LOCUS       NM_020654               4973 bp    mRNA    linear   PRI 10-DEC-2024
DEFINITION  Homo sapiens SUMO specific peptidase 7 (SENP7), transcript variant
            1, mRNA.
ACCESSION   NM_020654
VERSION     NM_020654.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4973)
  AUTHORS   Wu,Z., Huang,H., Han,Q., Hu,Z., Teng,X.L., Ding,R., Ye,Y., Yu,X.,
            Zhao,R., Wang,Z. and Zou,Q.
  TITLE     SENP7 senses oxidative stress to sustain metabolic fitness and
            antitumor functions of CD8+ T cells
  JOURNAL   J Clin Invest 132 (7) (2022)
   PUBMED   35143421
  REMARK    GeneRIF: SENP7 senses oxidative stress to sustain metabolic fitness
            and antitumor functions of CD8+ T cells.
REFERENCE   2  (bases 1 to 4973)
  AUTHORS   Suhail,A., Rizvi,Z.A., Mujagond,P., Ali,S.A., Gaur,P., Singh,M.,
            Ahuja,V., Awasthi,A. and Srikanth,C.V.
  TITLE     DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal
            Inflammation via Expansion of Gamma-Delta T Cells
  JOURNAL   Cell Rep 29 (11), 3522-3538 (2019)
   PUBMED   31825833
  REMARK    GeneRIF: DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers
            Intestinal Inflammation via Expansion of Gamma-Delta T Cells.
REFERENCE   3  (bases 1 to 4973)
  AUTHORS   Ji,P., Liang,S., Li,P., Xie,C., Li,J., Zhang,K., Zheng,X., Feng,M.,
            Li,Q., Jiao,H., Chi,X., Zhao,W., Zhang,S. and Wang,X.
  TITLE     Speckle-type POZ protein suppresses hepatocellular carcinoma cell
            migration and invasion via ubiquitin-dependent proteolysis of
            SUMO1/sentrin specific peptidase 7
  JOURNAL   Biochem Biophys Res Commun 502 (1), 30-42 (2018)
   PUBMED   29777712
  REMARK    GeneRIF: SPOP inhibits hepatocellular carcinoma (HCC) cell
            metastasis via ubiquitin-dependent SENP7 proteolysis and may thus
            serve as a new opinion for the prevention of HCC metastasis.
REFERENCE   4  (bases 1 to 4973)
  AUTHORS   Karami,S., Lin,F.M., Kumar,S., Bahnassy,S., Thangavel,H.,
            Quttina,M., Li,Y., Ren,J. and Bawa-Khalfe,T.
  TITLE     Novel SUMO-Protease SENP7S Regulates beta-catenin Signaling and
            Mammary Epithelial Cell Transformation
  JOURNAL   Sci Rep 7, 46477 (2017)
   PUBMED   28429743
  REMARK    GeneRIF: non-tumorigenic MCF10-2A cells with reduced SENP7S exhibit
            greater cell proliferation and anchorage-dependent growth. SENP7S
            depletion directly potentiates tumorigenic properties of MCF10-2A
            cells with induction of anchorage-independent growth and
            self-renewal in 3D-spheroid conditions. Collectively, the results
            identify SENP7S as a novel mediator of beta-catenin signaling and
            normal mammary epithelial cell physiology.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4973)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   6  (bases 1 to 4973)
  AUTHORS   Bawa-Khalfe,T., Lu,L.S., Zuo,Y., Huang,C., Dere,R., Lin,F.M. and
            Yeh,E.T.
  TITLE     Differential expression of SUMO-specific protease 7 variants
            regulates epithelial-mesenchymal transition
  JOURNAL   Proc Natl Acad Sci U S A 109 (43), 17466-17471 (2012)
   PUBMED   23045645
  REMARK    GeneRIF: differential splicing of the SENP7 regulates either tumor
            suppression or progression
REFERENCE   7  (bases 1 to 4973)
  AUTHORS   Alegre,K.O. and Reverter,D.
