LOCUS       NM_004404               3251 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens septin 2 (SEPTIN2), transcript variant 4, mRNA.
ACCESSION   NM_004404
VERSION     NM_004404.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3251)
  AUTHORS   Yin,Z., Zhang,L., Liu,R., Tong,L., Jiang,C. and Kang,L.
  TITLE     Circ_0057558 accelerates the development of prostate cancer through
            miR-1238-3p/SEPT2 axis
  JOURNAL   Pathol Res Pract 243, 154317 (2023)
   PUBMED   36738516
  REMARK    GeneRIF: Circ_0057558 accelerates the development of prostate
            cancer through miR-1238-3p/SEPT2 axis.
REFERENCE   2  (bases 1 to 3251)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3251)
  AUTHORS   Kang,N., Matsui,T.S., Liu,S. and Deguchi,S.
  TITLE     ARHGAP4-SEPT2-SEPT9 complex enables both up- and down-modulation of
            integrin-mediated focal adhesions, cell migration, and invasion
  JOURNAL   Mol Biol Cell 32 (21), ar28 (2021)
   PUBMED   34524873
  REMARK    GeneRIF: ARHGAP4-SEPT2-SEPT9 complex enables both up- and
            down-modulation of integrin-mediated focal adhesions, cell
            migration, and invasion.
REFERENCE   4  (bases 1 to 3251)
  AUTHORS   Mendonca,D.C., Guimaraes,S.L., Pereira,H.D., Pinto,A.A., de
            Farias,M.A., de Godoy,A.S., Araujo,A.P.U., van Heel,M.,
            Portugal,R.V. and Garratt,R.C.
  TITLE     An atomic model for the human septin hexamer by cryo-EM
  JOURNAL   J Mol Biol 433 (15), 167096 (2021)
   PUBMED   34116125
  REMARK    GeneRIF: An atomic model for the human septin hexamer by cryo-EM.
REFERENCE   5  (bases 1 to 3251)
  AUTHORS   Neubauer,K. and Zieger,B.
  TITLE     The Mammalian Septin Interactome
  JOURNAL   Front Cell Dev Biol 5, 3 (2017)
   PUBMED   28224124
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3251)
  AUTHORS   Beites,C.L., Xie,H., Bowser,R. and Trimble,W.S.
  TITLE     The septin CDCrel-1 binds syntaxin and inhibits exocytosis
  JOURNAL   Nat Neurosci 2 (5), 434-439 (1999)
   PUBMED   10321247
REFERENCE   7  (bases 1 to 3251)
  AUTHORS   Kinoshita,A., Kinoshita,M., Akiyama,H., Tomimoto,H., Akiguchi,I.,
            Kumar,S., Noda,M. and Kimura,J.
  TITLE     Identification of septins in neurofibrillary tangles in Alzheimer's
            disease
  JOURNAL   Am J Pathol 153 (5), 1551-1560 (1998)
   PUBMED   9811347
REFERENCE   8  (bases 1 to 3251)
  AUTHORS   Hsu,S.C., Hazuka,C.D., Roth,R., Foletti,D.L., Heuser,J. and
            Scheller,R.H.
  TITLE     Subunit composition, protein interactions, and structures of the
            mammalian brain sec6/8 complex and septin filaments
  JOURNAL   Neuron 20 (6), 1111-1122 (1998)
   PUBMED   9655500
REFERENCE   9  (bases 1 to 3251)
  AUTHORS   Kinoshita,M., Kumar,S., Mizoguchi,A., Ide,C., Kinoshita,A.,
            Haraguchi,T., Hiraoka,Y. and Noda,M.
  TITLE     Nedd5, a mammalian septin, is a novel cytoskeletal component
            interacting with actin-based structures
  JOURNAL   Genes Dev 11 (12), 1535-1547 (1997)
   PUBMED   9203580
REFERENCE   10 (bases 1 to 3251)
  AUTHORS   Mori,T., Miura,K., Fujiwara,T., Shin,S., Inazawa,J. and Nakamura,Y.
