LOCUS       NM_144710               3014 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens septin 10 (SEPTIN10), transcript variant 1, mRNA.
ACCESSION   NM_144710
VERSION     NM_144710.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3014)
  AUTHORS   Weiler,S.M.E., Bissinger,M., Rose,F., von Bubnoff,F., Lutz,T.,
            Ori,A., Schirmacher,P. and Breuhahn,K.
  TITLE     SEPTIN10-mediated crosstalk between cytoskeletal networks controls
            mechanotransduction and oncogenic YAP/TAZ signaling
  JOURNAL   Cancer Lett 584, 216637 (2024)
   PUBMED   38242197
  REMARK    GeneRIF: SEPTIN10-mediated crosstalk between cytoskeletal networks
            controls mechanotransduction and oncogenic YAP/TAZ signaling.
REFERENCE   2  (bases 1 to 3014)
  AUTHORS   Shen,B., Gao,H., Zhang,D., Yu,H., Chen,J., Huang,S., Gu,P. and
            Zhong,Y.
  TITLE     miR-124-3p regulates the proliferation and differentiation of
            retinal progenitor cells through SEPT10
  JOURNAL   Cell Tissue Res 392 (3), 689-704 (2023)
   PUBMED   36802303
  REMARK    GeneRIF: miR-124-3p regulates the proliferation and differentiation
            of retinal progenitor cells through SEPT10.
REFERENCE   3  (bases 1 to 3014)
  AUTHORS   Zhu,H., Tang,X., Zhang,H., Zhou,M., Liu,H., Chu,H. and Zhang,Z.
  TITLE     Exosomal circCLIP1 regulates PM2.5-induced airway obstruction via
            targeting SEPT10 in vitro
  JOURNAL   Ecotoxicol Environ Saf 254, 114750 (2023)
   PUBMED   36950992
  REMARK    GeneRIF: Exosomal circCLIP1 regulates PM2.5-induced airway
            obstruction via targeting SEPT10 in vitro.
REFERENCE   4  (bases 1 to 3014)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3014)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   6  (bases 1 to 3014)
  AUTHORS   Xu,M., Takanashi,M., Oikawa,K., Nishi,H., Isaka,K., Yoshimoto,T.,
            Ohyashiki,J. and Kuroda,M.
  TITLE     Identification of a novel role of Septin 10 in
            paclitaxel-resistance in cancers through a functional genomics
            screen
  JOURNAL   Cancer Sci 103 (4), 821-827 (2012)
   PUBMED   22320903
  REMARK    GeneRIF: we found that paclitaxel-resistant tumors had decreased
            expression of SEPT10.
REFERENCE   7  (bases 1 to 3014)
  AUTHORS   Liu,M., Shen,S., Chen,F., Yu,W. and Yu,L.
  TITLE     Linking the septin expression with carcinogenesis
  JOURNAL   Mol Biol Rep 37 (7), 3601-3608 (2010)
   PUBMED   20195767
REFERENCE   8  (bases 1 to 3014)
  AUTHORS   Benedetti,D., Bomben,R., Dal-Bo,M., Marconi,D., Zucchetto,A.,
            Degan,M., Forconi,F., Del-Poeta,G., Gaidano,G. and Gattei,V.
  TITLE     Are surrogates of IGHV gene mutational status useful in B-cell
            chronic lymphocytic leukemia? The example of Septin-10
  JOURNAL   Leukemia 22 (1), 224-226 (2008)
   PUBMED   17657217
  REMARK    GeneRIF: Lack of SEPT10 transcript is associated with B-cell
            chronic lymphocytic leukemia
REFERENCE   9  (bases 1 to 3014)
  AUTHORS   Sui,L., Zhang,W., Liu,Q., Chen,T., Li,N., Wan,T., Yu,M. and Cao,X.
