LOCUS       NM_003612               3376 bp    mRNA    linear   PRI 20-MAY-2024
DEFINITION  Homo sapiens semaphorin 7A (JohnMiltonHagen blood group) (SEMA7A),
            transcript variant 1, mRNA.
ACCESSION   NM_003612
VERSION     NM_003612.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3376)
  AUTHORS   Huang,J., Zhao,C. and Zhang,S.
  TITLE     Semaphorin 7A promotes endothelial permeability and inflammation
            via plexin C1 and integrin beta1 in Kawasaki disease
  JOURNAL   BMC Pediatr 24 (1), 285 (2024)
   PUBMED   38678170
  REMARK    GeneRIF: Semaphorin 7A promotes endothelial permeability and
            inflammation via plexin C1 and integrin beta1 in Kawasaki disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3376)
  AUTHORS   Scott,G.A., McClelland,L.A., Fricke,A.F. and Fender,A.
  TITLE     Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is
            a potential tumor suppressor for melanoma progression
  JOURNAL   J Invest Dermatol 129 (4), 954-963 (2009)
   PUBMED   18987670
REFERENCE   3  (bases 1 to 3376)
  AUTHORS   Scott,G.A., McClelland,L.A. and Fricke,A.F.
  TITLE     Semaphorin 7a promotes spreading and dendricity in human
            melanocytes through beta1-integrins
  JOURNAL   J Invest Dermatol 128 (1), 151-161 (2008)
   PUBMED   17671519
  REMARK    GeneRIF: beta1-integrins and Plexin C1 receptors are ligands for
            Semaphorin 7a, and that signaling by these receptors has opposing
            effects on Semaphorin 7a-induced dendrite formation.
REFERENCE   4  (bases 1 to 3376)
  AUTHORS   Koh,J.M., Oh,B., Lee,J.Y., Lee,J.K., Kimm,K., Kim,G.S., Park,B.L.,
            Cheong,H.S., Shin,H.D., Hong,J.M., Kim,T.H., Park,E.K. and Kim,S.Y.
  TITLE     Association study of semaphorin 7a (sema7a) polymorphisms with bone
            mineral density and fracture risk in postmenopausal Korean women
  JOURNAL   J Hum Genet 51 (2), 112-117 (2006)
   PUBMED   16372136
  REMARK    GeneRIF: Polymorphisms in SEMA7A may play a role in decreased bone
            mineral density and increased risk of vertebral fracture.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3376)
  AUTHORS   Maurin,J.C., Delorme,G., Machuca-Gayet,I., Couble,M.L.,
            Magloire,H., Jurdic,P. and Bleicher,F.
  TITLE     Odontoblast expression of semaphorin 7A during innervation of human
            dentin
  JOURNAL   Matrix Biol 24 (3), 232-238 (2005)
   PUBMED   15907379
  REMARK    GeneRIF: SEMA 7A might be a molecule involved in the terminal
            innervation of the dentin-pulp complex.
REFERENCE   6  (bases 1 to 3376)
  AUTHORS   Holmes,S., Downs,A.M., Fosberry,A., Hayes,P.D., Michalovich,D.,
            Murdoch,P., Moores,K., Fox,J., Deen,K., Pettman,G., Wattam,T. and
            Lewis,C.
  TITLE     Sema7A is a potent monocyte stimulator
  JOURNAL   Scand J Immunol 56 (3), 270-275 (2002)
   PUBMED   12193228
  REMARK    GeneRIF: Sema7A is a potent stimulator of cytokine production,
            chemotaxis and superoxide release in monocytes
REFERENCE   7  (bases 1 to 3376)
  AUTHORS   Angelisova,P., Drbal,K., Cerny,J., Hilgert,I. and Horejsi,V.
  TITLE     Characterization of the human leukocyte GPI-anchored glycoprotein
            CDw108 and its relation to other similar molecules
  JOURNAL   Immunobiology 200 (2), 234-245 (1999)
   PUBMED   10416131
REFERENCE   8  (bases 1 to 3376)
  AUTHORS   Yamada,A., Kubo,K., Takeshita,T., Harashima,N., Kawano,K., Mine,T.,
            Sagawa,K., Sugamura,K. and Itoh,K.
  TITLE     Molecular cloning of a glycosylphosphatidylinositol-anchored
            molecule CDw108
  JOURNAL   J Immunol 162 (7), 4094-4100 (1999)
   PUBMED   10201933
REFERENCE   9  (bases 1 to 3376)
  AUTHORS   Xu,X., Ng,S., Wu,Z.L., Nguyen,D., Homburger,S., Seidel-Dugan,C.,
            Ebens,A. and Luo,Y.
  TITLE     Human semaphorin K1 is glycosylphosphatidylinositol-linked and
            defines a new subfamily of viral-related semaphorins
  JOURNAL   J Biol Chem 273 (35), 22428-22434 (1998)
   PUBMED   9712866
REFERENCE   10 (bases 1 to 3376)
  AUTHORS   Lange,C., Liehr,T., Goen,M., Gebhart,E., Fleckenstein,B. and
            Ensser,A.