  TITLE     Isolation and mapping of a human gene (DIFF6) homologous to yeast
            CDC3, CDC10, CDC11, and CDC12, and mouse Diff6
  JOURNAL   Cytogenet Cell Genet 73 (3), 224-227 (1996)
   PUBMED   8697812
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB091579.1, AF038404.1, BX648000.1 and AA482233.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004404.4.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.127806.1,
                                           SRR1660807.58519.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391971.7/ ENSP00000375832.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                DB091579.1         65-103
            40-1878             AF038404.1         43-1881
            1879-3231           BX648000.1         1962-3314
            3232-3251           AA482233.1         9-28                c
FEATURES             Location/Qualifiers
     source          1..3251
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..3251
                     /gene="SEPTIN2"
                     /gene_synonym="DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;
                     SEPT2; Septin-2"
                     /note="septin 2"
                     /db_xref="GeneID:4735"
                     /db_xref="HGNC:HGNC:7729"
                     /db_xref="MIM:601506"
     exon            1..58
                     /gene="SEPTIN2"
                     /gene_synonym="DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;
                     SEPT2; Septin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            59..84
                     /gene="SEPTIN2"
                     /gene_synonym="DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;
                     SEPT2; Septin-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1161
                     /gene="SEPTIN2"
                     /gene_synonym="DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;
                     SEPT2; Septin-2"
                     /note="isoform a is encoded by transcript variant 4;
                     neural precursor cell expressed, developmentally
                     down-regulated 5; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="septin-2 isoform a"
                     /protein_id="NP_004395.1"
                     /db_xref="CCDS:CCDS2548.1"
                     /db_xref="GeneID:4735"
                     /db_xref="HGNC:HGNC:7729"
                     /db_xref="MIM:601506"
                     /translation="MSKQQPTQFINPETPGYVGFANLPNQVHRKSVKKGFEFTLMVVG
                     ESGLGKSTLINSLFLTDLYPERVIPGAAEKIERTVQIEASTVEIEERGVKLRLTVVDT
                     PGYGDAINCRDCFKTIISYIDEQFERYLHDESGLNRRHIIDNRVHCCFYFISPFGHGL
                     KPLDVAFMKAIHNKVNIVPVIAKADTLTLKERERLKKRILDEIEEHNIKIYHLPDAES
                     DEDEDFKEQTRLLKASIPFSVVGSNQLIEAKGKKVRGRLYPWGVVEVENPEHNDFLKL
                     RTMLITHMQDLQEVTQDLHYENFRSERLKRGGRKVENEDMNKDQILLEKEAELRRMQE
                     MIARMQAQMQMQMQGGDGDGGALGHHV"
     exon            85..205
                     /gene="SEPTIN2"
                     /gene_synonym="DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;
                     SEPT2; Septin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            206..292
                     /gene="SEPTIN2"
                     /gene_synonym="DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;
                     SEPT2; Septin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            293..416
                     /gene="SEPTIN2"
                     /gene_synonym="DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;
                     SEPT2; Septin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            417..551
                     /gene="SEPTIN2"
                     /gene_synonym="DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;
                     SEPT2; Septin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..669
                     /gene="SEPTIN2"
                     /gene_synonym="DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;
                     SEPT2; Septin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            670..771
                     /gene="SEPTIN2"
                     /gene_synonym="DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;
                     SEPT2; Septin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..917
                     /gene="SEPTIN2"
                     /gene_synonym="DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;
                     SEPT2; Septin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1001
                     /gene="SEPTIN2"
                     /gene_synonym="DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;
                     SEPT2; Septin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1059
                     /gene="SEPTIN2"
                     /gene_synonym="DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;
                     SEPT2; Septin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1190
