LOCUS       NM_001031702            4855 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens semaphorin 5B (SEMA5B), transcript variant 1, mRNA.
ACCESSION   NM_001031702
VERSION     NM_001031702.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4855)
  AUTHORS   Maki-Nevala,S., Sarhadi,V.K., Knuuttila,A., Scheinin,I.,
            Ellonen,P., Lagstrom,S., Ronty,M., Kettunen,E.,
            Husgafvel-Pursiainen,K., Wolff,H. and Knuutila,S.
  TITLE     Driver Gene and Novel Mutations in Asbestos-Exposed Lung
            Adenocarcinoma and Malignant Mesothelioma Detected by Exome
            Sequencing
  JOURNAL   Lung 194 (1), 125-135 (2016)
   PUBMED   26463840
  REMARK    GeneRIF: SEMA5B could possibly serve as a candidate gene for
            alterations associated with asbestos exposure.
REFERENCE   2  (bases 1 to 4855)
  AUTHORS   Wu,C., Hu,Z., He,Z., Jia,W., Wang,F., Zhou,Y., Liu,Z., Zhan,Q.,
            Liu,Y., Yu,D., Zhai,K., Chang,J., Qiao,Y., Jin,G., Liu,Z., Shen,Y.,
            Guo,C., Fu,J., Miao,X., Tan,W., Shen,H., Ke,Y., Zeng,Y., Wu,T. and
            Lin,D.
  TITLE     Genome-wide association study identifies three new susceptibility
            loci for esophageal squamous-cell carcinoma in Chinese populations
  JOURNAL   Nat Genet 43 (7), 679-684 (2011)
   PUBMED   21642993
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4855)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   4  (bases 1 to 4855)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 4855)
  AUTHORS   O'Connor,T.P., Cockburn,K., Wang,W., Tapia,L., Currie,E. and
            Bamji,S.X.
  TITLE     Semaphorin 5B mediates synapse elimination in hippocampal neurons
  JOURNAL   Neural Dev 4, 18 (2009)
   PUBMED   19463192
  REMARK    GeneRIF: Sema5B regulates the development and maintenance of
            synapse size and number in hippocampal neurons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4855)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 4855)
  AUTHORS   Adams,R.H., Betz,H. and Puschel,A.W.
  TITLE     A novel class of murine semaphorins with homology to thrombospondin
            is differentially expressed during early embryogenesis
  JOURNAL   Mech Dev 57 (1), 33-45 (1996)
   PUBMED   8817451
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA115188.1, DA797213.1, AB040878.1, BC077726.1, AK091481.1,
            BC002776.2 and AC078794.13.
            
            On May 17, 2019 this sequence version replaced NM_001031702.3.
            
            Summary: This gene encodes a member of the semaphorin protein
            family which regulates axon growth during development of the
            nervous system. The encoded protein has a characteristic Sema
            domain near the N-terminus, through which semaphorins bind to
            plexin, and five thrombospondin type 1 repeats in the C-terminal
            region of the protein. The protein product may be cleaved and exist
            as a secreted molecule (PMID: 19463192). Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) encodes isoform 1. Variants 1
            and 2 encode the same protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB040878.1, BC077726.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357599.8/ ENSP00000350215.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                DA115188.1         50-83
            35-307              DA797213.1         1-273
            308-996             AB040878.1         123-811
            997-1483            BC077726.1         729-1215
            1484-3602           AK091481.1         1673-3791
