LOCUS       NM_018243               5545 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens septin 11 (SEPTIN11), transcript variant 2, mRNA.
ACCESSION   NM_018243
VERSION     NM_018243.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5545)
  AUTHORS   Li,W., Liu,M., Zhou,M., Zhou,X., Zhang,D., Duan,J., Zhang,A. and
            Xu,B.
  TITLE     Downregulation of SEPTIN11 inhibits endometrial epithelial cell
            adhesive function in patients with elevated peripheral blood
            natural killer cell counts
  JOURNAL   Reprod Biomed Online 47 (2), 103203 (2023)
   PUBMED   37349244
  REMARK    GeneRIF: Downregulation of SEPTIN11 inhibits endometrial epithelial
            cell adhesive function in patients with elevated peripheral blood
            natural killer cell counts.
REFERENCE   2  (bases 1 to 5545)
  AUTHORS   Fu,L., Wang,X., Yang,Y., Chen,M., Kuerban,A., Liu,H., Dong,Y.,
            Cai,Q., Ma,M. and Wu,X.
  TITLE     Septin11 promotes hepatocellular carcinoma cell motility by
            activating RhoA to regulate cytoskeleton and cell adhesion
  JOURNAL   Cell Death Dis 14 (4), 280 (2023)
   PUBMED   37080972
  REMARK    GeneRIF: Septin11 promotes hepatocellular carcinoma cell motility
            by activating RhoA to regulate cytoskeleton and cell adhesion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5545)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 5545)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5545)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5545)
  AUTHORS   Kojima,K., Sakai,I., Hasegawa,A., Niiya,H., Azuma,T., Matsuo,Y.,
            Fujii,N., Tanimoto,M. and Fujita,S.
  TITLE     FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell
            line CNLBC1 derived from chronic neutrophilic leukemia in
            transformation with t(4;11)(q21;q23)
  JOURNAL   Leukemia 18 (5), 998-1005 (2004)
   PUBMED   14999297
REFERENCE   7  (bases 1 to 5545)
  AUTHORS   Kim,D.S., Hubbard,S.L., Peraud,A., Salhia,B., Sakai,K. and
            Rutka,J.T.
  TITLE     Analysis of mammalian septin expression in human malignant brain
            tumors
  JOURNAL   Neoplasia 6 (2), 168-178 (2004)
   PUBMED   15140406
REFERENCE   8  (bases 1 to 5545)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   9  (bases 1 to 5545)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 5545)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC008083.2, AK001711.1, AK027633.1, AK124592.1, BQ021538.1,
            CA394082.1, BQ221260.1, AI741944.1 and AI580485.1.
            
            On Jun 2, 2019 this sequence version replaced NM_018243.3.
            
            Summary: SEPT11 belongs to the conserved septin family of
            filament-forming cytoskeletal GTPases that are involved in a
            variety of cellular functions including cytokinesis and vesicle
            trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al.,
            2004 [PubMed 15485874]).[supplied by OMIM, Jul 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an exon in the 5' coding region that results in use of an
            alternate start codon compared to variant 1. It encodes isoform 2,
            which has a novel N-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2620350.1,
                                           SRR1803612.79002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264893.11/ ENSP00000264893.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1837              BC008083.2         25-1861
            1838-2458           AK001711.1         1779-2399
            2459-3793           AK027633.1         1912-3246
