LOCUS       NM_017893               4489 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens semaphorin 4G (SEMA4G), transcript variant 1, mRNA.
ACCESSION   NM_017893
VERSION     NM_017893.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4489)
  AUTHORS   Shen,Z., Sun,Y. and Niu,G.
  TITLE     Variants in TPO rs2048722, PTCSC2 rs925489 and SEMA4G rs4919510
            affect thyroid carcinoma susceptibility risk
  JOURNAL   BMC Med Genomics 16 (1), 19 (2023)
   PUBMED   36737753
  REMARK    GeneRIF: Variants in TPO rs2048722, PTCSC2 rs925489 and SEMA4G
            rs4919510 affect thyroid carcinoma susceptibility risk.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4489)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4489)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4489)
  AUTHORS   Wu,S., Yuan,W., Shen,Y., Lu,X., Li,Y., Tian,T., Jiang,L.,
            Zhuang,X., Wu,J. and Chu,M.
  TITLE     The miR-608 rs4919510 polymorphism may modify cancer susceptibility
            based on type
  JOURNAL   Tumour Biol 39 (6), 1010428317703819 (2017)
   PUBMED   28653886
  REMARK    GeneRIF: These findings provide evidence that the miR-608 rs4919510
            polymorphism may modify cancer susceptibility in a type-specific
            manner. Furthermore, SEMA4G may function as an oncogene or tumour
            suppressor to regulate tumour development in a type-specific
            manner. Further studies with experimental evaluations are
            warranted.
REFERENCE   5  (bases 1 to 4489)
  AUTHORS   Horikawa,Y., Wood,C.G., Yang,H., Zhao,H., Ye,Y., Gu,J., Lin,J.,
            Habuchi,T. and Wu,X.
  TITLE     Single nucleotide polymorphisms of microRNA machinery genes modify
            the risk of renal cell carcinoma
  JOURNAL   Clin Cancer Res 14 (23), 7956-7962 (2008)
   PUBMED   19047128
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 4489)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4489)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   8  (bases 1 to 4489)
  AUTHORS   Pasterkamp,R.J. and Kolodkin,A.L.
  TITLE     Semaphorin junction: making tracks toward neural connectivity
  JOURNAL   Curr Opin Neurobiol 13 (1), 79-89 (2003)
   PUBMED   12593985
  REMARK    Review article
REFERENCE   9  (bases 1 to 4489)
  AUTHORS   Dickson,B.J.
  TITLE     Molecular mechanisms of axon guidance
  JOURNAL   Science 298 (5600), 1959-1964 (2002)
   PUBMED   12471249
  REMARK    Review article
            Erratum:[Science. 2003 Jan 24;299(5606):515]
REFERENCE   10 (bases 1 to 4489)
  AUTHORS   Holtmaat,A.J., De Winter,F., De Wit,J., Gorter,J.A., da Silva,F.H.
            and Verhaagen,J.
  TITLE     Semaphorins: contributors to structural stability of hippocampal
            networks?
  JOURNAL   Prog Brain Res 138, 17-38 (2002)
   PUBMED   12432760
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133215.17.
            
            On Mar 23, 2021 this sequence version replaced NM_017893.3.