            3603-4741           BC002776.2         206-1344
            4742-4855           AC078794.13        42546-42659
FEATURES             Location/Qualifiers
     source          1..4855
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.1"
     gene            1..4855
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /note="semaphorin 5B"
                     /db_xref="GeneID:54437"
                     /db_xref="HGNC:HGNC:10737"
                     /db_xref="MIM:609298"
     exon            1..300
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            301..462
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..3794
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /note="isoform 1 is encoded by transcript variant 1; sema
                     domain, seven thrombospondin repeats (type 1 and type
                     1-like), transmembrane domain (TM) and short cytoplasmic
                     domain, (semaphorin) 5B"
                     /codon_start=1
                     /product="semaphorin-5B isoform 1"
                     /protein_id="NP_001026872.2"
                     /db_xref="CCDS:CCDS35491.1"
                     /db_xref="GeneID:54437"
                     /db_xref="HGNC:HGNC:10737"
                     /db_xref="MIM:609298"
                     /translation="MPCGFSPSPVAHHLVPGPPDTPAQQLRCGWTVGGWLLSLVRGLL
                     PCLPPGARTAEGPIMVLAGPLAVSLLLPSLTLLVSHLSSSQDVSSEPSSEQQLCALSK
                     HPTVAFEDLQPWVSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQAT
                     EWASSEDTRRSCQSKGKTEEECQNYVRVLIVAGRKVFMCGTNAFSPMCTSRQVGNLSR
                     TIEKINGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQ
                     YNSKWLNEPNFVAAYDIGLFAYFFLRENAVEHDCGRTVYSRVARVCKNDVGGRFLLED
                     TWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQDLIYGVFTTNVNSIAASAVCAFNL
                     SAISQAFNGPFRYQENPRAAWLPIANPIPNFQCGTLPETGPNENLTERSLQDAQRLFL
                     MSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTASRS
                     LHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQGACL
                     GARDPYCGWDGKQQRCSTLEDSSNMSLWTQNITACPVRNVTRDGGFGPWSPWQPCEHL
                     DGDNSGSCLCRARSCDSPRPRCGGLDCLGPAIHIANCSRNGAWTPWSSWALCSTSCGI
                     GFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCPVPIFWASWGSWSKCSSNCGG
                     GMQSRRRACENGNSCLGCGVEFKTCNPEGCPEVRRNTPWTPWLPVNVTQGGARQEQRF
                     RFTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDALVEVLLRSGSTSPHTVSGGW
                     AAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQACPVRGAWS
                     CWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCATQACPEGWSPWS
                     EWSKCTDDGAQSRSRHCEELLPGSSACAGNSSQSRPCPYSEIPVILPASSMEEATDCA
                     GFNLIHLVATGISCFLGSGLLTLAVYLSCQHCQRQSQESTLVHPATPNHLHYKGGGTP
                     KNEKYTPMEFKTLNKNNLIPDDRANFYPLQQTNVYTTTYYPSPLNKHSFRPEASPGQR
                     CFPNS"
     exon            463..666
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            667..766
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            767..812
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            813..875
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            876..974
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1188
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1474
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1610
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1818
