LOCUS       NM_001304792            3639 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens SUMO specific peptidase 6 (SENP6), transcript variant
            3, mRNA.
ACCESSION   NM_001304792
VERSION     NM_001304792.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3639)
  AUTHORS   Wang,Y.W., Jia,K.G., Xing,H.J., Pan,Y., Zeng,C.S., Chen,L.,
            Su,Q.J., Shen,W.T., Chen,J., Chen,C., Cao,Q. and Wang,Y.Y.
  TITLE     [Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance
            in Neuroglioma Cells via Inducing the Mitophagy]
  JOURNAL   Mol Biol (Mosk) 58 (1), 126-129 (2024)
   PUBMED   38062972
  REMARK    GeneRIF: [Interaction of SENP6 with PINK1 Promotes Temozolomide
            Resistance in Neuroglioma Cells via Inducing the Mitophagy].
REFERENCE   2  (bases 1 to 3639)
  AUTHORS   He,Q., Chen,Z., Li,J., Liu,J., Zuo,Z., Lin,B., Song,K., Zhou,C.,
            Lai,H., Huang,Q. and Guo,X.
  TITLE     SENP6-Mediated deSUMOylation of VEGFR2 Enhances Its Cell Membrane
            Transport in Angiogenesis
  JOURNAL   Int J Mol Sci 24 (3), 2544 (2023)
   PUBMED   36768878
  REMARK    GeneRIF: SENP6-Mediated deSUMOylation of VEGFR2 Enhances Its Cell
            Membrane Transport in Angiogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3639)
  AUTHORS   Chen,K., Wang,Q., Liu,X., Wang,F., Ma,Y., Zhang,S., Shao,Z.,
            Yang,Y. and Tian,X.
  TITLE     Single Cell RNA-Seq Identifies Immune-Related Prognostic Model and
            Key Signature-SPP1 in Pancreatic Ductal Adenocarcinoma
  JOURNAL   Genes (Basel) 13 (10), 1760 (2022)
   PUBMED   36292645
  REMARK    GeneRIF: Single Cell RNA-Seq Identifies Immune-Related Prognostic
            Model and Key Signature-SPP1 in Pancreatic Ductal Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3639)
  AUTHORS   Schick,M., Zhang,L., Maurer,S., Maurer,H.C., Isaakaidis,K.,
            Schneider,L., Patra,U., Schunck,K., Rohleder,E., Hofstetter,J.,
            Baluapuri,A., Scherger,A.K., Slotta-Huspenina,J., Hettler,F.,
            Weber,J., Engleitner,T., Maresch,R., Slawska,J., Lewis,R.,
            Istvanffy,R., Habringer,S., Steiger,K., Baiker,A.,
            Oostendorp,R.A.J., Miething,C., Lenhof,H.P., Bassermann,F.,
            Chapuy,B., Wirth,M., Wolf,E., Rad,R., Muller,S. and Keller,U.
  TITLE     Genetic alterations of the SUMO isopeptidase SENP6 drive
            lymphomagenesis and genetic instability in diffuse large B-cell
            lymphoma
  JOURNAL   Nat Commun 13 (1), 281 (2022)
   PUBMED   35022408
  REMARK    GeneRIF: Genetic alterations of the SUMO isopeptidase SENP6 drive
            lymphomagenesis and genetic instability in diffuse large B-cell
            lymphoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3639)
  AUTHORS   Mitra,S., Bodor,D.L., David,A.F., Abdul-Zani,I., Mata,J.F.,
            Neumann,B., Reither,S., Tischer,C. and Jansen,L.E.T.
  TITLE     Genetic screening identifies a SUMO protease dynamically
            maintaining centromeric chromatin
  JOURNAL   Nat Commun 11 (1), 501 (2020)
   PUBMED   31980633
  REMARK    GeneRIF: SENP6 activity is required throughout the cell cycle,
            suggesting that a dynamic SUMO cycle underlies a continuous
            surveillance of the centromere complex.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3639)
  AUTHORS   Bailey,D. and O'Hare,P.
  TITLE     Characterization of the localization and proteolytic activity of
            the SUMO-specific protease, SENP1
  JOURNAL   J Biol Chem 279 (1), 692-703 (2004)
   PUBMED   14563852
  REMARK    GeneRIF: SENP1 localization is influenced by expression and
            localization of SUMO-1-conjugated target proteins within the cell.
