LOCUS       NM_003007               1622 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens semenogelin 1 (SEMG1), mRNA.
ACCESSION   NM_003007
VERSION     NM_003007.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1622)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1622)
  AUTHORS   Shuvalov,O., Kizenko,A., Petukhov,A., Fedorova,O., Daks,A.,
            Bottrill,A., Snezhkina,A.V., Kudryavtseva,A.V. and Barlev,N.
  TITLE     SEMG1/2 augment energy metabolism of tumor cells
  JOURNAL   Cell Death Dis 11 (12), 1047 (2020)
   PUBMED   33311447
  REMARK    GeneRIF: SEMG1/2 augment energy metabolism of tumor cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1622)
  AUTHORS   Sakaguchi,D., Miyado,K., Iwamoto,T., Okada,H., Yoshida,K., Kang,W.,
            Suzuki,M., Yoshida,M. and Kawano,N.
  TITLE     Human Semenogelin 1 Promotes Sperm Survival in the Mouse Female
            Reproductive Tract
  JOURNAL   Int J Mol Sci 21 (11), 3961 (2020)
   PUBMED   32486486
  REMARK    GeneRIF: Human Semenogelin 1 Promotes Sperm Survival in the Mouse
            Female Reproductive Tract.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1622)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1622)
  AUTHORS   Malm,J., Hellman,J., Magnusson,H., Laurell,C.B. and Lilja,H.
  TITLE     Isolation and characterization of the major gel proteins in human
            semen, semenogelin I and semenogelin II
  JOURNAL   Eur J Biochem 238 (1), 48-53 (1996)
   PUBMED   8665951
REFERENCE   6  (bases 1 to 1622)
  AUTHORS   Ulvsback,M., Lazure,C., Lilja,H., Spurr,N.K., Rao,V.V., Loffler,C.,
            Hansmann,I. and Lundwall,A.
  TITLE     Gene structure of semenogelin I and II. The predominant proteins in
            human semen are encoded by two homologous genes on chromosome 20
  JOURNAL   J Biol Chem 267 (25), 18080-18084 (1992)
   PUBMED   1517240
REFERENCE   7  (bases 1 to 1622)
  AUTHORS   Lilja,H., Abrahamsson,P.A. and Lundwall,A.
  TITLE     Semenogelin, the predominant protein in human semen. Primary
            structure and identification of closely related proteins in the
            male accessory sex glands and on the spermatozoa
  JOURNAL   J Biol Chem 264 (3), 1894-1900 (1989)
   PUBMED   2912989
REFERENCE   8  (bases 1 to 1622)
  AUTHORS   Li,C.H., Hammonds,R.G. Jr., Ramasharma,K. and Chung,D.
  TITLE     Human seminal alpha inhibins: isolation, characterization, and
            structure
  JOURNAL   Proc Natl Acad Sci U S A 82 (12), 4041-4044 (1985)
   PUBMED   3889920
REFERENCE   9  (bases 1 to 1622)
  AUTHORS   Lilja,H. and Jeppsson,J.O.
  TITLE     Amino acid sequence of the predominant basic protein in human
            seminal plasma
  JOURNAL   FEBS Lett 182 (1), 181-184 (1985)
   PUBMED   3972122
REFERENCE   10 (bases 1 to 1622)
  AUTHORS   Ramasharma,K., Sairam,M.R., Seidah,N.G., Chretien,M., Manjunath,P.,
            Schiller,P.W., Yamashiro,D. and Li,C.H.
  TITLE     Isolation, structure, and synthesis of a human seminal plasma
            peptide with inhibin-like activity
  JOURNAL   Science 223 (4641), 1199-1202 (1984)
   PUBMED   6422553
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP325874.1, J04440.1,
            BC055416.1 and AA687874.1.
            
            On Nov 24, 2018 this sequence version replaced NM_003007.4.