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..2026
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2144
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2326
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2470
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2618
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2844
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..3063
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            3064..3234
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3384
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3429
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            3430..3635
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..4855
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4722..4727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /note="hexamer: ATTAAA"
     polyA_site      4741
                     /gene="SEMA5B"
                     /gene_synonym="SEMAG; SemG"
                     /note="major polyA site"
ORIGIN      
        1 ctccctgctc tctccgagcg ccgggtcggg agctagttgg agcgcggggg ttggtgccag
       61 agcccagctc cgccgagccg ggcgggtcgg cagcgcatcc agcggctgct gggagcccga
      121 gcgcagcggg cgcgggcccg ggtggggact gcaccggagc gctgagagct ggaggccgtt
      181 cctgcgcggc cgccccattc ccagaccggc cgccagccca tctggttagc tcccgccgct
      241 ccgcgccgcc cgggagtcgg gagccgcggg gaaccgggca cctgcacccg cctctgggag
      301 tgagtggttc cagctggtgc ctggcctgtg tctcttggat gccctgtggc ttcagtccgt
      361 ctcctgttgc ccaccacctc gtccctgggc cgcctgatac cccagcccaa cagctaaggt
      421 gtggatggac agtagggggc tggcttctct cactggtcag gggtcttctc ccctgtctgc
      481 ctcccggagc taggactgca gaggggccta tcatggtgct tgcaggcccc ctggctgtct
      541 cgctgttgct gcccagcctc acactgctgg tgtcccacct ctccagctcc caggatgtct
      601 ccagtgagcc cagcagtgag cagcagctgt gcgcccttag caagcacccc accgtggcct
      661 ttgaagacct gcagccgtgg gtctctaact tcacctaccc tggagcccgg gatttctccc
      721 agctggcttt ggacccctcc gggaaccagc tcatcgtggg agccaggaac tacctcttca
      781 gactcagcct tgccaatgtc tctcttcttc aggccacaga gtgggcctcc agtgaggaca
      841 cgcgccgctc ctgccaaagc aaagggaaga ctgaggagga gtgtcagaac tacgtgcgag
      901 tcctgatcgt cgccggccgg aaggtgttca tgtgtggaac caatgccttt tcccccatgt
      961 gcaccagcag acaggtgggg aacctcagcc ggactattga gaagatcaat ggtgtggccc
     1021 gctgccccta tgacccacgc cacaactcca cagctgtcat ctcctcccag ggggagctct
     1081 atgcagccac ggtcatcgac ttctcaggtc gggaccctgc catctaccgc agcctgggca
     1141 gtgggccacc gcttcgcact gcccaatata actccaagtg gcttaatgag ccaaacttcg
     1201 tggcagccta tgatattggg ctgtttgcat acttcttcct gcgggagaac gcagtggagc
     1261 acgactgtgg acgcaccgtg tactctcgcg tggcccgcgt gtgcaagaat gacgtggggg
     1321 gccgattcct gctggaggac acatggacca cattcatgaa ggcccggctc aactgctccc
     1381 gcccgggcga ggtccccttc tactataacg agctgcagag tgccttccac ttgccggagc
     1441 aggacctcat ctatggagtt ttcacaacca acgtaaacag catcgcggct tctgctgtct
     1501 gcgccttcaa cctcagtgct atctcccagg ctttcaatgg cccatttcgc taccaggaga
     1561 accccagggc tgcctggctc cccatagcca accccatccc caatttccag tgtggcaccc
     1621 tgcctgagac cggtcccaac gagaacctga cggagcgcag cctgcaggac gcgcagcgcc
     1681 tcttcctgat gagcgaggcc gtgcagccgg tgacacccga gccctgtgtc acccaggaca
     1741 gcgtgcgctt ctcacacctc gtggtggacc tggtgcaggc taaagacacg ctctaccatg
     1801 tactctacat tggcaccgag tcgggcacca tcctgaaggc gctgtccacg gcgagccgca
     1861 gcctccacgg ctgctacctg gaggagctgc acgtgctgcc ccccgggcgc cgcgagcccc
     1921 tgcgcagcct gcgcatcctg cacagcgccc gcgcgctctt cgtggggctg agagacggcg
     1981 tcctgcgggt cccactggag aggtgcgccg cctaccgcag ccagggggca tgcctggggg
