LOCUS       NM_020796               6828 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens semaphorin 6A (SEMA6A), transcript variant 2, mRNA.
ACCESSION   NM_020796
VERSION     NM_020796.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6828)
  AUTHORS   Tian,S., Liu,Y., Wu,H., Liu,H., Zeng,J., Choi,M.Y., Chen,H.,
            Gerhard,R. and Dong,M.
  TITLE     Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as
            Receptors for Paeniclostridium sordellii Toxin TcsL
  JOURNAL   Cell Host Microbe 27 (5), 782-792 (2020)
   PUBMED   32302524
  REMARK    GeneRIF: Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B
            as Receptors for Paeniclostridium sordellii Toxin TcsL.
REFERENCE   2  (bases 1 to 6828)
  AUTHORS   Chen,L.H., Liao,C.Y., Lai,L.C., Tsai,M.H. and Chuang,E.Y.
  TITLE     Semaphorin 6A Attenuates the Migration Capability of Lung Cancer
            Cells via the NRF2/HMOX1 Axis
  JOURNAL   Sci Rep 9 (1), 13302 (2019)
   PUBMED   31527696
  REMARK    GeneRIF: Semaphorin 6A Attenuates the Migration Capability of Lung
            Cancer Cells via the NRF2/HMOX1 Axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6828)
  AUTHORS   Peter,C.J., Saito,A., Hasegawa,Y., Tanaka,Y., Nagpal,M., Perez,G.,
            Alway,E., Espeso-Gil,S., Fayyad,T., Ratner,C., Dincer,A., Gupta,A.,
            Devi,L., Pappas,J.G., Lalonde,F.M., Butman,J.A., Han,J.C.,
            Akbarian,S. and Kamiya,A.
  TITLE     In vivo epigenetic editing of Sema6a promoter reverses
            transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene
  JOURNAL   Nat Commun 10 (1), 4112 (2019)
   PUBMED   31511512
  REMARK    GeneRIF: RNA-guided epigenetic editing of Sema6a gene promoters via
            a dCas9-SunTag system with C11orf46 binding normalized SEMA6A
            expression and rescued transcallosal dysconnectivity via repressive
            chromatin remodeling by the SETDB1 repressor complex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6828)
  AUTHORS   Kobakhidze,N., Tabagari,S. and Chichua,G.
  TITLE     NEW GENETIC MARKERS ASSOCIATED WITH SUSCEPTIBILITY TO EXFOLIATION
            SYNDROME AMONG GEORGIAN POPULATION
  JOURNAL   Georgian Med News (294), 41-45 (2019)
   PUBMED   31687947
  REMARK    GeneRIF: The A alleles of SEMA6A and POMP genes are likely the risk
            factors of disease development in Georgians
REFERENCE   5  (bases 1 to 6828)
  AUTHORS   Lim,H.S., Kim,C.S., Kim,J.S., Yu,S.K., Go,D.S., Lee,S.A.,
            Moon,S.M., Chun,H.S., Kim,S.G. and Kim,D.K.
  TITLE     Suppression of Oral Carcinoma Oncogenic Activity by microRNA-203
            via Down-regulation of SEMA6A
  JOURNAL   Anticancer Res 37 (10), 5425-5433 (2017)
   PUBMED   28982852
  REMARK    GeneRIF: miR-203 induces the apoptosis of YD-38 human oral cancer
            cells by directly targeting SEMA6A.
REFERENCE   6  (bases 1 to 6828)
  AUTHORS   Gautier,G., de Saint-Vis,B., Senechal,B., Pin,J.J., Bates,E.E.,
            Caux,C., Geissmann,F. and Garrone,P.
  TITLE     The class 6 semaphorin SEMA6A is induced by interferon-gamma and
            defines an activation status of langerhans cells observed in
            pathological situations
  JOURNAL   Am J Pathol 168 (2), 453-465 (2006)
   PUBMED   16436660
  REMARK    GeneRIF: Strong expression of SEMA6A is associated with langerhans
            cells of histiocytosis or dermatopathic lymphadenitis
REFERENCE   7  (bases 1 to 6828)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   8  (bases 1 to 6828)
  AUTHORS   Leighton,P.A., Mitchell,K.J., Goodrich,L.V., Lu,X., Pinson,K.,
            Scherz,P., Skarnes,W.C. and Tessier-Lavigne,M.
  TITLE     Defining brain wiring patterns and mechanisms through gene trapping
            in mice
  JOURNAL   Nature 410 (6825), 174-179 (2001)
   PUBMED   11242070
REFERENCE   9  (bases 1 to 6828)
  AUTHORS   Klostermann,A., Lutz,B., Gertler,F. and Behl,C.
