LOCUS       NM_001788               4284 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens septin 7 (SEPTIN7), transcript variant 1, mRNA.
ACCESSION   NM_001788
VERSION     NM_001788.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4284)
  AUTHORS   Cavini,I.A., Winter,A.J., D'Muniz Pereira,H., Woolfson,D.N.,
            Crump,M.P. and Garratt,R.C.
  TITLE     X-ray structure of the metastable SEPT14-SEPT7 coiled coil reveals
            a hendecad region crucial for heterodimerization
  JOURNAL   Acta Crystallogr D Struct Biol 79 (Pt 10), 881-894 (2023)
   PUBMED   37712436
  REMARK    GeneRIF: X-ray structure of the metastable SEPT14-SEPT7 coiled coil
            reveals a hendecad region crucial for heterodimerization.
REFERENCE   2  (bases 1 to 4284)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4284)
  AUTHORS   Mendonca,D.C., Guimaraes,S.L., Pereira,H.D., Pinto,A.A., de
            Farias,M.A., de Godoy,A.S., Araujo,A.P.U., van Heel,M.,
            Portugal,R.V. and Garratt,R.C.
  TITLE     An atomic model for the human septin hexamer by cryo-EM
  JOURNAL   J Mol Biol 433 (15), 167096 (2021)
   PUBMED   34116125
  REMARK    GeneRIF: An atomic model for the human septin hexamer by cryo-EM.
REFERENCE   4  (bases 1 to 4284)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4284)
  AUTHORS   Zhu,M., Wang,F., Yan,F., Yao,P.Y., Du,J., Gao,X., Wang,X., Wu,Q.,
            Ward,T., Li,J., Kioko,S., Hu,R., Xie,W., Ding,X. and Yao,X.
  TITLE     Septin 7 interacts with centromere-associated protein E and is
            required for its kinetochore localization
  JOURNAL   J Biol Chem 283 (27), 18916-18925 (2008)
   PUBMED   18460473
  REMARK    GeneRIF: SEPT7 forms a link between kinetochore distribution of
            CENP-E and the mitotic spindle checkpoint.
REFERENCE   6  (bases 1 to 4284)
  AUTHORS   Surka,M.C., Tsang,C.W. and Trimble,W.S.
  TITLE     The mammalian septin MSF localizes with microtubules and is
            required for completion of cytokinesis
  JOURNAL   Mol Biol Cell 13 (10), 3532-3545 (2002)
   PUBMED   12388755
REFERENCE   7  (bases 1 to 4284)
  AUTHORS   Joberty,G., Perlungher,R.R., Sheffield,P.J., Kinoshita,M., Noda,M.,
            Haystead,T. and Macara,I.G.
  TITLE     Borg proteins control septin organization and are negatively
            regulated by Cdc42
  JOURNAL   Nat Cell Biol 3 (10), 861-866 (2001)
   PUBMED   11584266
REFERENCE   8  (bases 1 to 4284)
  AUTHORS   Oegema,K., Savoian,M.S., Mitchison,T.J. and Field,C.M.
  TITLE     Functional analysis of a human homologue of the Drosophila actin
            binding protein anillin suggests a role in cytokinesis
  JOURNAL   J Cell Biol 150 (3), 539-552 (2000)
   PUBMED   10931866
REFERENCE   9  (bases 1 to 4284)
  AUTHORS   Hsu,S.C., Hazuka,C.D., Roth,R., Foletti,D.L., Heuser,J. and
            Scheller,R.H.
  TITLE     Subunit composition, protein interactions, and structures of the
            mammalian brain sec6/8 complex and septin filaments
  JOURNAL   Neuron 20 (6), 1111-1122 (1998)
   PUBMED   9655500
REFERENCE   10 (bases 1 to 4284)
  AUTHORS   Nakatsuru,S., Sudo,K. and Nakamura,Y.
  TITLE     Molecular cloning of a novel human cDNA homologous to CDC10 in
            Saccharomyces cerevisiae
  JOURNAL   Biochem Biophys Res Commun 202 (1), 82-87 (1994)
   PUBMED   8037772
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC414394.1, AC007551.1,
            BC093640.1, AC087072.2, AI651908.1 and BF941061.1.
            
            On Jul 22, 2020 this sequence version replaced NM_001788.5.