     2041 cccgggaccc gtactgtggc tgggacggga agcagcaacg ttgcagcaca ctcgaggaca
     2101 gctccaacat gagcctctgg acccagaaca tcaccgcctg tcctgtgcgg aatgtgacac
     2161 gggatggggg cttcggccca tggtcaccat ggcaaccatg tgagcacttg gatggggaca
     2221 actcaggctc ttgcctgtgt cgagctcgat cctgtgattc ccctcgaccc cgctgtgggg
     2281 gccttgactg cctggggcca gccatccaca tcgccaactg ctccaggaat ggggcgtgga
     2341 ccccgtggtc atcgtgggcg ctgtgcagca cgtcctgtgg catcggcttc caggtccgcc
     2401 agcgaagttg cagcaaccct gctccccgcc acgggggccg catctgcgtg ggcaagagcc
     2461 gggaggaacg gttctgtaat gagaacacgc cttgcccggt gcccatcttc tgggcttcct
     2521 ggggctcctg gagcaagtgc agcagcaact gtggaggggg catgcagtcg cggcgtcggg
     2581 cctgcgagaa cggcaactcc tgcctgggct gcggcgtgga gttcaagacg tgcaaccccg
     2641 agggctgccc cgaagtgcgg cgcaacaccc cctggacgcc gtggctgccc gtgaacgtga
     2701 cgcagggcgg ggcacggcag gagcagcggt tccgcttcac ctgccgcgcg ccccttgcag
     2761 acccgcacgg cctgcagttc ggcaggagaa ggaccgagac gaggacctgt cccgcggacg
     2821 gctccggctc ctgcgacacc gacgccctgg tggaggtcct cctgcgcagc gggagcacct
     2881 ccccgcacac ggtgagcggg ggctgggccg cctggggccc gtggtcgtcc tgctcccggg
     2941 actgcgagct gggcttccgc gtccgcaaga gaacgtgcac taacccggag ccccgcaacg
     3001 ggggcctgcc ctgcgtgggc gatgctgccg agtaccagga ctgcaacccc caggcttgcc
     3061 cagttcgggg tgcttggtcc tgctggacct catggtctcc atgctcagct tcctgtggtg
     3121 ggggtcacta tcaacgcacc cgttcctgca ccagccccgc accctcccca ggtgaggaca
     3181 tctgtctcgg gctgcacacg gaggaggcac tatgtgccac acaggcctgc ccagaaggct
     3241 ggtcgccctg gtctgagtgg agtaagtgca ctgacgacgg agcccagagc cgaagccggc
     3301 actgtgagga gctcctccca gggtccagcg cctgtgctgg aaacagcagc cagagccgcc
     3361 cctgccccta cagcgagatt cccgtcatcc tgccagcctc cagcatggag gaggccaccg
     3421 actgtgcagg gttcaatctc atccacttgg tggccacggg catctcctgc ttcttgggct
     3481 ctgggctcct gaccctagca gtgtacctgt cttgccagca ctgccagcgt cagtcccagg
     3541 agtccacact ggtccatcct gccaccccca accatttgca ctacaagggc ggaggcaccc
     3601 cgaagaatga aaagtacaca cccatggaat tcaagaccct gaacaagaat aacttgatcc
     3661 ctgatgacag agccaacttc tacccattgc agcagaccaa tgtgtacacg actacttact
     3721 acccaagccc cctgaacaaa cacagcttcc ggcccgaggc ctcacctgga caacggtgct
     3781 tccccaacag ctgataccgc cgtcctgggg acttgggctt cttgccttca taaggcacag
     3841 agcagatgga gatgggacag tggagccagt ttggttttct ccctctgcac taggccaaga
     3901 acttgctgcc ttgcctgtgg ggggtcccat ccggcttcag agagctctgg ctggcattga
     3961 ccatggggga aagggctggt ttcaggctga catatggccg caggtccagt tcagcccagg
     4021 tctctcatgg ttatcttcca acccactgtc acgctgacac tatgctgcca tgcctgggct
     4081 gtggacctac tgggcatttg aggaattgga gaatggagat ggcaagaggg caggctttta
     4141 agtttgggtt ggagacaact tcctgtggcc cccacaagct gagtctggcc ttctccagct
     4201 ggccccaaaa aaggcctttg ctacatcctg attatctctg aaagtaatca atcaagtggc
     4261 tccagtagct ctggattttc tgccagggct gggccattgt ggtgctgccc cagtatgaca
     4321 tgggaccaag gccagcgcag gttatccacc tctgcctgga agtctatact ctacccaggg
     4381 catccctctg gtcagaggca gtgagtactg ggaactggag gctgacctgt gcttagaagt
     4441 cctttaatct gggctggtac aggcctcagc cttgccctca atgcacgaaa ggtggcccag
     4501 gagagaggat caatgccata ggaggcagaa gtctggcctc tgtgcctcta tggagactat
     4561 cttccagttg ctgctcaaca gagttgttgg ctgagacctg cttgggagtc tctgctggcc
     4621 cttcatctgt tcaggaacac acacacacac acactcacac acgcacacac aatcacaatt
     4681 tgctacagca acaaaaaaga cattgggctg tggcattatt aattaaagat gatatccagt
     4741 ctccaaatgt ctctgtgcat ctgtgcgtgg gctcctcttg catagtctag gcaatctgag
     4801 caatgcacca gggtggcaga tggtctctca aggcggggga aatgccccaa gtagc
//