  TITLE     The orthologous human and murine semaphorin 6A-1 proteins
            (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated
            phosphoprotein-like protein (EVL) via a novel carboxyl-terminal
            zyxin-like domain
  JOURNAL   J Biol Chem 275 (50), 39647-39653 (2000)
   PUBMED   10993894
REFERENCE   10 (bases 1 to 6828)
  AUTHORS   Zhou,L., White,F.A., Lentz,S.I., Wright,D.E., Fisher,D.A. and
            Snider,W.D.
  TITLE     Cloning and expression of a novel murine semaphorin with structural
            similarity to insect semaphorin I
  JOURNAL   Mol Cell Neurosci 9 (1), 26-41 (1997)
   PUBMED   9204478
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC032619.1, AF279656.1, AB037789.1, AL544905.3 and AI110626.1.
            
            On Jun 2, 2019 this sequence version replaced NM_020796.4.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            central coding region, compared to variant 1. The resulting isoform
            (2) lacks an internal segment, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032619.1, SRR14038194.2938023.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343348.11/ ENSP00000345512.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               BC032619.1         115-328
            215-530             AF279656.1         195-510
            531-3585            BC032619.1         645-3699
            3586-4049           AB037789.1         3209-3672
            4050-4118           AL544905.3         1-69
            4119-6758           BC032619.1         4227-6866
            6759-6828           AI110626.1         22-91               c
FEATURES             Location/Qualifiers
     source          1..6828
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.1"
     gene            1..6828
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /note="semaphorin 6A"
                     /db_xref="GeneID:57556"
                     /db_xref="HGNC:HGNC:10738"
                     /db_xref="MIM:605885"
     exon            1..639
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     exon            640..777
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     CDS             678..3770
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; semaphorin 6A-1; sema VIa; SEMA6A-1; semaphorin
                     VIA; sema domain, transmembrane domain (TM), and
                     cytoplasmic domain, (semaphorin) 6A"
                     /codon_start=1
                     /product="semaphorin-6A isoform 2 precursor"
                     /protein_id="NP_065847.1"
                     /db_xref="CCDS:CCDS47256.1"
                     /db_xref="GeneID:57556"
                     /db_xref="HGNC:HGNC:10738"
                     /db_xref="MIM:605885"
                     /translation="MRSEALLLYFTLLHFAGAGFPEDSEPISISHGNYTKQYPVFVGH
                     KPGRNTTQRHRLDIQMIMIMNGTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQA
                     DVDTCRMKGKHKDECHNFIKVLLKKNDDALFVCGTNAFNPSCRNYKMDTLEPFGDEFS
                     GMARCPYDAKHANVALFADGKLYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLK
                     EPYFVQAVDYGDYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSF
                     LKARLNCSVPGDSHFYFNILQAVTDVIRINGRDVVLATFSTPYNSIPGSAVCAYDMLD
                     IASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLERYATSNEFPDDTLNFI
                     KTHPLMDEAVPSIFNRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILKF
                     LARIGNSGFLNDSLFLEEMSVYNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVI
                     KVPLGRCERHGKCKKTCIASRDPYCGWIKEGGACSHLSPNSRLTFEQDIERGNTDGLG
                     DCHNSFVALNGHSSSLLPSTTTSDSTAQEGYESRGGMLDWKHLLDSPDSTDPLGAVSS
                     HNHQDKKGVIRESYLKGHDQLVPVTLLAIAVILAFVMGAVFSGITVYCVCDHRRKDVA
                     VVQRKEKELTHSRRGSMSSVTKLSGLFGDTQSKDPKPEAILTPLMHNGKLATPGNTAK
                     MLIKADQHHLDLTALPTPESTPTLQQKRKPSRGSREWERNQNLINACTKDMPPMGSPV
                     IPTDLPLRASPSHIPSVVVLPITQQGYQHEYVDQPKMSEVAQMALEDQAATLEYKTIK
                     EHLSSKSPNHGVNLVENLDSLPPKVPQREASLGPPGASLSQTGLSKRLEMHHSSSYGV
                     DYKRSYPTNSLTRSHQATTLKRNNTNSSNSSHLSRNQSFGRGDNPPPAPQRVDSIQVH
                     SSQPSGQAVTVSRQPSLNAYNSLTRSGLKRTPSLKPDVPPKPSFAPLSTSMKPNDACT
                     "
     exon            778..895
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     exon            896..956
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1019
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1121
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1212
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1332
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1421
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1639
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1771
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1927
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2104
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2245
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2326
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2385
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2406
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2571
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..6828
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4614..4619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /note="hexamer: AATAAA"
     polyA_site      4635
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /note="major polyA site"
     regulatory      6804..6809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
                     /note="hexamer: AATAAA"
     polyA_site      6828
                     /gene="SEMA6A"
                     /gene_synonym="HT018; SEMA; SEMA6A1; SEMAQ; VIA"
ORIGIN      
        1 agaggagtag tgagcggcac ggggtgaggc tgcagccaac tccgctcccc gcgcactcgg
       61 ctgcccaggc gctcggaacc cagcagcggc gctcctccgc ggtgccggtc gcccgcgatg
      121 cccgcttagc agcgtgtagc agcggccagc atcaccacac ccgcggcacc gcgctgccgg
      181 ccgcagagcc gggccagagc cttgcacccc tgccccagcc cccaccccgc cccccgccct
      241 gaaatgactt gttaatcggc gcagacacca ccaaggggac tcaccgaagt ggaatccaag
      301 tggaatttgg atttggagaa gagtttcttg aacatttacc ctcttccttg ttggttttct
      361 ttttcttttt cttctttttt tttttggctt cttttttcct ctccccttct ccgctcgtca
      421 ttggagatga acacatcgcg tttgcatccc agaaagtagt cgccgcgact atttccccca
      481 aagagacaag cacacatgta ggaatgacaa aggcttgcga aggagagagc gcagcccgcg
      541 gcccggagag atcccctcga taatggatta ctaaatggga tacacgctgt accagttcgc
      601 tccgagcccc ggccgcctgt ccgtcgatgc accgaaaagg gtgaagtaga gaaataaagt
      661 ctccccgctg aactactatg aggtcagaag ccttgctgct atatttcaca ctgctacact
      721 ttgctggggc tggtttccca gaagattctg agccaatcag tatttcgcat ggcaactata
      781 caaaacagta tccggtgttt gtgggccaca agccaggacg gaacaccaca cagaggcaca
      841 ggctggacat ccagatgatt atgatcatga acggaaccct ctacattgct gctagggacc
      901 atatttatac tgttgatata gacacatcac acacggaaga aatttattgt agcaaaaaac
      961 tgacatggaa atctagacag gccgatgtag acacatgcag aatgaaggga aaacataagg
     1021 atgagtgcca caactttatt aaagttcttc taaagaaaaa cgatgatgca ttgtttgtct
