LOCUS       NM_021627               5596 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SUMO specific peptidase 2 (SENP2), mRNA.
ACCESSION   NM_021627
VERSION     NM_021627.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5596)
  AUTHORS   Jiang,Y., Xiao,S., Huang,S., Zhao,X., Ding,S., Huang,Q., Xiao,W.,
            Li,Z. and Zhu,H.
  TITLE     Extracellular vesicle-mediated regulation of imatinib resistance in
            chronic myeloid leukemia via the miR-629-5p/SENP2/PI3K/AKT/mTOR
            axis
  JOURNAL   Hematology 29 (1), 2379597 (2024)
   PUBMED   39056503
  REMARK    GeneRIF: Extracellular vesicle-mediated regulation of imatinib
            resistance in chronic myeloid leukemia via the
            miR-629-5p/SENP2/PI3K/AKT/mTOR axis.
REFERENCE   2  (bases 1 to 5596)
  AUTHORS   Galan-Vidal,J., Garcia-Gaipo,L., Molinuevo,R., Dias,S., Tsoi,A.,
            Gomez-Roman,J., Elder,J.T., Hochegger,H. and Gandarillas,A.
  TITLE     Sumo-regulatory SENP2 controls the homeostatic squamous
            mitosis-differentiation checkpoint
  JOURNAL   Cell Death Dis 15 (8), 596 (2024)
   PUBMED   39152119
  REMARK    GeneRIF: Sumo-regulatory SENP2 controls the homeostatic squamous
            mitosis-differentiation checkpoint.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5596)
  AUTHORS   Liu,Y., Liu,K., Thorne,R.F., Shi,R., Zhang,Q., Wu,M. and Liu,L.
  TITLE     Mitochondrial SENP2 regulates the assembly of SDH complex under
            metabolic stress
  JOURNAL   Cell Rep 42 (2), 112041 (2023)
   PUBMED   36708515
  REMARK    GeneRIF: Mitochondrial SENP2 regulates the assembly of SDH complex
            under metabolic stress.
REFERENCE   4  (bases 1 to 5596)
  AUTHORS   Nan,J., Lee,J.S., Moon,J.H., Lee,S.A., Park,Y.J., Lee,D.S.,
            Chung,S.S. and Park,K.S.
  TITLE     SENP2 regulates mitochondrial function and insulin secretion in
            pancreatic beta cells
  JOURNAL   Exp Mol Med 54 (1), 72-80 (2022)
   PUBMED   35064188
  REMARK    GeneRIF: SENP2 regulates mitochondrial function and insulin
            secretion in pancreatic beta cells.
REFERENCE   5  (bases 1 to 5596)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 5596)
  AUTHORS   Best,J.L., Ganiatsas,S., Agarwal,S., Changou,A., Salomoni,P.,
            Shirihai,O., Meluh,P.B., Pandolfi,P.P. and Zon,L.I.
  TITLE     SUMO-1 protease-1 regulates gene transcription through PML
  JOURNAL   Mol Cell 10 (4), 843-855 (2002)
   PUBMED   12419228
REFERENCE   7  (bases 1 to 5596)
  AUTHORS   Zhang,H., Saitoh,H. and Matunis,M.J.
  TITLE     Enzymes of the SUMO modification pathway localize to filaments of
            the nuclear pore complex
  JOURNAL   Mol Cell Biol 22 (18), 6498-6508 (2002)
   PUBMED   12192048
REFERENCE   8  (bases 1 to 5596)
  AUTHORS   Kadoya,T., Yamamoto,H., Suzuki,T., Yukita,A., Fukui,A., Michiue,T.,
            Asahara,T., Tanaka,K., Asashima,M. and Kikuchi,A.
  TITLE     Desumoylation activity of Axam, a novel Axin-binding protein, is
            involved in downregulation of beta-catenin
  JOURNAL   Mol Cell Biol 22 (11), 3803-3819 (2002)
   PUBMED   11997515
REFERENCE   9  (bases 1 to 5596)
  AUTHORS   Hang,J. and Dasso,M.
  TITLE     Association of the human SUMO-1 protease SENP2 with the nuclear
            pore
  JOURNAL   J Biol Chem 277 (22), 19961-19966 (2002)
   PUBMED   11896061
  REMARK    GeneRIF: association with the pore plays an important negative role
            in the regulation of SENP2
REFERENCE   10 (bases 1 to 5596)
  AUTHORS   Nishida,T., Kaneko,F., Kitagawa,M. and Yasuda,H.
