LOCUS       NM_152699               6244 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens SUMO specific peptidase 5 (SENP5), transcript variant
            1, mRNA.
ACCESSION   NM_152699
VERSION     NM_152699.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6244)
  AUTHORS   Zhang,X., Ding,T., Yang,F., Zhang,J., Xu,H., Bai,Y., Shi,Y.,
            Yang,J., Chen,C., Zhu,C. and Zhang,H.
  TITLE     Peptidylprolyl isomerase A guides SENP5/GAU1 DNA-lncRNA triplex
            generation for driving tumorigenesis
  JOURNAL   Nat Commun 15 (1), 9068 (2024)
   PUBMED   39433793
  REMARK    GeneRIF: Peptidylprolyl isomerase A guides SENP5/GAU1 DNA-lncRNA
            triplex generation for driving tumorigenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6244)
  AUTHORS   Liu,T., Wang,H., Chen,Y., Wan,Z., Du,Z., Shen,H., Yu,Y., Ma,S.,
            Xu,Y., Li,Z., Yu,N., Zhang,F., Cao,K., Cai,J., Zhang,W., Gao,F. and
            Yang,Y.
  TITLE     SENP5 promotes homologous recombination-mediated DNA damage repair
            in colorectal cancer cells through H2AZ deSUMOylation
  JOURNAL   J Exp Clin Cancer Res 42 (1), 234 (2023)
   PUBMED   37684630
  REMARK    GeneRIF: SENP5 promotes homologous recombination-mediated DNA
            damage repair in colorectal cancer cells through H2AZ
            deSUMOylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6244)
  AUTHORS   Yu,B., Lin,Q., Huang,C., Zhang,B., Wang,Y., Jiang,Q., Zhang,C. and
            Yi,J.
  TITLE     SUMO proteases SENP3 and SENP5 spatiotemporally regulate the kinase
            activity of Aurora A
  JOURNAL   J Cell Sci 134 (13) (2021)
   PUBMED   34313310
  REMARK    GeneRIF: SUMO proteases SENP3 and SENP5 spatiotemporally regulate
            the kinase activity of Aurora A.
REFERENCE   4  (bases 1 to 6244)
  AUTHORS   Zhang,X., Wang,C., Zhao,D., Chen,X., Zhang,C., Zheng,J. and Liu,X.
  TITLE     Zinc deficiency induces abnormal development of the myocardium by
            promoting SENP5 overexpression
  JOURNAL   PLoS One 15 (11), e0242606 (2020)
   PUBMED   33211757
  REMARK    GeneRIF: Zinc deficiency induces abnormal development of the
            myocardium by promoting SENP5 overexpression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6244)
  AUTHORS   Hasegawa,Y., Taylor,D., Ovchinnikov,D.A., Wolvetang,E.J., de
            Torrente,L. and Mar,J.C.
  TITLE     Variability of Gene Expression Identifies Transcriptional
            Regulators of Early Human Embryonic Development
  JOURNAL   PLoS Genet 11 (8), e1005428 (2015)
   PUBMED   26288249
  REMARK    GeneRIF: Results from a study on gene expression variability
            markers in early-stage human embryos shows that SENP5 is a putative
            expression variability marker for the 3-day, 8-cell embryo stage.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6244)
  AUTHORS   Ding,X., Sun,J., Wang,L., Li,G., Shen,Y., Zhou,X. and Chen,W.
  TITLE     Overexpression of SENP5 in oral squamous cell carcinoma and its
            association with differentiation
  JOURNAL   Oncol Rep 20 (5), 1041-1045 (2008)
   PUBMED   18949399
  REMARK    GeneRIF: altered subcellular localization of SENP5 in oral squamous
            cell carcinoma (OSCC) cells and the correlation between SENP5
            expression and the differentiation of OSCC.
REFERENCE   7  (bases 1 to 6244)
  AUTHORS   Mikolajczyk,J., Drag,M., Bekes,M., Cao,J.T., Ronai,Z. and
            Salvesen,G.S.
  TITLE     Small ubiquitin-related modifier (SUMO)-specific proteases:
            profiling the specificities and activities of human SENPs
  JOURNAL   J Biol Chem 282 (36), 26217-26224 (2007)
   PUBMED   17591783
REFERENCE   8  (bases 1 to 6244)
  AUTHORS   Gong,L. and Yeh,E.T.
