LOCUS       NM_001358351            5907 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens semaphorin 6D (SEMA6D), transcript variant 8, mRNA.
ACCESSION   NM_001358351 XM_005254687
VERSION     NM_001358351.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5907)
  AUTHORS   Nakanishi,Y., Izumi,M., Matsushita,H., Koyama,Y., Diez,D.,
            Takamatsu,H., Koyama,S., Nishide,M., Naito,M., Mizuno,Y.,
            Yamaguchi,Y., Mae,T., Noda,Y., Nakaya,K., Nojima,S., Sugihara,F.,
            Okuzaki,D., Ikawa,M., Shimada,S., Kang,S. and Kumanogoh,A.
  TITLE     Semaphorin 6D tunes amygdalar circuits for emotional, metabolic,
            and inflammatory outputs
  JOURNAL   Neuron 112 (17), 2955-2972 (2024)
   PUBMED   39002542
  REMARK    GeneRIF: Semaphorin 6D tunes amygdalar circuits for emotional,
            metabolic, and inflammatory outputs.
REFERENCE   2  (bases 1 to 5907)
  AUTHORS   Thomas,T., Perdue,M.V., Khalaf,S., Landi,N., Hoeft,F., Pugh,K. and
            Grigorenko,E.L.
  TITLE     Neuroimaging genetic associations between SEMA6D, brain structure,
            and reading skills
  JOURNAL   J Clin Exp Neuropsychol 43 (3), 276-289 (2021)
   PUBMED   33960276
  REMARK    GeneRIF: Neuroimaging genetic associations between SEMA6D, brain
            structure, and reading skills.
REFERENCE   3  (bases 1 to 5907)
  AUTHORS   Dong,L. and Qu,F.
  TITLE     CircUBAP2 promotes SEMA6D expression to enhance the cisplatin
            resistance in osteosarcoma through sponging miR-506-3p by
            activating Wnt/beta-catenin signaling pathway
  JOURNAL   J Mol Histol 51 (4), 329-340 (2020)
   PUBMED   32472335
  REMARK    GeneRIF: CircUBAP2 promotes SEMA6D expression to enhance the
            cisplatin resistance in osteosarcoma through sponging miR-506-3p by
            activating Wnt/beta-catenin signaling pathway.
            Erratum:[J Mol Histol. 2020 Aug;51(4):471. doi:
            10.1007/s10735-020-09894-5.. PMID: 32666371]
REFERENCE   4  (bases 1 to 5907)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   5  (bases 1 to 5907)
  AUTHORS   Qu,S., Yang,Z., Tao,H., Ji,F., Chen,P., Liang,J. and Lu,Y.
  TITLE     [Semaphorin 6D and Snail are highly expressed in gastric cancer and
            positively correlated with malignant clinicopathological indexes]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 35 (10), 932-937 (2019)
   PUBMED   31814570
  REMARK    GeneRIF: The high expression of SEMA6D and Snail in gastric cancer
            are related to the malignant clinicopathological indexes of gastric
            cancer.
REFERENCE   6  (bases 1 to 5907)
  AUTHORS   Takegahara,N., Takamatsu,H., Toyofuku,T., Tsujimura,T., Okuno,T.,
            Yukawa,K., Mizui,M., Yamamoto,M., Prasad,D.V., Suzuki,K., Ishii,M.,
            Terai,K., Moriya,M., Nakatsuji,Y., Sakoda,S., Sato,S., Akira,S.,
            Takeda,K., Inui,M., Takai,T., Ikawa,M., Okabe,M., Kumanogoh,A. and
            Kikutani,H.
  TITLE     Plexin-A1 and its interaction with DAP12 in immune responses and
            bone homeostasis
  JOURNAL   Nat Cell Biol 8 (6), 615-622 (2006)
   PUBMED   16715077
REFERENCE   7  (bases 1 to 5907)
  AUTHORS   Toyofuku,T., Zhang,H., Kumanogoh,A., Takegahara,N., Suto,F.,
            Kamei,J., Aoki,K., Yabuki,M., Hori,M., Fujisawa,H. and Kikutani,H.