REFERENCE   7  (bases 1 to 3639)
  AUTHORS   Tojo,M., Matsuzaki,K., Minami,T., Honda,Y., Yasuda,H., Chiba,T.,
            Saya,H., Fujii-Kuriyama,Y. and Nakao,M.
  TITLE     The aryl hydrocarbon receptor nuclear transporter is modulated by
            the SUMO-1 conjugation system
  JOURNAL   J Biol Chem 277 (48), 46576-46585 (2002)
   PUBMED   12354770
REFERENCE   8  (bases 1 to 3639)
  AUTHORS   Goodson,M.L., Hong,Y., Rogers,R., Matunis,M.J., Park-Sarge,O.K. and
            Sarge,K.D.
  TITLE     Sumo-1 modification regulates the DNA binding activity of heat
            shock transcription factor 2, a promyelocytic leukemia nuclear body
            associated transcription factor
  JOURNAL   J Biol Chem 276 (21), 18513-18518 (2001)
   PUBMED   11278381
REFERENCE   9  (bases 1 to 3639)
  AUTHORS   Kim,K.I., Baek,S.H., Jeon,Y.J., Nishimori,S., Suzuki,T., Uchida,S.,
            Shimbara,N., Saitoh,H., Tanaka,K. and Chung,C.H.
  TITLE     A new SUMO-1-specific protease, SUSP1, that is highly expressed in
            reproductive organs
  JOURNAL   J Biol Chem 275 (19), 14102-14106 (2000)
   PUBMED   10799485
REFERENCE   10 (bases 1 to 3639)
  AUTHORS   Yeh,E.T., Gong,L. and Kamitani,T.
  TITLE     Ubiquitin-like proteins: new wines in new bottles
  JOURNAL   Gene 248 (1-2), 1-14 (2000)
   PUBMED   10806345
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356057.12, AK096455.1, AF306508.1, AL589656.5 and AA768785.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001304792.1.
            
            Summary: Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM
            601912), are structurally related to ubiquitin (MIM 191339) and can
            be ligated to target proteins in a similar manner as ubiquitin.
            However, covalent attachment of UBLs does not result in degradation
            of the modified proteins. SUMO1 modification is implicated in the
            targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as
            well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008)
            from degradation by the 26S proteasome. Like ubiquitin, UBLs are
            synthesized as precursor proteins, with 1 or more amino acids
            following the C-terminal glycine-glycine residues of the mature UBL
            protein. Thus, the tail sequences of the UBL precursors need to be
            removed by UBL-specific proteases, such as SENP6, prior to their
            conjugation to target proteins (Kim et al., 2000 [PubMed
            10799485]). SENPs also display isopeptidase activity for
            deconjugation of SUMO-conjugated substrates (Lima and Reverter,
            2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009].
            
            Transcript Variant: This variant (3) lacks an exon in the 5' coding
            region and its 3' terminal exon extends past a splice site that is
            used in variant 1. This results in a novel 3' coding region and 3'
            UTR, compared to variant 1. It encodes isoform 3 which has a
            shorter C-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096455.1, SRR1803615.225275.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AL356057.12        123980-124026
            48-1250             AK096455.1         1-1203
            1251-1746           AF306508.1         642-1137
            1747-2747           AK096455.1         1700-2700
            2748-3173           AL589656.5         3202-3627
            3174-3639           AA768785.1         16-481              c
FEATURES             Location/Qualifiers
     source          1..3639
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.1"
     gene            1..3639
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /note="SUMO specific peptidase 6"
                     /db_xref="GeneID:26054"
                     /db_xref="HGNC:HGNC:20944"
                     /db_xref="MIM:605003"
     exon            1..697