                     /gene="SEPTIN2"
                     /gene_synonym="DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;
                     SEPT2; Septin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..3251
                     /gene="SEPTIN2"
                     /gene_synonym="DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;
                     SEPT2; Septin-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3224..3229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEPTIN2"
                     /gene_synonym="DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;
                     SEPT2; Septin-2"
                     /note="hexamer: AATAAA"
     polyA_site      3251
                     /gene="SEPTIN2"
                     /gene_synonym="DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;
                     SEPT2; Septin-2"
                     /note="major polyA site"
ORIGIN      
        1 agcgctgggc gggtccgcgg cgcggtcggt cggcgcctgt tctcgggctg tttggcggac
       61 gaagcttcac aaaagatgtc taagcaacag ccaactcagt ttataaatcc agaaacacct
      121 ggctatgttg gatttgcaaa cctccccaat caagttcacc gaaaatcagt gaaaaaaggt
      181 tttgagttca cactgatggt ggtcggtgaa tcaggtctag gaaaatcgac tctcataaac
      241 agcctattcc taactgatct gtacccagaa agagtcatac ctggagcagc agaaaaaatt
      301 gaaagaactg tccagattga ggcttcaact gttgaaattg aagagcgagg ggtcaagcta
      361 cgcctgacag tggtagatac ccctggctat ggtgacgcta tcaactgcag agattgtttt
      421 aagacaatta tctcctatat tgatgagcaa tttgagaggt acctgcatga cgagagcggc
      481 ttgaacaggc ggcacatcat tgataatagg gtgcattgtt gcttttactt tatttcacct
      541 tttggacatg gacttaagcc cttagatgtg gcgtttatga aggcaataca caacaaggtg
      601 aatattgtgc ctgtcattgc aaaagctgac actctcaccc tgaaggaacg ggagcggctg
      661 aagaaaagga ttctggatga aattgaagaa cataacatca aaatctatca cttacctgat
      721 gcagaatcag atgaagatga agattttaaa gagcagacta gacttctcaa ggctagcatc
      781 ccattctctg tggttggatc caatcagttg attgaagcca aaggaaagaa ggtcagaggc
      841 cgcctctacc cctggggtgt tgtggaagtg gagaacccag agcacaatga ctttctgaag
      901 ctgagaacca tgctcatcac ccacatgcag gatctccagg aggtgaccca ggaccttcat
      961 tatgaaaact tccgttctga gagactcaag agaggcggca ggaaagtgga gaatgaggac
     1021 atgaataaag accagatctt gctggaaaaa gaagctgagc tccgccgcat gcaagagatg
     1081 attgcaagga tgcaggcgca gatgcagatg cagatgcagg gcggggatgg cgatggcggg
     1141 gctctcgggc accacgtgta aggtgatgtg cacatatcaa gaagtcagag aaaacacttt
     1201 cctggataaa aaagaaaaca ttccagatgc atgatccagc tgtgtgtttt caatccttgg
     1261 gagggtgcca tccacatttt aacagtacct gtgcctgaga atttaatttt taaaagactt
     1321 tgatgtgttt ttgtatgaag tacttttaac gtatgtattt cattgctgtg tcacactctg
     1381 tgttttgtga ggtgaatgtc ttccttttct ttctccctaa ccactaatgt tagaattgat
     1441 ttccaagaat cggcatgtat acttaatact gaatttcttt gatttaactg acttaacaac
     1501 tgactaacca ttgatgagca ctcctgattt ttatctagaa cattcagatt taccataatg
     1561 ttccttagtg gtagaggtgt gtgcctagtg atgtagaaag atacactgac ttggtgcaag
     1621 gccatctgct taccacatca caccacttgg agatctttgc ttccttgctt ttatgtttgt
     1681 acacaacacc taaaaccagt tttgctgcta taattctata ctgttgattc gtctgcgatt
     1741 ttatctgtta accaaataaa acataataga atttcctaat gagatatatc tttatactta
     1801 aacagctttt ttagaggtga gttttaaaga agtctcttaa ttctgatgct aggttgtttt
     1861 taaaaccact atgcaaagaa ctcaccacaa gccacctttt gtagtgttct ccactaatac
     1921 tggttatcct gtgctacaga gaaaatcaaa gcagtcataa gctccagttt tcgtattgca
     1981 aataagactc ttacctacaa aatgagattc agtgaactaa tttggttttt actcaaccaa
     2041 attaaaaatt tttttaagga aaattagcag ttggtctatt cagaatcaaa cctttttata
     2101 ttttatactg cactttagtg tattttctgt cactgtaggt atagaagatc tgcctcccct
     2161 gtggaaattg gggtctgttg gtgggcgtgc ccctgaagcc tggcttgggt tgaaaagtgt
     2221 tcccgcccta aggccttggt gccctgaacc tctgatgcct accgggttct cctgatttga
     2281 gtttccttta aatactccct ttttgagtaa ttttctgatg ggaggaaagt agcagtcatc
     2341 atctttttgt gtgcaggctg tctcatttat ttttagccat tgtcgtttca ttcattttgt
     2401 gtaatataaa ccgtgtgtca tgtcaaagtg aaagacattt caaatctgta gcataggcta
     2461 gtgggcaggt ccgcacagtc gaagccacac ctggtctgtt ttctgtgcac tgtagcctta
     2521 gtgtcacctt tcttcttgtg tctccttatg gtacactcca gcggttgcct tttttatcat
     2581 ttctactgaa gttgggaaat tcaaccccag aaattgacag atgaaaggag acaatggttg
     2641 tgtagggaga tggagaaaat gcttaatctg aggatgagac agggtttttt catttttgtg
     2701 ggggctagaa aaaacataaa atgaggcagt taaataataa tagttaatga aggtgtgcta
     2761 cagaaaataa tctggtgttc ttgctaactt tgcccttcac tgttgcttaa ttgtgaacag
     2821 ccaaaagcta tatgttatgg cttattgtgt gaaggtaact aagaagtggt gttccatgac
     2881 ttcagagtac atccatgcgg agtccattat ttgagtttga catttaataa ctttgctgga
     2941 aaatctgtaa aaaagaaaaa caagtttgct agtgactaag ccccgcatat gtgagtgaaa
     3001 gtacttcagg cacgctgcct cctggtaaca gctatgcagg gagggaggac ccacactgct
     3061 acacttctga tcccctttgg ttttactacc caaatctaaa tagatacttt tgataataga
     3121 taactgctct tttactaaga catagtctct acctatagaa atgtattttg aaaacactta
     3181 ttttacacag caattttgta tccatttaaa ctaacctttt atcaataaag cactattgtt
     3241 tagatattaa a
//
