LOCUS       NM_001098811            2751 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens septin 8 (SEPTIN8), transcript variant 1, mRNA.
ACCESSION   NM_001098811
VERSION     NM_001098811.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2751)
  AUTHORS   Liu,H., Yan,P., Wu,C., Rao,M., Zhu,J., Lv,L., Li,W., Liang,Y.,
            Qi,S., Lu,K. and Kong,E.
  TITLE     Palmitoylated Sept8-204 modulates learning and anxiety by
            regulating filopodia arborization and actin dynamics
  JOURNAL   Sci Signal 16 (814), eadi8645 (2023)
   PUBMED   38051778
  REMARK    GeneRIF: Palmitoylated Sept8-204 modulates learning and anxiety by
            regulating filopodia arborization and actin dynamics.
REFERENCE   2  (bases 1 to 2751)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2751)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2751)
  AUTHORS   Keele,G.R., Prokop,J.W., He,H., Holl,K., Littrell,J., Deal,A.W.,
            Kim,Y., Kyle,P.B., Attipoe,E., Johnson,A.C., Uhl,K.L.,
            Sirpilla,O.L., Jahanbakhsh,S., Robinson,M., Levy,S., Valdar,W.,
            Garrett,M.R. and Solberg Woods,L.C.
  TITLE     Sept8/SEPTIN8 involvement in cellular structure and kidney damage
            is identified by genetic mapping and a novel human tubule hypoxic
            model
  JOURNAL   Sci Rep 11 (1), 2071 (2021)
   PUBMED   33483609
  REMARK    GeneRIF: Sept8/SEPTIN8 involvement in cellular structure and kidney
            damage is identified by genetic mapping and a novel human tubule
            hypoxic model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2751)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2751)
  AUTHORS   Macara,I.G., Baldarelli,R., Field,C.M., Glotzer,M., Hayashi,Y.,
            Hsu,S.C., Kennedy,M.B., Kinoshita,M., Longtine,M., Low,C.,
            Maltais,L.J., McKenzie,L., Mitchison,T.J., Nishikawa,T., Noda,M.,
            Petty,E.M., Peifer,M., Pringle,J.R., Robinson,P.J., Roth,D.,
            Russell,S.E., Stuhlmann,H., Tanaka,M., Tanaka,T., Trimble,W.S.,
            Ware,J., Zeleznik-Le,N.J. and Zieger,B.
  TITLE     Mammalian septins nomenclature
  JOURNAL   Mol Biol Cell 13 (12), 4111-4113 (2002)
   PUBMED   12475938
REFERENCE   7  (bases 1 to 2751)
  AUTHORS   Yang,T., Gao,Y.K. and Chen,J.Y.
  TITLE     KIAA0202, a human septin family member, interacting with hPFTAIRE1
  JOURNAL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34 (4),
            520-525 (2002)
   PUBMED   12098780
REFERENCE   8  (bases 1 to 2751)
  AUTHORS   Blaser,S., Jersch,K., Hainmann,I., Wunderle,D., Zgaga-Griesz,A.,
            Busse,A. and Zieger,B.
  TITLE     Human septin-septin interaction: CDCrel-1 partners with KIAA0202
  JOURNAL   FEBS Lett 519 (1-3), 169-172 (2002)
   PUBMED   12023038
REFERENCE   9  (bases 1 to 2751)
  AUTHORS   Wenderfer,S.E., Slack,J.P., McCluskey,T.S. and Monaco,J.J.
  TITLE     Identification of 40 genes on a 1-Mb contig around the IL-4
            cytokine family gene cluster on mouse chromosome 11
  JOURNAL   Genomics 63 (3), 354-373 (2000)
   PUBMED   10704283
REFERENCE   10 (bases 1 to 2751)
  AUTHORS   Frazer,K.A., Ueda,Y., Zhu,Y., Gifford,V.R., Garofalo,M.R.,
            Mohandas,N., Martin,C.H., Palazzolo,M.J., Cheng,J.F. and Rubin,E.M.
  TITLE     Computational and biological analysis of 680 kb of DNA sequence
            from the human 5q31 cytokine gene cluster region
  JOURNAL   Genome Res 7 (5), 495-512 (1997)
   PUBMED   9149945
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF440761.1, AF440762.1 and
            BU739074.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001098811.1.