  TITLE     Characterization of a family of nucleolar SUMO-specific proteases
            with preference for SUMO-2 or SUMO-3
  JOURNAL   J Biol Chem 281 (23), 15869-15877 (2006)
   PUBMED   16608850
REFERENCE   9  (bases 1 to 6244)
  AUTHORS   Di Bacco,A., Ouyang,J., Lee,H.Y., Catic,A., Ploegh,H. and Gill,G.
  TITLE     The SUMO-specific protease SENP5 is required for cell division
  JOURNAL   Mol Cell Biol 26 (12), 4489-4498 (2006)
   PUBMED   16738315
  REMARK    GeneRIF: Knockdown of SENP5 resulted in increased levels of SUMO-1
            and SUMO-2/3, inhibition of cell proliferation, defects in nuclear
            morphology, and appearance of binucleate cells, revealing an
            essential role for SENP5 in mitosis and/or cytokinesis.
REFERENCE   10 (bases 1 to 6244)
  AUTHORS   Yeh,E.T., Gong,L. and Kamitani,T.
  TITLE     Ubiquitin-like proteins: new wines in new bottles
  JOURNAL   Gene 248 (1-2), 1-14 (2000)
   PUBMED   10806345
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC399261.1, BC030705.2, AC011322.29 and AL049229.2.
            
            On Nov 22, 2018 this sequence version replaced NM_152699.4.
            
            Summary: The reversible posttranslational modification of proteins
            by the addition of small ubiquitin-like SUMO proteins (see SUMO1;
            MIM 601912) is required for numerous biologic processes.
            SUMO-specific proteases, such as SENP5, are responsible for the
            initial processing of SUMO precursors to generate a C-terminal
            diglycine motif required for the conjugation reaction. They also
            have isopeptidase activity for the removal of SUMO from high
            molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed
            16738315]).[supplied by OMIM, Jun 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.188126.1,
                                           SRR1803617.136834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323460.10/ ENSP00000327197.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                DC399261.1         65-154
            91-500              DC399261.1         156-565
            501-2758            BC030705.2         514-2771
            2759-5214           AC011322.29        56908-59363         c
            5215-6244           AL049229.2         672-1701
FEATURES             Location/Qualifiers
     source          1..6244
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..6244
                     /gene="SENP5"
                     /note="SUMO specific peptidase 5"
                     /db_xref="GeneID:205564"
                     /db_xref="HGNC:HGNC:28407"
                     /db_xref="MIM:612845"
     exon            1..154
                     /gene="SENP5"
                     /inference="alignment:Splign:2.1.0"
     exon            155..1698
                     /gene="SENP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..2453
                     /gene="SENP5"
                     /EC_number="3.4.22.68"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SUMO1/sentrin specific protease 5; sentrin-specific
                     protease 5; sentrin/SUMO-specific protease SENP5;
                     SUMO1/sentrin specific peptidase 5"
                     /codon_start=1
                     /product="sentrin-specific protease 5 isoform 1"
                     /protein_id="NP_689912.2"
                     /db_xref="CCDS:CCDS3322.1"
                     /db_xref="GeneID:205564"