  TITLE     New eukaryotic semaphorins with close homology to semaphorins of
            DNA viruses
  JOURNAL   Genomics 51 (3), 340-350 (1998)
   PUBMED   9721204
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312257.1, AK001895.1,
            AC090826.15, BF792612.1 and AI972833.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003612.4.
            
            Summary: This gene encodes a member of the semaphorin family of
            proteins. The encoded preproprotein is proteolytically processed to
            generate the mature glycosylphosphatidylinositol (GPI)-anchored
            membrane glycoprotein. The encoded protein is found on activated
            lymphocytes and erythrocytes and may be involved in
            immunomodulatory and neuronal processes. The encoded protein
            carries the John Milton Hagen (JMH) blood group antigens. Mutations
            in this gene may be associated with reduced bone mineral density
            (BMD). Alternative splicing results in multiple transcript
            variants, at least one of which encodes an isoform that is
            proteolytically processed. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record represents the SEMA7A*001.1.1
            allele.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312257.1, AF069493.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261918.9/ ENSP00000261918.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1347              AK312257.1         1-1347
            1348-2639           AK001895.1         590-1881
            2640-2743           AC090826.15        147151-147254       c
            2744-3089           BF792612.1         1-346
            3090-3376           AI972833.1         13-299              c
FEATURES             Location/Qualifiers
     source          1..3376
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..3376
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /note="semaphorin 7A (JohnMiltonHagen blood group)"
                     /db_xref="GeneID:8482"
                     /db_xref="HGNC:HGNC:10741"
                     /db_xref="MIM:607961"
     exon            1..218
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..2041
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; sema domain, immunoglobulin domain (Ig), and
                     GPI membrane anchor, (semaphorin) 7A (JMH blood group);
                     John Milton Hagen blood group H-Sema K1; sema domain,
                     immunoglobulin domain (Ig), and GPI membrane anchor, 7A;
                     semaphorin 7A (John Milton Hagen blood group);
                     semaphorin-7A; sema L; sema K1; semaphorin-K1;
                     semaphorin-L; JMH blood group antigen; john-Milton-Hargen
                     human blood group Ag; semaphorin 7A, GPI membrane anchor
                     (John Milton Hagen blood group)"
                     /codon_start=1
                     /product="semaphorin-7A isoform 1 preproprotein"
                     /protein_id="NP_003603.1"
                     /db_xref="CCDS:CCDS10262.1"
                     /db_xref="GeneID:8482"
                     /db_xref="HGNC:HGNC:10741"
                     /db_xref="MIM:607961"
                     /translation="MTPPPPGRAAPSAPRARVPGPPARLGLPLRLRLLLLLWAAAASA
                     QGHLRSGPRIFAVWKGHVGQDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPE
                     GKNASVRTVNIGSTKGSCLDKRDCENYITLLERRSEGLLACGTNARHPSCWNLVNGTV
                     VPLGEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV
                     MQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSL
                     SVSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAV
                     CVYSLGDIDKVFRTSSLKGYHSSLPNPRPGKCLPDQQPIPTETFQVADRHPEVAQRVE
                     PMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFA
                     FNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRD
                     PYCGWDQGRCISIYSSERSVLQSINPAEPHKECPNPKPDKAPLQKVSLAPNSRYYLSC
                     PMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQYGHYFCEAQEGSYFREA
                     QHWQLLPEDGIMAEHLLGHACALAASLWLGVLPTLTLGLLVH"
     exon            219..370
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            371..412
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            413..505
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            506..590
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            591..701
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            702..841
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1026
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1135
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1334