  TITLE     Dual roles of Sema6D in cardiac morphogenesis through
            region-specific association of its receptor, Plexin-A1, with
            off-track and vascular endothelial growth factor receptor type 2
  JOURNAL   Genes Dev 18 (4), 435-447 (2004)
   PUBMED   14977921
REFERENCE   8  (bases 1 to 5907)
  AUTHORS   Qu,X., Wei,H., Zhai,Y., Que,H., Chen,Q., Tang,F., Wu,Y., Xing,G.,
            Zhu,Y., Liu,S., Fan,M. and He,F.
  TITLE     Identification, characterization, and functional study of the two
            novel human members of the semaphorin gene family
  JOURNAL   J Biol Chem 277 (38), 35574-35585 (2002)
   PUBMED   12110693
  REMARK    GeneRIF: identification, characterization, and functional study of
            the two novel human members of the semaphorin gene family
REFERENCE   9  (bases 1 to 5907)
  AUTHORS   He,Z., Wang,K.C., Koprivica,V., Ming,G. and Song,H.J.
  TITLE     Knowing how to navigate: mechanisms of semaphorin signaling in the
            nervous system
  JOURNAL   Sci STKE 2002 (119), re1 (2002)
   PUBMED   11842242
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 5907)
  AUTHORS   Kinoshita,T. and Inoue,N.
  TITLE     Dissecting and manipulating the pathway for
            glycosylphos-phatidylinositol-anchor biosynthesis
  JOURNAL   Curr Opin Chem Biol 4 (6), 632-638 (2000)
   PUBMED   11102867
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK290032.1, AF389426.1 and
            AC018900.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 2, 2019 this sequence version replaced NM_001358351.2.
            
            Summary: Semaphorins are a large family, including both secreted
            and membrane associated proteins, many of which have been
            implicated as inhibitors or chemorepellents in axon pathfinding,
            fasciculation and branching, and target selection. All semaphorins
            possess a semaphorin (Sema) domain and a PSI domain (found in
            plexins, semaphorins and integrins) in the N-terminal extracellular
            portion. Additional sequence motifs C-terminal to the semaphorin
            domain allow classification into distinct subfamilies. Results
            demonstrate that transmembrane semaphorins, like the secreted ones,
            can act as repulsive axon guidance cues. This gene encodes a class
            6 vertebrate transmembrane semaphorin that demonstrates alternative
            splicing. Several transcript variants have been identified and
            expression of the distinct encoded isoforms is thought to be
            regulated in a tissue- and development-dependent manner. [provided
            by RefSeq, Nov 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290032.1, SRR11853561.9899.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000536845.7/ ENSP00000446152.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-517               AK290032.1         119-635
            518-1463            AF389426.1         715-1660
            1464-2557           AK290032.1         1582-2675
            2558-5907           AC018900.8         48011-51360
FEATURES             Location/Qualifiers
     source          1..5907
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     gene            1..5907
                     /gene="SEMA6D"
                     /note="semaphorin 6D"
                     /db_xref="GeneID:80031"
                     /db_xref="HGNC:HGNC:16770"
                     /db_xref="MIM:609295"
     exon            1..188
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            189..351
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..3464