                     /db_xref="HGNC:HGNC:28407"
                     /db_xref="MIM:612845"
                     /translation="MKKQRKILWRKGIHLAFSEKWNTGFGGFKKFYFHQHLCILKAKL
                     GRPVTWNRQLRHFQGRKKALQIQKTWIKDEPLCAKTKFNVATQNVSTLSSKVKRKDAK
                     HFISSSKTLLRLQAEKLLSSAKNSDHEYCREKNLLKAVTDFPSNSALGQANGHRPRTD
                     PQPSDFPMKFNGESQSPGESGTIVVTLNNHKRKGFCYGCCQGPEHHRNGGPLIPKKFQ
                     LNQHRRIKLSPLMMYEKLSMIRFRYRILRSQHFRTKSKVCKLRKAQRSWVQKVTGDHQ
                     ETRRENGEGGSCSPFPSPEPKDPSCRHQPYFPDMDSSAVVKGTNSHVPDCHTKGSSFL
                     GKELSLDEAFPDQQNGSATNAWDQSSCSSPKWECTELIHDIPLPEHRSNTMFISETER
                     EIMTLGQENQTSSVSDDRVKLSVSGADTSVSSVDGPVSQKAVQNENSYQMEEDGSLKQ
                     SILSSELLDHPYCKSPLEAPLVCSGLKLENQVGGGKNSQKASPVDDEQLSVCLSGFLD
                     EVMKKYGSLVPLSEKEVLGRLKDVFNEDFSNRKPFINREITNYRARHQKCNFRIFYNK
                     HMLDMDDLATLDGQNWLNDQVINMYGELIMDAVPDKVHFFNSFFHRQLVTKGYNGVKR
                     WTKKVDLFKKSLLLIPIHLEVHWSLITVTLSNRIISFYDSQGIHFKFCVENIRKYLLT
                     EAREKNRPEFLQGWQTAVTKCIPQQKNDSDCGVFVLQYCKCLALEQPFQFSQEDMPRV
                     RKRIYKELCECRLMD"
     exon            1699..1804
                     /gene="SENP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1943
                     /gene="SENP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..1991
                     /gene="SENP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2069
                     /gene="SENP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2207
                     /gene="SENP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2291
                     /gene="SENP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2342
                     /gene="SENP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..6244
                     /gene="SENP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5020..5025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SENP5"
                     /note="hexamer: AATAAA"
     polyA_site      5042
                     /gene="SENP5"
                     /note="major polyA site"
     regulatory      6222..6227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SENP5"
                     /note="hexamer: AATAAA"
     regulatory      6227..6232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SENP5"
                     /note="hexamer: ACTAAA"
     polyA_site      6240
                     /gene="SENP5"
     polyA_site      6244
                     /gene="SENP5"
                     /note="major polyA site"
ORIGIN      
        1 agaggaagct cggcggctgt ggccgcggcg aacaggccgg acgcctcgtc gctggcgggg
       61 cttcccttgg agctgacgaa ggcggggtcc gcggtccagg ctgctgccgc gacggggccg
      121 gcggcggggc agctgccagg aacgagggta gcagctgcat ccagatctca ttatgcatca
      181 gaaaaatgaa aaaacagagg aaaattctat ggaggaaagg aatccactta gccttttctg
      241 agaaatggaa tactgggttt ggaggcttta agaagtttta ttttcaccaa cacttgtgca
      301 ttctgaaagc taagctggga aggccagtta cttggaatag acagttgaga catttccagg
      361 gtagaaagaa agctcttcaa atccagaaaa cgtggatcaa ggatgaaccc ctttgtgcta
      421 agaccaagtt caatgtggct actcaaaatg ttagtacttt gtcctctaaa gtgaaaagaa
      481 aggacgctaa acacttcatt tcctcctcaa agactctcct gagactccaa gcagagaagc
      541 tgttgtcatc agcaaagaat tctgaccatg aatactgcag agagaaaaat ctcttgaagg
      601 cagttactga ctttccatca aatagtgctt taggtcaggc caatggtcac agacctagga
      661 cagacccaca accttctgac tttcccatga agttcaatgg ggagagccaa agtccaggtg