  TITLE     Cloning and functional characterization of human septin 10, a novel
            member of septin family cloned from dendritic cells
  JOURNAL   Biochem Biophys Res Commun 304 (2), 393-398 (2003)
   PUBMED   12711328
  REMARK    GeneRIF: Cloning and functional characterization of septin 10.
REFERENCE   10 (bases 1 to 3014)
  AUTHORS   Macara,I.G., Baldarelli,R., Field,C.M., Glotzer,M., Hayashi,Y.,
            Hsu,S.C., Kennedy,M.B., Kinoshita,M., Longtine,M., Low,C.,
            Maltais,L.J., McKenzie,L., Mitchison,T.J., Nishikawa,T., Noda,M.,
            Petty,E.M., Peifer,M., Pringle,J.R., Robinson,P.J., Roth,D.,
            Russell,S.E., Stuhlmann,H., Tanaka,M., Tanaka,T., Trimble,W.S.,
            Ware,J., Zeleznik-Le,N.J. and Zieger,B.
  TITLE     Mammalian septins nomenclature
  JOURNAL   Mol Biol Cell 13 (12), 4111-4113 (2002)
   PUBMED   12475938
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011753.6 and AC140485.3.
            
            On Nov 23, 2018 this sequence version replaced NM_144710.4.
            
            Summary: This gene encodes a member of the septin family of
            cytoskeletal proteins with GTPase activity. This protein localizes
            to the cytoplasm and nucleus and displays GTP-binding and GTPase
            activity. A pseudogene for this gene is located on chromosome 8.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2012].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF146760.1, SRR1660807.5199.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397712.7/ ENSP00000380824.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AC011753.6         68891-69059         c
            170-238             AC011753.6         48144-48212         c
            239-356             AC011753.6         40814-40931         c
            357-552             AC011753.6         40219-40414         c
            553-739             AC011753.6         29674-29860         c
            740-901             AC011753.6         22908-23069         c
            902-998             AC011753.6         20856-20952         c
            999-1167            AC011753.6         19459-19627         c
            1168-1300           AC011753.6         8180-8312           c
            1301-1488           AC011753.6         1143-1330           c
            1489-3014           AC140485.3         45361-46886         c
FEATURES             Location/Qualifiers
     source          1..3014
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q13"
     gene            1..3014
                     /gene="SEPTIN10"
                     /gene_synonym="SEPT10; Septin-10"
                     /note="septin 10"
                     /db_xref="GeneID:151011"
                     /db_xref="HGNC:HGNC:14349"
                     /db_xref="MIM:611737"
     exon            1..169
                     /gene="SEPTIN10"
                     /gene_synonym="SEPT10; Septin-10"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1504
                     /gene="SEPTIN10"
                     /gene_synonym="SEPT10; Septin-10"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="septin-10 isoform 1"
                     /protein_id="NP_653311.1"
                     /db_xref="CCDS:CCDS46383.1"
                     /db_xref="GeneID:151011"
                     /db_xref="HGNC:HGNC:14349"
                     /db_xref="MIM:611737"