            
            Summary: This gene encodes a protein that is highly similar to the
            CDC10 protein of Saccharomyces cerevisiae. The protein also shares
            similarity with Diff 6 of Drosophila and with H5 of mouse. Each of
            these similar proteins, including the yeast CDC10, contains a
            GTP-binding motif. The yeast CDC10 protein is a structural
            component of the 10 nm filament which lies inside the cytoplasmic
            membrane and is essential for cytokinesis. This human protein
            functions in gliomagenesis and in the suppression of glioma cell
            growth, and it is required for the association of
            centromere-associated protein E with the kinetochore. Alternative
            splicing results in multiple transcript variants. Several related
            pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11,
            14, 17 and 19. [provided by RefSeq, Jul 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S72008.1, AK223241.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000350320.11/ ENSP00000344868.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                DC414394.1         72-111
            41-163              AC007551.1         100788-100910
            164-1550            BC093640.1         1-1387
            1551-4106           AC087072.2         68710-71265
            4107-4279           AI651908.1         31-203              c
            4280-4284           BF941061.1         2-6                 c
FEATURES             Location/Qualifiers
     source          1..4284
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.2"
     gene            1..4284
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /note="septin 7"
                     /db_xref="GeneID:989"
                     /db_xref="HGNC:HGNC:1717"
                     /db_xref="MIM:603151"
     exon            1..214
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1467
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /note="isoform 1 is encoded by transcript variant 1; CDC10
                     (cell division cycle 10, S. cerevisiae, homolog); CDC10
                     protein homolog"
                     /codon_start=1
                     /product="septin-7 isoform 1"
                     /protein_id="NP_001779.3"
                     /db_xref="CCDS:CCDS94085.1"
                     /db_xref="GeneID:989"
                     /db_xref="HGNC:HGNC:1717"
                     /db_xref="MIM:603151"
                     /translation="MSVSARSAAAEERSVNSSTMVAQQKNLEGYVGFANLPNQVYRKS
                     VKRGFEFTLMVVGESGLGKSTLINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKE
                     GGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPDNRVQC
                     CLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKEIQEH
                     KIKIYEFPETDDEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVEN
                     GEHCDFTILRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTYNGVDNNKNKGQLTKS
                     PLAQMEEERREHVAKMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEA
                     QHKELEEKRRQFEDEKANWEAQQRILEQQNSSRTLEKNKKKGKIF"
     exon            215..219
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            220..322
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            323..429
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            430..530
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            531..665
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            666..783
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            784..876
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            877..973
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1025
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1151
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1287
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1427
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..4284
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2460..2465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /note="hexamer: AATAAA"
     polyA_site      2481
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /note="major polyA site"
     regulatory      3391..3396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /note="hexamer: AATAAA"
     polyA_site      3428
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
     regulatory      4260..4265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
                     /note="hexamer: AATAAA"
     polyA_site      4284
                     /gene="SEPTIN7"
                     /gene_synonym="CDC10; CDC3; NBLA02942; SEPT7; SEPT7A;
                     Septin-7"
ORIGIN      
        1 agtcgagcga gagcctgtgg aggagtccgc ctgctgtagc gtgcgtaagc aaggcagcta
       61 cgccgggcgg ctacgctgcg gaatcggcgt aggcgccttt ggagaatcgg cgggctgcgc
      121 tccgctgggg ctggtcgcgg agggggggag gggatgtcgg tcagtgcgag atccgctgct
      181 gctgaggaga ggagcgtcaa cagcagcacc atggtagctc aacagaagaa ccttgaaggc