  TITLE     Swapping small ubiquitin-like modifier (SUMO) isoform specificity
            of SUMO proteases SENP6 and SENP7
  JOURNAL   J Biol Chem 286 (41), 36142-36151 (2011)
   PUBMED   21878624
  REMARK    GeneRIF: Loop 1 insertion in SENP6 and SENP7 as a platform to
            discriminate between SUMO1 and SUMO2/3 isoforms in this subclass of
            the SUMO protease family.
REFERENCE   8  (bases 1 to 4973)
  AUTHORS   Nozawa,R.S., Nagao,K., Masuda,H.T., Iwasaki,O., Hirota,T.,
            Nozaki,N., Kimura,H. and Obuse,C.
  TITLE     Human POGZ modulates dissociation of HP1alpha from mitotic
            chromosome arms through Aurora B activation
  JOURNAL   Nat Cell Biol 12 (7), 719-727 (2010)
   PUBMED   20562864
REFERENCE   9  (bases 1 to 4973)
  AUTHORS   Lima,C.D. and Reverter,D.
  TITLE     Structure of the human SENP7 catalytic domain and poly-SUMO
            deconjugation activities for SENP6 and SENP7
  JOURNAL   J Biol Chem 283 (46), 32045-32055 (2008)
   PUBMED   18799455
  REMARK    GeneRIF: SENP6 and SENP7 exhibit lower rates for processing
            pre-SUMO1, pre-SUMO2, or pre-SUMO3 in comparison with SENP2
REFERENCE   10 (bases 1 to 4973)
  AUTHORS   Gong,L., Millas,S., Maul,G.G. and Yeh,E.T.
  TITLE     Differential regulation of sentrinized proteins by a novel
            sentrin-specific protease
  JOURNAL   J Biol Chem 275 (5), 3355-3359 (2000)
   PUBMED   10652325
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136599.1, BC129988.1 and AI858732.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020654.4.
            
            Summary: The reversible posttranslational modification of proteins
            by the addition of small ubiquitin-like SUMO proteins (see SUMO1;
            MIM 601912) is required for many cellular processes. SUMO-specific
            proteases, such as SENP7, process SUMO precursors to generate a
            C-terminal diglycine motif required for the conjugation reaction.
            They also display isopeptidase activity for deconjugation of
            SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed
            18799455]).[supplied by OMIM, Jun 2009].
            
            Transcript Variant: This variant (1, also known as SENP7L)
            represents the longest transcript and encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129988.1, SRR18074969.1161413.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394095.7/ ENSP00000377655.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               AL136599.1         56-372
            318-3615            BC129988.1         274-3571
            3616-4727           AL136599.1         3473-4584
            4728-4973           AI858732.1         17-262              c
FEATURES             Location/Qualifiers
     source          1..4973
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q12.3"
     gene            1..4973
                     /gene="SENP7"
                     /note="SUMO specific peptidase 7"
                     /db_xref="GeneID:57337"
                     /db_xref="HGNC:HGNC:30402"
                     /db_xref="MIM:612846"
     exon            1..122
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..3235
                     /gene="SENP7"
                     /EC_number="3.4.22.68"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sentrin-specific protease 7; SUMO-1-specific protease 2;
