LOCUS       NM_001267594            4456 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens SUMO specific peptidase 1 (SENP1), transcript variant
            1, mRNA.
ACCESSION   NM_001267594
VERSION     NM_001267594.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4456)
  AUTHORS   Song,C.C., Liu,T., Hogstrand,C., Zhong,C.C., Zheng,H., Sun,L.H. and
            Luo,Z.
  TITLE     SENP1 mediates zinc-induced ZnT6 deSUMOylation at Lys-409 involved
            in the regulation of zinc metabolism in Golgi apparatus
  JOURNAL   Cell Mol Life Sci 81 (1), 422 (2024)
   PUBMED   39367979
  REMARK    GeneRIF: SENP1 mediates zinc-induced ZnT6 deSUMOylation at Lys-409
            involved in the regulation of zinc metabolism in Golgi apparatus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4456)
  AUTHORS   Dong,J. and Zheng,X.
  TITLE     SENP1 knockdown potentiates the apoptosis, cell cycle arrest, and
            reduces cisplatin resistance of diffuse large B cell lymphoma cells
            via inducing ferroptosis
  JOURNAL   Biochem Cell Biol 102 (4), 319-330 (2024)
   PUBMED   38708853
  REMARK    GeneRIF: SENP1 knockdown potentiates the apoptosis, cell cycle
            arrest, and reduces cisplatin resistance of diffuse large B cell
            lymphoma cells via inducing ferroptosis.
REFERENCE   3  (bases 1 to 4456)
  AUTHORS   Wen,D., Xiao,H., Gao,Y., Zeng,H. and Deng,J.
  TITLE     N6-methyladenosine-modified SENP1, identified by IGF2BP3, is a
            novel molecular marker in acute myeloid leukemia and aggravates
            progression by activating AKT signal via de-SUMOylating HDAC2
  JOURNAL   Mol Cancer 23 (1), 116 (2024)
   PUBMED   38822351
  REMARK    GeneRIF: N6-methyladenosine-modified SENP1, identified by IGF2BP3,
            is a novel molecular marker in acute myeloid leukemia and
            aggravates progression by activating AKT signal via de-SUMOylating
            HDAC2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4456)
  AUTHORS   Wen,P., Li,H., Liu,L., Liu,X., Xu,Z. and Dong,J.
  TITLE     SENP1-Mediated deSUMOylation Regulates the Tumor Remodeling of
            Glioma Stem Cells Under Hypoxic Stress
  JOURNAL   Technol Cancer Res Treat 23, 15330338241257490 (2024)
   PUBMED   38803001
  REMARK    GeneRIF: SENP1-Mediated deSUMOylation Regulates the Tumor
            Remodeling of Glioma Stem Cells Under Hypoxic Stress.
REFERENCE   5  (bases 1 to 4456)
  AUTHORS   Cheng,J., Perkins,N.D. and Yeh,E.T.
  TITLE     Differential regulation of c-Jun-dependent transcription by
            SUMO-specific proteases
  JOURNAL   J Biol Chem 280 (15), 14492-14498 (2005)
   PUBMED   15701643
  REMARK    GeneRIF: p300 is essential for SENP1 to enhance c-Jun-dependent
            transcription because SENP1 can desumoylate the CRD1 domain of
            p300, thereby releasing the cis-repression of CRD1 on p300
REFERENCE   6  (bases 1 to 4456)
  AUTHORS   Xu,Z. and Au,S.W.
  TITLE     Mapping residues of SUMO precursors essential in differential
            maturation by SUMO-specific protease, SENP1
  JOURNAL   Biochem J 386 (Pt 2), 325-330 (2005)
   PUBMED   15487983
REFERENCE   7  (bases 1 to 4456)
  AUTHORS   Cheng,J., Wang,D., Wang,Z. and Yeh,E.T.
  TITLE     SENP1 enhances androgen receptor-dependent transcription through
            desumoylation of histone deacetylase 1
  JOURNAL   Mol Cell Biol 24 (13), 6021-6028 (2004)
   PUBMED   15199155
  REMARK    GeneRIF: SENP1's ability to enhance AR-dependent transcription is
            not mediated through desumoylation of AR, but rather through its
            ability to deconjugate histone deacetylase 1 (HDAC1), thereby
            reducing its deacetylase activity.