            
            Summary: This gene is a member of the septin family of nucleotide
            binding proteins, originally described in yeast as cell division
            cycle regulatory proteins. Septins are highly conserved in yeast,
            Drosophila, and mouse, and appear to regulate cytoskeletal
            organization. Disruption of septin function disturbs cytokinesis
            and results in large multinucleate or polyploid cells. Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.11325.1, AF440762.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378719.7/ ENSP00000367991.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1388              AF440761.1         137-1524
            1389-2745           AF440762.1         1525-2881
            2746-2751           BU739074.1         21-26               c
FEATURES             Location/Qualifiers
     source          1..2751
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..2751
                     /gene="SEPTIN8"
                     /gene_synonym="SEP2; SEPT8; Septin-8"
                     /note="septin 8"
                     /db_xref="GeneID:23176"
                     /db_xref="HGNC:HGNC:16511"
                     /db_xref="MIM:608418"
     exon            1..132
                     /gene="SEPTIN8"
                     /gene_synonym="SEP2; SEPT8; Septin-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1554
                     /gene="SEPTIN8"
                     /gene_synonym="SEP2; SEPT8; Septin-8"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="septin-8 isoform a"
                     /protein_id="NP_001092281.1"
                     /db_xref="CCDS:CCDS43358.1"
                     /db_xref="GeneID:23176"
                     /db_xref="HGNC:HGNC:16511"
                     /db_xref="MIM:608418"
                     /translation="MAATDLERFSNAEPEPRSLSLGGHVGFDSLPDQLVSKSVTQGFS
                     FNILCVGETGIGKSTLMNTLFNTTFETEEASHHEACVRLRPQTYDLQESNVQLKLTIV
                     DAVGFGDQINKDESYRPIVDYIDAQFENYLQEELKIRRSLFDYHDTRIHVCLYFITPT
                     GHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMGELVSNGVQIYQFP
                     TDDEAVAEINAVMNAHLPFAVVGSTEEVKVGNKLVRARQYPWGVVQVENENHCDFVKL
                     REMLIRVNMEDLREQTHSRHYELYRRCKLEEMGFQDSDGDSQPFSLQETYEAKRKEFL
                     SELQRKEEEMRQMFVNKVKETELELKEKERELHEKFEHLKRVHQEEKRKVEEKRRELE
                     EETNAFNRRKAAVEALQSQALHATSQQPLRKDKDKKNRSDIGAHQPGMSLSSSKVMMT
                     KASVEPLNCSSWWPAIQCCSCLVRDATWREGFL"
     exon            133..253
                     /gene="SEPTIN8"
                     /gene_synonym="SEP2; SEPT8; Septin-8"
                     /inference="alignment:Splign:2.1.0"
     exon            254..449
                     /gene="SEPTIN8"
                     /gene_synonym="SEP2; SEPT8; Septin-8"
                     /inference="alignment:Splign:2.1.0"
     exon            450..636
                     /gene="SEPTIN8"
                     /gene_synonym="SEP2; SEPT8; Septin-8"
                     /inference="alignment:Splign:2.1.0"
     exon            637..798
                     /gene="SEPTIN8"
                     /gene_synonym="SEP2; SEPT8; Septin-8"
                     /inference="alignment:Splign:2.1.0"
     exon            799..895
                     /gene="SEPTIN8"
                     /gene_synonym="SEP2; SEPT8; Septin-8"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1064
                     /gene="SEPTIN8"
                     /gene_synonym="SEP2; SEPT8; Septin-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1197
                     /gene="SEPTIN8"
                     /gene_synonym="SEP2; SEPT8; Septin-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1388
                     /gene="SEPTIN8"
                     /gene_synonym="SEP2; SEPT8; Septin-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..2751
                     /gene="SEPTIN8"
