LOCUS       NM_001363845            4079 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens septin 3 (SEPTIN3), transcript variant C, mRNA.
ACCESSION   NM_001363845 XM_017028862
VERSION     NM_001363845.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4079)
  AUTHORS   Toth,V., Vadaszi,H., Ravasz,L., Mittli,D., Matyas,D., Molnar,T.,
            Micsonai,A., Szaniszlo,T., Lorincz,P., Kovacs,R.A., Juhasz,T.,
            Beke-Somfai,T., Juhasz,G., Gyorffy,B.A., Kekesi,K.A. and Kardos,J.
  TITLE     Neuronal-specific septin-3 binds Atg8/LC3B, accumulates and
            localizes to autophagosomes during induced autophagy
  JOURNAL   Cell Mol Life Sci 79 (9), 471 (2022)
   PUBMED   35932293
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4079)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4079)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4079)
  AUTHORS   Rosa,H.V.D., Leonardo,D.A., Brognara,G., Brandao-Neto,J., D'Muniz
            Pereira,H., Araujo,A.P.U. and Garratt,R.C.
  TITLE     Molecular Recognition at Septin Interfaces: The Switches Hold the
            Key
  JOURNAL   J Mol Biol 432 (21), 5784-5801 (2020)
   PUBMED   32910969
  REMARK    GeneRIF: Molecular Recognition at Septin Interfaces: The Switches
            Hold the Key.
REFERENCE   5  (bases 1 to 4079)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4079)
  AUTHORS   Xue,J., Milburn,P.J., Hanna,B.T., Graham,M.E., Rostas,J.A. and
            Robinson,P.J.
  TITLE     Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein
            kinase-I in nerve terminals
  JOURNAL   Biochem J 381 (Pt 3), 753-760 (2004)
   PUBMED   15107017
REFERENCE   7  (bases 1 to 4079)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   8  (bases 1 to 4079)
  AUTHORS   Takehashi,M., Alioto,T., Stedeford,T., Persad,A.S., Banasik,M.,
            Masliah,E., Tanaka,S. and Ueda,K.
  TITLE     Septin 3 gene polymorphism in Alzheimer's disease
  JOURNAL   Gene Expr 11 (5-6), 263-270 (2004)
   PUBMED   15200238
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4079)
  AUTHORS   Methner,A., Leypoldt,F., Joost,P. and Lewerenz,J.
  TITLE     Human septin 3 on chromosome 22q13.2 is upregulated by neuronal
            differentiation
  JOURNAL   Biochem Biophys Res Commun 283 (1), 48-56 (2001)
   PUBMED   11322766
REFERENCE   10 (bases 1 to 4079)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z99716.4.
            
            On Aug 28, 2019 this sequence version replaced NM_001363845.1.
            
            Summary: This gene belongs to the septin family of GTPases. Members
            of this family are required for cytokinesis. Expression is
            upregulated by retinoic acid in a human teratocarcinoma cell line.
            The specific function of this gene has not been determined.
            Alternative splicing of this gene results in several transcript
            variants encoding different isoforms. [provided by RefSeq, May
            2018].