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             646..2703
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /EC_number="3.4.22.68"
                     /note="isoform 3 is encoded by transcript variant 3;
                     2810017C20Rik; SUMO1/sentrin specific protease 6;
                     sentrin-specific protease 6; SUMO-1-specific protease 1;
                     sentrin/SUMO-specific protease SENP6; SUMO1/sentrin
                     specific peptidase 6"
                     /codon_start=1
                     /product="sentrin-specific protease 6 isoform 3"
                     /protein_id="NP_001291721.1"
                     /db_xref="CCDS:CCDS78158.1"
                     /db_xref="GeneID:26054"
                     /db_xref="HGNC:HGNC:20944"
                     /db_xref="MIM:605003"
                     /translation="MAAGKSGGSAGEITFLEALARSESKRDGGFKNNWSFDHEEESEG
                     DTDKDGTNLLSVDEDEDSETSKGKKLNRRSEIVANSSGEFILKTYVRRNKSESFKTLK
                     GNPIGLNMLSNNKKLSENTQNTSLCSGTVVHGRRFHHAHAQIPVVKTAAQRKEYPPHV
                     QKVEINPVRLSRLQGVERIMKKTEESESQVEPEIKRKVQQKRHCSTYQPTPPLSPASK
                     KCLTHLEDLQRNCRQAITLNESTGPLLRTSIHQNSGGQKSQNTGLTTKKFYGNNVEKV
                     PIDIIVNCDDSKHTYLQTNGKVILPGAKIPKITNLKERKTSLSDLNDPIILSSDDDDD
                     NDRTNRRESISPQPADSACSSPAPSTGKVEAALNENTCRAERELRSIPEDSELNTVTL
                     PRKARMKDQFGNSIINTPLKRRKVFSQEPPDALALSCQSSFDSVILNCRSIRVGTLFR
                     LLIEPVIFCLDFIKIQLDEPDHDPVEIILNTSDLTKCEWCNVRKLPVVFLQAIPAVYQ
                     KLSIQLQMNKEDKVWNDCKGVNKLTNLEEQYIILIFQNGLDPPANMVFESIINEIGIK
                     NNISNFFAKIPFEEANGRLVACTRTYEESIKGSCGQKENKIKTVSFESKIQLRSKQEF
                     QFFDEEEETGENHTIFIGPVEKLIVYPPPPAKGGISVTNEDLHCLNEGEFLNDVIIDF
                     YLK"
     exon            698..791
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..852
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..998
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1103
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1174
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1320
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1618
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1848
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2016
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2050
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2245
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2472
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2582
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..3639
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2726..2731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /note="hexamer: ATTAAA"
     polyA_site      2748
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /note="major polyA site"
     regulatory      3540..3545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /note="hexamer: AATAAA"
     polyA_site      3561
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /note="major polyA site"
     regulatory      3619..3624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /note="hexamer: AACAAA"
     polyA_site      3639
                     /gene="SENP6"
                     /gene_synonym="SSP1; SUSP1"
                     /note="major polyA site"
ORIGIN      
        1 agcggcggcg gctggagctg ctgtggcgac cgacgcgagg cggtggcaga ggagacccac
       61 ccctgtccac atggacagtc gcaaaggcct ccgctgatgc attcacgcct gggcggggtg
      121 ggcggacggc cgtagcggcg gcggctgcag aacgagctag gggcctgggg gcgcctgacg
      181 gtcgcagaga cctcgccgct ccggcgcggc gggtgcggcc attttacggc ctgggacgaa
      241 gggaggcgtg tttgtgtgct cgctttcatt ctcctttctt gggaacccac ggctggggga
      301 agtttctcag gcagcctggg tgggcggtgg atggggagtc gtgggccgag aggaaccggg
      361 cccgggaagc gccgtcgtcg tcgtcgccgg tcgcgttccc ccggagaggc ctgagaagct
      421 cgggccgcgg gcctcgctgc ccgccagccc gcggacaggc ccgggcgcgc ctggcctgcc