                     /gene="SEMA6D"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 8; sema domain, transmembrane domain (TM), and
                     cytoplasmic domain, (semaphorin) 6D"
                     /codon_start=1
                     /product="semaphorin-6D isoform 4 precursor"
                     /protein_id="NP_001345280.1"
                     /db_xref="CCDS:CCDS32225.1"
                     /db_xref="GeneID:80031"
                     /db_xref="HGNC:HGNC:16770"
                     /db_xref="MIM:609295"
                     /translation="MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVF
                     RGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQ
                     QDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEI
                     SGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWI
                     KEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTS
                     FLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMD
                     DIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSF
                     IKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLK
                     VLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCII
                     RIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGNTAHLG
                     DCHEILPTSTTPDYKIFGGPTSDMEVSSSSVTTMASIPEITPKVIDTWRPKLTSSRKF
                     VVQDDPNTSDFTDPLSGIPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVA
                     VYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSN
                     LLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGH
                     GASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNI
                     DHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQNLMLDPMGS
                     MSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRH
                     SISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSS
                     YTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY"
     exon            352..463
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            464..524
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            525..587
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            588..689
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            690..780
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            781..900
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            901..989
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1207
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1339
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1495
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1669
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1810
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1888
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1950
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2007
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2175
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..5907
                     /gene="SEMA6D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5880..5885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA6D"
                     /note="hexamer: AATAAA"
     regulatory      5885..5890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA6D"
                     /note="hexamer: AATATA"
     polyA_site      5900
                     /gene="SEMA6D"
                     /note="major polyA site"
     polyA_site      5907
                     /gene="SEMA6D"
ORIGIN      
        1 gtcccgctgc tgctgctgct gctgcaaggg gtggtggcga gtttcaggat tctatcaagg