                     /translation="MASSEVARHLLFQSHMATKTTCMSSQGSDDEQIKRENIRSLTMS
                     GHVGFESLPDQLVNRSIQQGFCFNILCVGETGIGKSTLIDTLFNTNFEDYESSHFCPN
                     VKLKAQTYELQESNVQLKLTIVNTVGFGDQINKEESYQPIVDYIDAQFEAYLQEELKI
                     KRSLFTYHDSRIHVCLYFISPTGHSLKTLDLLTMKNLDSKVNIIPVIAKADTVSKTEL
                     QKFKIKLMSELVSNGVQIYQFPTDDDTIAKVNAAMNGQLPFAVVGSMDEVKVGNKMVK
                     ARQYPWGVVQVENENHCDFVKLREMLICTNMEDLREQTHTRHYELYRRCKLEEMGFTD
                     VGPENKPVSVQETYEAKRHEFHGERQRKEEEMKQMFVQRVKEKEAILKEAERELQAKF
                     EHLKRLHQEERMKLEEKRRLLEEEIIAFSKKKATSEIFHSQSFLATGSNLRKDKDRKN
                     SNFL"
     exon            170..238
                     /gene="SEPTIN10"
                     /gene_synonym="SEPT10; Septin-10"
                     /inference="alignment:Splign:2.1.0"
     exon            239..356
                     /gene="SEPTIN10"
                     /gene_synonym="SEPT10; Septin-10"
                     /inference="alignment:Splign:2.1.0"
     exon            357..552
                     /gene="SEPTIN10"
                     /gene_synonym="SEPT10; Septin-10"
                     /inference="alignment:Splign:2.1.0"
     exon            553..739
                     /gene="SEPTIN10"
                     /gene_synonym="SEPT10; Septin-10"
                     /inference="alignment:Splign:2.1.0"
     exon            740..901
                     /gene="SEPTIN10"
                     /gene_synonym="SEPT10; Septin-10"
                     /inference="alignment:Splign:2.1.0"
     exon            902..998
                     /gene="SEPTIN10"
                     /gene_synonym="SEPT10; Septin-10"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1167
                     /gene="SEPTIN10"
                     /gene_synonym="SEPT10; Septin-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1300
                     /gene="SEPTIN10"
                     /gene_synonym="SEPT10; Septin-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1488
                     /gene="SEPTIN10"
                     /gene_synonym="SEPT10; Septin-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..3014
                     /gene="SEPTIN10"
                     /gene_synonym="SEPT10; Septin-10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2809..2814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEPTIN10"
                     /gene_synonym="SEPT10; Septin-10"
                     /note="hexamer: AATAAA"
     polyA_site      2831
                     /gene="SEPTIN10"
                     /gene_synonym="SEPT10; Septin-10"
                     /note="major polyA site"
     regulatory      2993..2998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEPTIN10"
                     /gene_synonym="SEPT10; Septin-10"
                     /note="hexamer: AATAAA"
     polyA_site      3014
                     /gene="SEPTIN10"
                     /gene_synonym="SEPT10; Septin-10"
ORIGIN      
        1 cccttccccg tcgcggaggc agcctagcct cgcgccccgc ccgttgcttc tgccctccgg
       61 ccttcccgcc gccgtcgccg ggaccagccg ctcggggccg ggctgataca gccgcttcac
      121 cgtgcccctg cccgcgacca tggcctcctc cgaggtggcg cggcacctgc tctttcagtc
      181 tcacatggca acgaaaacaa cttgtatgtc ttcacaagga tcagatgatg aacagataaa
      241 aagagaaaac attcgttcgt tgactatgtc tggccatgtt ggttttgaga gtttgcctga
      301 tcagctggtg aacagatcca ttcagcaagg tttctgcttt aatattctct gtgtggggga
