LOCUS       NM_003966              11755 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens semaphorin 5A (SEMA5A), mRNA.
ACCESSION   NM_003966
VERSION     NM_003966.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11755)
  AUTHORS   Ye,Q., Liu,S., Lin,S. and Xie,W.
  TITLE     Circular RNA circSEMA5A facilitates colorectal cancer development
            by regulating microRNA-195-5p to target CCNE1 axis
  JOURNAL   Cell Signal 107, 110649 (2023)
   PUBMED   37164546
  REMARK    GeneRIF: Circular RNA circSEMA5A facilitates colorectal cancer
            development by regulating microRNA-195-5p to target CCNE1 axis.
REFERENCE   2  (bases 1 to 11755)
  AUTHORS   Wang,K., He,M., Fan,X., Zhou,J., Yang,J., Wang,L., Zhao,Z., Dai,C.
            and Zhang,Z.
  TITLE     SEMA5A-PLXNB3 Axis Promotes PDAC Liver Metastasis Outgrowth through
            Enhancing the Warburg Effect
  JOURNAL   J Immunol Res 2023, 3274467 (2023)
   PUBMED   36741230
  REMARK    GeneRIF: SEMA5A-PLXNB3 Axis Promotes PDAC Liver Metastasis
            Outgrowth through Enhancing the Warburg Effect.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11755)
  AUTHORS   Cheng,Q., Chen,M., Liu,M., Chen,X., Zhu,L., Xu,J., Xue,J., Wu,H.
            and Du,Y.
  TITLE     Semaphorin 5A suppresses ferroptosis through activation of
            PI3K-AKT-mTOR signaling in rheumatoid arthritis
  JOURNAL   Cell Death Dis 13 (7), 608 (2022)
   PUBMED   35835748
  REMARK    GeneRIF: Semaphorin 5A suppresses ferroptosis through activation of
            PI3K-AKT-mTOR signaling in rheumatoid arthritis.
            Erratum:[Cell Death Dis. 2023 Mar 14;14(3):196. doi:
            10.1038/s41419-023-05697-0.. PMID: 36918551]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11755)
  AUTHORS   Karatas,K.S., Bahceci,I., Telatar,T.G., Bahceci,B. and Hocaoglu,C.
  TITLE     Relationship between disease and disease severity and semaphorin 5A
            and hemogram level in obsessive-compulsive disorder
  JOURNAL   Nord J Psychiatry 75 (7), 509-515 (2021)
   PUBMED   33771090
  REMARK    GeneRIF: Relationship between disease and disease severity and
            semaphorin 5A and hemogram level in obsessive-compulsive disorder.
REFERENCE   5  (bases 1 to 11755)
  AUTHORS   Lobna,M., Nasren,E., Adi,S., Jacob,B., Maria,G.A., Marcus,M. and
            Zahava,V.
  TITLE     The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked
            to Semaphorin5A
  JOURNAL   Biomolecules 11 (3), 373 (2021)
   PUBMED   33801296
  REMARK    GeneRIF: The Expression of IL-17, in Chronic Spontaneous Urticaria
            Is Linked to Semaphorin5A.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11755)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 11755)
  AUTHORS   Artigiani,S., Conrotto,P., Fazzari,P., Gilestro,G.F., Barberis,D.,
            Giordano,S., Comoglio,P.M. and Tamagnone,L.
  TITLE     Plexin-B3 is a functional receptor for semaphorin 5A
  JOURNAL   EMBO Rep 5 (7), 710-714 (2004)
   PUBMED   15218527
  REMARK    GeneRIF: Plexin-B3 is a functional receptor for semaphorin 5A
REFERENCE   8  (bases 1 to 11755)
  AUTHORS   Simmons,A.D., Puschel,A.W., McPherson,J.D., Overhauser,J. and
            Lovett,M.