            
            Summary: The protein encoded by this gene is the predominant
            protein in semen. The encoded secreted protein is involved in the
            formation of a gel matrix that encases ejaculated spermatozoa. This
            preproprotein is proteolytically processed by the prostate-specific
            antigen (PSA) protease to generate multiple peptide products that
            exhibit distinct functions. One of these peptides, SgI-29, is an
            antimicrobial peptide with antibacterial activity. This proteolysis
            process also breaks down the gel matrix and allows the spermatozoa
            to move more freely. This gene and another similar semenogelin gene
            are present in a gene cluster on chromosome 20. [provided by
            RefSeq, Feb 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04440.1, ERR279825.1652.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2156266, SAMEA2159912
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000372781.4/
                                                  ENSP00000361867.3
            Protein has antimicrobial activity :: PMID: 18314226
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BP325874.1         70-84
            16-1385             J04440.1           1-1370
            1386-1390           BC055416.1         1206-1210
            1391-1621           J04440.1           1376-1606
            1622-1622           AA687874.1         6-6                 c
FEATURES             Location/Qualifiers
     source          1..1622
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..1622
                     /gene="SEMG1"
                     /gene_synonym="CT103; dJ172H20.2; SEMG; SGI"
                     /note="semenogelin 1"
                     /db_xref="GeneID:6406"
                     /db_xref="HGNC:HGNC:10742"
                     /db_xref="MIM:182140"
     exon            1..97
                     /gene="SEMG1"
                     /gene_synonym="CT103; dJ172H20.2; SEMG; SGI"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1410
                     /gene="SEMG1"
                     /gene_synonym="CT103; dJ172H20.2; SEMG; SGI"
                     /note="cancer/testis antigen 103; semen coagulating
                     protein; SgI-29; semenogelin I"
                     /codon_start=1
                     /product="semenogelin-1 preproprotein"
                     /protein_id="NP_002998.1"
                     /db_xref="CCDS:CCDS13345.1"
                     /db_xref="GeneID:6406"
                     /db_xref="HGNC:HGNC:10742"
                     /db_xref="MIM:182140"
                     /translation="MKPNIIFVLSLLLILEKQAAVMGQKGGSKGRLPSEFSQFPHGQK
                     GQHYSGQKGKQQTESKGSFSIQYTYHVDANDHDQSRKSQQYDLNALHKTTKSQRHLGG
                     SQQLLHNKQEGRDHDKSKGHFHRVVIHHKGGKAHRGTQNPSQDQGNSPSGKGISSQYS
                     NTEERLWVHGLSKEQTSVSGAQKGRKQGGSQSSYVLQTEELVANKQQRETKNSHQNKG
                     HYQNVVEVREEHSSKVQTSLCPAHQDKLQHGSKDIFSTQDELLVYNKNQHQTKNLNQD
                     QQHGRKANKISYQSSSTEERRLHYGENGVQKDVSQSSIYSQTEEKAQGKSQKQITIPS
                     QEQEHSQKANKISYQSSSTEERRLHYGENGVQKDVSQRSIYSQTEKLVAGKSQIQAPN
                     PKQEPWHGENAKGESGQSTNREQDLLSHEQKGRHQHGSHGGLDIVIIEQEDDSDRHLA
                     QHLNNDRNPLFT"
     exon            98..1454
                     /gene="SEMG1"
                     /gene_synonym="CT103; dJ172H20.2; SEMG; SGI"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1622
                     /gene="SEMG1"
                     /gene_synonym="CT103; dJ172H20.2; SEMG; SGI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1598..1603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMG1"
                     /gene_synonym="CT103; dJ172H20.2; SEMG; SGI"
                     /note="hexamer: AATAAA"
     polyA_site      1622
                     /gene="SEMG1"
                     /gene_synonym="CT103; dJ172H20.2; SEMG; SGI"
                     /note="major polyA site"
ORIGIN      
        1 agacaaggtt ttccaagcaa gatgaagccc aacatcatct ttgtactttc cctgctcctc
       61 atcttggaga agcaagcagc tgtgatggga caaaaaggtg gatcaaaagg ccgattacca
      121 agtgaatttt cccaatttcc acacggacaa aagggccagc actattctgg acaaaaaggc
      181 aagcaacaaa ctgaatccaa aggcagtttt tctattcaat acacatatca tgtagatgcc
      241 aatgatcatg accagtcccg aaaaagtcag caatatgatt tgaatgccct acataagacg
      301 acaaaatcac aacgacatct aggtggaagt caacaactgc tccataataa acaagaaggc
      361 agagaccatg ataaatcaaa aggtcatttt cacagggtag ttatacacca taaaggaggc
      421 aaagctcatc gtgggacaca aaatccttct caagatcagg ggaatagccc atctggaaag
      481 ggaatatcca gtcaatattc aaacacagaa gaaaggctgt gggttcatgg actaagtaaa
      541 gaacaaactt ccgtctctgg tgcacaaaaa ggtagaaaac aaggcggatc ccaaagcagt
      601 tatgttctcc aaactgaaga gctagtagct aacaaacaac aacgtgagac taaaaattct
      661 catcaaaata aagggcatta ccaaaatgtg gttgaagtga gagaggaaca ttcaagtaaa
      721 gtacaaacct cactctgtcc tgcgcaccaa gacaaactcc aacatggatc caaagacatt
      781 ttttctaccc aagatgagct cctagtatat aacaagaatc aacaccagac aaaaaatctc
      841 aatcaagatc aacagcatgg ccgaaaggca aataaaatat cataccaatc ttcaagtaca
      901 gaagaaagac gactccacta tggagaaaat ggtgtgcaga aagatgtatc ccaaagcagt
      961 atttatagcc aaactgaaga gaaagcacag ggcaagtctc aaaaacagat aacaattccc
     1021 agtcaagagc aagagcatag ccaaaaggca aataaaatat cataccaatc ttcaagtacg
     1081 gaagaaagac gactccacta tggagaaaat ggtgtgcaga aagatgtatc ccaacgcagt
     1141 atttatagcc aaactgaaaa gctagtagca ggcaagtctc aaatccaggc accaaatcct
     1201 aagcaagagc catggcatgg tgaaaatgca aaaggagagt ctggccaatc tacaaataga
     1261 gaacaagacc tactcagtca tgaacaaaaa ggcagacacc aacatggatc tcatggggga
     1321 ttggatattg taattataga gcaggaagat gacagtgatc gtcatttggc acaacatctt
     1381 aacaacgacc gaaacccatt atttacataa acctaccatt cggtaaccat gtgaaaggat
     1441 ggaccaatat caaggtgtca gttgacctca gtgaattctg tgatgtttct gagatgcaga
     1501 ctcccgtgta gtttcagatt cttggtccat ggatgacacc acctgcccat gcttccttga
     1561 attaggcttt cctaacctga agcgccttca aacttccaat aaagagatca ttttctgctt
     1621 ca
//