REFERENCE   8  (bases 1 to 4456)
  AUTHORS   Bailey,D. and O'Hare,P.
  TITLE     Characterization of the localization and proteolytic activity of
            the SUMO-specific protease, SENP1
  JOURNAL   J Biol Chem 279 (1), 692-703 (2004)
   PUBMED   14563852
REFERENCE   9  (bases 1 to 4456)
  AUTHORS   Bailey,D. and O'Hare,P.
  TITLE     Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific
            protease
  JOURNAL   J Gen Virol 83 (Pt 12), 2951-2964 (2002)
   PUBMED   12466471
  REMARK    GeneRIF: co-localizes with Herpes simplex virus 1 ICP0 in cell
            nucleus
REFERENCE   10 (bases 1 to 4456)
  AUTHORS   Gong,L., Millas,S., Maul,G.G. and Yeh,E.T.
  TITLE     Differential regulation of sentrinized proteins by a novel
            sentrin-specific protease
  JOURNAL   J Biol Chem 275 (5), 3355-3359 (2000)
   PUBMED   10652325
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312874.1, AC004801.2 and
            BX640784.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001267594.1.
            
            Summary: This gene encodes a cysteine protease that specifically
            targets members of the small ubiquitin-like modifier (SUMO) protein
            family. This protease regulates SUMO pathways by deconjugating
            sumoylated proteins. This protease also functions to process the
            precursor SUMO proteins into their mature form. Alternate splicing
            results in multiple transcript variants. [provided by RefSeq, Jun
            2012].
            
            Transcript Variant: This variant (1) encodes the functional
            protein. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292060.1, SRR1660805.199689.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000549518.6/ ENSP00000447328.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1323              AK312874.1         230-1552
            1324-2031           AK312874.1         1554-2261
            2032-4432           AC004801.2         93860-96260
            4433-4455           BX640784.1         4949-4971
            4456-4456           AC004801.2         96284-96284
FEATURES             Location/Qualifiers
     source          1..4456
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.11"
     gene            1..4456
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /note="SUMO specific peptidase 1"
                     /db_xref="GeneID:29843"
                     /db_xref="HGNC:HGNC:17927"
                     /db_xref="MIM:612157"
     exon            1..52
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            53..100
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2031
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /EC_number="3.4.22.68"
                     /note="SUMO1/sentrin specific protease 1;
                     sentrin/SUMO-specific protease SENP1; SUMO1/sentrin
                     specific peptidase 1"
                     /codon_start=1
                     /product="sentrin-specific protease 1"
                     /protein_id="NP_001254523.1"
                     /db_xref="CCDS:CCDS44868.2"
                     /db_xref="GeneID:29843"
                     /db_xref="HGNC:HGNC:17927"
                     /db_xref="MIM:612157"
                     /translation="MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQ
                     QILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNST
                     PSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSW
                     SGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLH
                     LSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYT
                     PDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSST
                     FFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRV
                     PLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRL
                     TITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQA
                     VKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQY
                     LKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQ
                     QHMPYFRKRMVWEILHRKLL"
     exon            101..231
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            232..316
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            317..476
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..648
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            649..752
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..1036
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1091
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1130
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1215
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1371
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1503
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1707
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1787
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1872
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1968
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..4456
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3769..3774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /note="hexamer: AATAAA"
     polyA_site      3791
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /note="major polyA site"
     regulatory      4132..4137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /note="hexamer: AATATA"
     polyA_site      4162
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /note="major polyA site"
     regulatory      4433..4438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
                     /note="hexamer: AATAAG"
     polyA_site      4456
                     /gene="SENP1"
                     /gene_synonym="SuPr-2"
ORIGIN      
        1 gcgttccgcg cccggccgga aaccccttcg catggcagcc ggttccggtt cggactttgt
       61 atctttgcta aagtcagtga tgtgaaaaga cttgaaatgg atgatattgc tgataggatg
      121 aggatggatg ctggagaagt gactttagtg aaccacaact ccgtattcaa aacccacctc
      181 ctgccacaaa caggttttcc agaggaccag ctttcgcttt ctgaccagca gattttatct
      241 tccaggcaag gacatttgga ccgatctttt acatgttcca caagaagtgc agcttataat
      301 ccaagctatt actcagataa tccttcctca gacagttttc ttggctcagg cgatttaaga
      361 acctttggcc agagtgcaaa tggccaatgg agaaattcta ccccatcgtc aagctcatct
      421 ttacaaaaat caagaaacag ccgaagtctt tacctcgaaa cccgaaagac ctcaagtgga
      481 ttatcaaaca gttttgcggg aaagtcaaac catcactgcc atgtatctgc atatgaaaaa
      541 tcttttccta ttaaacctgt tccaagtcca tcttggagtg gttcatgtcg tcgaagtctt
      601 ttgagcccca agaaaactca gaggcgacat gttagtacag cagaagagac agttcaagaa
      661 gaagaaagag agatttacag acagctgcta cagatggtca cagggaaaca gtttactata
      721 gccaaaccca ccacacattt tcctttacac ctgtctcgat gtcttagttc cagtaaaaat
      781 actttgaaag actcactgtt taaaaatgga aactcttgtg catctcagat cattggctct
      841 gatacttcat catctggatc tgccagcatt ttaactaacc aggaacagct gtcccacagt
      901 gtatattccc tatcttctta taccccagat gttgcatttg gatccaaaga ttctggtact
      961 cttcatcatc cccatcatca ccactctgtt ccacatcagc cagataactt agcagcttca
     1021 aatacacaat ctgaaggatc agactctgtg attttactga aagtgaaaga ttcccagact
     1081 ccaactccca gttctacttt cttccaggca gagctgtgga tcaaagaatt aactagtgtt
     1141 tatgattctc gagcacgaga aagattgcgc cagattgaag aacagaaggc attggcctta
     1201 cagcttcaaa accagagatt gcaggagcgg gaacattcag tacatgattc agtagaacta
     1261 catcttcgtg tacctcttga aaaggagatt cctgttactg ttgtccaaga aacacaaaaa
     1321 aaaggtcata aattaactga tagtgaagat gaatttcctg aaattacaga ggaaatggag
     1381 aaagaaataa agaatgtatt tcgtaatggg aatcaggatg aagttctcag tgaagcattt