       61 aagccaagac ctaaggagac agagggatat ctatttttac aatatttttc tttattttct
      121 ttcttccttg cgcgtggcaa gctttttttt ttctttttct tttttcttac cagcctcccc
      181 ccaatgaggt agctcagtgg catttctgag caggggccac cctgacttca ccttggccca
      241 ccatgagggt cttcctgctt tgtgcctaca tactgctgct gatggtttcc cagttgaggg
      301 cagtcagctt tcctgaagat gatgaacccc ttaatactgt cgactatcac tattcaaggc
      361 aatatccggt ttttagagga cgcccttcag gcaatgaatc gcagcacagg ctggactttc
      421 agctgatgtt gaaaattcga gacacacttt atattgctgg cagggatcaa gtttatacag
      481 taaacttaaa tgaaatgccc aaaacagaag taatacccaa caagaaactg acatggcgat
      541 caagacaaca ggatcgagaa aactgtgcta tgaaaggcaa gcataaagat gaatgccaca
      601 actttatcaa agtatttgtt ccaagaaacg atgagatggt ttttgtttgt ggtaccaatg
      661 cattcaatcc catgtgtaga tactacaggt tgagtacctt agaatatgat ggggaagaaa
      721 ttagtggcct ggcaagatgc ccatttgatg ccagacaaac caatgttgcc ctctttgctg
      781 atgggaagct gtattctgcc acagtggctg acttcttggc cagcgatgcc gttatttatc
      841 gaagcatggg tgatggatct gcccttcgca caataaaata tgattccaaa tggataaaag
      901 agccacactt tcttcatgcc atagaatatg gaaactatgt ctatttcttc tttcgagaaa
      961 tcgctgtcga acataataat ttaggcaagg ctgtgtattc ccgcgtggcc cgcatatgta
     1021 aaaacgacat gggtggttcc cagcgggtcc tggagaaaca ctggacttca tttctaaagg
     1081 ctcggctgaa ctgttctgtc cctggagatt cgtttttcta ctttgatgtt ctgcagtcta
     1141 ttacagacat aatacaaatc aatggcatcc ccactgtggt cggggtgttt accacgcagc
     1201 tcaatagcat ccctggttct gctgtctgtg catttagcat ggatgacatt gaaaaagtat
     1261 tcaaaggacg gtttaaggaa cagaaaactc cagattctgt ttggacagca gttcccgaag
     1321 acaaagtgcc aaagccaagg cctggctgtt gtgcaaaaca cggccttgcc gaagcttata
     1381 aaacctccat cgatttcccg gatgaaactc tgtcattcat caaatctcat cccctgatgg
     1441 actctgccgt tccacccatt gccgatgagc cctggttcac aaagactcgg gtcaggtaca
     1501 gactgacggc catctcagtg gaccattcag ccggacccta ccagaactac acagtcatct
     1561 ttgttggctc tgaagctggc atggtactta aagttctggc aaagaccagt cctttctctt
     1621 tgaacgacag cgtattactg gaagagattg aagcctacaa ccatgcaaag tgcagtgctg
     1681 agaatgagga agacaaaaag gtcatctcat tacagttgga taaagatcac cacgctttat
     1741 atgtggcgtt ctctagctgc attatccgca tccccctcag tcgctgtgag cgttatggat
     1801 catgtaaaaa gtcttgtatt gcatctcgtg acccgtattg tggctggtta agccagggat
     1861 cctgtggtag agtgacccca gggatgcttg ctgaaggata tgaacaagac acagaattcg
     1921 gcaacacagc tcatctaggg gactgccatg aaattttgcc tacttcaact acaccagatt
     1981 acaaaatatt tggcggtcca acatctgaca tggaggtatc ttcatcttct gttaccacaa
     2041 tggcaagtat cccagaaatc acacctaaag tgattgatac ctggagacct aaactgacaa
     2101 gctctcggaa atttgtagtt caagatgatc caaacacttc tgattttact gatcctttat
     2161 cgggtatccc aaagggtgta cgatgggaag tccagtctgg agagtccaac cagatggtcc
     2221 acatgaatgt cctcatcacc tgtgtctttg ctgcttttgt tttgggggca ttcattgcag
     2281 gtgtggcagt atactgctat cgagacatgt ttgttcggaa aaacagaaag atccataaag
     2341 atgcagagtc cgcccagtca tgcacagact ccagtggaag ttttgccaaa ctgaatggtc
     2401 tctttgacag ccctgtcaag gaataccaac agaatattga ttctcctaaa ctgtatagta
     2461 acctgctaac cagtcggaaa gagctaccac ccaatggaga tactaaatcc atggtaatgg
     2521 accatcgagg gcaacctcca gagttggctg ctcttcctac tcctgagtct acacccgtgc
     2581 ttcaccagaa gaccctgcag gccatgaaga gccactcaga aaaggcccat ggccatggag
     2641 cttcaaggaa agaaacccct cagttttttc cgtctagtcc gccacctcat tccccattaa
     2701 gtcatgggca tatccccagt gccattgttc ttccaaatgc tacccatgac tacaacacgt
     2761 ctttctcaaa ctccaatgct cacaaagctg aaaagaagct tcaaaacatt gatcaccctc
     2821 tcacaaagtc atccagtaag agagatcacc ggcgttctgt tgattccaga aataccctca
     2881 atgatctcct gaagcatctg aatgacccaa atagtaaccc caaagccatc atgggagaca
     2941 tccagatggc acaccagaac ttaatgctgg atcccatggg atcgatgtct gaggtcccac
