LOCUS       NM_003008               1978 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens semenogelin 2 (SEMG2), mRNA.
ACCESSION   NM_003008
VERSION     NM_003008.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1978)
  AUTHORS   Shuvalov,O., Kizenko,A., Petukhov,A., Fedorova,O., Daks,A.,
            Bottrill,A., Snezhkina,A.V., Kudryavtseva,A.V. and Barlev,N.
  TITLE     SEMG1/2 augment energy metabolism of tumor cells
  JOURNAL   Cell Death Dis 11 (12), 1047 (2020)
   PUBMED   33311447
  REMARK    GeneRIF: SEMG1/2 augment energy metabolism of tumor cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1978)
  AUTHORS   Roan,N.R., Muller,J.A., Liu,H., Chu,S., Arnold,F., Sturzel,C.M.,
            Walther,P., Dong,M., Witkowska,H.E., Kirchhoff,F., Munch,J. and
            Greene,W.C.
  TITLE     Peptides released by physiological cleavage of semen coagulum
            proteins form amyloids that enhance HIV infection
  JOURNAL   Cell Host Microbe 10 (6), 541-550 (2011)
   PUBMED   22177559
  REMARK    GeneRIF: Peptides released by physiological cleavage of Semg1 and
            Semg2 form amyloids that enhance HIV infection.
REFERENCE   3  (bases 1 to 1978)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 1978)
  AUTHORS   Canacci,A.M., Izumi,K., Zheng,Y., Gordetsky,J., Yao,J.L. and
            Miyamoto,H.
  TITLE     Expression of semenogelins I and II and its prognostic significance
            in human prostate cancer
  JOURNAL   Prostate 71 (10), 1108-1114 (2011)
   PUBMED   21557275
  REMARK    GeneRIF: These results suggest the involvement of semenogelins in
            prostate cancer and their prognostic values in predicting cancer
            progression after radical prostatectomy.
REFERENCE   5  (bases 1 to 1978)
  AUTHORS   Yoshida,K., Krasznai,Z.T., Krasznai,Z., Yoshiike,M., Kawano,N.,
            Yoshida,M., Morisawa,M., Toth,Z., Bazsane,Z.K., Marian,T. and
            Iwamoto,T.
  TITLE     Functional implications of membrane modification with semenogelins
            for inhibition of sperm motility in humans
  JOURNAL   Cell Motil Cytoskeleton 66 (2), 99-108 (2009)
   PUBMED   19089943
  REMARK    GeneRIF: Semenogelins (Sgs) modifies the membrane structure,
            indirectly inhibiting motility, and provides suggestions for a
            therapy for male infertility through selection of a functional
            sperm population using Sgs.
REFERENCE   6  (bases 1 to 1978)
  AUTHORS   Edstrom,A.M., Malm,J., Frohm,B., Martellini,J.A., Giwercman,A.,
            Morgelin,M., Cole,A.M. and Sorensen,O.E.
  TITLE     The major bactericidal activity of human seminal plasma is
            zinc-dependent and derived from fragmentation of the semenogelins
  JOURNAL   J Immunol 181 (5), 3413-3421 (2008)
   PUBMED   18714013
  REMARK    GeneRIF: antibacterial activity of the semenogelin-derived peptides
            generated in seminal plasma was strictly zinc-dependent both at
            neutral and low pH
REFERENCE   7  (bases 1 to 1978)
  AUTHORS   Lundwall,A.
  TITLE     The structure of the semenogelin gene locus--nucleotide sequence of
            the intergenic and the flanking DNA
  JOURNAL   Eur J Biochem 235 (3), 466-470 (1996)
   PUBMED   8654389
REFERENCE   8  (bases 1 to 1978)
  AUTHORS   Ulvsback,M., Lazure,C., Lilja,H., Spurr,N.K., Rao,V.V., Loffler,C.,
            Hansmann,I. and Lundwall,A.
  TITLE     Gene structure of semenogelin I and II. The predominant proteins in
            human semen are encoded by two homologous genes on chromosome 20
  JOURNAL   J Biol Chem 267 (25), 18080-18084 (1992)
   PUBMED   1517240
REFERENCE   9  (bases 1 to 1978)
  AUTHORS   Lilja,H. and Lundwall,A.
  TITLE     Molecular cloning of epididymal and seminal vesicular transcripts
            encoding a semenogelin-related protein
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4559-4563 (1992)
   PUBMED   1584792
REFERENCE   10 (bases 1 to 1978)
  AUTHORS   Schneider,K., Kausler,W., Tripier,D., Jouvenal,K. and Spiteller,G.
  TITLE     [Isolation and structure determination of two peptides occurring in
            human seminal plasma]
  JOURNAL   Biol Chem Hoppe Seyler 370 (4), 353-356 (1989)
   PUBMED   2757795
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049767.12.
            
            On May 17, 2019 this sequence version replaced NM_003008.2.
            
            Summary: The secreted protein encoded by this gene is involved in
            the formation of a gel matrix that encases ejaculated spermatozoa.