  TITLE     Characterization of a novel mammalian SUMO-1/Smt3-specific
            isopeptidase, a homologue of rat axam, which is an axin-binding
            protein promoting beta-catenin degradation
  JOURNAL   J Biol Chem 276 (42), 39060-39066 (2001)
   PUBMED   11489887
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF151697.2, BC040609.1, AL834380.1, BC018020.1 and AC016961.28.
            
            On Nov 23, 2018 this sequence version replaced NM_021627.2.
            
            Summary: SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein
            that can be covalently conjugated to other proteins. SENP2 is one
            of a group of enzymes that process newly synthesized SUMO1 into the
            conjugatable form and catalyze the deconjugation of
            SUMO1-containing species.[supplied by OMIM, Apr 2004].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027599.1, SRR1803612.111258.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296257.10/ ENSP00000296257.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AF151697.2         53-114
            63-1052             BC040609.1         1-990
            1053-2607           AL834380.1         929-2483
            2608-2659           BC018020.1         596-647
            2660-3146           AL834380.1         2536-3022
            3147-5596           AC016961.28        13190-15639
FEATURES             Location/Qualifiers
     source          1..5596
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.2"
     gene            1..5596
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /note="SUMO specific peptidase 2"
                     /db_xref="GeneID:59343"
                     /db_xref="HGNC:HGNC:23116"
                     /db_xref="MIM:608261"
     exon            1..220
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1889
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /EC_number="3.4.22.68"
                     /note="SUMO1/sentrin/SMT3 specific protease 2;
                     SMT3-specific isopeptidase 2; SUMO1/sentrin/SMT3 specific
                     peptidase 2; sentrin (SUMO1) specific peptidase 2;
                     sentrin/SUMO-specific protease SENP2"
                     /codon_start=1
                     /product="sentrin-specific protease 2"
                     /protein_id="NP_067640.2"
                     /db_xref="CCDS:CCDS33902.1"
                     /db_xref="GeneID:59343"
                     /db_xref="HGNC:HGNC:23116"
                     /db_xref="MIM:608261"
                     /translation="MYRWLVRILGTIFRFCDRSVPPARALLKRRRSDSTLFSTVDTDE
                     IPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNS
                     SSCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNR
                     RPGGRRHSKGNPESSLMWKPQEQAVTEMISEESGKGLRRPHCTVEEGVQKEEREKYRK
                     LLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLV
                     ETRGPLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSG
                     SNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDMEKEISNALGHGPQDEILSSA
                     FKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGG
                     YQAVKRWTKGVNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEIL
                     LQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPIT
                     FTQHQMPLFRKKMVWEILHQQLL"
     exon            221..276
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            277..410
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            411..477
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            478..568
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..737
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            738..841
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            842..936
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..988
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1052