            
            Summary: Semaphorins are a large family of conserved secreted and
            membrane associated proteins which possess a semaphorin (Sema)
            domain and a PSI domain (found in plexins, semaphorins and
            integrins) in the N-terminal extracellular portion. Based on
            sequence and structural similarities, semaphorins are put into
            eight classes: invertebrates contain classes 1 and 2, viruses have
            class V, and vertebrates contain classes 3-7. Semaphorins serve as
            axon guidance ligands via multimeric receptor complexes, some (if
            not all) containing plexin proteins. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.1499729.1,
                                           SRR14038195.2065170.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000210633.4/ ENSP00000210633.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AL133215.17        52328-52415
            89-596              AL133215.17        55353-55860
            597-745             AL133215.17        55953-56101
            746-808             AL133215.17        56371-56433
            809-907             AL133215.17        60456-60554
            908-1001            AL133215.17        61119-61212
            1002-1115           AL133215.17        61351-61464
            1116-1285           AL133215.17        61673-61842
            1286-1455           AL133215.17        61926-62095
            1456-1600           AL133215.17        62672-62816
            1601-1823           AL133215.17        62946-63168
            1824-1939           AL133215.17        63402-63517
            1940-2115           AL133215.17        63646-63821
            2116-2177           AL133215.17        63992-64053
            2178-4489           AL133215.17        66129-68440
FEATURES             Location/Qualifiers
     source          1..4489
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.31"
     gene            1..4489
                     /gene="SEMA4G"
                     /note="semaphorin 4G"
                     /db_xref="GeneID:57715"
                     /db_xref="HGNC:HGNC:10735"
                     /db_xref="MIM:618991"
     exon            1..88
                     /gene="SEMA4G"
                     /inference="alignment:Splign:2.1.0"
     exon            89..596
                     /gene="SEMA4G"
                     /inference="alignment:Splign:2.1.0"
     CDS             473..3004
                     /gene="SEMA4G"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sema domain, immunoglobulin domain (Ig),
                     transmembrane domain (TM) and short cytoplasmic domain,
                     (semaphorin) 4G"
                     /codon_start=1
                     /product="semaphorin-4G isoform 1 precursor"
                     /protein_id="NP_060363.2"
                     /db_xref="CCDS:CCDS7501.1"
                     /db_xref="GeneID:57715"
                     /db_xref="HGNC:HGNC:10735"
                     /db_xref="MIM:618991"
                     /translation="MWGRLWPLLLSILTATAVPGPSLRRPSRELDATPRMTIPYEELS
                     GTRHFKGQAQNYSTLLLEEASARLLVGARGALFSLSANDIGDGAHKEIHWEASPEMQS
                     KCHQKGKNNQTECFNHVRFLQRLNSTHLYACGTHAFQPLCAAIDAEAFTLPTSFEEGK
                     EKCPYDPARGFTGLIIDGGLYTATRYEFRSIPDIRRSRHPHSLRTEETPMHWLNDAEF
                     VFSVLVRESKASAVGDDDKVYYFFTERATEEGSGSFTQSRSSHRVARVARVCKGDLGG
                     KKILQKKWTSFLKARLICHIPLYETLRGVCSLDAETSSRTHFYAAFTLSTQWKTLEAS
                     AICRYDLAEIQAVFAGPYMEYQDGSRRWGRYEGGVPEPRPGSCITDSLRSQGYNSSQD
                     LPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNIRYTHLTGTPVTTPAGPTYDLLFLGT
                     ADGWIHKAVVLGSGMHIIEETQVFRESQSVENLVISLLQHSLYVGAPSGVIQLPLSSC