  TITLE     Molecular cloning and mapping of human semaphorin F from the
            Cri-du-chat candidate interval
  JOURNAL   Biochem Biophys Res Commun 242 (3), 685-691 (1998)
   PUBMED   9464278
REFERENCE   9  (bases 1 to 11755)
  AUTHORS   Simmons,A.D., Overhauser,J. and Lovett,M.
  TITLE     Isolation of cDNAs from the Cri-du-chat critical region by direct
            screening of a chromosome 5-specific cDNA library
  JOURNAL   Genome Res 7 (2), 118-127 (1997)
   PUBMED   9049630
REFERENCE   10 (bases 1 to 11755)
  AUTHORS   Adams,R.H., Betz,H. and Puschel,A.W.
  TITLE     A novel class of murine semaphorins with homology to thrombospondin
            is differentially expressed during early embryogenesis
  JOURNAL   Mech Dev 57 (1), 33-45 (1996)
   PUBMED   8817451
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC034214.5, AC027335.6,
            AC091906.3, AC022446.6, AC027336.4 and AC021088.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003966.2.
            
            Summary: This gene belongs to the semaphorin gene family that
            encodes membrane proteins containing a semaphorin domain and
            several thrombospondin type-1 repeats. Members of this family are
            involved in axonal guidance during neural development. This gene
            has been implicated as an autism susceptibility gene.[provided by
            RefSeq, Jan 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK307587.1, U52840.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382496.10/ ENSP00000371936.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-492               AC034214.5         88711-89202
            493-589             AC027335.6         105639-105735
            590-790             AC091906.3         159186-159386       c
            791-890             AC091906.3         117076-117175       c
            891-936             AC091906.3         97735-97780         c
            937-999             AC022446.6         156953-157015       c
            1000-1098           AC022446.6         145994-146092       c
            1099-1312           AC022446.6         143799-144012       c
            1313-1598           AC022446.6         121080-121365       c
            1599-1734           AC022446.6         116293-116428       c
            1735-1939           AC022446.6         109392-109596       c
            1940-2147           AC022446.6         73613-73820         c
            2148-2265           AC022446.6         55629-55746         c
            2266-2447           AC027336.4         86738-86919         c
            2448-2591           AC027336.4         83080-83223         c
            2592-2739           AC027336.4         72222-72369         c
            2740-2965           AC027336.4         30503-30728         c
            2966-3184           AC027336.4         26969-27187         c
            3185-3355           AC027336.4         18169-18339         c
            3356-3511           AC027336.4         15955-16110         c
            3512-3559           AC027336.4         14492-14539         c
            3560-3771           AC027336.4         8455-8666           c
            3772-9630           AC027336.4         1240-7098           c