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1229
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1361
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1565
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1645
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1730
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1826
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..5596
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3116..3121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /note="hexamer: AATAAA"
     polyA_site      3146
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /note="major polyA site"
     regulatory      5574..5579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
                     /note="hexamer: AATAAA"
     polyA_site      5596
                     /gene="SENP2"
                     /gene_synonym="AXAM2; SMT3IP2"
ORIGIN      
        1 acaaatcagc gaccgaactc tggcggtggt ggttaagacg gcgaaggcgg cagcggcggc
       61 gacagctctg gggtttgcgt ctcggggtgt gtcggccgcc gctgctgctt gggcctggta
      121 tgtacagatg gctggttagg attctcggca ccattttccg tttctgcgac cggtcggtgc
      181 cccctgcccg ggccctcctg aagaggcggc gctcagacag cactctgttt tctacagtgg
      241 acactgatga aataccagcc aaaagaccaa gattagattg ctttattcac caagtgaaaa
      301 acagtctcta caatgctgcc agcttatttg gattcccatt ccagctgacc acaaagccca
      361 tggtaacttc tgcttgtaat ggaacacgga atgtggcccc ttcaggagag gtattttcga
      421 actcttcatc ttgtgaactg acaggttctg gatcctggaa caacatgctg aaactgggta
      481 ataaatctcc taatggaata agtgactatc caaagatcag agtgacagtt acccgagatc
      541 agccacgcag agtcctgcct tcctttggtt ttactttgaa ctcagaaggc tgtaatagaa
      601 gaccaggtgg ccgtcgccat agcaaaggta atccagagag ttctttaatg tggaaacctc
      661 aggaacaggc tgtaacagag atgatttctg aagagagtgg caagggtctg aggcgtcccc
      721 attgtactgt ggaggagggt gttcaaaaag aggaaagaga gaagtaccga aagttattgg
      781 aacgacttaa agaaagtggt catggaaact ctgtctgtcc tgtaacttca aattatcaca
      841 gttctcaaag aagtcagatg gacacattaa agaccaaagg ctggggggaa gagcaaaatc
      901 acggagtcaa aacaactcag tttgttccaa aacaatatag acttgttgaa acaaggggac
      961 ctctatgttc attgagaagt gaaaagaggt gttcaaaggg gaaaattact gatacagaga
     1021 cgatggtcgg aatcagattt gaaaatgaaa gtaggagggg ataccaactg gagcctgacc
     1081 tatcagaaga agtgtcggcc cgactccgcc tgggcagtgg aagcaatggc ttactcagga
     1141 ggaaagtgtc aataattgag acaaaggaaa agaattgctc aggcaaagag agggacagaa
     1201 gaacggacga tctccttgaa cttacagagg acatggaaaa ggaaatcagt aatgccctag
     1261 gccatggccc acaggatgaa atcctaagta gtgctttcaa attgcgaatt actcgaggag
     1321 atattcagac attaaagaac tatcactggc tcaatgatga agtcattaat ttttacatga
     1381 atcttctggt ggaaagaaat aaaaagcaag gctatccagc acttcatgta ttcagtactt
     1441 tcttctatcc taaattaaag tctgggggtt accaagcagt gaaacgatgg accaaagggg
     1501 taaatctctt tgaacaagaa attattctgg tgcctattca tcggaaggta cattggagcc
     1561 tggtggtgat tgacctaaga aaaaagtgtc ttaaatatct ggattctatg ggacaaaagg
     1621 gccacaggat ctgtgagatt ctccttcagt atttacagga tgaaagtaag accaaaagaa
     1681 atagtgatct gaatctttta gagtggaccc atcacagcat gaaaccacac gagattcctc
     1741 aacagctgaa tgggagtgat tgtggaatgt ttacttgtaa atatgcagat tatatttcta
     1801 gggacaaacc tatcacattt actcagcacc agatgcctct cttccggaag aagatggtgt
     1861 gggaaatcct tcatcagcag ttgctgtgag aaaactttgc ctggtccctc tagctgctgg
     1921 tggttctttc acagacattt ccatatacct catgcattgt gggttaaaaa gtccctgcat
     1981 cacttctgtt ctcacaggta ctgagctgtc aaaagtgcat gaaggcctct cactgtactc
     2041 tagtcctgac ttggggtgca gagggctgct tgcaatcctg tttgtaaggc tgtgcctgct
     2101 cagagctttg gactgttcaa cccacacaag aacaaacgct aactaatatt ttttttaaga
     2161 gattcttttc cctatgaatg tgggaaatgc aggatttatt ctgtgaattg tttgtttctg
     2221 tgtgtttgtt cagcgtattc attcactcac tcgtttgcaa acataatggg cagtggtcat
     2281 ttactgctgc tcttttacag ttagctctaa attacttgtt tgaactattt atttctgaaa
     2341 ggaatgttac tcaagctgcc actccctgct gaagagcagg agggaactct cactgggggc
     2401 ggaaggaagt ggagctggag cagtaactgc caacatgaag ctggagggtt tgggattttt