            3794-3863           AK124592.1         4075-4144
            3864-3893           AK027633.1         3317-3346
            3894-3973           BQ021538.1         238-317
            3974-4288           AK027633.1         3427-3741
            4289-4523           CA394082.1         128-362
            4524-5133           BQ221260.1         161-770
            5134-5243           AI741944.1         328-437             c
            5244-5545           AI580485.1         28-329              c
FEATURES             Location/Qualifiers
     source          1..5545
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..5545
                     /gene="SEPTIN11"
                     /gene_synonym="SEPT11; Septin-11"
                     /note="septin 11"
                     /db_xref="GeneID:55752"
                     /db_xref="HGNC:HGNC:25589"
                     /db_xref="MIM:612887"
     exon            1..179
                     /gene="SEPTIN11"
                     /gene_synonym="SEPT11; Septin-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1442
                     /gene="SEPTIN11"
                     /gene_synonym="SEPT11; Septin-11"
                     /note="isoform 2 is encoded by transcript variant 2;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="septin-11 isoform 2"
                     /protein_id="NP_060713.1"
                     /db_xref="CCDS:CCDS34018.1"
                     /db_xref="GeneID:55752"
                     /db_xref="HGNC:HGNC:25589"
                     /db_xref="MIM:612887"
                     /translation="MAVAVGRPSNEELRNLSLSGHVGFDSLPDQLVNKSTSQGFCFNI
                     LCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTV
                     GFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHS
                     LKSLDLVTMKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPTDE
                     ETVAEINATMSVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREM
                     LIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGEL
                     QKKEEEMRQMFVMRVKEKEAELKEAEKELHEKFDLLKRTHQEEKKKVEDKKKELEEEV
                     NNFQKKKAAAQLLQSQAQQSGAQQTKKDKDKKNASFT"
     exon            180..294
                     /gene="SEPTIN11"
                     /gene_synonym="SEPT11; Septin-11"
                     /inference="alignment:Splign:2.1.0"
     exon            295..490
                     /gene="SEPTIN11"
                     /gene_synonym="SEPT11; Septin-11"
                     /inference="alignment:Splign:2.1.0"
     exon            491..677
                     /gene="SEPTIN11"
                     /gene_synonym="SEPT11; Septin-11"
                     /inference="alignment:Splign:2.1.0"
     exon            678..839
                     /gene="SEPTIN11"
                     /gene_synonym="SEPT11; Septin-11"
                     /inference="alignment:Splign:2.1.0"
     exon            840..936
                     /gene="SEPTIN11"
                     /gene_synonym="SEPT11; Septin-11"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1105
                     /gene="SEPTIN11"
                     /gene_synonym="SEPT11; Septin-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1238
                     /gene="SEPTIN11"
                     /gene_synonym="SEPT11; Septin-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1426
                     /gene="SEPTIN11"
                     /gene_synonym="SEPT11; Septin-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..5545
                     /gene="SEPTIN11"
                     /gene_synonym="SEPT11; Septin-11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5523..5528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEPTIN11"
