LOCUS       NM_015670               2567 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens SUMO specific peptidase 3 (SENP3), mRNA.
ACCESSION   NM_015670
VERSION     NM_015670.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2567)
  AUTHORS   Chen,X., Li,D., Su,Q., Ling,X., Yang,Y., Liu,Y., Zhu,X., He,A.,
            Ding,S., Xu,R., Liu,Z., Long,X., Zhang,J., Yang,Z., Qi,Y. and Wu,H.
  TITLE     SENP3 mediates the deSUMOylation and degradation of YAP1 to
            regulate the progression of triple-negative breast cancer
  JOURNAL   J Biol Chem 300 (10), 107764 (2024)
   PUBMED   39270822
  REMARK    GeneRIF: SENP3 mediates the deSUMOylation and degradation of YAP1
            to regulate the progression of triple-negative breast cancer.
REFERENCE   2  (bases 1 to 2567)
  AUTHORS   Wang,J., Xiu,M., Wang,J., Gao,Y. and Li,Y.
  TITLE     METTL16-SENP3-LTF axis confers ferroptosis resistance and
            facilitates tumorigenesis in hepatocellular carcinoma
  JOURNAL   J Hematol Oncol 17 (1), 78 (2024)
   PUBMED   39218945
  REMARK    GeneRIF: METTL16-SENP3-LTF axis confers ferroptosis resistance and
            facilitates tumorigenesis in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2567)
  AUTHORS   Wang,P., Yang,L., Guo,Y., Qi,S., Liang,J., Tian,G. and Tian,Z.
  TITLE     SENP3 mediates the activation of the Wnt/beta-catenin signaling
            pathway to accelerate the growth and metastasis of oesophagal
            squamous cell carcinoma in mice
  JOURNAL   Funct Integr Genomics 24 (2), 40 (2024)
   PUBMED   38383667
  REMARK    GeneRIF: SENP3 mediates the activation of the Wnt/beta-catenin
            signaling pathway to accelerate the growth and metastasis of
            oesophagal squamous cell carcinoma in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2567)
  AUTHORS   Ma,Y.N., Zou,Y.D., Liu,Z.L., Wu,G.X., Zhou,Y.Z., Luo,C.X.,
            Huang,X.T., Xie,M.L., Xu,S.N. and Li,X.
  TITLE     SENP3 Promotes Mantle Cell Lymphoma Development through Regulating
            Wnt10a Expression
  JOURNAL   Curr Med Sci 44 (1), 134-143 (2024)
   PUBMED   38273178
  REMARK    GeneRIF: SENP3 Promotes Mantle Cell Lymphoma Development through
            Regulating Wnt10a Expression.
REFERENCE   5  (bases 1 to 2567)
  AUTHORS   Wu,X., Li,J.H., Xu,L., Li,Y.X., Zhu,X.X., Wang,X.Y., Wu,X.,
            Zhao,W., Ni,X. and Yin,X.Y.
  TITLE     SUMO specific peptidase 3 halts pancreatic ductal adenocarcinoma
            metastasis via deSUMOylating DKC1
  JOURNAL   Cell Death Differ 30 (7), 1742-1756 (2023)
   PUBMED   37188742
  REMARK    GeneRIF: SUMO specific peptidase 3 halts pancreatic ductal
            adenocarcinoma metastasis via deSUMOylating DKC1.
REFERENCE   6  (bases 1 to 2567)
  AUTHORS   Dou,Y., Milne,T.A., Tackett,A.J., Smith,E.R., Fukuda,A.,
            Wysocka,J., Allis,C.D., Chait,B.T., Hess,J.L. and Roeder,R.G.
  TITLE     Physical association and coordinate function of the H3 K4
            methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
  JOURNAL   Cell 121 (6), 873-885 (2005)
   PUBMED   15960975
REFERENCE   7  (bases 1 to 2567)
  AUTHORS   Bouras,T., Fu,M., Sauve,A.A., Wang,F., Quong,A.A., Perkins,N.D.,
            Hay,R.T., Gu,W. and Pestell,R.G.
  TITLE     SIRT1 deacetylation and repression of p300 involves lysine residues
            1020/1024 within the cell cycle regulatory domain 1
  JOURNAL   J Biol Chem 280 (11), 10264-10276 (2005)
   PUBMED   15632193
REFERENCE   8  (bases 1 to 2567)
  AUTHORS   Gregoire,S. and Yang,X.J.
  TITLE     Association with class IIa histone deacetylases upregulates the
            sumoylation of MEF2 transcription factors
  JOURNAL   Mol Cell Biol 25 (6), 2273-2287 (2005)
   PUBMED   15743823
  REMARK    Erratum:[Mol Cell Biol. 2006 Apr;26(8):3335]
REFERENCE   9  (bases 1 to 2567)
  AUTHORS   Nishida,T., Tanaka,H. and Yasuda,H.
  TITLE     A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized
            in the nucleolus at interphase
  JOURNAL   Eur J Biochem 267 (21), 6423-6427 (2000)
   PUBMED   11029585
REFERENCE   10 (bases 1 to 2567)
  AUTHORS   Yeh,E.T., Gong,L. and Kamitani,T.