            9631-11755          AC021088.5         72586-74710         c
FEATURES             Location/Qualifiers
     source          1..11755
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.31"
     gene            1..11755
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /note="semaphorin 5A"
                     /db_xref="GeneID:9037"
                     /db_xref="HGNC:HGNC:10736"
                     /db_xref="MIM:609297"
     exon            1..492
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            493..589
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            590..790
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     CDS             667..3891
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /note="semaphorin F; sema F; sema domain, seven
                     thrombospondin repeats (type 1 and type 1-like),
                     transmembrane domain (TM) and short cytoplasmic domain,
                     (semaphorin) 5A"
                     /codon_start=1
                     /product="semaphorin-5A precursor"
                     /protein_id="NP_003957.2"
                     /db_xref="CCDS:CCDS3875.1"
                     /db_xref="GeneID:9037"
                     /db_xref="HGNC:HGNC:10736"
                     /db_xref="MIM:609297"
                     /translation="MKGTCVIAWLFSSLGLWRLAHPEAQGTTQCQRTEHPVISYKEIG
                     PWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKK
                     ACYSKGKSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQISGMAR
                     CPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPN
                     FVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARL
                     NCSRPGEVPFYYNELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGP
                     FKYQENSRSAWLPYPNPNPHFQCGTVDQGLYVNLTERNLQDAQKFILMHEVVQPVTTV
                     PSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSSSCLLEEIEL
                     FPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTRSTCIGAQDPYCGWDV
                     VMKKCTSLEESLSMTQWEQSISACPTRNLTVDGHFGVWSPWTPCTHTDGSAVGSCLCR
                     TRSCDSPAPQCGGWQCEGPGMEIANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSN
                     PTPRHGGRVCVGQNREERYCNEHLLCPPHMFWTGWGPWERCTAQCGGGIQARRRICEN
                     GPDCAGCNVEYQSCNTNPCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADP
                     NLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSR
                     DCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCPVDGVWSCWSPWTKCSAT
                     CGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCPESWSEWSDWSECEASGVQ
                     VRARQCILLFPMGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNMFHMI
                     AVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVSPAPLNTSITNHINKLDKYDS
                     VEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY"
     exon            791..890
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            891..936
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            937..999
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1098
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1312