            
            Transcript Variant: This variant (C) represents the longest
            transcript and encodes the longest isoform (C).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.159373.1,
                                           SRR1803612.151034.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000644076.2/ ENSP00000494051.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               Z99716.4           112683-112917
            236-1758            Z99716.4           114714-116236
            1759-1950           Z99716.4           124885-125076
            1951-2079           Z99716.4           129224-129352
            2080-2161           Z99716.4           130446-130527
            2162-2299           Z99716.4           130862-130999
            2300-2417           Z99716.4           132807-132924
            2418-2513           Z99716.4           134813-134908
            2514-2613           Z99716.4           135904-136003
            2614-2665           Z99716.4           137530-137581
            2666-2759           Z99716.4           137861-137954
            2760-4079           Z99716.4           140142-141461
FEATURES             Location/Qualifiers
     source          1..4079
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..4079
                     /gene="SEPTIN3"
                     /gene_synonym="bK250D10.3; SEP3; SEPT3"
                     /note="septin 3"
                     /db_xref="GeneID:55964"
                     /db_xref="HGNC:HGNC:10750"
                     /db_xref="MIM:608314"
     exon            1..235
                     /gene="SEPTIN3"
                     /gene_synonym="bK250D10.3; SEP3; SEPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            236..1758
                     /gene="SEPTIN3"
                     /gene_synonym="bK250D10.3; SEP3; SEPT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..2825
                     /gene="SEPTIN3"
                     /gene_synonym="bK250D10.3; SEP3; SEPT3"
                     /note="isoform C is encoded by transcript variant C;
                     neuronal-specific septin-3"
                     /codon_start=1
                     /product="neuronal-specific septin-3 isoform C"
                     /protein_id="NP_001350774.1"
                     /db_xref="CCDS:CCDS87030.1"
                     /db_xref="GeneID:55964"
                     /db_xref="HGNC:HGNC:10750"
                     /db_xref="MIM:608314"
                     /translation="MDHNFAPAPPEMQSHGAPGPGTSFSHSHVLGRPIRPSRLPGGGS
                     PLTPVLRKTIHLDTFPQSHIPQTSSRLGLGARTRSVPPQETGIALGASLSPLPTSSLV
                     PRKLSSISLTLHQNSQARSLDRPLSHWEELPTPGKKAAPHEGGRVSSPGSPPVTLVPG
                     GRVHSEGPGNPGLTKSNRMLATEKPLVSSYLALPFQSRLAQSAPVLAEPGSLGQGHLV
                     SVTDHMPTRASPGKGKPRARGIPRPRGRLQRANTTVNLTAMDTRTDAARHLATMATNR
                     PSLAINLATPNTSQLDTGTEFPALDIKLGTARDLSSVGTVKSGKTVNLATAGTIKPGT
                     AMNLTTVGTTKPGMVMDLIASEPDKLGKAMATRSTAKPDMTTEGIAMDSATSDPVKPD
                     TITATVGTSRLETAMALARVNRAKLGTAKNSLALDTSRMGTAVGSVVPVTPDPATGKT
                     TLGSVNNLTISDVATCLLMPSRSTDLALDNTNAAMDRATEPASLDLATEYKGLPETRT
                     DAAMSELVPEPRPKPAVPMKPMSINSNLLGYIGIDTIIEQMRKKTMKTGFDFNIMVVG
                     QSGLGKSTLVNTLFKSQVSRKASSWNREEKIPKTVEIKAIGHVIEEGGVKMKLTVIDT
                     PGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHS
                     LRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFD
                     EDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALL
                     RDFVIRTHLQDLKEVTHNIHYETYRAKRLNDNGGLPPGEGLLGTVLPPVPATPCPTAE
                     "
     exon            1759..1950
                     /gene="SEPTIN3"
                     /gene_synonym="bK250D10.3; SEP3; SEPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2079
                     /gene="SEPTIN3"
                     /gene_synonym="bK250D10.3; SEP3; SEPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2161
                     /gene="SEPTIN3"
                     /gene_synonym="bK250D10.3; SEP3; SEPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2299
                     /gene="SEPTIN3"
                     /gene_synonym="bK250D10.3; SEP3; SEPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2417
                     /gene="SEPTIN3"
                     /gene_synonym="bK250D10.3; SEP3; SEPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2513
                     /gene="SEPTIN3"
                     /gene_synonym="bK250D10.3; SEP3; SEPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2613
                     /gene="SEPTIN3"
                     /gene_synonym="bK250D10.3; SEP3; SEPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2665
                     /gene="SEPTIN3"
                     /gene_synonym="bK250D10.3; SEP3; SEPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2759
                     /gene="SEPTIN3"
                     /gene_synonym="bK250D10.3; SEP3; SEPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2760..4079
                     /gene="SEPTIN3"
                     /gene_synonym="bK250D10.3; SEP3; SEPT3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4054..4059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEPTIN3"
                     /gene_synonym="bK250D10.3; SEP3; SEPT3"
                     /note="hexamer: ACTAAA"
     polyA_site      4079
                     /gene="SEPTIN3"
                     /gene_synonym="bK250D10.3; SEP3; SEPT3"
                     /note="major polyA site"
ORIGIN      
        1 agagcccagc ccagcacggt ctccggggat gtagctggtg ggacagtgag cagagggctg
       61 ggccctgtgc ctggggactg tggcctggag gctgagcagg agctgaggag gggaccagag
      121 ggacaaggcc cctaagctgg ccaccatggc cagactctga gtgcagggga ggtgaggggc
      181 ctgcgtgtgc cttatcttcc cagacacact ggatccttct tgtcctctga tcaagggaaa
      241 gacaaacgac ctggatggac cacaactttg ctcctgctcc tccagagatg cagtcgcatg
      301 gagctccagg cccgggaacc tccttctccc atagccatgt gctggggcgc cctatccgcc
      361 cctcgagact ccctggagga gggtcccccc tcacccccgt cctcaggaag accatccatc
      421 tggatacctt cccccaaagc catatcccac agacctccag ccggctgggc cttggagcca
      481 ggacccggag tgtgccccca caggagacgg gcatcgctct gggggcttcc ttgagccccc
      541 tgcccaccag cagccttgta cccaggaagc tcagctccat ctccttgact ctccatcaga
      601 acagccaggc acggtccctg gatcgcccac tttctcactg ggaagagttg cctaccccag
      661 gaaagaaggc tgctccccat gaaggaggga gggtgtcctc gccaggctcg ccacctgtga
      721 ccctagtgcc agggggcagg gtccactctg agggcccagg gaacccaggt ctgaccaaat
      781 ccaacaggat gcttgccacg gagaagcccc tggtgagttc ctacctagcc ttacctttcc
      841 aatcccggtt agcccagagt gcaccagtcc ttgcagagcc aggctcgttg ggccaggggc
      901 accttgtctc agtgactgac cacatgccta ccagagcttc tccaggaaaa ggcaagcccc
      961 gggccagggg gatccccaga ccccgggggc gtctccaaag ggccaacacg actgtgaatt
     1021 tgactgctat ggacacaagg acagacgcag ccagacattt agccacaatg gccaccaaca
     1081 gacctagctt ggctatcaat ttagccacac caaacacatc ccaactggac acaggcacag
     1141 agttccctgc cctggatatc aagctgggca cagccagaga cttgtcttcg gtagggacag
     1201 tcaagtcagg caaaaccgtg aacttggcta cagcaggcac aatcaagccg ggcacagcca