      241 tatgtgggat ttgccaatct cccaaatcaa gtatacagaa aatcggtgaa gagaggtttt
      301 gaattcacgc ttatggtagt gggtgaatct ggattgggaa agtcgacatt aatcaactca
      361 ttattcctca cagatttgta ttctccagag tatccaggtc cttctcatag aattaaaaag
      421 actgtacagg tggaacaatc caaagtttta atcaaagaag gtggtgttca gttgctgctc
      481 acaatagttg ataccccagg atttggagat gcagtggata atagtaattg ctggcagcct
      541 gttatcgact acattgatag taaatttgag gactacctaa atgcagaatc acgagtgaac
      601 agacgtcaga tgcctgataa cagggtgcag tgttgtttat acttcattgc tccttcagga
      661 catggactta aaccattgga tattgagttt atgaagcgtt tgcatgaaaa agtgaatatc
      721 atcccactta ttgccaaagc agacacactc acaccagagg aatgccaaca gtttaaaaaa
      781 cagataatga aagaaatcca agaacataaa attaaaatat acgaatttcc agaaacagat
      841 gatgaagaag aaaataaact tgttaaaaag ataaaggacc gtttacctct tgctgtggta
      901 ggtagtaata ctatcattga agttaatggc aaaagggtca gaggaaggca gtatccttgg
      961 ggtgttgctg aagttgaaaa tggtgaacat tgtgatttta caatcctaag aaatatgttg
     1021 ataagaacac acatgcagga cttgaaagat gttactaata atgtccacta tgagaactac
     1081 agaagcagaa aacttgcagc tgtgacttat aatggagttg ataacaacaa gaataaaggg
     1141 cagctgacta agagccctct ggcacaaatg gaagaagaaa gaagggagca tgtagctaaa
     1201 atgaagaaga tggagatgga gatggagcag gtgtttgaga tgaaggtcaa agaaaaagtt
     1261 caaaaactga aggactctga agctgagctc cagcggcgcc atgagcaaat gaaaaagaat
     1321 ttggaagcac agcacaaaga attggaggaa aaacgtcgtc agttcgagga tgagaaagca
     1381 aactgggaag ctcaacaacg tattttagaa caacagaact cttcaagaac cttggaaaag
     1441 aacaagaaga aagggaagat cttttaaact ctctattgac caccagttaa cgtattagtt
     1501 gccaatatgc cagcttggac atcagtgttt gttggatccg tttgaccaat ttgcaccagt
     1561 tttatccata atgatggatt taacagcatg acaaaaatta tttttttttt tgttcttgat
     1621 ggagattaag atgccttgaa ttgtctaggg tgttctgtac ttagaaagta agagctctaa
     1681 gtacctttcc tacattttct ttttttatta aacagatatc ttcagtttaa tgcaagagaa
     1741 cattttactg ttgtacaatc atgttctggt ggtttgattg tttacaggat attccaaaat
     1801 aaaaggactc tggaagattt tcattgagga taaattgcca taatatgatg caaactgtgc
     1861 ttctctatga taattacaat acaaaggttc cattcagtgc agcatataca ataatgtaat
     1921 ttagtctaac acagttgacc ctattttttg acacttccat tgtttaaaaa tacacatgga
     1981 aaaaaaaaaa accctatatg cttactgtgc acctagagct tttttataac aacgtctttt
     2041 tgtttgtttg ttttggattc tttaaatata tattattctc atttagtgcc ctctttagcc
     2101 agaatctcat tactgcttca tttttgtaat aacatttaat ttagatattt tccatatatt
     2161 ggcactgcta aaatagaata tagcatcttt catatggtag gaaccaacaa ggaaactttc
     2221 ctttaactcc ctttttacac tttatggtaa gtagcagggg gggaaatgca tttatagatc
     2281 atttctaggc aaaattgtga agctaatgac caacctgttt ctacctatat gcagtctctt
     2341 tattttacta gaaatgggaa tcatggcctc ttgaagagaa aaaagtcacc attctgcatt
     2401 tagctgtatt catatattgc atttctgtat tttttgtttg tattgtaaaa aattcacata
     2461 ataaacgatg ttgtgatgta atattgtgtg aggtcttaaa tatcctacag tcgatgtaca
     2521 agagtagagt atgtttggga agaaactttt cagcttaagt ttgcctcctc tacaatgaca
     2581 tcttttatat gcttgtctca tttagaatgc atatgtgctg attttctaat ttaagagata
     2641 ccatatctct ctattcattt ctatctctca tttgtatgct tatttttctg agaacatttt
     2701 ttttttcccc cagacagggt cttgcttcat tgcccaggct ggagtgcggt ggcacaaaca
     2761 cgacttgact gcagcctcaa ccctctgggc tcaagcagtc ctcctgcctc agccccctga
     2821 gtatctggga ttgcaggcgt gcaccaccac gcctggctaa tttttgtatt ttttgcagcc
     2881 tcccaaagtt ctgggattac aggcatgagc cgtcatgcct ggcctctgag aacagtttct
     2941 gactcattca gattaggtat actctcaagt ccctggaaac tgaaattttt tttaactgta
     3001 aagagggtag tgtcatttct tttcttaagg tcaagtgaca tagattttaa tgtaatgcat
     3061 aatttaggta agaaattaat taatgtagcc tagtttatta tcttgaaatg ttttacccta
     3121 tttacttttt aaaattaatg acctaagcgg agggaataat tataagtcaa tagcagagag
     3181 attgttgttt gggtgtttat ttttttcagt ttttgttttg agagattggg ttaacacctc
     3241 tagccaaaat tgtttggttt tagggaggct aacaataacc tactgaattt ggaaaatgca
     3301 aaggtaaaaa atgtatatag actgcctgct gaactggtta agtactactg cttctgggaa
     3361 atactatttc aaaattctat gtattataat aataaatttg taagacattc attattctac
     3421 catcctaatg aaaactttca gaagtctttc tttatccatg gcatgcccag ggttttacct
     3481 gaatctgata caggatctat ataactttac taggactttt gattgttgac tccaggctta
     3541 ggtatatcag aaggttcttt ttgccatttg gcctgtggat gtctgagaag atcattcaca
     3601 atacatgtaa aattcaggta ggcctaagga aaggccagcc tgtagaaagc aaaatggcag
     3661 tgtctgttct ccactgttgg aggcattatg taatttaagt atcctgttag ccactgtctt
     3721 tctgctaatt aagtggggct gaacaagtaa gcactaataa taccagtgaa ccacttgggc
     3781 accttgtggg tagagttttg ctgccaccta gtggaatggg atatcattgc ttccatatca
     3841 ggttcacaag caagttaagt gggcacagtt tatttctgtg tagctcaggc tgtaatcttg
     3901 aaagctgagg agatacccat gcctctcaga ctcattagct gggtgtcaca ttaccacctg
     3961 cacattctga cccaccgcat cttaatatgt tttgtcctct tggagaaact aggagtagaa
     4021 gtcaggatat ggtaggtaag ggggaaaaag gaaagacggc ttgatagcta tgaatgcatg
     4081 aggagcgaaa tgttgactca gttatctaga tcatggtctc caaacctgat gctatttcct
     4141 tacaaaaata tttgttgagc atgtgtccat aattatatgt attgaacaat gaaaatatgt
     4201 gtcaacaaat gtactgctac actaatgtga acattatgga acaaaatttg aaagagtgaa
     4261 ataaaaggtt tacactttcc ccaa
//