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1598
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1734
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1939
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2147
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2265
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2447
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2591
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2739
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2965
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3184
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3355
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3511
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3559
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3771
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            3772..11755
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5353..5358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /note="hexamer: AATAAT"
     polyA_site      5370
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /note="major polyA site"
     regulatory      11733..11738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
                     /note="hexamer: AATAAA"
     polyA_site      11755
                     /gene="SEMA5A"
                     /gene_synonym="SEMAF; semF"
ORIGIN      
        1 acttgccggg aaggcggcgc cggtggcggc tgctctccct gagcccgctc ccgagcgctg
       61 ctttcccgcc gcgggtgggc ttcgcagcct caggccagcc gcggcccttg gcccgctgca
      121 gccccggccc tccaccttcc ccgtgcaggg gcggcccggc cagtgtcgct catcccggga
      181 cgctcccttc tcccacccag gactgccccg cggagctggc ttggacaccc aactttgcca
      241 cctcgagggt cgtctctgct gggcgcgaac ctgcccaccc accggttggc cgcgcgctcg
      301 gggaccgtgc tcgtggcccc caagccggtg cccccattct ggaactcagc gagtaggggg
      361 cggctctggg gaagtggcag ggggcggctg cagctgctgc ctccacttcc ctagccaggt
      421 gctgaagagg atcctcggag ccgctctggc ccccaggcgc tggatgactg gcaccagcgc
      481 tcctcgcacc tgtgttggtg tgtgagactt gggctggagt gcccacgtgg ctgtggagtc
      541 agtgtgattc atgattgagg aaacgcgtcc tccatcctct ctctccttgg cactttccac
      601 acatgaggag aagaagagct tctgtttaga agacacgtgc ccagagtcag aggccccttg
      661 cccaccatga agggaacctg tgttatagca tggctgttct caagcctggg gctgtggaga
      721 ctcgcccacc cagaggccca gggtacgact cagtgccaga gaaccgagca tccagtcatc
      781 tcctataaag aaattggccc ctggttacgg gagttcagag cgaagaatgc tgtggatttc
      841 tcgcagttaa catttgaccc aggacagaaa gaacttgttg taggagcaag aaactacctc
      901 ttcaggttac agcttgagga tctgtctctt atccaggctg tggaatggga gtgtgatgaa
      961 gctaccaaaa aggcctgtta cagcaaaggc aaatcaaagg aggaatgtca gaactacatc
     1021 cgggtgcttc tggtgggtgg cgaccggtta ttcacctgtg ggaccaatgc attcacgcct
     1081 gtctgcacca accgctcgtt gagcaacctg actgagatcc atgatcagat cagtggcatg
     1141 gcccgctgtc cctacagtcc ccagcacaat tccacagcgc tcctcacagc tggtggggag
     1201 ctctatgctg ctacagccat ggattttcca ggacgtgatc ctgccattta ccgaagccta
     1261 ggcattttac ctcctctccg cacggcgcag tacaactcca aatggctcaa tgagccaaac
     1321 tttgtgtcat cttatgacat cggaaatttt acctacttct ttttccgaga aaatgcagta
     1381 gagcatgact gtgggaaaac agtgttctcc agagctgccc gggtgtgcaa gaacgatatt
     1441 ggtgggcgct tcctgctgga agacacctgg accacattca tgaaggctcg cctgaactgc