                     sentrin/SUMO-specific protease SENP7; SUMO1/sentrin
                     specific peptidase 7"
                     /codon_start=1
                     /product="sentrin-specific protease 7 isoform 1"
                     /protein_id="NP_065705.3"
                     /db_xref="CCDS:CCDS2941.2"
                     /db_xref="GeneID:57337"
                     /db_xref="HGNC:HGNC:30402"
                     /db_xref="MIM:612846"
                     /translation="MDKRKLGRRPSSSEIITEGKRKKSSSDLSEIRKMLNAKPEDVHV
                     QSPLSKFRSSERWTLPLQWERSLRNKVISLDHKNKKHIRGCPVTSKSSPERQLKVMLT
                     NVLWTDLGRKFRKTLPRNDANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSE
                     RIPRVILTNVLGTELGRKYIRTPPVTEGSLSDTDNLQSEQLSSSSDGSLESYQNLNPH
                     KSCYLSERGSQRSKTVDDNSAKQTAHNKEKRRKDDGISLLISDTQPEDLNSGSRGCDH
                     LEQESRNKDVKYSDSKVELTLISRKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDST
                     ISTEFEKPSENYHQDPKLPEEITTKPTKSDFTKLSSLNSQELTLSNATKSASAGSTTE
                     TVENSNSIDIVGISSLVEKDENELNTIEKPILRGHNEGNQSLISAEPIVVSSDEEGPV
                     EHKSSEILKLQSKQDRETTNENESTSESALLELPLITCESVQMSSELCPYNPVMENIS
                     SIMPSNEMDLQLDFIFTSVYIGKIKGASKGCVTITKKYIKIPFQVSLNEISLLVDTTH
                     LKRFGLWKSKDDNHSKRSHAILFFWVSSDYLQEIQTQLEHSVLSQQSKSSEFIFLELH
                     NPVSQREELKLKDIMTEISIISGELELSYPLSWVQAFPLFQNLSSKESSFIHYYCVST
                     CSFPAGVAVAEEMKLKSVSQPSNTDAAKPTYTFLQKQSSGCYSLSITSNPDEEWREVR
                     HTGLVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVIIDFYLKYLILEKASDELV
                     ERSHIFSSFFYKCLTRKENNLTEDNPNLSMAQRRHKRVRTWTRHINIFNKDYIFVPVN
                     ESSHWYLAVICFPWLEEAVYEDFPQTVSQQSQAQQSQNDNKTIDNDLRTTSTLSLSAE
                     DSQSTESNMSVPKKMCKRPCILILDSLKAASVQNTVQNLREYLEVEWEVKLKTHRQFS
                     KTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFKDPIVNFELPIHLEKWFPRHVIKTKR
                     EDIRELILKLHLQQQKGSSS"
     exon            123..172
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            173..268
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            269..366
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            367..564
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            565..759
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            760..878
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1060
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1400
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1558
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1705
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1739
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1919
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2188
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2322
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2439
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2562
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2655
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2780
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2833
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2877
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..2946
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3097
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..4973