                     /gene_synonym="SEP2; SEPT8; Septin-8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2726..2731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEPTIN8"
                     /gene_synonym="SEP2; SEPT8; Septin-8"
                     /note="hexamer: AATAAA"
     polyA_site      2751
                     /gene="SEPTIN8"
                     /gene_synonym="SEP2; SEPT8; Septin-8"
                     /note="major polyA site"
ORIGIN      
        1 attcagccgc agccgcccgg gcggagcgcg tcccgcagcc ggctggtccc tgtcgctgcc
       61 cctgcgctcg tcccagccca cccgcccggt gcggagctcg ccatggcggc caccgacctg
      121 gagcgcttct cgaatgcaga gccagagccc cggagcctct ccctgggcgg ccatgtgggt
      181 ttcgacagcc tccccgacca gctggtcagc aagtcggtca ctcagggctt cagcttcaac
      241 atcctctgtg tgggggagac cggcattggc aaatccacac tgatgaacac actcttcaac
      301 acgaccttcg agactgagga agccagtcac catgaggcat gcgtgcgcct gcggccccag
      361 acctatgacc tccaggagag caacgtgcag ctcaagctga ccattgtgga tgccgtgggc
      421 tttggggatc agatcaataa ggatgagagt tacaggccca tagttgacta catcgatgcg
      481 cagtttgaaa attatctgca ggaggagctg aagatccgcc gctcgctctt cgactaccat
      541 gacacaagga tccacgtttg cctctacttc atcacgccca cagggcactc cctgaagtct
      601 ctagatctag tgaccatgaa gaaactagac agcaaggtga acattattcc catcatcgcc
      661 aaggctgaca ccatctccaa gagcgagctc cacaagttca agatcaagat catgggcgag
      721 ttggtcagca acggggtcca gatctaccag ttccccacgg atgatgaggc tgttgcagag
      781 attaacgcag tcatgaatgc acatctgccc tttgccgtgg tgggcagcac cgaggaggtg
      841 aaggtgggga acaagctggt ccgagcacgg cagtacccct ggggagtggt gcaggtggag
      901 aatgagaatc actgcgactt cgtgaagctg cgggagatgt tgatccgggt gaacatggaa
      961 gacctccgcg agcagaccca cagccggcac tacgagctct accggcgctg caagttggag
     1021 gagatgggct ttcaggacag cgatggtgac agccagccct tcagcctaca agagacatac
     1081 gaggccaaga ggaaggagtt cctaagtgag ctgcagagga aggaggaaga gatgaggcag
     1141 atgtttgtca acaaagtgaa ggagacagag ctggagctga aggagaagga aagggagctc
     1201 catgagaagt ttgagcacct gaagcgggtc caccaggagg agaagcgcaa ggtggaggaa
     1261 aagcgccggg aactggagga ggagaccaac gccttcaatc gccggaaggc tgcggtggag
     1321 gccctgcagt cgcaggcctt gcacgccacc tcgcagcagc ccctgaggaa ggacaaggac
     1381 aagaagaaca gatcagatat aggagcacac cagccgggca tgagcctctc cagctctaag
     1441 gtgatgatga ccaaggccag tgtggagccc ttgaactgca gcagctggtg gcccgccata
     1501 cagtgctgca gctgcctggt cagggatgcg acgtggaggg aaggattcct ctgaggcagc
     1561 agctccaaca catggggcca gctcaggacc accagggcat ggaactggag accatggttt
     1621 ttaatgttag aacagaaaac gccatacttt tcctatatca atgatcaaaa gtgcaaacaa
     1681 tttaaatttc catcagggaa catcaaatgt tgcccaaccc ttttcattcc tatccatggc
     1741 tccgtaaggg gcttgaggct taatgcccat cctgtggcca agctgagctt ccactccggg
     1801 accaaaaaaa aaaaaaagtc tgctttgtga catcatcgtt atgagcggaa agtacctaga
     1861 tgacaatgtt tccattctga aaaatagaaa catactattc aagaccaagg tagcagaaaa
     1921 gttacttgta tctgcttatc ataagacgaa actctgcaac ttggcaacgg tggccagttt
     1981 tcgtaatgaa acagtcttta gtaatttaat cttcatgctt cataacaaac caaaacccca
     2041 tgagatttcc acattgcata attttgcctt actaacagaa tcatatcctt aaggatgacc
     2101 atcattcccc caactaaaac aaatacaaac taatgtatga tattttttta agtgccagat
     2161 caatatggtc taaagcttca ataaggattg tgtgtaggtg aataaagaca gctaagtgaa
     2221 tgtgtgtaaa gtgtagcaaa agcagacaga tatttatgta cagtattcat agaatggaaa
     2281 gttaaatatt tttgcagtgt gtatttaaaa gagaaactca ccataatagt gccgtctaaa
     2341 aatctttgta aagttaattt aatgtccttt agaagtggga gtctggtgga actgtgttgg
     2401 atttaagata ccttttcact cttccgtatg tcatgagcct tgtgcgtcac ctcactgtgg
     2461 tgcatgtgca agggcgtgtg cacgcctgtg ctttgccatc ccatgttgta aacagctgtt
     2521 ccaaaggcac aaacgagttt agggtagact ctgtaaacac ctccttactc actatagtca
     2581 agaagtccag cggcgtccca atatagaggt cccagtgcag tctgtccaga atagccagct
     2641 ccatcctcag cagctcattc ggggaatagt cagagccata gtgctttgtg aagtctttta
     2701 cttgtggaat aaactgtaaa aagaaaataa agaggccaaa gccctacatc a
//