     1501 tcccgtcctg gggaagtccc cttttactac aacgaattgc agagtacttt cttcctgcct
     1561 gagctggatt tgatctatgg catctttacc accaatgtga acagcattgc ggcctcagct
     1621 gtgtgcgtct tcaacctgag cgccatcgcg caggccttct ctgggccctt caagtaccaa
     1681 gaaaactcgc gctcggcctg gctaccgtat cccaacccaa acccccactt ccagtgtggc
     1741 accgtggacc agggcctgta cgtgaacctg accgagagaa atctgcagga tgctcagaag
     1801 ttcattctga tgcatgaggt ggtacagcca gtgaccacag tgccctcctt catggaggac
     1861 aatagccgct tttcccacgt ggcagtcgac gtggtgcagg gcagagaagc gctcgtccac
     1921 atcatctatt tggccacaga ttacggaacc attaagaaag tgcgggtacc cctgaatcag
     1981 acctcaagca gctgtttgct ggaagagatt gagctcttcc ctgagaggcg gagggagccc
     2041 atcaggagcc tgcagatcct gcacagccag agtgtcctgt tcgtgggcct gcgggagcac
     2101 gtggtcaaga tccccctgaa gaggtgccag ttctaccgca cacgcagcac ctgcattggg
     2161 gcccaggacc cttactgtgg ctgggatgtg gtaatgaaga aatgcacaag cctggaggag
     2221 agcctgagca tgacgcagtg ggaacagagc atctctgcgt gtccgaccag gaatctcacc
     2281 gtggatgggc actttggtgt gtggtctccg tggacgcctt gcacgcacac agatggcagc
     2341 gccgtgggat cctgcctctg tcgaacccgc tcctgcgaca gcccggcccc gcagtgtggt
     2401 ggctggcagt gcgagggccc tggcatggag atcgccaact gttccaggaa cggaggctgg
     2461 actccctgga cctcgtggtc tccctgcagc actacctgtg ggatcggctt ccaggtgcgg
     2521 cagcgctcct gcagcaaccc cactcccagg cacgggggcc gggtgtgcgt gggacagaac
     2581 cgcgaggaaa gatactgcaa tgaacatttg ctatgtcccc cacacatgtt ctggacaggc
     2641 tggggtcctt gggaacggtg cacagcccaa tgcgggggtg gcattcaagc tcgccgcagg
     2701 atctgtgaga atgggcctga ctgtgcaggc tgcaatgtgg agtaccagtc ttgcaacacc
     2761 aacccgtgtc ctgagctgaa gaagaccacg ccctggacac cctggacacc tgtcaacatc
     2821 tctgacaacg gcggccacta tgagcaacga ttccgataca catgcaaagc ccgcctggct
     2881 gatccgaatt tgctggaagt gggaagacag agaatcgaaa tgcggtactg ttctagcgac
     2941 ggcaccagtg gctgctccac agatgggctt tctggggatt tcctgcgtgc tgggagatac
     3001 tctgcccaca cggtcaacgg ggcttggtca gcctggacgt cgtggtcaca gtgcagccgt
     3061 gactgcagca ggggcattcg gaaccggaag cgtgtttgca acaaccccga acccaagtat
     3121 gggggaatgc cttgccttgg cccatctctg gaataccagg aatgcaacat tttgccctgc
     3181 ccagtggatg gcgtgtggtc ttgctggtcc ccctggacaa aatgttcagc aacatgcggc
     3241 ggtggacact atatgaggac ccgctcttgc tccaatccag ccccggccta tggaggggac
     3301 atctgcctgg ggctgcacac agaagaggca ctctgcaaca cgcagccctg cccagagagc
     3361 tggtcggagt ggtcggactg gtctgagtgt gaagcctctg gcgtccaagt ccgcgcccgc
     3421 cagtgcatcc tcctgttccc catgggcagc cagtgctccg ggaacaccac ggagagccgg
     3481 ccgtgtgtgt ttgactctaa tttcatccca gaagtatctg tggcaagatc cagtagcgta
     3541 gaagagaaaa ggtgtggaga gttcaacatg ttccacatga tcgccgtggg gctgagcagc
     3601 tccatcctcg gctgcctcct caccctgctc gtctatactt actgccagcg gtaccagcag
     3661 caatcccacg atgcgactgt catccacccc gtctcacctg ccccccttaa taccagcata
     3721 accaaccaca tcaacaaact ggacaagtac gactcggtgg aggccatcaa ggcatttaac
     3781 aaaaacaact tgatcctaga ggaaagaaac aaatacttca acccacatct cactgggaag
     3841 acctattcta atgcctactt tacagatctc aataattatg atgagtacta acagctttca
     3901 tgtttttggc ttcttgtaaa tccccagttc ctcaaggcct gtgccccatg actgcccatg
     3961 tttctgaggc ttcagagtcg aagtttggat acatttcaag tgcatttcaa gccaccagag