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1462
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1617
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1679
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..3376
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3356..3361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /note="hexamer: AATAAA"
     polyA_site      3376
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /note="major polyA site"
ORIGIN      
        1 agtctcggct gattgccgct gtcgctcccg gggccacggg atgacgcctc ctccgcccgg
       61 acgtgccgcc cccagcgcac cgcgcgcccg cgtccctggc ccgccggctc ggttggggct
      121 tccgctgcgg ctgcggctgc tgctgctgct ctgggcggcc gccgcctccg cccagggcca
      181 cctaaggagc ggaccccgca tcttcgccgt ctggaaaggc catgtagggc aggaccgggt
      241 ggactttggc cagactgagc cgcacacggt gcttttccac gagccaggca gctcctctgt
      301 gtgggtggga ggacgtggca aggtctacct ctttgacttc cccgagggca agaacgcatc
      361 tgtgcgcacg gtgaatatcg gctccacaaa ggggtcctgt ctggataagc gggactgcga
      421 gaactacatc actctcctgg agaggcggag tgaggggctg ctggcctgtg gcaccaacgc
      481 ccggcacccc agctgctgga acctggtgaa tggcactgtg gtgccacttg gcgagatgag
      541 aggctacgcc cccttcagcc cggacgagaa ctccctggtt ctgtttgaag gggacgaggt
      601 gtattccacc atccggaagc aggaatacaa tgggaagatc cctcggttcc gccgcatccg
      661 gggcgagagt gagctgtaca ccagtgatac tgtcatgcag aacccacagt tcatcaaagc
      721 caccatcgtg caccaagacc aggcttacga tgacaagatc tactacttct tccgagagga
      781 caatcctgac aagaatcctg aggctcctct caatgtgtcc cgtgtggccc agttgtgcag
      841 gggggaccag ggtggggaaa gttcactgtc agtctccaag tggaacactt ttctgaaagc
      901 catgctggta tgcagtgatg ctgccaccaa caagaacttc aacaggctgc aagacgtctt
      961 cctgctccct gaccccagcg gccagtggag ggacaccagg gtctatggtg ttttctccaa
     1021 cccctggaac tactcagccg tctgtgtgta ttccctcggt gacattgaca aggtcttccg
     1081 tacctcctca ctcaagggct accactcaag ccttcccaac ccgcggcctg gcaagtgcct
     1141 cccagaccag cagccgatac ccacagagac cttccaggtg gctgaccgtc acccagaggt
     1201 ggcgcagagg gtggagccca tggggcctct gaagacgcca ttgttccact ctaaatacca
     1261 ctaccagaaa gtggccgtcc accgcatgca agccagccac ggggagacct ttcatgtgct
     1321 ttacctaact acagacaggg gcactatcca caaggtggtg gaaccggggg agcaggagca
     1381 cagcttcgcc ttcaacatca tggagatcca gcccttccgc cgcgcggctg ccatccagac
     1441 catgtcgctg gatgctgagc ggaggaagct gtatgtgagc tcccagtggg aggtgagcca
     1501 ggtgcccctg gacctgtgtg aggtctatgg cgggggctgc cacggttgcc tcatgtcccg
     1561 agacccctac tgcggctggg accaaggccg ctgcatctcc atctacagct ccgaacggtc
     1621 agtgctgcaa tccattaatc cagccgagcc acacaaggag tgtcccaacc ccaaaccaga
     1681 caaggcccca ctgcagaagg tttccctggc cccaaactct cgctactacc tgagctgccc
     1741 catggaatcc cgccacgcca cctactcatg gcgccacaag gagaacgtgg agcagagctg
     1801 cgaacctggt caccagagcc ccaactgcat cctgttcatc gagaacctca cggcgcagca
     1861 gtacggccac tacttctgcg aggcccagga gggctcctac ttccgcgagg ctcagcactg
     1921 gcagctgctg cccgaggacg gcatcatggc cgagcacctg ctgggtcatg cctgtgccct
     1981 ggccgcctcc ctctggctgg gggtgctgcc cacactcact cttggcttgc tggtccacta
     2041 gggcctcccg aggctgggca tgcctcaggc ttctgcagcc cagggcacta gaacgtctca
     2101 cactcagagc cggctggccc gggagctcct tgcctgccac ttcttccagg ggacagaata
     2161 acccagtgga ggatgccagg cctggagacg tccagccgca ggcggctgct gggccccagg
     2221 tggcgcacgg atggtgaggg gctgagaatg agggcaccga ctgtgaagct ggggcatcga
     2281 tgacccaaga ctttatcttc tggaaaatat ttttcagact cctcaaactt gactaaatgc
     2341 agcgatgctc ccagcccaag agcccatggg tcggggagtg ggtttggata ggagagctgg
     2401 gactccatct cgaccctggg gctgaggcct gagtccttct ggactcttgg tacccacatt
     2461 gcctccttcc cctccctctc tcatggctgg gtggctggtg ttcctgaaga cccagggcta
     2521 ccctctgtcc agccctgtcc tctgcagctc cctctctggt cctgggtccc acaggacagc
     2581 cgccttgcat gtttattgaa ggatgtttgc tttccggacg gaaggacgga aaaagctcta
     2641 tttttatgtt aggcttattt catgtatagc tacttccgac tgcatctgta tgaaaatacc
     2701 aaaactacat gcgggggggt gggtgggaaa gggaggggct gggaagggat gggttgggga
     2761 gcgggggtga tcccagtctg aggctcccgg ggatgagata agagtctgga gacgggcatg
     2821 ggttcttgga gagtggcatg agctggctct gccctgggag cccggtctga gggggacgtt
     2881 gttggagccc ctagtgttgg gggtggttat gggagggggt ggggtgaggg aaacgggaga
     2941 atgaaggaga aaactgagcc ctagtttcac cgtgttcatt tggaaggacg agccgggtcc
     3001 tcagggggag gttccaggac tctgcccttg gcgttgaggg ttggggggcg gggggcctcc
     3061 tcccttcctc tcagccccct tccccagggg ctgtgcttcc atgctcctag cctcccacct
     3121 tcgctcagga catgttataa cttaggctaa actgtgaaaa ttccggtggg gatggcctgg
     3181 gccgagctct ccaggcaggc ggccctgccc ccagccctgt ccatccattt caggggggag
     3241 ctgggccctt ctccggctgt gtctggccac ccagggcagt ggctggggcc agtggccttc
     3301 cagctttggc ccctgcacct cttctcaatg cactttaata atgtaacata ttactaataa
     3361 acaagctatt tattta
//
