LOCUS       NM_032108               3862 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens semaphorin 6B (SEMA6B), mRNA.
ACCESSION   NM_032108
VERSION     NM_032108.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3862)
  AUTHORS   Castellotti,B., Canafoglia,L., Freri,E., Tappata,M., Messina,G.,
            Magri,S., DiFrancesco,J.C., Fanella,M., Di Bonaventura,C.,
            Morano,A., Granata,T., Gellera,C., Franceschetti,S. and
            Michelucci,R.
  TITLE     Progressive myoclonus epilepsies due to SEMA6B mutations. New
            variants and appraisal of published phenotypes
  JOURNAL   Epilepsia Open 8 (2), 645-650 (2023)
   PUBMED   36719163
  REMARK    GeneRIF: Progressive myoclonus epilepsies due to SEMA6B mutations.
            New variants and appraisal of published phenotypes.
REFERENCE   2  (bases 1 to 3862)
  AUTHORS   Cordovado,A., Schaettin,M., Jeanne,M., Panasenkava,V.,
            Denomme-Pichon,A.S., Keren,B., Mignot,C., Doco-Fenzy,M., Rodan,L.,
            Ramsey,K., Narayanan,V., Jones,J.R., Prijoles,E.J., Mitchell,W.G.,
            Ozmore,J.R., Juliette,K., Torti,E., Normand,E.A., Granger,L.,
            Petersen,A.K., Au,M.G., Matheny,J.P., Phornphutkul,C.,
            Chambers,M.K., Fernandez-Ramos,J.A., Lopez-Laso,E., Kruer,M.C.,
            Bakhtiari,S., Zollino,M., Morleo,M., Marangi,G., Mei,D., Pisano,T.,
            Guerrini,R., Louie,R.J., Childers,A., Everman,D.B., Isidor,B.,
            Audebert-Bellanger,S., Odent,S., Bonneau,D., Gilbert-Dussardier,B.,
            Redon,R., Bezieau,S., Laumonnier,F., Stoeckli,E.T., Toutain,A. and
            Vuillaume,M.L.
  TITLE     SEMA6B variants cause intellectual disability and alter dendritic
            spine density and axon guidance
  JOURNAL   Hum Mol Genet 31 (19), 3325-3340 (2022)
   PUBMED   35604360
  REMARK    GeneRIF: SEMA6B variants cause intellectual disability and alter
            dendritic spine density and axon guidance.
REFERENCE   3  (bases 1 to 3862)
  AUTHORS   Shu,L., Xu,Y., Tian,Q., Chen,Y., Wang,Y., Xi,H., Wang,H., Xiao,N.
            and Mao,X.
  TITLE     A Frameshift Variant in the SEMA6B Gene Causes Global Developmental
            Delay and Febrile Seizures
  JOURNAL   Neurosci Bull 37 (9), 1357-1360 (2021)
   PUBMED   34110594
  REMARK    GeneRIF: A Frameshift Variant in the SEMA6B Gene Causes Global
            Developmental Delay and Febrile Seizures.
REFERENCE   4  (bases 1 to 3862)
  AUTHORS   Lv,X.J., Chen,X., Wang,Y., Yu,S., Pang,L. and Huang,C.
  TITLE     Aberrant expression of semaphorin 6B affects cell phenotypes in
            thyroid carcinoma by activating the Notch signalling pathway
  JOURNAL   Endokrynol Pol 72 (1), 29-36 (2021)
   PUBMED   33125690
  REMARK    GeneRIF: Aberrant expression of semaphorin 6B affects cell
            phenotypes in thyroid carcinoma by activating the Notch signalling
            pathway.
REFERENCE   5  (bases 1 to 3862)
  AUTHORS   Tian,S., Liu,Y., Wu,H., Liu,H., Zeng,J., Choi,M.Y., Chen,H.,
            Gerhard,R. and Dong,M.
  TITLE     Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as
            Receptors for Paeniclostridium sordellii Toxin TcsL
  JOURNAL   Cell Host Microbe 27 (5), 782-792 (2020)
   PUBMED   32302524
  REMARK    GeneRIF: Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B
            as Receptors for Paeniclostridium sordellii Toxin TcsL.
REFERENCE   6  (bases 1 to 3862)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   7  (bases 1 to 3862)
  AUTHORS   Collet,P., Domenjoud,L., Devignes,M.D., Murad,H., Schohn,H. and
            Dauca,M.