      721 agagtggcac gattgtggtc accttgaaca accataagag aaagggcttt tgttacggct
      781 gctgccaagg gccggagcac cacaggaatg ggggaccctt gattccaaaa aagttccaac
      841 ttaaccaaca tagaaggata aaattatctc ctcttatgat gtatgagaaa ttatccatga
      901 ttagatttcg gtacaggatt ctcagatccc agcacttcag aaccaaaagc aaggtttgca
      961 agctaagaaa agcccagcga agctgggtac agaaagtcac tggggaccat caagagaccc
     1021 gtagggagaa cggtgagggt ggcagttgca gcccatttcc ttccccagaa cctaaagacc
     1081 cttcttgtcg gcatcagccg tactttccag atatggacag cagtgctgtg gtgaagggga
     1141 cgaactctca tgtgcctgat tgccacacta aaggaagctc tttcttgggc aaggagctta
     1201 gtttagacga agcattccct gaccaacaga atggcagtgc cacaaacgcc tgggaccagt
     1261 catcctgttc ttctcctaag tgggagtgta cagagctgat tcatgacatc cccttaccag
     1321 aacatcgttc taataccatg ttcatttcag aaactgaaag agaaattatg actctgggtc
     1381 aggaaaatca gacaagttct gtcagtgatg acagagtaaa actgtcagtg tctggagcag
     1441 atacatctgt gagtagcgta gatgggcctg tgtcccaaaa ggctgttcaa aatgagaact
     1501 cataccagat ggaggaggat ggatctctca agcagagcat tcttagttct gagttgctgg
     1561 accaccctta ctgtaaaagt ccactggagg ctcccttggt gtgcagtgga ctcaaactag
     1621 aaaatcaagt aggaggtgga aagaacagtc agaaagcctc tccagtggat gatgaacagc
     1681 tgtcagtctg tctttctgga ttcctagatg aggttatgaa gaagtatggc agtttggttc
     1741 cactcagtga aaaagaagtc cttggaagat taaaagatgt ctttaatgaa gacttttcta
     1801 atagaaaacc atttatcaat agggaaataa caaactatcg ggccagacat caaaaatgta
     1861 acttccgtat cttctataat aaacacatgc tggatatgga cgacctggcg actctggatg
     1921 gtcagaactg gctgaatgac caggtcatta atatgtatgg tgagctgata atggatgcag
     1981 tcccagacaa agttcacttc ttcaacagct tttttcatag acagctggta accaaaggat
     2041 ataatggagt aaaaagatgg actaaaaagg tggatttgtt taaaaagagt cttctgttga
     2101 ttcctattca cctggaagtc cactggtctc tcattactgt gacactctct aatcgaatta
     2161 tttcatttta tgattcccaa ggcattcatt ttaagttttg tgtagagaat ataagaaagt
     2221 atttgctgac tgaagccaga gaaaaaaata gacctgaatt tcttcagggt tggcagactg
     2281 ctgttacgaa gtgtattcca caacagaaaa acgacagtga ctgtggagtc tttgtgctcc
     2341 agtactgcaa gtgcctcgcc ttagagcagc ctttccagtt ttcacaagaa gacatgcccc
     2401 gagtgcggaa gaggatttac aaggagctat gtgagtgccg gctcatggac tgaaactcag
     2461 cagggactct gggaagtctg accaagttgg agcagatggt ttgttacttg aatctccaaa
     2521 cacttagttg aatttttaca gatatttcag atcagtggtg ttgggccact attgttacct
     2581 caaatttatt ttttgccctt attcatttct ccagctacca tgtactattg tttaatgttc
     2641 agtttggttt catttttaat tttatggttc tgtgcgtccc ccatatttaa tatttattat
     2701 tcaaacgcat gcatatagac agagcatgca gtgaagagta ttaaaaaaaa aagcttagta
     2761 gatttggtgc agcttttgaa acttagttag acgtgaactg aatacaggtt tcaaatttac
     2821 tcccagaacc taaaaatgca agatgttttt gatacaacat aactctgaga atagtaagtg
     2881 ttccctgggg cattaagggt agctgggggt ggttttgaca aatccagtcc tgttttactt
     2941 taccagcggc aactttcacc aacttccctc tccaagtgag tcttagagag tgcagtccat
     3001 tccttttgaa gggtgagatg gaagtggtcg taaactgact ggtgtcttct gtttctggag
     3061 gcacacttgt aagcacagtg gctgctttgg gaggagtaag gtgtgagaaa aagcaacctt
     3121 ggaggccagt aacaatgaca gatttcaatc gtggttttag gaattataat acgtggcata
     3181 catctcataa aggcttttgc tgggatattg aattccctga atttttctgt tttcgacctg
     3241 ttaaaaaaat cttaacatcc atcaaactag tggtcaaaca aatgagaatg cagctgttct
     3301 cagagtaatt tttaagttgt catttccctg tgttgcctcc caattggaag aagttaaggt
     3361 ttaccaaatg catttctatt tcaagggtat ctgaaacgta aacattcaaa actgaaggct
     3421 gactgacttg agatgttttg caggtggctg gagagaagag ggaaggtaat agagacaact