                     /gene="SENP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4880..4885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SENP7"
                     /note="hexamer: ATTAAA"
     polyA_site      4905
                     /gene="SENP7"
                     /note="major polyA site"
     regulatory      4951..4956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SENP7"
                     /note="hexamer: AATAAA"
     polyA_site      4973
                     /gene="SENP7"
ORIGIN      
        1 ctttcccctc cccctccctc tccaagccgg aggggtcctg aggtgacagc gcctgcaact
       61 gaaatttcag cagcgggaga agatggacaa gagaaagctc gggcgacggc catcttcatc
      121 cgaaatcatc acagaaggaa aaaggaaaaa gtcatcttct gatttatcgg agataagaaa
      181 gatgttaaat gcaaaaccag aggatgtcca tgttcaatca ccactgtcca aattcagaag
      241 ctcagaacgc tggactctcc ctttgcagtg ggaaagaagc ctaaggaata aagtcatctc
      301 tctagaccat aaaaataaaa aacatatccg agggtgtcct gttacttcca agtcatcacc
      361 agaaaggcaa ctcaaagtta tgttgacgaa tgtcctatgg acggatttag gacgaaaatt
      421 cagaaagacc ctacctagaa acgatgctaa tttatgtgat gccaacaagg tgcaatcaga
      481 ctcattgcct tcgacatctg ttgacagcct agagacatgt caaaaattag aacctcttcg
      541 ccaaagcctt aatttatctg aaaggatacc cagagttata ttgacgaatg tcctgggaac
      601 ggagttagga agaaaataca taaggacccc acctgtaact gagggaagtt tgagtgatac
      661 agacaacttg caatcagagc aactttcttc atcatctgat ggcagcctag aatcttatca
      721 aaatctaaac cctcacaaga gctgttattt atctgaaagg ggctcacaac gaagtaagac
      781 agtagatgac aattctgcaa agcagactgc gcacaataaa gaaaaacgaa gaaaggatga
      841 tggcatttct cttttaatat ctgatactca gcctgaagac cttaacagtg gaagtagagg
      901 ttgtgatcat ctcgaacagg aaagcagaaa caaggatgtt aaatattctg attcaaaagt
      961 ggaactcact ctgatttcca ggaagacaaa gagaaggctt agaaataatt tacctgattc
     1021 tcaatattgt acttctttgg ataagtcaac agaacagaca aaaaaacaag aagatgactc
     1081 aacaatatcc actgagtttg aaaagccaag tgaaaactat catcaggatc caaaactgcc
     1141 tgaagaaatt acaactaaac ctacaaaaag tgattttact aaactatcct cacttaacag
     1201 tcaggagttg actttgagta atgccaccaa aagtgcctct gccggttcaa ccactgaaac
     1261 cgttgagaac tctaattcca ttgatattgt ggggatttct tccctggttg agaaggatga
     1321 gaatgagttg aataccatag aaaagcctat tctaagagga cataatgaag ggaaccaatc
     1381 actgatctca gctgaaccaa ttgttgtttc cagtgatgaa gaaggacctg ttgaacataa
     1441 aagttcagaa attcttaagt tacaatctaa gcaagaccgt gagacaacta atgaaaatga
     1501 gagtacttct gaatcagcat tgttagaact accattgatt acatgtgaat ctgtacagat
     1561 gtcatctgaa ttatgcccat ataatcctgt catggagaac atttccagta ttatgcctag
     1621 taatgagatg gatctacaac tggattttat atttacttct gtttatattg gtaaaataaa
     1681 aggagcttct aaaggttgtg ttacaatcac aaaaaaatat attaagatcc catttcaagt
     1741 gtccctgaat gagatttcat tgctagtgga taccacacat ttaaagcggt ttgggttatg
     1801 gaaaagtaag gatgataatc acagtaaaag gagtcatgct attcttttct tctgggtctc
     1861 ttcagattat cttcaagaga ttcagaccca attagaacac tctgtattaa gccagcaatc
     1921 aaaatctagt gaattcattt tccttgaact acacaatcct gtttcacaaa gagaagaatt
     1981 gaagctgaaa gatattatga cggaaataag tataatcagt ggagaattag agctttctta
     2041 cccgttgtct tgggttcagg catttccttt gtttcagaac ctctcttcaa aagaaagttc
     2101 ttttattcat tattactgtg tttcaacttg ttctttccct gctggtgttg ctgttgctga
     2161 agaaatgaag ctgaaatcag tatctcagcc ctcaaacaca gatgcggcca agcctactta
     2221 caccttcctg cagaagcaaa gtagcggttg ctactccctt tctattacat ctaatccaga