  TITLE     The human semaphorin 6B gene is down regulated by PPARs
  JOURNAL   Genomics 83 (6), 1141-1150 (2004)
   PUBMED   15177567
  REMARK    GeneRIF: Gene SEMA6B is strongly down regulated by peroxisome
            proliferator-activated receptors.
REFERENCE   8  (bases 1 to 3862)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 3862)
  AUTHORS   Correa,R.G., Sasahara,R.M., Bengtson,M.H., Katayama,M.L.,
            Salim,A.C., Brentani,M.M., Sogayar,M.C., de Souza,S.J. and
            Simpson,A.J.
  TITLE     Human semaphorin 6B [(HSA)SEMA6B], a novel human class 6 semaphorin
            gene: alternative splicing and all-trans-retinoic acid-dependent
            downregulation in glioblastoma cell lines
  JOURNAL   Genomics 73 (3), 343-348 (2001)
   PUBMED   11350127
REFERENCE   10 (bases 1 to 3862)
  AUTHORS   Buchanan,J.G., Dunn,A.D. and Edgar,A.R.
  TITLE     C-nucleoside studies. Part III. Glycofuranosylethynes from
            2,3:5,6-di-O-isopropylidene-D-mannose
  JOURNAL   J Chem Soc Perkin 1 (1), 68-75 (1976)
   PUBMED   942725
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA818632.1, DB257858.1 and
            BC142617.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032108.3.
            
            Summary: This gene encodes a member of the semaphorin family, a
            group of proteins characterized by the presence of a conserved
            semaphorin (sema) domain. Whereas some semaphorins are
            transmembrane proteins, others are secreted. Semaphorins play a
            major role in axon guidance. The protein encoded by this gene may
            be involved in both peripheral and central nervous system
            development. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142617.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000586582.6/ ENSP00000467290.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                DA818632.1         76-125
            51-451              DB257858.1         176-576
            452-3862            BC142617.1         470-3880
FEATURES             Location/Qualifiers
     source          1..3862
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3862
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /note="semaphorin 6B"
                     /db_xref="GeneID:10501"
                     /db_xref="HGNC:HGNC:10739"
                     /db_xref="MIM:608873"
     exon            1..155
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /inference="alignment:Splign:2.1.0"
     exon            156..308
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2854
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /note="semaphorin VIB; semaphorin Z; semaphorin-6Ba; sema
                     domain, transmembrane domain (TM), and cytoplasmic domain,
                     (semaphorin) 6B"
                     /codon_start=1
                     /product="semaphorin-6B precursor"
                     /protein_id="NP_115484.2"
                     /db_xref="CCDS:CCDS12131.1"
                     /db_xref="GeneID:10501"
                     /db_xref="HGNC:HGNC:10739"
                     /db_xref="MIM:608873"
                     /translation="MQTPRASPPRPALLLLLLLLGGAHGLFPEEPPPLSVAPRDYLNH
                     YPVFVGSGPGRLTPAEGADDLNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTELRYQR
                     KLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDESTLFVCGSNAFNPVCANYSIDT
                     LQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRT
                     VKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPR
                     VLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVVSLGGRPVVLAVFSTPSNSIPGS