     4021 tgtcccattg ctgccaaaaa tacacgtctt taaaagcaac aaaaattgaa ataagacatc
     4081 gtgaaaatct tgaccattgt tgaatgagcc agggtgtgaa gtttttaatt gtgttcatcc
     4141 tatttttctg acaagtccat tggtttgttt tttgagcatt attttataaa tgtgccaccc
     4201 acattggaag gagtctttct ttagaacttt ggagtgtaaa tcttcatgat gttgtaattc
     4261 aagaaaatag gcactttctc tgaaagacct gctccttcca caagaagtgc ataggtccat
     4321 aatatttcat aaaatgaaga aaaagaatgt ggccaaacaa ttattcacca tggattgccc
     4381 aactttccaa atctggataa agctgtggga ttcttggaag cagcttgagt gttttcatct
     4441 tgcctgggaa gcccaggaat tccacctggt ccacaccggc agaagttaca gtagactgtg
     4501 aggcacccca ccttgctcct gatgcagttt ctgtgccatt gctggtgctg gtggaggcag
     4561 cggagcagag gctcaggcac aatgaagcgt ggatgtgttc tgcaggttgc tgcaaaactc
     4621 accttattct gacttttgga tttcatggca ttccaggaag ctccttgcca tgctgttggc
     4681 ctggaagtcc acctgtctgg tccatagtga cgtcctgaag agccagtctg taaaataacc
     4741 aaccacttac ttagcgtttg gatagactcc atgccttctc tctccctgca aagaaaaatc
     4801 ttgaacattt atgatgtcaa ttagtgaaag tattgaaaat actaaattat aactaaaagc
     4861 aactttttat gttattgaaa atattgaaag aactgatatt aatgataatc attttatttt
     4921 tcatctctct gatataccca atgtgtggca atcagcccct accacgagca ttaataccat
     4981 gtaaagctgg ctttctggag tctgccaggt ccacacgaag tgctaccccc agtttctgct
     5041 gttacttgct gcctccaggc caggggagca ggagatgctc agctctggtg ccttttcttt
     5101 tatttcagtg ctgccttccc acccacccag tccattcacc ctcacctctc cctgcatgga
     5161 ggcaacagca tttcaagatg taccttggga agtcaggata gctggaagta agggtttttg
     5221 ggatccctgt ggtctcttca ctgatcatcg ataagcattt aagagtgtgc taacaccatt
     5281 cacagaggtc cctggaaaaa aatatataat tttctcacaa acaaccaata cataacctat
     5341 ggcagttggt tgaataatta ttgaaaaaaa gaacacgact gaaaaagttc atctgatgcc
     5401 tctgagcatg tgataaagtc ctgggtagac acggaaacgt gttcttacaa atgaaccttc
     5461 ggatctatga aagaaaatat agtaggggga ctaaggaaca tagaatttta ttagcatatg
     5521 tgattttacc cttatctttg tttctaattt aaagaaacaa tttcagaaag tgttagaaga
     5581 attctatgtt taataatgaa tattgttgag ttcaaaatat tctcatatac ccagatttac
     5641 agagatgaca cagtattgaa atggcaggtg ggctctgtaa gttattttgg attaatgaca
     5701 ttcagggtct ttgcagtggg gacttcatgt tgcctctcac tcattcctca tatgtcagag
     5761 tcttctgtct atatgcacat gctcaaagtc catactcagt aggggaaatc tagccggatg
     5821 gttctccaat tgttcctcgg ctggattttc atcatcagat atttcaactc atctcatcag
     5881 tttcttgtaa gaaaaaaaca ttttcacttt gtagcacatt ttagttattt ttgagtcttc
     5941 ttccctaata gtttgtaagc ttaaagggac attttatttt ccctggtaaa gaggattcta
     6001 atatttcaag aatgtttcac tggaattgat gggaaatggt ttctaaatgg catcgaagct
     6061 ggtctttaat gagtcttttg caatgacttg ggaaaaacac cctccctcac tacaggatct
     6121 tcatgttgtt aataatataa acaaaccttt gaaattagca ttgcaaaaga atcccatttt
     6181 tgtttcgtac cacactgttc aaaggaaaat tgtttatctc tcttcctttc tctctctctc
     6241 ttatttgaca gaatagcaag tgtttagata atttcagata tattctaagt attttaccag
     6301 ctgtggaata agttgtgttt gtccatcact gtgtagctac cgttcacatg ttctggctct
     6361 gtactccacg cttatcgcgt gaaccctcac atgttggact ttcacagtgt gatctctcac
     6421 ctgtcttgga aactccttca taaagccgct cttccttagg cctgggctgt ttggaagtcc
     6481 tggtgaaact ttgcggttca cattttaaat tcctgaatga ccttttcatt ctctctttct
     6541 ttatctttgt ttttgtcctt cattccctcc ttttgttctt ccttcctgcc ttcttttctt