     2461 tttgtttttg tttttttgag gctcaaaaaa tgctgggaga aatgaaaatg ctgtgggata
     2521 gggctcctgt tgcctttcag aggaagtctg acactacagc gttggcacag tgccgtgaac
     2581 agtggaactg tgcccaaggg actctgatta tccaagcatc ttccgaagag tgttgtggtc
     2641 accttaaaga gacttcccct tctggaaatg tggtgacttg gcttagtctt caaactggat
     2701 tcatggattt gaagtaactg taaaccctaa atcttcattt tcatcccaga tctggttgag
     2761 tataaacctc agaattgtag gggctggcct gagctgttta tttcaaaaga tactattcaa
     2821 tttaaagcta tttttcctca gagtttttgt tttctatata ttaagtctaa attaagtttt
     2881 ctactcatta agactaacat ctccccactc catccccact gaaatttgtg gaagaaaatt
     2941 tagtacttgg ctctgaggtt gccagttata caataatcta ttttgcatat gaaagtttgt
     3001 atttaacttt tttgttcatt aaaaacctta ctgatatggt tataacttca gacagtttag
     3061 agttggtcag aacatatttt gcaagatcta gtgcctagtg ttgcttttct gatgtaataa
     3121 aaggtggtct ggcagaacct aaaaaagtat atgctgaaat gatttctaac cctctcccta
     3181 cttaaacctc ccagacttgt tctggttcat aaaagcaaga ggtaaaactg gaaaaattgt
     3241 gcacgtgtta cctatgaatc tacacgcctg ccatttgcag tgctccggct gctggtccca
     3301 gaggtatact ggttacagct attgcagcca gttccctgag acttgtaaaa ctcctggttt
     3361 aggacatggg gcctgtggtg tggatggaaa atgctgggcc tactggatgg tcagccagag
     3421 gccatgtggt gggtgatgac tgaagcggga gcaggttgta ccacacctct cccccccccc
     3481 tcccactccc cctccctccc tctcccctcc ccctccctcc ctcccccctc cctccctccc
     3541 ccccctcccc ctccctcccc ctccctctct ccctaacacc caccctcccc ctttccccca
     3601 ccctcccccc ttctcccctt tccccaccct ccctcccccc ttccccctcc cccccccccc
     3661 cccgcagccc ctgctccttt ctctgggctc ctggcattgt gccagtgagt gctgggacca
     3721 ggtaatgagc acagccaaaa aggccagagg ttcactaggt cagcatcata ccaaacgcct
     3781 ggctttcacc aggcatcagt gtgcttcact tgagagtttg gtaccatggt taagatcgag
     3841 tccatgctag gtaagtcctg ttaggaatgt cagtttgtat tccgcccacg tgaatgatgc
     3901 tgagcttaat gtattatttt gaggggcttc ttcagagcag ttctcactga gctttccatt
     3961 aacctacact cttccggacg gctcttaaaa cttgcaggac ataatgaaat tgggaagagc
     4021 agagtgttga agtctatagc atggccttct gcttgaccct gagttcctga attgaatgtg
     4081 ggagaccaca ggccatactt ctctaggcac tcacatgtct cccttggcat aaggaaacat
     4141 gttagtaata tagtttttta gatccaaaca gtttatttgg atctaaaagt ttaagtgttc
     4201 agttgaaaaa cagctattga ttttattagt agcaaattat caccattaaa gccagtggtt
     4261 ttttttttgt tttttttttt tgtttttttt tttttttttt gcgacagagt ctcttgtcgc
     4321 ccaggctgga gtacaatggt gtgatctcag ctcactgcaa cctccgcctc ccaggttcaa
     4381 gcgattctcc tgcctcagcc tcctgcgtag ctgggattac aggtgcccac caccacaccc
     4441 tgctaatttt tgtactttta gtagagatgg ggtttcgcca tgttggccag gctggtcttg
     4501 aactgctgac ctcaggtgat ccacccgcct cggcctccca aagtgctggt attacagtca
     4561 tgagccacct cacccagcct gtttttgaga cggagtttca cttttgtcgc ccaggctgga
     4621 gtgcaatggc gctatctcag ctcactgcaa cccccacctc ccaggttcaa gcgattctcc
     4681 tgcctcagcc tcccgagtag ctgggattac aggcatgtgc caccacccct ggctaatttt
     4741 gtatttttag tggagacggg gtttctccat gttggtcagg ctggtcttaa actcccgacc
     4801 tcaagtgatc tgcccgcctc ggcctcccaa agtgctggga ttacaggcgt gagccattgc
     4861 acctgtccct gccagtgtgt ttttaaaata gtttaggggg ttgagaaaag atgcagtgag
     4921 ccattattct cctttagcag gtagtctctt aaaaattgat gtggatttta aaaatatacc
     4981 attgagaaca cgtatctttc tcaaacttga ccttgaacag agctggatgg gggtgggagg
     5041 gaaacagatt tggggcatat ggaagatatt cttgggagcc ccatattcta cctcagttac
     5101 cgaaggctat tagaacctct gaatttttcc tcctctgaaa tcctaagcac aacttcagaa
     5161 aaccatgtct gatagcggat gtcttcctgc tgtgaggagc tgcttgatgt ggggaccaag
     5221 gtgtgggtgt gggcggaatg tatcctagta gaaacagtga acctcagata tgaataaata
     5281 agcaagagac cgaaagttaa gtgtgtgaca acctcagtac tgtagttaag ctacattctt
     5341 taaattagct tttgtgaact gattgggaac ctaatctctt ttgtaactgt ttgagaaaaa
     5401 ctctgaagca cctgatattc aaacaaactt atggtactta ctaactcatt tgtaaattgg
     5461 cgatgtagct ggctgtagta ttgctttgat aatttttttc ttttaattta cctaatatat
     5521 ataaggaagg ggtttggata tattaaaata ggtgttaatt ttatctattt accaataaat
     5581 tcatctcttt aattca
//