     1441 cgcctgacca ttacacgcaa agatattcaa actctaaacc atctgaattg gctcaatgat
     1501 gagatcatca atttctacat gaatatgctg atggagcgaa gtaaagagaa gggcttgcca
     1561 agtgtgcatg catttaatac ctttttcttc actaaattaa aaacggctgg ttatcaggca
     1621 gtgaaacgtt ggacaaagaa agtagatgta ttttctgttg acattctttt ggtgcccatt
     1681 cacctgggag tacactggtg tctagctgtt gtggacttta gaaagaagaa tattacctat
     1741 tacgactcca tgggtgggat aaacaatgaa gcctgcagaa tactcttgca atacctaaag
     1801 caagaaagca ttgacaagaa aaggaaagag tttgacacca atggctggca gcttttcagc
     1861 aagaaaagcc aggagattcc tcagcagatg aatggaagtg actgtgggat gtttgcctgc
     1921 aaatatgctg actgtattac caaagacaga ccaatcaact tcacacagca acacatgcca
     1981 tacttccgga agcggatggt ctgggagatc ctccaccgaa aactcttgtg aagactgtct
     2041 cacttagcag accttgacca tgtgggggac cagctctttg ttgtctacag ccagagacct
     2101 tggaaacagc tgctcccagc cctctgctgt tgtaacaccc ttgatcctgg accaggccct
     2161 ggcgagatgc attcacaagc acatctgcct ttccttttgt atctcagata ctatttttgc
     2221 aaagaaactt tggtgctgtg aaaggggtga gggacatccc taagctgaag agagagactg
     2281 cttttcactt cttcagttct gccatcttgt tttcaaaggg ctccagcctc actcagtccc
     2341 taattatggg actgagaaaa gcttggaaag aatcttggtt tcatataaat tcttgttgtt
     2401 aggccttact aagaagtagg aaagggcatg ggcaaaaggt agggataaaa accaccagca
     2461 tatacatgga catacacaca cacccacaca cacaaacaca cacacacaca caattttcac
     2521 gatgtatggt caggaatgtg actgtaaact ggactttggg gcccaggcat aagtcccttc
     2581 ctccaggacc tttcctattt atatgtccct atacaaaatc catctgcttt tatacgtagc
     2641 tgttttatca tctgtagctt catcctatcc ggaggcacag cacatgagcc ctggacaggt
     2701 cccaaagttc caagcagtcc tttccgtgaa agcaggggtt tgcatgtgct accaacacat
     2761 gatacgggga agacccaccc agggagcggt ttcagtggcg caacaaagca ccacttttac
     2821 tgttgcctac ttctgaccaa gaagaaaaag gaccttagta tttagcataa aattccagcg
     2881 ctggatgaat gcagatctag tttggtctgt ggctagttta aatatgtttc taaccacaga
     2941 gaatttcata tatatataca tatatatata cacatacata tatatatata tatatgtatg
     3001 tataaaattt cacagggata tgcttttttt tttaaagact gaatgtgttc accatttagc
     3061 ctgtagattt atttccattt tccaaattcc agcacacaga gatcccagcc cctatgagta
     3121 gggtgtttgt ggactaccta atggaatatt tttgaggcct ggatgaactt tgccatatgg
     3181 gtagaggtta cagagggagg tgatattttc agctaaaaaa aaaaacgggt ggagtttgga
     3241 ctgatcaact tgagatttaa aaactgctat tccttttgtt ctttctagca tctctcccca
     3301 ccctctgaga gctcctcagg cttagatagt gaagtgatca aatgccagtg tcattttgta
     3361 cttaagttcc aaagtaggaa cattttatac ttttttctgt attgtaatag gtagttttgt
     3421 atgaaatctt ttctcctctc ccgttgtacc gcattctttc cagcattgtg ctttttccct
     3481 gggcttattt gaaaatttta ctgttttata caagctcgtt tagtacattt ttctatgttt
     3541 taccacaagt tacaatttga aaagaaaact atttttttta aatattccat tgttaactga
     3601 atgttactgt ttccactcca gcaactacat gtcctccctt caactgcctg ccttttgggg
     3661 aaagaccacc ttttgtgtgt ttgttttttc tctctctttc tttccctttc tctttctatc
     3721 tctctttatt tttctttctt tttctttgtt tttgagtttt ctataggaaa taaatagctt
     3781 tctatatatg agttgctggg gaccttcaca ttctctttta gaaagctgtg gcatgcagtc
     3841 tcattgcagg actcctggaa tattgtctgg ttcttggtat ttactgtatg taagcaacaa
     3901 cttgaaaggt ggcaatatgg tgtcgatttg gactatgaat caaaagacct ttttcaggtt
     3961 ctttcactat tgtctggggg actcagaaca agattgttct ctgtatttat tgtttgtcca
     4021 tttaggtaac atctgtctta ccttcctcac agactttgta cagaccaaag caacaaatat
     4081 ttattgccat gtatagcaga aaatgaaaca tgcaacaaaa gcactttgaa aaatatataa
     4141 ggaattgttg agcctgtctg aatttgggcc ccctttctga ctaatgcagt tttgcacaag
     4201 gtagaagtta gtgaccctga gaccatctta ccaccctgga cctggtccaa atacagactt
     4261 acacagtgga ccattctttc ctgagctagc caacaagagc aggagtagta tctggaaact
     4321 ttcccctttg tttaggggta ggctttgatg accaggaaaa aaaaaaaggt atttctgcat
     4381 tttatggccc aaaggcatgt tattaatatc ttatgtaatt tactttaaac taaataagac
     4441 ttttttctcc tgtgtt
//