     1261 tgaatctgac tacagttggg acaaccaagc cagggatggt catggatttg atagcctcag
     1321 aaccagacaa gctgggcaaa gccatggcta caagaagcac agccaaacca gatatgacca
     1381 cagagggtat agccatggat tcagcaacat cagacccagt caagccggac acaatcacag
     1441 ctacagtggg caccagtagg ttggaaacag ccatggcttt ggccagagtg aacagagcca
     1501 agctgggcac ggctaagaat tctcttgctt tggacacaag caggatgggc acagctgtgg
     1561 gttcagttgt gccagtaacc ccagacccag ccactgggaa gaccacactg ggcagtgtta
     1621 ataacctaac catatcagac gttgctacat gcctgctaat gccaagcaga tccacagacc
     1681 tagccctgga caacactaat gctgccatgg acagagccac agagcctgcc tcactggacc
     1741 tggccacaga atacaaaggg ctcccagaga ccaggacgga cgcagccatg tcagagctgg
     1801 tgcctgagcc caggcctaag ccagcggtgc ccatgaagcc catgagcatc aactccaacc
     1861 tgctgggcta catcggcatc gacaccatca tcgagcagat gcgcaagaag accatgaaga
     1921 ccggtttcga cttcaacatc atggtcgttg gccagagtgg actgggcaaa tcaacgctgg
     1981 tcaacacgct cttcaaatcc caagtgagcc gcaaggcctc cagctggaac cgggaggaga
     2041 agatccccaa gacagtggag atcaaagcta tcgggcatgt gatagaggaa ggcggtgtca
     2101 aaatgaagct gaccgtcatc gacaccccag gctttggaga ccaaatcaac aatgaaaact
     2161 gctgggagcc cattgagaag tacatcaatg agcagtacga gaagttcctg aaggaggagg
     2221 tcaacatcgc caggaagaaa cgcatccctg acactcgtgt ccactgctgc ctttacttca
     2281 tctctcccac aggacactcc ttgcgacctc tggatcttga gttcatgaaa cacctcagca
     2341 aggttgtgaa catcatccct gtcattgcta aggctgacac catgaccctg gaggagaagt
     2401 ctgaattcaa gcaaagggtt cgcaaggagc ttgaagtaaa tggcattgaa ttctaccccc
     2461 agaaggaatt tgatgaggat ttggaggata agacggagaa tgacaaaatc aggcaggaga
     2521 gcatgccttt tgctgtggtg ggaagtgaca aggagtacca agtgaatggc aagagggtcc
     2581 tcggccgaaa aactccatgg gggatcatcg aagtggaaaa cctcaaccac tgtgagtttg
     2641 ccctgcttcg agactttgtc atcaggaccc acctccagga cctcaaggaa gtgacacaca
     2701 acatccacta tgagacttac agggccaagc ggctcaatga caatggaggc ctccctccgg
     2761 gagaaggcct cctgggcact gtccttccac ctgtgccagc caccccctgc cccactgctg
     2821 aatgaaggcc atttcaagcg ctgcttctca ctccattcct ctcagctgtt attgctgcag
     2881 ggccaagccc tttttagtgc tgtgctcgtc cagctcacca ccacagcccc tctcagccct
     2941 cagtaggtgg gaggggccag ctgcctcttt aggccagttg catcctccat ttatccaaac
     3001 cactcctctc ctcccagtgg agtggggttc tgccagtaca gccctactgc atcatctgcg
     3061 tcagccggtc ctagcccatc tgcagggtga aagaactcat caagagctcc ttctgccctt
     3121 gtaagcccat cccagctact tgtaaccatc tctaagggca atggcattgc tccctaccca
     3181 ttcatctgca tgagctactc ttggcttcct taaagggtca agaaagcaat ttttctgctt
     3241 actagattca ttgagatcag ctgtgtgagc cccaaagtgg gacaagggtg tctccttcat
     3301 tacttaaaga tattcatgag ggtgggtcac tacagatgtt ggggagcaag ggctaggatc
     3361 actttttaaa aaatcaccac ttgtggctgt cccagagtgc ggttgtacat cctccccacc
     3421 tcataacgca gccactgagg aagagtggtt ttcctaagaa gacattgctg gagttgactt
     3481 tcttctgtcc aaacaaacaa acaaaaacta aacacacaca caaaccccca gaaacccaca
     3541 atatgtacac gctaaggaaa aactagcacc cttctgtcca ctcagcaata agagggatct
     3601 cttcccacct accctaccta ctcctacccc caaccccctt ccccattaat gtgagtaatg
     3661 aattagcctg accacaggtg gtcactgtag gctaatggaa aatacccaag ggagggcaaa
     3721 gccccccatc agatgcatga atgtttgcga atgttgactg ccactgcccc acacactgtg
     3781 tctttataga attccccttt gcccaccctc ttcctgtctc cacctggaca caacttgctc
     3841 aaaggctggt gacttgtggg ccattcatct acaaccaagt cctgatggag caagaggccc
     3901 acgcctaggg gatgcaagaa caacccgttt cttaaatgtt accagtccca gccaatctta
     3961 cggtgacatt acagttaaat ttcccaattg aaaacaagca aacagacact caaactggtc
     4021 ctgtaattgt tgctagactt tatgtgttgt acaactaaac attgctgttt gaacagtaa
//