                     AVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYNASSALP
                     DDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSE
                     AGTVLKFLVRPNASTSGTSGLSVFLEEFETYRPDRCGRPGGGETGQRLLSLELDAASG
                     GLLAAFPRCVVRVPVARCQQYSGCMKNCIGSQDPYCGWAPDGSCIFLSPGTRAAFEQD
                     VSGASTSGLGDCTGLLRASLSEDRAGLVSVNLLVTSSVAAFVVGAVVSGFSVGWFVGL
                     RERRELARRKDKEAILAHGAGEAVLSVSRLGERRAQGPGGRGGGGGGGAGVPPEALLA
                     PLMQNGWAKATLLQGGPHDLDSGLLPTPEQTPLPQKRLPTPHPHPHALGPRAWDHGHP
                     LLPASASSSLLLLAPARAPEQPPAPGEPTPDGRLYAARPGRASHGDFPLTPHASPDRR
                     RVVSAPTGPLDPASAADGLPRPWSPPPTGSLRRPLGPHAPPAATLRRTHTFNSGEARP
                     GDRHRGCHARPGTDLAHLLPYGGADRTAPPVP"
     exon            309..432
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /inference="alignment:Splign:2.1.0"
     exon            433..493
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /inference="alignment:Splign:2.1.0"
     exon            494..556
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /inference="alignment:Splign:2.1.0"
     exon            557..658
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /inference="alignment:Splign:2.1.0"
     exon            659..749
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /inference="alignment:Splign:2.1.0"
     exon            750..869
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /inference="alignment:Splign:2.1.0"
     exon            870..958
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1176
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1308
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1458
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1641
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1788
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1866
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1925
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..3862
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3841..3846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /note="hexamer: AATAAA"
     polyA_site      3862
                     /gene="SEMA6B"
                     /gene_synonym="EPM11; SEM-SEMA-Y; SEM-SEMA-Z; SEMA-VIB;
                     SEMAN; semaZ"
                     /note="major polyA site"
ORIGIN      
        1 agaatccctg agccagaagg ccagggcagg gctgggggat acccctgctg ctcagacagg
       61 aaaatgggct cggagcttgc ccaatacttc ccagaaggac gaggctgctg aacttctcat
      121 tcggggctcc gggacctgga ctgtacccct ttctggcgtc acctcctcct gtcgcctggc
      181 cctcgccatg cagaccccgc gagcgtcccc tccccgcccg gccctgctgc ttctgctgct
      241 gctactgggg ggcgcccacg gcctctttcc tgaggagccg ccgccgctta gcgtggcccc
      301 cagggactac ctgaaccact atcccgtgtt tgtgggcagc gggcccggac gcctgacccc
      361 cgcagaaggt gctgacgacc tcaacatcca gcgagtcctg cgggtcaaca ggacgctgtt
      421 cattggggac agggacaacc tctaccgcgt agagctggag ccccccacgt ccacggagct
      481 gcggtaccag aggaagctga cctggagatc taaccccagc gacataaacg tgtgtcggat
      541 gaagggcaaa caggagggcg agtgtcgaaa cttcgtaaag gtgctgctcc ttcgggacga
      601 gtccacgctc tttgtgtgcg gttccaacgc cttcaacccg gtgtgcgcca actacagcat
      661 agacaccctg cagcccgtcg gagacaacat cagcggtatg gcccgctgcc cgtacgaccc
      721 caagcacgcc aatgttgccc tcttctctga cgggatgctc ttcacagcta ctgttaccga
      781 cttcctagcc attgatgctg tcatctaccg cagcctcggg gacaggccca ccctgcgcac
      841 cgtgaaacat gactccaagt ggttcaaaga gccttacttt gtccatgcgg tggagtgggg
      901 cagccatgtc tacttcttct tccgggagat tgcgatggag tttaactacc tggagaaggt