                     /gene_synonym="SEPT11; Septin-11"
                     /note="hexamer: AATATA"
     polyA_site      5545
                     /gene="SEPTIN11"
                     /gene_synonym="SEPT11; Septin-11"
                     /note="major polyA site"
ORIGIN      
        1 gagcagatgc cgctggctgc cagcgggacg ccggcgagca gagcgcagcc gcgagggagg
       61 cgcgagggag gcgagccgga gcccgagcac tagcagcagc cggagtcggc gtaaagcacc
      121 cgggcgcagc cggagccggt gccgcagctg cgatggccgt ggccgtgggg agaccgtcta
      181 atgaagagct tcgaaacttg tctttgtctg gccatgtggg atttgacagc ctccctgacc
      241 agctggtcaa caagtctact tctcaaggat tctgtttcaa catcctttgt gttggtgaga
      301 caggcattgg caaatccacg ttaatggaca ctttgttcaa caccaaattt gaaagtgacc
      361 cagctactca caatgaacca ggtgttcggt taaaagccag aagttatgag cttcaggaaa
      421 gcaatgtacg gctgaagtta accattgttg acaccgtggg atttggagac cagataaata
      481 aagatgacag ctataagccg atagtagaat atattgatgc ccagttcgag gcctacctgc
      541 aagaggaatt gaagattaaa cgttctctct tcaactacca tgacacgagg atccatgcct
      601 gcctctactt tattgcccct actggacatt cactaaagtc cctggatctg gtcaccatga
      661 aaaagctgga cagtaaggtg aacatcattc caataattgc aaaagctgac accattgcca
      721 agaatgaact gcacaaattc aagagtaaga tcatgagtga actggtcagc aatggggtcc
      781 agatatatca gtttcccact gatgaagaaa cggtggcaga gattaacgca acaatgagtg
      841 tccatctccc atttgcagtg gttggcagca ccgaagaggt gaagattggc aacaagatgg
      901 caaaggccag gcagtacccc tggggtgtgg tgcaggttga gaatgaaaat cattgcgatt
      961 ttgtgaaact tcgagagatg ctgatccgcg tgaacatgga ggacttgcga gagcagactc
     1021 acacccgcca ctatgaattg taccgacgct gtaagcttga agagatgggg ttcaaggaca
     1081 ctgaccctga cagcaaaccc ttcagtcttc aggagacata tgaagcaaaa aggaatgaat
     1141 tcctgggaga actgcagaag aaagaagaag aaatgagaca aatgtttgtt atgagagtga
     1201 aggagaaaga agctgaactt aaggaggcag agaaagagct tcacgagaag tttgaccttc
     1261 taaagcggac acaccaagaa gaaaagaaga aagtggaaga caagaagaag gagcttgagg
     1321 aggaggtgaa caacttccag aagaagaaag cagcggctca gttactacag tcccaggccc
     1381 agcaatctgg ggcccagcaa accaagaaag acaaggataa gaaaaatgca agcttcacat
     1441 aaagcctggc aagccaagga tgttcccgca ttcacctgct tttgcagtaa tatcgtatct
     1501 ctgccatgtg tgttctttag ttttatttta ttttatttta tttttttacc cttcctcaaa
     1561 caccagtaac tattattaac tcgttttgct gaatgttgtt gggtggtaga aaatgataga
     1621 acaagggaat aaccgcgaat gctctgtgca gctggactct gtttccggaa agtaaatgat
     1681 ttgcttttta tgcctgttct gaatggcagc acgaagcagg cctgttactt gtatgtcgct
     1741 ttggacagag gaaagtgggg taaaatgcta cctgtacgtc tgacatgaaa acttctcacc
     1801 gcctcagcag ctgaactaaa aacctgaata gccatgacaa gagtttgcat tttcttgatg
     1861 attcatctcc atgagtgcac aatccctgaa ctcactgtct tttctccaca cttgtcctaa
     1921 gccaaggtag atttgtacgt agacagactg gtgagcaagc attatatttt atttttaccc
     1981 ttgcatgaca ttttcatttt aatcaataac attatttggc ctgagcttgt gggtctgttc
     2041 agactgtctc ctctcatggt ttgaaactgc atctgaatgc ctgccttcaa tcctggccaa
     2101 gttggagtag actggtatga gaaaactatg attagttcac atttactggt gcatccttga
     2161 tcctctcaca gatagaggtc ttaaaggttg gatcatgtaa cattgcttag tagaagaatc
     2221 ttcttctaag gatgatgggc tttctacagc ctgcttacca ctaacagtaa ggaatctttc
     2281 ataaacacac ctcagtttgt tcccagtggg cttagaggga ggacctgatg actgattcca
     2341 ggatacttgt acttctaata acatttttca tgaatcatga gaaaatttcc acagatactt
     2401 cccttagaaa atttgctata aactctgtat cattggtagc acaaatttga gcgaggcctt
     2461 gtcaatttta aggtggaaat aggaaggacc acaacatgac ccgtaagtca agaaggtaga
     2521 catttcatat ccagcttcct tgcttagtct cctttcagta tttggcaata aaagaaagaa
     2581 gaaatagaac agctgaagtc tcaaatcatt gtctggaatt ttcctcacct tggctagctc