     3481 tagtcccatg ggagcgcagc aaccgtgtca ggttctttct cctgtcccat tagtgacctc
     3541 agtaacatgc agggtacgtc tggcttctgc atggccagtg ctgacactag cacagctgtt
     3601 cttctccttc tgttgaacct catcttctga agaaaggcca agtggccctt gtccatacac
     3661 ttagctgcat taggatgaat atcacgcgtc tcacatcttt aatccagcct ttcgtgacat
     3721 gttggaaaga tacatgtgaa acctacccag ttaccctttc tgaattggga ggaaaaccaa
     3781 ccaatgtatg tatgagaaac tcagaagtct gaatagaaaa acaaagtaaa tggcagaaga
     3841 ttctcgagtt tatgcccgcg taggtttgga gtgttgaaaa agctaaaatg tttagtttca
     3901 cttggccctg aggtatggtt gagaaggctg actgccagca gttgaggatt gagtccgacc
     3961 atgtttacat gcagggttcc caacaccagt ggtgacactg ggaagcagcc ccagcacttt
     4021 cctctcctga gtcctccaga cccaaaatcc ttaatgtcaa accaggtcag tgtttcttac
     4081 tgtgtttcaa gtcgttaaaa agactgagag tagaggcact ttatgctgct ataggtgggg
     4141 ttctgtcagc gttaggaaaa aatgacagtt tagggtaagg aagatctcat aatgagtttt
     4201 tcaaacataa ttatgcaaac atgagatttt tcaaaacatg ccagaaattt gcctctgatt
     4261 tttttttttt tttttttttt ttttttgtgg gggtgtggta taccaaagta gccagtcact
     4321 gggctgtcag ttcaaaatgt cttgtacttc agagtgagga agtgtttcag ttcctcagtg
     4381 acagaacctg gcatgcagaa gagacagaat tgttcctgta agaaaatcaa cgccgagaga
     4441 gagctgccca aatccagtga ctcttccact tccagtctca tgcttcatag ggcaccttga
     4501 ggtgtgctgc ccagtgtggc ttagactaaa tgttgagttt gggttttttg tttttttttt
     4561 tttttgagtc agagtctcac tgtccctcag gctggagtgc aatggcgcaa tcttgcctca
     4621 ctgcaacctc cacctcccag gttcaagcga ttctcctgcc tcagcctccc aagtagctgg
     4681 gattacaggt gtgtgccacc acgccccacc gatttttgta cttttagtag agacaggatt
     4741 tcaccatgtt ggccaggctg gtcttgaact cctgacctca agtgatctgc ccgcctgggc
     4801 ctcccaaagt gctgggatta caggcgggag ccaccgtgcc tggccaatgt taagtatttt
     4861 aaaagtcatt ttaaaatatt tgtcattgat gaaacttggt ttcagcacac gtaattgctt
     4921 tccctctctt cttgtgatta ggtgtaaacc tctatttaac tcaagtccta gattagaatg
     4981 tcctttgtcc tgatgtttgc agtaattgct tccttggtta ataaagatat ttttgaaata
     5041 tactctggac tgttggtgaa agaggcaggc atggctttac tggtactagt ttggcactga
     5101 actgtttggg tgcccatgag gtaggcagac cttatgcttt ttttttttga gacggagtct
     5161 tgctctgttg cccaggctgg agtgcagtga tgtgatctcg gctcactgca acccctgcct
     5221 cccaggttca agtgattctc ctgcctcagc ttccccaata gctgggacta caggtgtgcg
     5281 ccaccactcc cagctaattt ttgtattttt agtagagaca gggttttgcc atgttggtca
     5341 ggctggtctc ggaactcctg acctcaggtg atccacccgc ctctgcctca caaagtgctg
     5401 ggattacagg catgagctac cgtgcctggc ctaaacctta cgcttttgag gttgagtgca
     5461 ggccttgtga taactaagcg ctacttttga cgagccttca acaagctgcc cagtcctctc
     5521 ctcagcagac gcatcaggtt gtagttgcat ctttacagtg gtctttcctt ttattaaatc
     5581 tatagcagtg aatatagatt tgattcaact tttagttacg ttctctcaag aatcctaatc
     5641 aactttcagt tagcctctta agaaagggaa aaaaaggtgc tgccagtcat ccccaaatta
     5701 tgtttttggc tgtgcattct attttctaca tagcactgaa tctgagtaac agtcatcctg
     5761 gatttatagt tggaacagaa cagtaacaga cctaactggg actcagccag cactagcctc
     5821 atcttagctg ccccttttct ctgctttgca gtttactgct tccctgggct agccataacg
     5881 gggttctggg caggtcagac tcttcagcaa gacagtgtat taatagtgtg aattagatac
     5941 actgatgacc tgctctgcct agttaagaaa ctgaattaat cagcagttac aaagcacata
     6001 ctttgttacg tgctaggctt tgcctcctgg cctctagata attaagacgg cccagggaat
     6061 accagcagag aagtgctaat tgtatttggg tgttacaaaa gcagacctag acgagctgtt
     6121 cacttaactg gtacctgttg gtcagaaaaa gaatttattt agagattatg atcatgtaaa
     6181 attacagtac tcaacccttc tagcaaagta tttttttgaa aaataaacta aatgccttta
     6241 taaa
//