     2281 tgaagaatgg cgagaagtca ggcacactgg acttgttcag aagttgattg tatatcctcc
     2341 accacctact aaggggggat taggagtaac taatgaagat ctggagtgtt tagaagaagg
     2401 agagtttctt aatgatgtaa tcattgattt ttaccttaag tatcttatat tggagaaggc
     2461 atcagatgaa cttgttgaac gaagtcacat ttttagtagc tttttctata aatgcttgac
     2521 aagaaaggaa aataatttaa cagaagataa tccaaatctt tcaatggcac agagaagaca
     2581 taaaagagta agaacatgga ctcgtcacat aaacattttt aataaagatt acatctttgt
     2641 acctgtaaat gagtcgtctc actggtatct cgcagtcatt tgttttccat ggttagaaga
     2701 agctgtgtat gaagattttc cacaaactgt atcccagcag tcccaggctc agcagtccca
     2761 aaatgacaac aaaacaatag ataatgatct acgtactact tcgacactgt ctttgagtgc
     2821 agaggattcc caaagtaccg agtcgaatat gtcagtacca aagaaaatgt gtaaaaggcc
     2881 atgtattctt atactagact ccttgaaagc tgcttctgta caaaacacag ttcagaattt
     2941 acgagagtat ttagaggtag agtgggaagt taaactaaaa actcatcgtc aattcagcaa
     3001 aacaaacatg gtggatctat gccctaaagt tcctaaacag gacaatagca gtgattgtgg
     3061 agtatattta ttgcagtatg tggaaagctt cttcaaggat cctattgtta actttgaact
     3121 tccaattcat ttggagaagt ggtttcctcg tcatgtaata aagaccaaac gggaagatat
     3181 tcgagagctc atcttgaaac ttcatttaca gcaacagaag ggcagcagta gctagttaat
     3241 ctgtacaaac atgacacaga tgttctctaa gattactgga aagcctctta ccagcatttg
     3301 tgttagccag ctcacagaga agaaaataac ttgcagtagt tttataataa gtcattggaa
     3361 cattatttaa aatatgtagg acacattatt agaattgttg ggatctcata gatggaatgg
     3421 gaatgggggt gatatagata aacttactag atataaatta aaattttata aatatttcat
     3481 atttttctga gtaaatatga ttggattatg caacagcata tgtaatatgg gaatgttttg
     3541 tagataataa aacttacatg atctgtactt ccacgtgact gggtgctgag gggagttaaa
     3601 gcctccctgg tgccagcccc agtgcttgtc aaatttgctg acaggtcaca tcatattgta
     3661 attctattct ttgcagctca agcatgcagt atgaatactg tgtatttttt aaaaaaataa
     3721 tttagtatca aggcttcaga aaatgccatt tacggcatcc cttctgtatg taacaaaaag
     3781 acattcataa tgttaggaag atgataaaaa ttcgctcttt taaagtgcag cttattattc
     3841 tcaattgcta aatacgatta ctctgctttt tttttttcat ttcttttgat gtcatatgtg
     3901 agtatcttat aatttagttc atttgttcag ggtaaaattt gaaacaaaaa attttacctg
     3961 tgcaaaatag ttttttaaaa attatacatg tagctcaact tgaggtactg ctatataaat
     4021 attcactcac attatcacgg aatttatgta tagtttctct aatatagaag ataaaattgg
     4081 tgtcctcata actttaacaa agaaaaccct cagtcctatt tattaatggg tagaattaaa
     4141 tatataattt tatagctcag tttacccagt attcatctgc aaagccagat tgctctcatt
     4201 gcttttatat ttttaaattg tagcttttag agacctatga tcctcatgga acttaatttt
     4261 ttattaaata ttcaggtaac agttctgaat tcatgtgata atggtggcat tatatatgat
     4321 taaacacttc agaactttct aatgttatca ggagtatttt gagggagata tgattatatt
     4381 gtattttctc agataagaaa aatgtttttt aacaatatta ttttaatctg ttttaagcat
     4441 ctcttagatt tacattataa ctacataaag cagtgaagca aaggcaaatt aagataaagc
     4501 tagaaagtct gaacatttta tttcaaaatc atacgaatcg gggtcagtta agcctcagta
     4561 ttcttagctt ttgttgattt tggcactatc tttatattat taaatatatt tgttgtttgg
     4621 atatttcata taaagatggc tataattaca tatttcattc ccaatttgtg tgtgttgggg
     4681 ggtactttta aaggtgacta ttgttttgta catctaattt tgggaaagca agtctataag
     4741 acatcttgtg atttcttaat gtttttgttt gtatgttttt caaagatatc actgtccttt
     4801 atcatgtttt gaagattgtt taaaattcat tttcctaaat taatgtgcaa gtaatgtttt
     4861 gaggatatca gtgttttata ttaaacatat ttccaattca ttaaattgag gtgtaatttt
     4921 tttccttaag aaacatgagc tactgttaga aataaatttc cagttgtatg ctg
//
