgttatat atatatgcta aatctttata tacagaaata tcagtacttg
     1921 aacaaattca aagcacattt ggtttattaa cccttgctcc ttgcatggct cattaggttc
     1981 aaattataac tgatttacat tttcagctat atttactttt taaatgcttg agtttcccat
     2041 tttaaaatct aaactagaca tcttaattgg tgaaagttgt ttaaactact tattgttggt
     2101 aggcacatcg tgtcaagtga agtagtttta taggtatggg ttttttctcc cccttcacca
     2161 gggtgggtgg aataagttga tttggccaat gtgtaatatt taaactgttc tgtaaaataa
     2221 gtgtctggcc atttggtatg atttctgtgt gtgaaaggtc ccaaaatcaa aatggtacat
     2281 ccataatcag ccaccattta acccttcctt gttctaaaac aaaaaccaaa gggcgctggt
     2341 tggtagggtg aggtggggga gtattttaat ttttggaatt tgggaagcag acagctttac
     2401 tttgtaaggt tggaacagca gcactataca tgaaatataa accaaaaacc tttactgttt
     2461 ctaaatttcc tagattgcta ttatttggtt gtaagttgag tattccacag aaagtggtaa
     2521 ttatctcttc tctcttcctc cattagaaaa ttaggtaaat aatggattcc tataatggga
     2581 gcatcaccac ttattaaaac acacatagaa tgatgaatta aaaaagtttt ctaggattgt
     2641 cttttattct gccacattta ttgataaaca gtgaaggaat ttttaaaaaa tttttaagaa
     2701 ttgtttgtca cgtcattttt agaaatgttc tacctgtata tggtaatgtc cagttttaaa
     2761 aatattggac atcttcaatc ttaaacattt ctatttagct gattggttct cacatatact
     2821 tctaaaagaa acttttatgt tataagagtt actttttgga taagatttat taatctcagt
     2881 tacctactat tctgacattt taggaaggag gtaattgttt ttaatgatgg ataaacttgt
     2941 gctggtgttt tggatcttat gatgctgagc atgttctgca ctggtgctaa tgtctaatat
     3001 aattttatat ttacacacat acgtgctacc cagagattaa tttagtccat atgaactatt
     3061 gacccattgt tcattgagac agcaacatac gcactcctaa atcagtgtgt ttagactttt
     3121 caagtatcta actcatttcc aaacatgtac catgttttat aaacctcttg atttccagca
     3181 acatactata gaaaacacct gctactcaaa acacaacttc tcagtgtcat ccattgctgt
     3241 cgtgagagac aacatagcaa tatctggtat gttgcaagct ttcaagatag cctgaactta
     3301 aaaagttggt gcattagttg tatctgatgg atataaattt gcctcctagt tcactttgtg
     3361 tcaagagcta aaactgtgaa cctaactttc tcttattggt gggtaataac tgaaaataaa
     3421 gatttatttt catgctcact tcttaaaagt cataaaaaca atcaaatagg atcatgttta
     3481 ttgtcatgtg tttcctggtt tctgacctgt gtgcacaccc ctgtgtgttt ataattttta
     3541 aattgaattt tatatggggt ttttatttgc taaaaaccag gctgttgaat cacatttggg
     3601 aagggtactt atcttaatga ctaatgactt aattgggaaa gttgaattct tgtaaaatac
     3661 aaaatccaag gacttcttgg atttaatctg attgtcactt cttagcagat cacttttttg
     3721 ataatgaaag ttaagcatac tgaatgctac ttttgattga caaactggct ataatagtct
     3781 aggggaaaaa tccctaaaca gataaagatt cctaaagtaa tggtggcagc tgatgtttca
     3841 gtgaactttt atcttgatgc gtttaaatgg aagtaatgcc agacctgaga tttttaaggc
     3901 atttttacag cttgtattga aatgattgga gacatggttt ctttattagc tattttgaga
     3961 cctgtggagt taagcaagac ttttaaaaat tggcaccata tacatctagt tagttccttt
     4021 actcttattt ttttaaataa aagtagtaca catcatttcc agggttgtaa atatatttgg
     4081 ggcttgtttt tggtatggat ttaaaaggag gatattaagt attcattcta attttgttat
     4141 ttttctagtt gccagagatg gttgcactga aatagaacag ggagttgcat acaaagccta
     4201 aatgtgtatt ggatttcgaa aatactaggt tggtgcaatt ggttttgtac caacctaaca
     4261 tgtctttagg aaagtaccat catgtggaag gaaacaacag gtgttaaaag gttcaaagga