     6601 ctttcctttc ttctttcttt aattcttcct ttcttcctat tttcttggta caagtggaac
     6661 aaaaaccaac acatagtttt aagctacacc tttctgcacc tgatgtaaaa tgacattaat
     6721 cactatttaa cttctaaaat tatttctgaa tacagttgga gataggctgg ttttcatgag
     6781 gaagctggct tggctttagt cttacattta aattctttga aagtggctcc cagtgctatt
     6841 cagggtcctt tcttgaggcc agactcatca ccatctacta ttgattttac agtgcactga
     6901 cagtttacag gaaggagaag aacagaattt ctgcacacta cacaacatgt gggcttcctg
     6961 tagctccagg gacatgtagc tttggtgaaa ctggggtttt gtaacctctg aatgatatgg
     7021 acttagtgaa ttctaaggaa ctcagggggc acgtggtcag gctccaccgc acagaagagc
     7081 cacagtctcc agactcatgg cgttccctcc agaactcccc attcccctct gagcatattt
     7141 ctatgctgct gcttcttgtg acttacatga ggcatctcag cttcttcatg tttgtaggga
     7201 tggttcccta agcctgttca agtaggctct cactagagtt accattcata tttgagaaga
     7261 aaagaacatt taataaatgt atgtgtgggg ctgaggttct aaaggaattg aaaagagacg
     7321 ataaacattg aatgagggtg agggcatccc tgctggggag aaacctctgt ccctaggaag
     7381 agtccgttca tgtcatgtgg tttgggatga accaggggtc tggccccatc gggtcacagg
     7441 tgatggcaaa tagaaaagaa gcaaatggag gaaatagtcg gataagtagg tgacgtgaaa
     7501 ggcaggacct ggtcacccca gcaagtgcta tggacagttc ccggaaacgg ttgcccactt
     7561 cacaggtcca tgggtctgac ccttggactc tgccaggatc aactgcccag agtgccagag
     7621 ttttagccaa aggtgtactt acttccttat ttatctgcaa aaggatggaa actgtgggag
     7681 tcaaagccta ttttgctgag tgttcccact ggagtctctg gtagaattag caggtcatgc
     7741 tgtcaaaatc atggacaaag gctgggtgca gtggctcatg cctataatcc cagcactttg
     7801 ggaggccaag gtgggcggat cacctgagct caggagtttg agaccagcct gggcaacatg
     7861 gggaaactcc atctctacaa aatatacaaa atattagcca gccatcgtgg tgcgtgcctg
     7921 tggtcccagt ttcttgggag gctgaggcgg gagtatcatt tgagccagga ggttgaggtt
     7981 gcagtgagct gagatcacat cactgcactc catcctgggt gacagagaga gaccctgtct
     8041 caaaaaaaaa aaaaaagaac aaagtcttag cggggggtct ctatgtcccc aagtggctct
     8101 ctaaggggat ccattagcgt ataattgaat atcaaaggga attttacctt aaacatatat
     8161 caagtctata ctcagctaat cgttttgtct aaacacagcc ttgttagcat ttgaatttac
     8221 aaatattcat ttgcttattt gcagtgttcc ttttgctttt agaataaatc ataaatattt
     8281 ccccaatact gtcaagatac ttcttcaact ttgtccctga accatcagct ttctttaggg
     8341 tccgggtatc ctttacactt caatggggtt ttcttgtgtg tgtcattggg ggtaactcca
     8401 ttgacctcag catttctatc tcaagagatg gctctggaac acagaaccag aggcaacagg
     8461 tactaatggt tgataaaatt aacagcgact gcataaccat tttccacatg gcagggctgt
     8521 gcttaagccc cacacctcca ataatcaatt tctatgacgg tactaataac cttaactata
     8581 tgcaaattct tcaccactta tgatatggta caaactggag tttacagatg gccttggcct
     8641 tgcctagccc atttgttcat cctaacttct tcatcacttc ctgatgcact tggggaagca
     8701 tgttgacaca acgttaccaa tatttgatta cctatggtta tctgcaatta cctacgctta
     8761 tcttatcaga ccctagatgc catttgagcc ccttacttct ttgggcagtg ggtgaaatgg
     8821 gagaacatag agaaatgttc actttgacct aagaaacgca taaaagggaa tgccatgcac
     8881 aatgtaagat aaaatgtttg gggacagggg atcatcgtga aatttatttc tgctattctg
     8941 ccctattgag gtcattaatt ataatggatt taaagatttt tttttaaact ctacaaacac
     9001 taagccaagg aattcaggtt atctgctatg ttaacctaat aaagcaaagg aaaataagtt
     9061 gctttaatcc ttgcttgtta acctaataaa gcaaaggaaa atatgttgct ttaatccttg
     9121 cttcttttct cttttggtaa tagaaaaggt aaataagatg taatgttgaa ctgctggtga