      481 tttgtatagg cccgtctgaa cgtgggagcg cagcccgcct gacggctgag cccgaggccc
      541 gcaaccctgc ggcgtctacc ctcctccggc gcggcccctc atcccggcga gcacggcggc
      601 ggtgtgggcc atggattaag aaggaggcgg cgtgggagga ggaagatggc ggccggcaag
      661 agcggcggta gcgcagggga gattactttt ctggaagctt tggctagatc agagtctaag
      721 agagatggag gttttaaaaa taattggagc tttgatcatg aagaagaaag tgaaggagat
      781 acagataaag atgggacaaa tctgctcagt gtggatgaag atgaggattc tgaaacctca
      841 aaaggaaaaa agttaaatcg tcgatctgaa attgttgcta atagctctgg tgaattcatc
      901 ttgaagacat atgtaagacg aaacaagtct gaaagtttta aaactttgaa aggcaaccca
      961 attggactta acatgttgag caacaataag aaattgagtg aaaatacgca aaatacgtca
     1021 ttatgttctg gaactgtagt tcatggtaga cgttttcatc atgctcatgc acagatacca
     1081 gtagtaaaaa cagcagccca aaggaaagaa tacccacctc atgtccaaaa agttgaaatt
     1141 aatcctgtaa ggttaagtcg gctccaaggt gttgaacgta taatgaagaa aacagaagag
     1201 tccgaatcac aagtggagcc tgaaattaag aggaaagtac aacagaaacg acactgtagt
     1261 acctatcagc ctactcctcc tctatctcct gcttcaaaaa aatgtttaac ccatttagag
     1321 gatttgcaaa gaaattgcag acaagctatt actttgaatg agtctactgg accattatta
     1381 agaacgtcaa ttcatcagaa ttctggagga cagaagtcac aaaacacagg attaacaacc
     1441 aagaagtttt atggcaacaa tgtggaaaag gttccaattg atattattgt gaattgtgat
     1501 gacagtaaac acacttattt acagactaat ggaaaagtca ttttacctgg ggcaaaaata
     1561 cccaaaatca caaacttgaa agaaaggaaa acaagtttgt cagacctaaa tgatccaatc
     1621 attttgtcca gtgatgatga tgatgacaac gacagaacta acagaagaga aagcatatct
     1681 cctcagcctg ctgattcagc atgttcttcc cctgcaccat ccactggaaa agtagaagca
     1741 gcgctaaatg aaaatacttg cagagcagag cgtgaactac gaagcattcc agaagactca
     1801 gagttaaata cagttacatt gccaagaaaa gcaagaatga aagaccagtt tggcaattct
     1861 attatcaaca cacctctgaa acgtcgtaaa gtgttttctc aagaacctcc agatgcttta
     1921 gctttaagct gccaaagttc ctttgacagt gtcattttaa actgtcgaag tatacgagta
     1981 ggaacactct tccggctgtt aatagagcct gtaatttttt gtttagattt tatcaagata
     2041 cagctagacg aaccagacca tgatcctgta gagattatat taaatacctc tgatctaact
     2101 aaatgtgaat ggtgtaatgt ccgaaaatta cctgtagtgt ttcttcaagc aattccagca
     2161 gtttatcaaa agctgagcat ccaactgcaa atgaataagg aggataaagt ttggaatgat
     2221 tgtaaaggag taaataaatt aacaaattta gaagaacaat atataatttt aatttttcaa
     2281 aatggccttg atcctccggc aaatatggta tttgaaagta tcattaatga aattggtata
     2341 aagaataaca tctccaattt ttttgcgaaa attccctttg aagaagctaa tggcagactt
     2401 gttgcctgta caagaaccta tgaagagagc atcaaaggaa gttgtgggca aaaggaaaac
     2461 aaaattaaaa ctgtatcatt tgaatctaaa atacaactta gaagcaaaca agaatttcag
     2521 ttttttgatg aagaagaaga aactggagaa aaccacacca tcttcattgg cccagtagaa
     2581 aagttgatag tatatccacc acctccagct aagggaggca tctctgttac caatgaggac
     2641 ctgcactgtc taaatgaagg agaattttta aatgatgtta ttatagactt ttatttgaag
     2701 taagttaatt ttccactgat cttttattaa atctttaaca ttccgtcata tcttatgtct
     2761 ttgttttcca gagtcaggct ttttgagttt taaattccat ctctgccact tactgtgtga
     2821 catttgggga gttatttttt ctgtttctgt ctttgcacat tttaaaaatg agaattctat
     2881 ctaaaaagtt gtgaaaattg ggccagggag atatctggct tatgtctata atcctgacac
     2941 tttgggaggt caaggtggga ggatcgcttg agcccaagag ttcacgacca gcctgggaaa
     3001 caaagtgaga ccttgtctcc acaaaaaatt taaaaattag ccagtcatat acctatagtc
     3061 ccagccactt gggaggctca gacaggaaga ttacctgagc ccatgagttc gaagttgcac
     3121 tgagccatga tggcgccact gcactccagc ctggtcaaca aagcaaaact ctacccccac
     3181 acccaccccc gaaaacagga gttgtgagaa ttaaatgaga tcgtacatat caagtagtag
     3241 gaaaaatgcc tagtacagtg ttagaagttt atggtcttgt aggaagcaca aatacagaat
     3301 taaagcaatg atagaagcat taacatggta cagtcctagc agatgagaga atgcttcatt
     3361 atctttggag gttgggagat atgagggacc aggaagcttt cctggaagag cttacattat
     3421 gacccaatat acattatgac ccaacataac acatgtatac acctatgtgc aatgtgttta
     3481 tacatttatc aatttgtatg tttttactgg tttgtgatat aaaatggaca tgtatatgaa
     3541 ataaaacaga acttagcatc agtatgcata gttctctgta atattttcta gtttcttata
     3601 ctgtgtttca ttaaacaaaa caaaactttt aaaaattga
//