      361 aactggaatt ggaaaatcaa cactgattga cacattgttt aatactaatt ttgaagacta
      421 tgaatcctca catttttgcc caaatgttaa acttaaagct cagacatatg aactccagga
      481 aagtaatgtt caattgaaat tgaccattgt gaatacagtg ggatttggtg accaaataaa
      541 taaagaagag agctaccaac caatagttga ctacatagat gctcagtttg aggcctatct
      601 ccaagaagaa ctgaagatta agcgttctct ctttacctac catgattctc gcatccatgt
      661 gtgtctctac ttcatttcac cgacaggcca ctctctgaag acacttgatc tcttaaccat
      721 gaagaacctt gacagcaagg taaacattat accagtgatt gccaaagcag atacggtttc
      781 taaaactgaa ttacagaagt ttaagatcaa gctcatgagt gaattggtca gcaatggcgt
      841 ccagatatac cagttcccaa cggatgatga cactattgct aaggtcaacg ctgcaatgaa
      901 tggacagttg ccgtttgctg ttgtgggaag tatggatgag gtaaaagtcg gaaacaagat
      961 ggtcaaagct cgccagtacc cttggggtgt tgtacaagtg gaaaatgaaa accactgtga
     1021 ctttgtaaag ctgcgggaaa tgctcatttg tacaaatatg gaggacctgc gagagcagac
     1081 ccataccagg cactatgagc tttacaggcg ctgcaaactg gaggaaatgg gctttacaga
     1141 tgtgggccca gaaaacaagc cagtcagtgt tcaagagacc tatgaagcca aaagacatga
     1201 gttccatggt gaacgtcaga ggaaggaaga agaaatgaaa cagatgtttg tgcagcgagt
     1261 aaaggagaaa gaagccatat tgaaagaagc tgagagagag ctacaggcca aatttgagca
     1321 ccttaagaga cttcaccaag aagagagaat gaagcttgaa gaaaagagaa gacttttgga
     1381 agaagaaata attgctttct ctaaaaagaa agctacctcc gagatatttc acagccagtc
     1441 ctttctggca acaggcagca acctgaggaa ggacaaggac cgtaagaact ccaatttttt
     1501 gtaaaacaga agttccagag cacagaaggt catcatcaca agcaaacttt attaaaaaaa
     1561 aactagaagt gtgctttgat tttgctgtta tttgttttat cacttctata tttggtgaac
     1621 agccacagtt actgatattt atggaaaagt actttcaagt acaaggtcaa tacataagcc
     1681 agagtgaatg atactacaag ttgagcatct ctaattcaaa aatctgaaat ccagaagctt
     1741 caaaatctga atctttttga gcactgactt gaccccacaa gtggaaaatt ccccacccga
     1801 cacctttgct ttctgatggt tcagtttaaa cagattttgt ttcttgcaca aaatttttgt
     1861 ataaattact ttcaggctat atgtataagg tggatgtgaa acatgaatta tgtaattaga
     1921 gtcgggtccc gttgtgtata tgcagatatt ccaaacctga aatccaaaac acttctggtc
     1981 cctagcattt tggataaggg atactcagct tgtacctata tattcatata tattcactgt
     2041 tgttagaaat gtttaagttg ctgttctgtg atgaatctaa atcttttctc ttgctaccaa
     2101 gctattgtca ctgcagtgca ttataccaaa gagcgaagtc agtgccactg aaaatacaga
     2161 acccattaat atcgtggcta tctgattaca tttatattcc aagatgaacc ttttttatat
     2221 atgctaaaaa ttttggggaa tatgttttgg gatgtattat ggagctaaaa ctctaacctc
     2281 ttaatagttt tatagaactt aaaaattttt tatacaatta cccaattggt gatatgatct
     2341 taagcttttg tgtcagatta tttaatatga tgacttcatg ctttattatg ccttattatg
     2401 gctgacgtat tactgtggtg aaacaaaata tctttaaaag ttaaaacatc cagatatata
     2461 agctattttt tcctaaggat aaagtacctt tgagcatgag tgtatcacag ctttcattag
     2521 gaaaactttt cattacatac ttgtttaaac tctgtcttcc agggtaaaaa taataaggtt
     2581 gaatcatttt attaaaaata ctttttaaga aaataactat gaacatctga atattaaaga
     2641 tataaaaatg cacataattc atatttcagg tggtatttgc attcagtgcc ttactggtat
     2701 tctcagaaca ttttaatgat ttctaacatt tcttaacagt catagatata tacattttca
     2761 ttttttgtac ttgaatattc taaataaaac tgacatttac tcttgacaaa taaaacatat
     2821 atttactaaa atgtgtttaa ttttcctttc tgaaaactct cattttaaaa acgttcattt
     2881 aattatgtat ttgaattatt ttggagatga ggtattttat gagtattttc agacaatgaa
     2941 acttattagt ctgtgtcaga ttctgagcaa tcatagagtc atctaagttg taaataaaac
     3001 cttgcatagc acaa
//