      961 ggtggtgtcc cgcgtggccc gagtgtgcaa gaacgacgtg ggaggctccc cccgcgtgct
     1021 ggagaagcag tggacgtcct tcctgaaggc gcggctcaac tgctctgtac ccggagactc
     1081 ccatttctac ttcaacgtgc tgcaggctgt cacgggcgtg gtcagcctcg ggggccggcc
     1141 cgtggtcctg gccgtttttt ccacgcccag caacagcatc cctggctcgg ctgtctgcgc
     1201 ctttgacctg acacaggtgg cagctgtgtt tgaaggccgc ttccgagagc agaagtcccc
     1261 cgagtccatc tggacgccgg tgccggagga tcaggtgcct cgaccccggc ccgggtgctg
     1321 cgcagccccc gggatgcagt acaatgcctc cagcgccttg ccggatgaca tcctcaactt
     1381 tgtcaagacc caccctctga tggacgaggc ggtgccctcg ctgggccatg cgccctggat
     1441 cctgcggacc ctgatgaggc accagctgac tcgagtggct gtggacgtgg gagccggccc
     1501 ctggggcaac cagaccgttg tcttcctggg ttctgaggcg gggacggtcc tcaagttcct
     1561 cgtccggccc aatgccagca cctcagggac gtctgggctc agtgtcttcc tggaggagtt
     1621 tgagacctac cggccggaca ggtgtggacg gcccggcggt ggcgagacag ggcagcggct
     1681 gctgagcttg gagctggacg cagcttcggg gggcctgctg gctgccttcc cccgctgcgt
     1741 ggtccgagtg cctgtggctc gctgccagca gtactcgggg tgtatgaaga actgtatcgg
     1801 cagtcaggac ccctactgcg ggtgggcccc cgacggctcc tgcatcttcc tcagcccggg
     1861 caccagagcc gcctttgagc aggacgtgtc cggggccagc acctcaggct taggggactg
     1921 cacaggactc ctgcgggcca gcctctccga ggaccgcgcg gggctggtgt cggtgaacct
     1981 gctggtaacg tcgtcggtgg cggccttcgt ggtgggagcc gtggtgtccg gcttcagcgt
     2041 gggctggttc gtgggcctcc gtgagcggcg ggagctggcc cggcgcaagg acaaggaggc
     2101 catcctggcg cacggggcgg gcgaggcggt gctgagcgtc agccgcctgg gcgagcgcag
     2161 ggcgcagggt cccgggggcc ggggcggagg cggtggcggt ggcgccgggg ttcccccgga
     2221 ggccctgctg gcgcccctga tgcagaacgg ctgggccaag gccacgctgc tgcagggcgg
     2281 gccccacgac ctggactcgg ggctgctgcc cacgcccgag cagacgccgc tgccgcagaa
     2341 gcgcctgccc actccgcacc cgcaccccca cgccctgggc ccccgcgcct gggaccacgg
     2401 ccaccccctg ctcccggcct ccgcttcatc ctccctcctg ctgctggcgc ccgcccgggc
     2461 ccccgagcag ccccccgcgc ctggggagcc gacccccgac ggccgcctct atgctgcccg
     2521 gcccggccgc gcctcccacg gcgacttccc gctcaccccc cacgccagcc cggaccgccg
     2581 gcgggtggtg tccgcgccca cgggcccctt ggacccagcc tcagccgccg atggcctccc
     2641 gcggccctgg agcccgcccc cgacgggcag cctgaggagg ccactgggcc cccacgcccc
     2701 tccggccgcc accctgcgcc gcacccacac gttcaacagc ggcgaggccc ggcctgggga
     2761 ccgccaccgc ggctgccacg cccggccggg cacagacttg gcccacctcc tcccctatgg
     2821 gggggcggac aggactgcgc cccccgtgcc ctaggccggg ggccccccga tgccttggca
     2881 gtgccagcca cgggaaccag gagcgagaga cggtgccaga acgccggggc ccggggcaac
     2941 tccgagtggg tgctcaagtc ccccccgcga cccacccgcg gagtgggggg ccccctccgc
     3001 cacaaggaag cacaaccagc tcgccctccc cctacccggg gccgcaggac gctgagacgg
     3061 tttgggggtg ggtgggcggg aggactttgc tatggatttg aggttgacct tatgcgcgta
     3121 ggttttggtt ttttttgcag ttttggtttc ttttgcggtt ttctaaccaa ttgcacaact
     3181 ccgttctcgg ggtggcggca ggcaggggag gcttggacgc cggtggggaa tggggggcca
     3241 cagctgcaga cctaagccct cccccacccc tggaaaggtc cctccccaac ccaggcccct
     3301 ggcgtgtgtg ggtgtgcgtg cgtgtgcgtg ccgtgttcgt gtgcaagggg ccggggaggt
     3361 gggcgtgtgt gtgcgtgcca gcgaaggctg ctgtgggcgt gtgtgtcaag tgggccacgc
     3421 gtgcagggtg tgtgtccacg agcgacgatc gtggtggccc cagcggcctg ggcgttggct
     3481 gagccgacgc tggggcttcc agaaggcccg ggggtctccg aggtgccggt taggagtttg
     3541 aacccccccc actctgcaga gggaagcggg gacaatgccg gggtttcagg caggagacac
     3601 gaggagggcc tgcccggaag tcacatcggc agcagctgtc taaagggctt gggggcctgg
     3661 ggggcggcga aggtgggtgg ggcccctctg taaatacggc cccagggtgg tgagagagtc
     3721 ccatgccacc cgtccccttg tgacctcccc cctctgacct ccagctgacc atgcatgcca
     3781 cgtggctggc tgggtcctct gccctctctg gagtttgcct cccccagccc cctccccatc
     3841 aataaaactc tgtttacaac ca
//