            Proteolysis by the prostate-specific antigen (PSA) breaks down the
            gel matrix and allows the spermatozoa to move more freely. The
            encoded protein is found in lesser abundance than a similar
            semenogelin protein. An antibacterial activity has been found for a
            antimicrobial peptide isolated from this protein. The genes
            encoding these two semenogelin proteins are found in a cluster on
            chromosome 20. [provided by RefSeq, Jan 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070306.1, M81652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465411 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000372769.4/
                                                  ENSP00000361855.3
            Protein has antimicrobial activity :: PMID: 18714013
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AL049767.12        95987-96079
            94-1810             AL049767.12        96323-98039
            1811-1978           AL049767.12        98905-99072
FEATURES             Location/Qualifiers
     source          1..1978
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..1978
                     /gene="SEMG2"
                     /gene_synonym="SGII"
                     /note="semenogelin 2"
                     /db_xref="GeneID:6407"
                     /db_xref="HGNC:HGNC:10743"
                     /db_xref="MIM:182141"
     exon            1..93
                     /gene="SEMG2"
                     /gene_synonym="SGII"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1766
                     /gene="SEMG2"
                     /gene_synonym="SGII"
                     /note="semenogelin II"
                     /codon_start=1
                     /product="semenogelin-2 precursor"
                     /protein_id="NP_002999.1"
                     /db_xref="CCDS:CCDS13346.1"
                     /db_xref="GeneID:6407"
                     /db_xref="HGNC:HGNC:10743"
                     /db_xref="MIM:182141"
                     /translation="MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLPSGSSQFPHGQK
                     GQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGG
                     SQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCS
                     NTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKG
                     HYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQD
                     QEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHS
                     QDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRI
                     PSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQV
                     TIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQI
                     QTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNIVITEHEVAQD
                     DHLTQQYNEDRNPIST"
     exon            94..1810
                     /gene="SEMG2"
                     /gene_synonym="SGII"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1978
                     /gene="SEMG2"
                     /gene_synonym="SGII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagatttttc aagcaagatg aagtccatca tcctctttgt cctttccctg ctccttatct
       61 tggagaagca agcagctgtg atgggacaaa aaggtggatc aaaaggccaa ttgccaagcg
      121 gatcttccca atttccacat ggacaaaagg gccagcacta ttttggacaa aaagaccaac
      181 aacatactaa atccaaaggc agtttttcta ttcaacacac atatcatgta gacatcaatg
      241 atcatgactg gacccgaaaa agtcagcaat atgatttgaa tgccctacat aaggcgacaa
      301 aatcaaaaca acacctaggt ggaagtcaac aactgctcaa ttataaacaa gaaggcagag
      361 accatgataa atcaaaaggt cattttcaca tgatagttat acatcataaa ggaggccaag
      421 ctcatcatgg gacacaaaat ccttctcaag atcaggggaa tagcccatct ggaaagggat
      481 tatccagtca atgttcaaac acagaaaaaa ggctatgggt tcatggacta agtaaagaac
      541 aagcttcagc ctctggtgca caaaaaggta gaacacaagg tggatcccaa agcagttatg
      601 ttctccaaac tgaagaacta gtagttaaca aacaacaacg tgagactaaa aattctcatc
      661 aaaataaagg gcattaccaa aatgtggttg acgtgagaga ggaacattca agtaaactac
      721 aaacttcact ccatcctgca catcaagaca gactccaaca tggacccaaa gacattttta
      781 ctacccaaga tgagctccta gtatataaca agaatcaaca ccagacaaaa aatctcagtc
      841 aagatcaaga gcatggccgg aaggcacata aaatatcata cccgtcttca cgtacagaag
      901 aaagacaact tcaccatgga gaaaagagtg tacagaaaga tgtatccaaa ggcagcattt
      961 ctatccaaac tgaagagaaa atacatggca agtctcaaaa ccaggtaaca attcatagtc
     1021 aagatcaaga gcatggccat aaggaaaata aaatatcata ccaatcttca agtacagaag
     1081 aaagacatct caactgtgga gaaaagggca tccagaaagg tgtatccaaa ggcagtattt
     1141 cgatccaaac tgaagagcaa atacatggca agtctcaaaa ccaggtaaga attcctagtc
     1201 aagctcaaga gtatggccat aaggaaaata aaatatcata ccaatcttcg agtacagaag
     1261 aaagacgtct caacagtgga gaaaaggatg tacagaaagg tgtatccaaa ggcagtattt
     1321 ctatccaaac tgaagagaaa atacatggca agtctcaaaa ccaggtaaca attcctagtc
     1381 aagatcaaga gcatggccat aaggaaaata aaatgtcata ccaatcttca agtacagaag
     1441 aaagacgact caactatgga ggaaagagca cgcagaaaga tgtatcccaa agcagtattt
     1501 ctttccaaat tgaaaagcta gtagaaggca agtctcaaat ccagacacca aatcctaatc
     1561 aagatcaatg gtctggccaa aatgcaaaag gaaagtctgg tcaatctgca gatagcaaac
     1621 aagacctact cagtcatgaa caaaaaggca gatacaaaca ggaatccagt gagtcacata
     1681 atattgtaat tactgagcat gaggttgccc aagatgatca tttgacacaa caatataatg
     1741 aagacagaaa tccaatatct acatagccct gttgcttagc aaccacttga aaagctggac
     1801 caatagcaag gtgtcacccg acctcagtga agtctttgat gtttctgaga ggcagactcc
     1861 catgtggtcc cagatccttg gtccatggat gacaccacct tcccatgctt ccttgcatta
     1921 ggctttctaa acccggagcc ccttcaaact tccaataaag ggatcatttt ctgcttta
//