  TITLE     Ubiquitin-like proteins: new wines in new bottles
  JOURNAL   Gene 248 (1-2), 1-14 (2000)
   PUBMED   10806345
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016876.10, BQ956948.1, BQ424754.1, CX165088.1, BC048306.1 and
            BF514106.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015670.5.
            
            Summary: The reversible posttranslational modification of proteins
            by the addition of small ubiquitin-like SUMO proteins (see SUMO1;
            MIM 601912) is required for numerous biologic processes.
            SUMO-specific proteases, such as SENP3, are responsible for the
            initial processing of SUMO precursors to generate a C-terminal
            diglycine motif required for the conjugation reaction. They also
            have isopeptidase activity for the removal of SUMO from high
            molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed
            16738315]).[supplied by OMIM, Jun 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.418579.1,
                                           SRR1163655.396429.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321337.12/ ENSP00000314029.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC016876.10        32383-32455         c
            74-103              BQ956948.1         1-30
            104-596             BQ424754.1         35-527
            597-838             CX165088.1         460-701
            839-2501            BC048306.1         4-1666
            2502-2567           BF514106.1         16-81               c
FEATURES             Location/Qualifiers
     source          1..2567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..2567
                     /gene="SENP3"
                     /gene_synonym="SMT3IP1; SSP3; Ulp1"
                     /note="SUMO specific peptidase 3"
                     /db_xref="GeneID:26168"
                     /db_xref="HGNC:HGNC:17862"
                     /db_xref="MIM:612844"
     exon            1..345
                     /gene="SENP3"
                     /gene_synonym="SMT3IP1; SSP3; Ulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..1071
                     /gene="SENP3"
                     /gene_synonym="SMT3IP1; SSP3; Ulp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..2081
                     /gene="SENP3"
                     /gene_synonym="SMT3IP1; SSP3; Ulp1"
                     /EC_number="3.4.22.68"
                     /note="sentrin/SUMO-specific protease 3;
                     SUMO1/sentrin/SMT3 specific peptidase 3; SUMO-1-specific
                     protease 3"
                     /codon_start=1
                     /product="sentrin-specific protease 3"
                     /protein_id="NP_056485.2"
                     /db_xref="CCDS:CCDS73958.1"
                     /db_xref="GeneID:26168"
                     /db_xref="HGNC:HGNC:17862"
                     /db_xref="MIM:612844"
                     /translation="MKETIQGTGSWGPEPPGPGIPPAYSSPRRERLRWPPPPKPRLKS
                     GGGFGPDPGSGTTVPARRLPVPRPSFDASASEEEEEEEEEEDEDEEEEVAAWRLPPRW
                     SQLGTSQRPRPSRPTHRKTCSQRRRRAMRAFRMLLYSKSTSLTFHWKLWGRHRGRRRG
                     LAHPKNHLSPQQGGATPQVPSPCCRFDSPRGPPPPRLGLLGALMAEDGVRGSPPVPSG
                     PPMEEDGLRWTPKSPLDPDSGLLSCTLPNGFGGQSGPEGERSLAPPDASILISNVCSI
                     GDHVAQELFQGSDLGMAEEAERPGEKAGQHSPLREEHVTCVQSILDEFLQTYGSLIPL
                     STDEVVEKLEDIFQQEFSTPSRKGLVLQLIQSYQRMPGNAMVRGFRVAYKRHVLTMDD
                     LGTLYGQNWLNDQVMNMYGDLVMDTVPEKVHFFNSFFYDKLRTKGYDGVKRWTKNVDI
                     FNKELLLIPIHLEVHWSLISVDVRRRTITYFDSQRTLNRRCPKHIAKYLQAEAVKKDR
                     LDFHQGWKGYFKMNVARQNNDSDCGAFVLQYCKHLALSQPFSFTQQDMPKLRRQIYKE
                     LCHCKLTV"
     exon            1072..1311
                     /gene="SENP3"
                     /gene_synonym="SMT3IP1; SSP3; Ulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1423
                     /gene="SENP3"
                     /gene_synonym="SMT3IP1; SSP3; Ulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1571
                     /gene="SENP3"
                     /gene_synonym="SMT3IP1; SSP3; Ulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1619
                     /gene="SENP3"
                     /gene_synonym="SMT3IP1; SSP3; Ulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1697