     1081 gtggaactaa tgccttcaac ccttcctgca gaaactataa gatggataca ttggaaccat
     1141 tcggggatga attcagcgga atggccagat gcccatatga tgccaaacat gccaacgttg
     1201 cactgtttgc agatggaaaa ctatactcag ccacagtgac tgacttcctt gccattgacg
     1261 cagtcattta ccggagtctt ggagaaagcc ctaccctgcg gaccgtcaag cacgattcaa
     1321 aatggttgaa agaaccatac tttgttcaag ccgtggatta cggagattat atctacttct
     1381 tcttcaggga aatagcagtg gagtataaca ccatgggaaa ggtagttttc ccaagagtgg
     1441 ctcaggtttg taagaatgat atgggaggat ctcaaagagt cctggagaaa cagtggacgt
     1501 cgttcctgaa ggcgcgcttg aactgctcag ttcctggaga ctctcatttt tatttcaaca
     1561 ttctccaggc agttacagat gtgattcgta tcaacgggcg tgatgttgtc ctggcaacgt
     1621 tttctacacc ttataacagc atccctgggt ctgcagtctg tgcctatgac atgcttgaca
     1681 ttgccagtgt ttttactggg agattcaagg aacagaagtc tcctgattcc acctggacac
     1741 cagttcctga tgaacgagtt cctaagccca ggccaggttg ctgtgctggc tcatcctcct
     1801 tagaaagata tgcaacctcc aatgagttcc ctgatgatac cctgaacttc atcaagacgc
     1861 acccgctcat ggatgaggca gtgccctcca tcttcaacag gccatggttc ctgagaacaa
     1921 tggtcagata ccgccttacc aaaattgcag tggacacagc tgctgggcca tatcagaatc
     1981 acactgtggt ttttctggga tcagagaagg gaatcatctt gaagtttttg gccagaatag
     2041 gaaatagtgg ttttctaaat gacagccttt tcctggagga gatgagtgtt tacaactctg
     2101 aaaaatgcag ctatgatgga gtcgaagaca aaaggatcat gggcatgcag ctggacagag
     2161 caagcagctc tctgtatgtt gcgttctcta cctgtgtgat aaaggttccc cttggccggt
     2221 gtgaacgaca tgggaagtgt aaaaaaacct gtattgcctc cagagaccca tattgtggat
     2281 ggataaagga aggtggtgcc tgcagccatt tatcacccaa cagcagactg acttttgagc
     2341 aggacataga gcgtggcaat acagatggtc tgggggactg tcacaattcc tttgtggcac
     2401 tgaatgggca ttccagttcc ctcttgccca gcacaaccac atcagattcg acggctcaag
     2461 aggggtatga gtctagggga ggaatgctgg actggaagca tctgcttgac tcacctgaca
     2521 gcacagaccc tttgggggca gtgtcttccc ataatcacca agacaagaag ggagtgattc
     2581 gggaaagtta cctcaaaggc cacgaccagc tggttcccgt caccctcttg gccattgcag
     2641 tcatcctggc tttcgtcatg ggggccgtct tctcgggcat caccgtctac tgcgtctgtg
     2701 atcatcggcg caaagacgtg gctgtggtgc agcgcaagga gaaggagctc acccactcgc
     2761 gccggggctc catgagcagc gtcaccaagc tcagcggcct ctttggggac actcaatcca
     2821 aagacccaaa gccggaggcc atcctcacgc cactcatgca caacggcaag ctcgccactc
     2881 ccggcaacac ggccaagatg ctcattaaag cagaccagca ccacctggac ctgacggccc
     2941 tccccacccc agagtcaacc ccaacgctgc agcagaagcg gaagcccagc cgcggcagcc
     3001 gcgagtggga gaggaaccag aacctcatca atgcctgcac aaaggacatg ccccccatgg
     3061 gctcccctgt gattcccacg gacctgcccc tgcgggcctc ccccagccac atccccagcg
     3121 tggtggtcct gcccatcacg cagcagggct accagcatga gtacgtggac cagcccaaaa
     3181 tgagcgaggt ggcccagatg gcgctggagg accaggccgc cacactggag tataagacca
     3241 tcaaggaaca tctcagcagc aagagtccca accatggggt gaaccttgtg gagaacctgg
     3301 acagcctgcc ccccaaagtt ccacagcggg aggcctccct gggtcccccg ggagcctccc
     3361 tgtctcagac cggtctaagc aagcggctgg aaatgcacca ctcctcttcc tacggggttg
     3421 actataagag gagctacccc acgaactcgc tcacgagaag ccaccaggcc accactctca
     3481 aaagaaacaa cactaactcc tccaattcct ctcacctctc cagaaaccag agctttggca
     3541 ggggagacaa cccgccgccc gccccgcaga gggtggactc catccaggtg cacagctccc
     3601 agccatctgg ccaggccgtg actgtctcga ggcagcccag cctcaacgcc tacaactcac
     3661 tgacaaggtc ggggctgaag cgtacgccct cgctaaagcc ggacgtaccc cccaaaccat
     3721 cctttgctcc cctttccaca tccatgaagc ccaatgatgc gtgtacataa tcccaggggg
     3781 agggggtcag gtgtcgaacc agcaggcaag gcgaggtgcc cgctcagctc agcaaggttc
     3841 tcaactgcct cgagtaccca ccagaccaag aaggcctgcg gcagagccga ggacgctggg
     3901 tcctcctctc tgggacacag gggtactcac gaaaactggg ccgcgtggtt tggtgaaggt