                     SRYRSCYDCILARDPYCGWDPGTHACAAATTIANRSQGSRTALIQDIERGNRGCESSR
                     DTGPPPPLKTRSVLRGDDVLLPCDQPSNLARALWLLNGSMGLSDGQGGYRVGVDGLLV
                     TDAQPEHSGNYGCYAEENGLRTLLASYSLTVRPATPAPAPKAPATPGAQLAPDVRLLY
                     VLAIAALGGLCLILASSLLYVACLREGRRGRRRKYSLGRASRAGGSAVQLQTVSGQCP
                     GEEDEGDDEGAGGLEGSCLQIIPGEGAPAPPPPPPPPPPAELTNGLVALPSRLRRMNG
                     NSYVLLRQSNNGVPAGPCSFAEELSRILEKRKHTQLVEQLDESSV"
     exon            597..745
                     /gene="SEMA4G"
                     /inference="alignment:Splign:2.1.0"
     exon            746..808
                     /gene="SEMA4G"
                     /inference="alignment:Splign:2.1.0"
     exon            809..907
                     /gene="SEMA4G"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1001
                     /gene="SEMA4G"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1115
                     /gene="SEMA4G"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1285
                     /gene="SEMA4G"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1455
                     /gene="SEMA4G"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1600
                     /gene="SEMA4G"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1823
                     /gene="SEMA4G"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1939
                     /gene="SEMA4G"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2115
                     /gene="SEMA4G"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2177
                     /gene="SEMA4G"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..4489
                     /gene="SEMA4G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4467..4472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA4G"
                     /note="hexamer: AATAAA"
     polyA_site      4489
                     /gene="SEMA4G"
                     /note="major polyA site"
ORIGIN      
        1 agccgcggcc ccttcctctc gcagctggtg ctgtggggcc gcggagccgc gcgtcgctgt
       61 ctctatggcc ccggatccga gcgcaaagaa aacggacctc agaaaaccag gactagctct
      121 actgtcgggg gcagggtgac cccatcagta acctacaacc cctctagaac ttcacaactc
      181 cctctcacca tggagtttgc atttgatgca gaaaggcatg tgatccctcc ctccttctga
      241 cctcttagct ggggattcca tggccacaca accctgtgac tccatgtccc cccgattcca
      301 ggacccccca tggccccatg attccttgac tcctatgacc ttatgacccc tgaccttcca
      361 agtgacttcc ttggactttg acccctgtga ctgtgcttcc cattccccgc ccccacaacc
      421 tgtgactctg gctccctttg ggggtcttgt tagtctgggc ctccccagga agatgtgggg
      481 gaggctctgg cccctcctcc tcagcatcct cacagcaact gcagtcccag gaccctcact
      541 gcggagaccg tctagagaac tagatgccac ccctcggatg accataccct atgaagagct
      601 ctctgggacc cggcacttca agggccaagc ccagaactac tcaacactgc tgctggagga
      661 ggcctcagca aggctgctgg tgggagcccg aggtgccctg ttctctctca gtgccaacga
      721 cataggagat ggggctcaca aagagatcca ctgggaagcc tccccagaga tgcaaagcaa
      781 atgtcatcaa aaagggaaaa acaaccagac ggagtgcttt aaccatgtgc ggttcctgca
      841 gcggctcaat tctacccacc tctatgcatg tgggactcac gccttccagc ccctctgtgc
      901 agccattgat gctgaggcct tcaccttgcc aaccagcttc gaggagggga aggagaagtg
      961 tccttatgac ccagcccgtg gcttcacagg cctcatcatt gatggaggcc tctacacagc
     1021 cactaggtat gaattccgga gcattcctga catccgccgg agccgccacc cacactccct
     1081 gagaactgag gagacaccaa tgcattggct caatgatgcg gagtttgtgt tctccgtcct
     1141 cgtgcgggag agcaaggcca gtgcagtggg tgatgatgac aaggtgtact acttcttcac
     1201 ggagcgtgcc actgaggagg gctctggcag cttcactcag agccgcagca gtcaccgtgt
     1261 ggcccgtgtg gctcgtgtct gcaagggaga cctgggaggg aagaagatcc tgcagaagaa
     1321 gtggacttcc ttcctgaaag cccgtctcat ctgccacatt ccactgtatg agacactgcg
     1381 tggggtctgc agcctggatg ctgaaacctc aagccgtaca cacttctatg cagccttcac