     9181 tgatttctaa aacgactctt taaatactcc tttcctatgg acttatatta aagatgcatt
     9241 gtacacattg ttttagcaga tagatcaaag atatactcag tggtcatctg ttgcattatc
     9301 agaaatttga tacatgttac agaagcatga ggaagggaat cctatccact tttgaaaata
     9361 gagttcacat tgcaagcgac atagggcatt atcaaaacca attcagagcc tggcacaaaa
     9421 tgtatacttc ctagtgaaag ctgtctcaaa acacagcctt tttgatggat catattagct
     9481 catatctgcc atagaaaggc aatcaagctt actccctgca atcggagtca atatcaattc
     9541 ttgctcaagc aaacatgttt tacagtgttg gcgcaatggc aggaactagt caagggcact
     9601 ttcagatctg gaaagaggaa agaggaggta gaaaatcact cttttgtgtt tcttaaactg
     9661 tcaatcaagc aagaaaattt attccacccc ttcatatttg ctctaaaatc tggggccagt
     9721 agttgaaatg tgatcttgtt ctttctcagc cttttggcaa tttaatgcca aatattccaa
     9781 atgttagatg aatggcagta ataaaatgat tcaaatgttt gataaataca agctgagagc
     9841 aaaatctgga ctctgaaaaa tcggaactat tttatcatgt tgctaaaatg agagcatcat
     9901 tttcttccct ctctgtaagt gcggtagttt aatttcctag aaaaagttgc tagtgccttg
     9961 tttaagatga tcatttatca tttcatgtgg atattattgg tctaattaga aggagaagat
    10021 tgattggatt tactttaaag aaaattattc tcctatgtct ctttgaactc aggaatagaa
    10081 aatgaccaag aagcacatca tcttcagatg tgatttttgc cctcactggg gatgtagaac
    10141 cagaataggt acaacatatg ctcagaagag aggtgacttc agtattagcc ttctagaaac
    10201 taacatcact ttaattttta catgttccaa aaaaaatcat agtgattgtt ctgtaataag
    10261 aatgttaacg tgatgcctat agaagttaga ggtttttgtt tctgtttctc ttcaggcaag
    10321 tccatagata gaggaaaatc agacacaggc tggtgacaac tggtatagat acagtgagca
    10381 tggaatgaga accacctaca acattgcctg attattttta agtttatatc aaaactgctt
    10441 cacaagttca caaaagttgt cactcttaat ttgggttaag aaaagtaata gtattatctc
    10501 tgctgaagtt gattgttttt ctcttttacc atgactgttg gccaaaagca agctgaacct
    10561 ctgcactttg aaacaaagca cagtatgaat ctttaaccca agcacttagt ttcaccactg
    10621 agattctaca tcatctgcaa gaaaatgcac aaacttttgg tccaatgttg gattcttcaa
    10681 aagtgcatag caaaactttt gtgctatgcc gcttgatgta acttttaaag atgttatcaa
    10741 atgttaaatg cctcattctg cgttaatttg ctgttggctg ttttgtgaac acaaaataaa
    10801 cttgagattt tttttttttt ttttttttgt gaaactcctc caaagccaat ttcagccctt
    10861 ggtaagcttg cagacagtta ctgatcttaa atttaatttt aaaagacaat gtatcttaat
    10921 tataatttag ctttttaaaa caatgagata gctttacatt tcccctttgt ttgaatgaga
    10981 aaatggatct tgggttgcta tgctagaaca cttgtagatt gctgggtcct ttgtaagggg
    11041 gccatggaca caccacactt tctttcaatc cttacatttg aagcattgat attcttcaaa
    11101 accttcttgt tacatgtgcg caatagaaat ttctaatgtt catgactttt atctttcctg
    11161 tccatcaatt cactggttgt aaatgcttcc tgagagctgt ctaggtctgt atcccagatt
    11221 gttgcttaat gacatctgac agatgcattg ttttctgaaa tcagcttaag acaccaattg
    11281 tggcaactgg aaactcatta cctgctgcat tggatcaact atggaagttg gagcaggggt
    11341 gggcggaggt cacctaacca atcaatggaa ggcaactcac acctgctcca agcctcagct
    11401 ttgagaaaca aacacgttta taagaaaaaa tatatagcta ttattacaga agtgaatatg
    11461 ttgtgctctc ttactgctct tggtgcattg acagtttctg tatctcaacc ctattcatct
    11521 ttatgaaaaa gcattctgaa gatctatcct cagcactgct gagtgtgcag tcacactttc
    11581 ctaccaaccc ccttcttacc atctctagct gccatttgtg gggggaacaa aacaagggaa
    11641 tcctgattgt gtacagtata aattgtatta tattttttgt acttatgttt tatgtaaata
    11701 gtttgtctca ttcaattgta tgtgagcatt gaaataaatc ctaccattta gggga
//