     3001 ctaaagtccc taaccgggag gcatcgctat actcccctcc ttcaactctc cccagaaata
     3061 gcccaaccaa gcgagtggat gtccccacca ctcctggagt cccaatgact tctctggaaa
     3121 gacaaagagg ttatcacaaa aattcctccc agaggcactc tatatctgct atgcctaaaa
     3181 acttaaactc accaaatggt gttttgttat ccagacagcc tagtatgaac cgtggaggat
     3241 atatgcccac ccccactggg gcgaaggtgg actatattca gggaacacca gtgagtgttc
     3301 atctgcagcc ttccctctcc agacagagca gctacaccag taatggcact cttcctagga
     3361 cgggactaaa gaggacgccg tccttaaaac ctgacgtgcc accaaagcct tcctttgttc
     3421 ctcaaacccc atctgtcaga ccactgaaca aatacacata ctaggcctca agtgtgctat
     3481 tcccatgtgg ctttatcctg tccgtgttgt tgagaggatg atgttgtaag ggtaccttaa
     3541 aacaagagac tcgcttgtat tttaagagaa ccaagtggcc aaagaaactc tttctaactt
     3601 tggcaacatc agaacttgcc acatgtagct actgcagcaa ggcttctgtg tacttgcctg
     3661 aaaacaaagg aaggtgctgg tcattccatt tcttttgttt gaagctaaag agatgtgtag
     3721 ctcacagggg ctaccttacc agtataaaga gctgataaca gtactcagaa gaatctgtga
     3781 acaaatactt gaaaatgggt tcaatgtaga ctgccattat gtgtggtctt cccattaaat
     3841 gtgaacattt taatatgtat gcattcacct tgcctcttgc acaaatgtca aaaaaaagat
     3901 ggtaatatct caaagaaatg aacttgtaga ttaccaagca gtttgctaaa aattcaatct
     3961 ttgacccaag ctgtagcatt tttttttcat gtgtggcatc tttttcatgc caccaacaaa
     4021 cttgttgtgt gtgtgcgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt tctgtaccca
     4081 ctaggatttg tttaggtgcc cattgcatct ttttgtgcta tggagttgtt tacattaagc
     4141 atgaccgaac gagagacaat actatttccc acaggagtcc attgggttca gctttgaaag
     4201 aggaatagaa tcgaggctcc tttgaccatc aaaatgatga actttactta tgtggtaccc
     4261 aatgccagaa tgtaagagtt gcaagtgatt ttgtgctgct attcattaaa acttgtattc
     4321 cagtcttgcc agcttaagga gatcaagata ttaagaggta tccttgattt attttccagt
     4381 attcagtagt aaaattttcc tgtccactgt gaatcaaagc ctgagtcact ctatttaacc
     4441 ttggacacac taataaggtt ttattttgat tgtgttcgtt tccccccccc caatagtaaa
     4501 atttctcctc ctttaactcc tcctaccccc caaggtaaga aacaaaaaac aaacaaacaa
     4561 acaaaaatag aagacaaaag aaagacatat gaaaggaatt gtaattggct taacagaaac
     4621 agtctgtaaa aacctaacag tggtgcaatc atgttgtctg tgttgtgtta tgtgagaatt
     4681 ttctcctaag tcatgcaggt aatgacaata tactgtaaat accacatgtg agtttacctg
     4741 aatctgtgca ttttgtgcct tattcatgag aatgatagaa gtactaaaat ctgtcaagtg
     4801 ttttcagtat agcacattat ttactgagtg ccagttgtaa atgtttttca accagcacct
     4861 aaaaagactc ttttcaaaaa atcacagaaa caacctagga caattatttg ttacataatc
     4921 cgacctcata gcagcattac attctttgcc gtgataaaca ttccactcct gctttcctaa
     4981 ggatgaaaca gtgataatgt gaactcaaat gaggtttcct gggtaatgtg acacctgcag
     5041 aaactataga gcgtcattta tacgtagttt ggcagaaacc acttacggct gatgatgcgc
     5101 aaccctgctg actgtttcag ttaatatgct gcacaccaca cacttgttta gtgaaccaaa
     5161 tctagaaagt accaaggcag aggtatgctc ctgctgtaat caggcaaatg agttcaactg
     5221 gatttctttt gacaatactg ttggtaccta ttacttgggg gaggacatgt tgcagaagac
     5281 cagatcattt ttatacagaa tgtgaaatac tgatacagtt attctttttt ttaaagaaca
     5341 ttgttttata aagaacgtga tttccagtga tctctggaag cgctaaagct aaaatttctg
     5401 ttcttgaaac acttcagctt tgcaactaaa atattacaga ttaataataa attaaaccaa
     5461 ccaatgataa acactactca gtccaccaac aacaaacgtg tttgaattca ccttaccaat
     5521 attaatccca gcgtgtgtaa aacagaacag taactctatg tgaccccaga taacattttg
     5581 taacattgtg cttccttgta gtttgtaatg tgagttcaat cagtatttat gttgaaattt
     5641 ctaacattaa atctagtctc tatcctgtta atttaatttt taaatgcttt atccatttgt
     5701 gcaaaggtaa acgcagattg tatctttttt aatggtacgg cataaaaagt aaccctcaag
     5761 tgaagtgtct ctatactgtt ttatagagta ctttaacatg aatagatacc ttgtaaactt
     5821 gtattgtgga tgtgtaaata atatgtactt tgggttttta acaccgcatg taaagtcaaa
     5881 ataaaatata caaatcatta tatcctg
//