     1441 gctgagcaca cagtggaaga ccctggaggc ctcagccatc tgccgctatg acctggcaga
     1501 gatccaggct gtctttgcag gaccctatat ggaataccag gatggttccc ggcgctgggg
     1561 tcgctatgag ggtggggtgc ctgagccccg gcctggctcg tgtatcacag attcattgcg
     1621 cagccaaggc tacaattcat cccaagactt gccatccctg gtcctggact ttgtaaagtt
     1681 gcacccactg atggctcggc ccgttgtgcc cacacgtgga cggcccctgc tgctcaagcg
     1741 caacatacgc tacacacacc ttacagggac acctgtcacc acgcctgctg gacctaccta
     1801 tgacctgctc tttctgggca cagctgatgg ctggatccac aaggccgtag tcctgggctc
     1861 tgggatgcac attattgaag agacacaagt gttcagggag tcccagtctg tggaaaatct
     1921 agtcatctct ctattgcagc acagcctcta tgtgggggct cctagcggag tcatccagct
     1981 accactctcc agctgctccc gctaccgatc ctgctatgac tgcatcttgg cccgagaccc
     2041 ctactgtggc tgggaccctg gcacccatgc ctgcgcagca gccaccacca tagccaacag
     2101 gtcccaggga agcaggacag cactgataca ggacatagag agaggaaatc gaggctgtga
     2161 gagcagcagg gatacagggc caccaccacc actgaagacc cgctctgtgc tccggggtga
     2221 tgatgtcctc ctgccctgtg accagccatc caacctggcc cgggccttgt ggctactcaa
     2281 tgggagcatg ggcctgagcg atgggcaggg tggctaccgt gtgggcgtgg acgggctgct
     2341 ggttacagat gcacagcctg agcacagtgg caactatggc tgctatgccg aggaaaatgg
     2401 cctccgcacc ctgctggcct cctatagtct cacagtccgg ccagccactc ctgccccagc
     2461 tccaaaagcc cctgccacac ctggggcaca gctggcacct gatgtgagac tgctctatgt
     2521 gctagccatt gccgcgcttg gtggcctctg cctcatcctg gcctcctccc tcctctatgt
     2581 ggcctgtctg cgggaaggca gacgagggcg ccgacggaaa tactcactgg gtcgggccag
     2641 ccgggcagga ggatctgcgg tgcaactgca gacagtctca ggccagtgtc ctggagagga
     2701 agatgagggt gatgatgagg gggctggggg cctggagggc agctgtctcc agatcatccc
     2761 tggggaggga gccccagccc caccaccccc accgccccca ccgccaccgg ctgagctgac
     2821 caatggcttg gtggcactgc ccagccggct gcggaggatg aatggcaata gctatgtgct
     2881 tctgaggcag agcaacaatg gagtaccagc agggccctgc tccttcgccg aggaactcag
     2941 ccgcatcctg gaaaaaagga agcacacgca gctcgtggag cagctagatg agagctctgt
     3001 ctgagcccag cctcccagaa caaatgctct tccaagccag cctatctgtc ccaggctggg
     3061 ccactgcctc cctaacacag ccaccctccc ttcattaccc ccactccata cccttctccc
     3121 aactttttga tgtccctgta gggctggcca gtcaggccca gccaaagccc cctcctcagt
     3181 ctccacagac ccacatgtga gcagcccagg cccatcggtg ctcctcagag gtaggtgctc
     3241 cctcaggatc aggtgccctg cagacccaga gccagttcct atcccctaac ctaaacactt
     3301 ataggtgagg actccatcct cctgttccat tcatctgccc aaaccctttc tctttctccc
     3361 aggcagggct ctgcaggtcc atatgggctc aatgtcacca ccctctgcat ggccctgtgt
     3421 gctggatggt cctgaaacca gacaagacct ctgccagcca cctaagccct gcgtacattc
     3481 acatgcacac atggaagaat gtttatcggc tgggctgcag tgcccccacc ctcaccttct
     3541 cctggtgcat tcttgtttca tccctgcttc tggacttggg gtaccctccc aattgccaca
     3601 tcctatctgg tcctcttccc cagccccatg tggtgacctc tttgtcaaga gcttgggaac
     3661 gggccagcct ggggaggtaa gactgcatca ctcccctcct ctcccttcct gtgtggccct
     3721 tgtgaatcag cctccccact ctccttggtc attctcaaga gtatgagaga cagagctcca
     3781 ggcatgtccc atccccatgc acatgtggta acacacacct gtatcacaca tgtgcttaca
     3841 tttccactca catgcacctc tgagcctccc ttgctgtctt ggacctgtct gttgggttta
     3901 gtccgtggac atttcagagg gagatccccc tcccatttaa ctgtcctcac aggcccttgc
     3961 ctaggatgga tgaccaacac tgcactcaat gagccagcct ctcttttggg ggaatcaagc
     4021 atttgcttcc tctagactac agcagggaaa gggaggagaa atctgatgtc tcaactggca
     4081 catgaagccc attcttggaa ctatgcaaag ggcagaggct gggagtttgg acgcttagct
     4141 cctacccctg tcctacctca ccggggcact ttcaggggcc aggggcctct gaagtctcta
     4201 ggcctatatg ggacaatcaa ttctgactga gctcccccat tcccctcggg tgaggatgac
     4261 tgttattttt gtagctgaga acgtggaatc ccacgggttt ttactgccct tcacccaacc
     4321 tctcccacct ccaccccaca atgaatgtat ttattgtgag aatggctaca cttctttagg
     4381 aatgccccca cttacaacca ggtgggtgga acaggcatgt gacagagtgg ggagcctggg
     4441 ctcagctcct ccccctgccg ttggttaata aacacccttt ttccccaca
//