     2641 cacctgctct ttgtctaagg cccttgcctc atcagggatt agaactggcc catatgccag
     2701 aacctgtact aaatgcctaa tttgtatgga agagtgcata tttaatctct tttctatact
     2761 gctcctttct gatgcttatc ctttcatctg tgtgattgtt ttttcccctc tactaacaag
     2821 atcctcccag ctttctctct acatgtagaa aggataacat ttctcatgaa cccactgccc
     2881 ctctgcattt tcctcactgg ttagagatta agtaaatagg atagaatatg ctgcgtctcc
     2941 cctgacacac actttctttt ttgaatgagc aagtctccat tttgatttca gcaaagattt
     3001 tttctccttt tctttgtcct caaccatact tagaggaaag aaggaatggt cttccatgaa
     3061 ctgattatgc ttaattaagc aaagtaagga aattagtttc atggaagcct aaacaaagct
     3121 ggaatagaaa ctacacacta gacacagcag tagtcatagt cttcacaggt ttaggagcta
     3181 ctggaccaac attcttgttt ttgcttttgt ttttttaaat aattctagtc tggagctaac
     3241 tgtggagcag ccaaatagta gctggcatgt tgattcaaac catgggctga atttgctcat
     3301 aggctgtgca tcagacaaaa gcttgaatat ttgtgttgta tgcttgttcc aaccaccgct
     3361 tgtgtgagca tttttgtggc ttgtacagaa agtacacttt taaattgtct cttgcatcac
     3421 taaaattttt ttaaaatgag cataacaacg aaaggcatcc agctgacttt ttgattccaa
     3481 gattattgat tggattgact tttttgcatt aaatttttcc cagcaaaata aatcatatgg
     3541 cgagtcaggg aataaaaagt caaaagaaac aaatagaagc tttttttttt aaaaaatgta
     3601 ttgcttctga acttttttct gccactgctc cctagccctg tttagtttgt tattgctgct
     3661 tttctttttt ctttctgtat ctatgccttt ttttcacagt agtccttggc tctgcacgga
     3721 ataaatgata ccctcaaatc taattggatg tgctttcgcc tttgcatgta agtacggtag
     3781 taagaaacct ttgagatctt tctgactttt caaaattaga gaaagcaaat gggatggata
     3841 gatttttttt ttcttttcaa ggggggcagg aaggtaatgg tttgagtagc ctttgtttaa
     3901 aaaaaagact aaatatattt aaaaggccac atttatattt ttttcacaag aaccacataa
     3961 taaattccac ttcttgacct gaatttggaa atccgaaatt actaatccag gccaggtgtg
     4021 gtggctcatg cctgtaatcc cagcactttg agaggccgag gtgggcagat cacttgaggc
     4081 ctggagttca agaccacctt ggcgaacacg gtgaaacccc gtctctacaa aaaatacaaa
     4141 aattagccag gcgtggtggc acgtgcctgt agtcccagct acttgggagg ctaagtcagg
     4201 agaattgctt gaacttggga gatggaggtt gcagtgagcc aagattgcac cactgcattc
     4261 caacctgggt gatgaagtga gactctccaa aaaaaaaaaa gaaattatta atccctgcct
     4321 gtgctctaca tagcctcatg ggcatcattg gatagctcag agggcccttg attctggcaa
     4381 ggcaaataaa gccagaatga gaaattacca tcttctacta gagaaaacca agagaaaaat
     4441 ttttatgcta ggatgccttt atgaccactt aattttttaa tcttagttta atggtctctc
     4501 cctggtgcta actgctgaca gtggccacct cttttttggg gattgagggg cctacataac
     4561 tagctggcct taccccatat cttttgttca aacataatac catctttttg cttcttctga
     4621 actttagatc tccataacac atgtactgta gaatgtgatg gaaaagcatt gatgagaatt
     4681 tattggcagt tcagattgtg ttttcccaac ttaggctctt tattaattgg ttaaggtttt
     4741 ctccaaaaag ggcatttcaa caatgggaat tatttaatgt aacagtgggc acagattact
     4801 tatcttcctt ctctgctttg tgactcacca gcagtaacac acacaatcca catcttgtgc
     4861 acctcaaatg aacagacttg gtttccttgc tttcttgaca tttccatgac tgtttcacat
     4921 acaaactatt gggtgaggtt tttcagctgt taccgaccca cgtcctgctg tctctgtgtg
     4981 gtcctacaaa aactgtccat tcccacccct ttgctttgcc atttgcaaga gtctggaatt
     5041 gtcaggtctc agcttcgaaa agtcctggtt ccactgacag gacacattct ttagtgggaa
     5101 ttaagaccta caaagtctag tttgtatgta ggtatgaagg gaatttttta aataaattga
     5161 aaagctgtga acagcattag aactttgtct atttcttaat tttaaaatat gctgatatgc
     5221 cttaaactgt agttgtagat ccttgtcatt ttgctgtttg aaaataacca atgtgttttc
     5281 taaaactgtc gtgtaatcta ctttcattgt taatgcagaa ttgtcatata tgtaagctgc
     5341 atgttagaca tttgtctttt ttaaactaaa gtaattgtat tgatgtgaag catatcattt
     5401 tttcaaatat gaaagtgatc acttagcaac atgcttggta atttggcatc tgttaaggta
     5461 ggagagtggt gaacagataa tctatgcata tatcactagt gccaagacat aaagcggggg
     5521 aaaatatatt tttacccaaa catta
//