                     /gene="SENP3"
                     /gene_synonym="SMT3IP1; SSP3; Ulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1835
                     /gene="SENP3"
                     /gene_synonym="SMT3IP1; SSP3; Ulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1919
                     /gene="SENP3"
                     /gene_synonym="SMT3IP1; SSP3; Ulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..1970
                     /gene="SENP3"
                     /gene_synonym="SMT3IP1; SSP3; Ulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2567
                     /gene="SENP3"
                     /gene_synonym="SMT3IP1; SSP3; Ulp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2541..2546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SENP3"
                     /gene_synonym="SMT3IP1; SSP3; Ulp1"
                     /note="hexamer: AATAAA"
     polyA_site      2567
                     /gene="SENP3"
                     /gene_synonym="SMT3IP1; SSP3; Ulp1"
                     /note="major polyA site"
ORIGIN      
        1 gtgacgtact aatcgtgcgc caccgctgcc ggtgggcccg gggctcgcgg gaggggaagg
       61 aggagggggg gaggagtggc ggcggcggcg gtggcgctgg tggcggcggt ggcggaggtg
      121 gaggtggagg tggaagctga agctgaagca gagccagagg cggcgcggcg gggtgctcgg
      181 cggcgcggca cgcggcccag aagcgttgga atcctgaatt gagacggctg cgcctaaaga
      241 cagcaggagt ggcggggccg ccgccgtcgc cggagagatg agccgggaag cttgaggccg
      301 gagacgcccg ccttcgggcc cgtccgcccg gcttccccgc tcccgggtac tggaagatga
      361 aagagactat acaagggacc gggtcctggg ggcctgagcc tcctggaccc ggcatacccc
      421 cagcttactc aagtcccagg cgggagcgtc ttcgttggcc cccacctccc aaaccccgac
      481 tcaagtcagg tggagggttt gggccagatc ctgggtcagg gaccacagtg ccagccagac
      541 gcctccctgt cccccgaccc tcttttgatg cctcagcaag tgaagaggag gaagaagagg
      601 aggaggagga ggatgaagat gaagaggagg aagtggcagc ttggaggctg cccccaagat
      661 ggagtcagct gggaacctcc cagcggcccc gcccttcccg ccccactcat cgaaaaacct
      721 gctcacagcg ccgccgccga gccatgagag ccttccggat gctgctctac tcaaaaagca
      781 cctcgctgac attccactgg aagctttggg ggcgccaccg gggccggcgg cggggcctcg
      841 cacaccccaa gaaccatctt tcaccccagc aagggggtgc gacgccacag gtgccatccc
      901 cctgttgtcg ttttgactcc ccccgggggc cacctccacc ccggctgggt ctgctaggtg
      961 ctctcatggc tgaggatggg gtgagagggt ctccaccagt gccctctggg ccccccatgg
     1021 aggaagatgg actcaggtgg actccaaagt ctcctctgga ccctgactcg ggcctccttt
     1081 catgtactct gcccaacggt tttgggggac aatctgggcc agaaggggag cgcagcttgg
     1141 caccccctga tgccagcatc ctcatcagca atgtgtgcag catcggggac catgtggccc
     1201 aggagctttt tcagggctca gatttgggca tggcagaaga ggcagagagg cctggggaga
     1261 aagccggcca gcacagcccc ctgcgagagg agcatgtgac ctgcgtacag agcatcttgg
     1321 acgaattcct tcaaacgtat ggcagcctca tacccctcag cactgatgag gtagtagaga
     1381 agctggagga cattttccag caggagtttt ccaccccttc caggaagggc ctggtgttgc
     1441 agctgatcca gtcttaccag cggatgccag gcaatgccat ggtgaggggc ttccgagtgg
     1501 cttataagcg gcacgtgctg accatggatg acttggggac cttgtatgga cagaactggc
     1561 tcaatgacca ggtgatgaac atgtatggag acctggtcat ggacacagtc cctgaaaagg
     1621 tgcatttctt caatagtttc ttctatgata aactccgtac caagggttat gatggggtga
     1681 aaaggtggac caaaaacgtg gacatcttca ataaggagct actgctaatc cccatccacc
     1741 tggaggtgca ttggtccctc atctctgttg atgtgaggcg acgcaccatc acctattttg
     1801 actcgcagcg taccctaaac cgccgctgcc ctaagcatat tgccaagtat ctacaggcag
     1861 aggcggtaaa gaaagaccga ctggatttcc accagggctg gaaaggttac ttcaaaatga
     1921 atgtggccag gcagaataat gacagtgact gtggtgcttt tgtgttgcag tactgcaagc
     1981 atctggccct gtctcagcca ttcagcttca cccagcagga catgcccaaa cttcgtcggc
     2041 agatctacaa ggagctgtgt cactgcaaac tcactgtgtg agcctcgtac cccagacccc
     2101 aagcccataa atgggaaggg agacatggga gtcccttccc aagaaactcc agttcctttc
     2161 ctctcttgcc tcttcccact cacttccctt tggtttttca tatttaaatg tttcaatttc
     2221 tgtatttttt tttctttgag agaatacttg ttgatttctg atgtgcaggg ggtggctaca
     2281 gaaaagcccc tttcttcctc tgtttgcagg ggagtgtggc cctgtggcct gggtggagca
     2341 gtcatcctcc cccttccccg tgcagggagc aggaaatcag tgctgggggt ggtgggcgga
     2401 caataggatc actgcctgcc agatcttcaa acttttatat atatatatat atatatatat
     2461 atatatatat atatatatat atatatatat atatatatat atatataaaa atatataaat
     2521 gccacggtcc tgctctggtc aataaaggat cctttgttga tacgtaa
//