     3961 ttgcaacggc ggggactcac cttcattctc ttccttcact ttcccccaca ccctacaaca
     4021 ggtcggaccc acaaaagact tcagttatca tcacaaacat gagccaaaag cacataccta
     4081 ccccatcccc cacccccaca cacacacaca cacacacatg cacacaacac atacacacac
     4141 acgcacagag gtgaacagaa actgaaacat tttgtccaca acttcacggg acgtggccag
     4201 actgggtttg cgttccaacc tgcaaaacac aaatacattt tttaaaatca agaaaattta
     4261 aaaagacaaa aaaaaaagaa ttcattgata attctaactc agactttaac aatggcagaa
     4321 gtttactatg cgcaaatact gtgaaatgcc cgccagtgtt acagctttct gttgcagcag
     4381 ataaatgcca tgttgggcaa ctatgtcata gatttctgct cctcctctct tttaatgaaa
     4441 taacgtgacc gttaacgcaa gtaactcttt atttattgtt cacccttttt ttccttaagg
     4501 aaaggactct tccaaatatc atcctatgaa cagctcttca gaaagcccat tgaaagttaa
     4561 actatttaac gtgaaatcca ttaactggaa taattgagtt tctttatttt tacaataaat
     4621 tcactgagta aataagttgg agctggaatt ctgagctttg tgtttggact gtctggtctg
     4681 tagctaaagg aaaaagttag gaggggaata tttatttaaa tctatcagtt cattgcctgg
     4741 tcaggtctct ggcctataaa catgcaaaaa aactaattca tgttaaagtc cttccagatc
     4801 ctaatttcta aagcaatcag gagagaaagc ttttagaatg gcacatcata tctcattgat
     4861 gccaacatgg ttttgtccat ggttctgact ttctgtgaag gcaccagctt gcaatatgcc
     4921 atcccatttc accttgcatg tgagacagca aacaaaatcc acaaatggtg tgaactaata
     4981 tgctggctgc taccttgcat aaattaatga tttgatcaca cgggttcttc gtggggttac
     5041 atctgtgaat agcctgtttt ccacatgtaa atttgtgcct tacaccttga gttgtgtaca
     5101 cttgtaaact ctttatgatc aactgttccc ccttttgaaa taagtgcaga tatttattta
     5161 accctccctt ccccaccctc tgccccactt ccagccctct gaaagattgg agtcaagcag
     5221 atggaagaat gcagtggtga tagttgtcat gcgacagcct gagaacgctg ggcagcacca
     5281 caccctccaa ttcacactgc cttctagttg tgccaactgg aaccaccctt tggctgtgct
     5341 gcgaagcatg gaccccagtg ttgttgtggg tgtgtcaaat cccctttcat cctcaagagc
     5401 tccctgcttc ccttagatta tttcaatacg gtgatatcct tatttgctag cagaaaaggg
     5461 actaacgtcc cattcctctt ttctgctgcg tccactggct agagagcagg cggtgcgcgg
     5521 ttgggcagac acctgggagg agtctccaag ccatgtgcac agcacacacg tgcagtgcac
     5581 acaaagaaat gacatggaaa tagatgcagg caggctggtc cctgctgtga ttaacgagta
     5641 actccaagta caaggccgac cacaatggat gctgcaaaaa cgttgactgg ggcaaaggat
     5701 tttttatttt attttttatt ttgttaatta tgtttttagg ggatgggagg tggtgtgtgt
     5761 ttttctcctc ttggttttca tttgctcaag cacacaaaag ggacttttgt ttactctatc
     5821 atgaacaaag gaactgtcca catactgtaa accatgagca gtgttgttgt tgttttttta
     5881 aacagtatat ttggtggtct ctttgtctgc ttttatttcc agttcgatct tctgggttta
     5941 gttttgtctt taaaaagaat tcaaaaaaag actgacaatg acagttttga gttggatagt
     6001 gaaaaagtgg agcctccata atcagtgtgg ttgccttcag acctgagtac ttagctgagg
     6061 gtgggtgaga gccctttgtt ccaaaagtcc attagttttg ctgttgttta ggagtaggtg
     6121 gttgttgttg tttttacttt tttttttttt ggcttttgta atggaatcca tgttcacatc
     6181 ctgtgaactc tgtctcctga aaccctgaag tatttcctag aacctgaaat attgttttct
     6241 tccttgaatt ttctctagaa atgcagaaat taggaaggtg atgggtctgt atccccctgc
     6301 ccccttcttt cccatgcttg actcccgaga gtactggcag tgcagcaccc atcattgacg
     6361 taagcggctg tcttgtccag tgtttgtagg catcactgcc tcagctgtta aggagacctg
     6421 tgtcaaaact tacatccaca ttcctacacc cccacaaccc atcacttctg gtgttaaccc
     6481 taaaataccc acatgtattg agctggtctt ctgcatttaa gtatttctcc ccagtttttt
     6541 tccccactgt gtgtgggggg agggtccata aacccgagtg tgcctttgct ttccaccctt
     6601 gctagacact ggtagatgca acaaactcag atttatattt gttgtaaagt tgtaaaaata
     6661 ttgtgatgtc accaattttc cttccatctc cacatcccct aacatctgat tcacgactta
     6721 atgtatgttg taagaaaaga aaaaagaaaa gaaaaaaagg gaaaaaagaa aagcaaggaa
     6781 aaggctcttt attacttaaa agtaataaaa cctgactgtt ctatatta
//
