LOCUS       NM_004263               6075 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens ssemaphorin 4F (SEMA4F), transcript variant 1, mRNA.
ACCESSION   NM_004263 NM_018524
VERSION     NM_004263.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6075)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   2  (bases 1 to 6075)
  AUTHORS   Armendariz,B.G., Bribian,A., Perez-Martinez,E., Martinez,A., de
            Castro,F., Soriano,E. and Burgaya,F.
  TITLE     Expression of Semaphorin 4F in neurons and brain oligodendrocytes
            and the regulation of oligodendrocyte precursor migration in the
            optic nerve
  JOURNAL   Mol Cell Neurosci 49 (1), 54-67 (2012)
   PUBMED   21945643
REFERENCE   3  (bases 1 to 6075)
  AUTHORS   Fan,Q., Barathi,V.A., Cheng,C.Y., Zhou,X., Meguro,A., Nakata,I.,
            Khor,C.C., Goh,L.K., Li,Y.J., Lim,W., Ho,C.E., Hawthorne,F.,
            Zheng,Y., Chua,D., Inoko,H., Yamashiro,K., Ohno-Matsui,K.,
            Matsuo,K., Matsuda,F., Vithana,E., Seielstad,M., Mizuki,N.,
            Beuerman,R.W., Tai,E.S., Yoshimura,N., Aung,T., Young,T.L.,
            Wong,T.Y., Teo,Y.Y. and Saw,S.M.
  TITLE     Genetic variants on chromosome 1q41 influence ocular axial length
            and high myopia
  JOURNAL   PLoS Genet 8 (6), e1002753 (2012)
   PUBMED   22685421
REFERENCE   4  (bases 1 to 6075)
  AUTHORS   Gabrovska,P.N., Smith,R.A., Tiang,T., Weinstein,S.R., Haupt,L.M.
            and Griffiths,L.R.
  TITLE     Semaphorin-plexin signalling genes associated with human breast
            tumourigenesis
  JOURNAL   Gene 489 (2), 63-69 (2011)
   PUBMED   21925246
  REMARK    GeneRIF: data seems to indicate that SEMA4F is involved in tumour
            progression in breast cancer
REFERENCE   5  (bases 1 to 6075)
  AUTHORS   Parrinello,S., Noon,L.A., Harrisingh,M.C., Wingfield Digby,P.,
            Rosenberg,L.H., Cremona,C.A., Echave,P., Flanagan,A.M., Parada,L.F.
            and Lloyd,A.C.
  TITLE     NF1 loss disrupts Schwann cell-axonal interactions: a novel role
            for semaphorin 4F
  JOURNAL   Genes Dev 22 (23), 3335-3348 (2008)
   PUBMED   19056885
  REMARK    GeneRIF: Sema4F levels were strongly reduced in a panel of human
            neurofibromas, confirming the relevance of these findings to the
            human disease.
REFERENCE   6  (bases 1 to 6075)
  AUTHORS   Ayala,G.E., Dai,H., Powell,M., Li,R., Ding,Y., Wheeler,T.M.,
            Shine,D., Kadmon,D., Thompson,T., Miles,B.J., Ittmann,M.M. and
            Rowley,D.
  TITLE     Cancer-related axonogenesis and neurogenesis in prostate cancer
  JOURNAL   Clin Cancer Res 14 (23), 7593-7603 (2008)
   PUBMED   19047084
REFERENCE   7  (bases 1 to 6075)
  AUTHORS   Park,Y.D., Park,D., Bhak,J. and Yang,J.M.
  TITLE     Proteomic approaches to the analysis of atopic dermatitis and new
            insights from interactomics
  JOURNAL   Proteomics Clin Appl 2 (3), 290-300 (2008)
   PUBMED   21136834
REFERENCE   8  (bases 1 to 6075)
  AUTHORS   Francks,C., Fisher,S.E., Olson,R.K., Pennington,B.F., Smith,S.D.,
            DeFries,J.C. and Monaco,A.P.