     4321 atgagaaata ggaagttact agaacctaac tgatgttgac cttagaggta agattattca
     4381 ggtatattag tggacctcca gtccaatggt atagcaaatt ccagggatct caggtgcatg
     4441 caattttact ttctaaagta aacacttaga aaatagatta taacccagac gttttggatt
     4501 atactgagac aaatatgtaa ataagtttta gcaagtctga acatgtacca gcgagatctt
     4561 caggttaact aagaaaagcc cagaaacttc attatttact gtgctttgta tggcataact
     4621 ggtaacaagg cagtaaaatg atacatattt gaactggacc atagtaatta aatgatttat
     4681 caatatcatt tgcaagataa ttgtcaggtt gagttaatag taagtggcag cttcccagaa
     4741 atttgggtta tttggcctaa gctgtgccct gggattacct cttcatcttc cttgactttt
     4801 aagttcaaat ttggaggtta tgtgaagtga ttgaaataaa tctttcaggc tgaggaagtc
     4861 ggtaatttca agaatatagt gaaaacaagg ttgtaatcta aacatgagaa gcttaagttt
     4921 aggaaatggt tagaatataa attgctaaag ccatcatgat tttggccaca gatgaaaata
     4981 tgaacactgg aaatgagcgc catttaaatg agatgctgta tgtaagccag gggtcagcaa
     5041 agttcagcct gtgacctggt gtgtgtgggg gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     5101 gtgtccgtgt ccctgagtta agaatggttt ttaggcttgt ataggattaa aaaaaaaaaa
     5161 aacccacaga aaaatgtagg cagcccagca taagataccg cctttcacag aaatgtttgc
     5221 tgaccccgga actgtcactc tcgggttaca agagtttgtt tctttgaaac agtctggctc
     5281 tgtcacccag gctggagtgc agtggcatga tctcaggtca ctgcagcctc cacctcccgg
     5341 gttcaagcaa ttctgcctca gcctcctgag tagctgggat tacaggtgtg caccaccaca
     5401 gacagctaat tttacaggtg tacaccacca cacccaagaa tcacttgaac ccgggaggtg
     5461 ggggttgcag tgagccaaga tcatagcact gtactccagt ctgggtgaca cactgtctga
     5521 aaaataaaag tttagttcta ggtacaaatt aagtggtcta cccaacagga agctgtgaaa
     5581 ttagaagtaa ttttaaagca tactttacac ctctatataa tcaaagtaag ggcaagataa
     5641 aacttgttag taaaacatgt tttattattt tttagatagg tagcctgcaa cataaaatat
     5701 attttgaaag ctgttaaggg gtgtataatc tgttaaaaaa taccatgatt agtatttcac
     5761 atttagtgac tcagatccct ttgtgtaagt cctttgcgtt gtgcaaagag gtttttctat
     5821 gagatgagaa ttatgaacac ttcatatagg taaattccat aggttgagct ggggcagaaa
     5881 ttaatggctc ctggagattg catctttttt tttttttttt tgagcttaga attcccattt
     5941 ggacagaatt tagcttttgt gctgttgatt acttctgtac taaactggta gccaattgtt
     6001 cacttctaaa tggaagggaa aaagttaccc acacaagtta gaaaatgatt taccgaatta
     6061 tttttttgag ttagtatgta tatactgttt taaatcagta atgtttgttc cttttgctgc
     6121 ccatttggga gtatgtggca attcctagtg ctcttgtatg acattactct tcttgagact
     6181 tgtatatgca agaaagtata tataaaagat gcctggtggt aactttgtat ctgagttctg
     6241 attcattatg gacttttaga aatctattta gataattggt tcatactagg tgctcaatta
     6301 ctctgacctt gtgtggctta atccttaaat agttgcttta ggtgttactg ggtggaagca
     6361 tggaaagtga agggctaata ttaaggattt ttatgtatta ctgagtaggg aaagtgggaa
     6421 gtagcttatc tttggacagt tgtattactt tgcactaatc accttgtttg cagttgtagc
     6481 tgattcagtt ctagatttta ggaccaaaaa gatctctaat ttaaagaaac agtttttata
     6541 tacctagaat gaagattctg tttaaagcgg ttttggttaa cttggttctt gacatttgcc
     6601 taaaattttg ttggattggg actaaaatgt tctattagcc aatgaataac gtccaagtaa
     6661 atttttgttt tattttggga a
//