  TITLE     Fine mapping of the chromosome 2p12-16 dyslexia susceptibility
            locus: quantitative association analysis and positional candidate
            genes SEMA4F and OTX1
  JOURNAL   Psychiatr Genet 12 (1), 35-41 (2002)
   PUBMED   11901358
  REMARK    GeneRIF: Fine mapping of the chromosome 2p12-16 dyslexia
            susceptibility candidate gene
REFERENCE   9  (bases 1 to 6075)
  AUTHORS   Schultze,W., Eulenburg,V., Lessmann,V., Herrmann,L., Dittmar,T.,
            Gundelfinger,E.D., Heumann,R. and Erdmann,K.S.
  TITLE     Semaphorin4F interacts with the synapse-associated protein
            SAP90/PSD-95
  JOURNAL   J Neurochem 78 (3), 482-489 (2001)
   PUBMED   11483650
REFERENCE   10 (bases 1 to 6075)
  AUTHORS   Encinas,J.A., Kikuchi,K., Chedotal,A., de Castro,F., Goodman,C.S.
            and Kimura,T.
  TITLE     Cloning, expression, and genetic mapping of Sema W, a member of the
            semaphorin family
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 2491-2496 (1999)
   PUBMED   10051670
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC306380.1, AL136552.1,
            AC007387.4 and CK905501.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004263.4.
            
            Summary: This gene encodes a transmembrane class IV semaphorin
            family protein, which plays a role in neural development. This gene
            may be involved in neurogenesis in prostate cancer, the development
            of neurofibromas, and breast cancer tumorigenesis. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.241466.1,
                                           SRR1660807.58907.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357877.7/ ENSP00000350547.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DC306380.1         20-38
            20-4292             AL136552.1         1-4273
            4293-5564           AC007387.4         35118-36389
            5565-6075           CK905501.1         29-539              c
FEATURES             Location/Qualifiers
     source          1..6075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     gene            1..6075
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /note="ssemaphorin 4F"
                     /db_xref="GeneID:10505"
                     /db_xref="HGNC:HGNC:10734"
                     /db_xref="MIM:603706"
     exon            1..275
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..2443
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; semaphorin M; semaphorin-4F; semaphorin-W; sema
                     domain immunoglobulin domain transmembrane domain (TM) and
                     short cytoplasmic domain (semaphorin) 4F; sema domain,
                     immunoglobulin domain (Ig), transmembrane domain (TM) and
                     short cytoplasmic domain, (semaphorin) 4F"
                     /codon_start=1
                     /product="semaphorin-4F isoform 1 precursor"
                     /protein_id="NP_004254.2"
                     /db_xref="CCDS:CCDS1955.1"
                     /db_xref="GeneID:10505"
                     /db_xref="HGNC:HGNC:10734"
                     /db_xref="MIM:603706"
                     /translation="MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTS
                     LPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDW
                     MVPEAHRQNCRKKGKKEDECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQV
                     ERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTL
                     PSWLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGD
                     LGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQW
                     EGATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLR
                     HFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEY
                     DVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPEPQPVENMKLYHSWLLVGSRTEVTQV
                     NTTNCGRLQSCSECILAQDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSLCPKEP
                     GERPVVFEVPVATAAHVVLPCSPSSAWASCVWHQPSGVTALTPRRDGLEVVVTPGAMG
                     AYACECQEGGAAHVVAAYSLVWGSQRDAPSRAHTVGAGLAGFFLGILAASLTLILIGR
                     RQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPSPEDERLPLALAKRGSGFGGF
                     SPPFLLDPCPSPAHIRLTGAPLATCDETSI"
     exon            276..427
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /inference="alignment:Splign:2.1.0"
     exon            428..487
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /inference="alignment:Splign:2.1.0"
     exon            488..586
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /inference="alignment:Splign:2.1.0"
     exon            587..680
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /inference="alignment:Splign:2.1.0"
     exon            681..800
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /inference="alignment:Splign:2.1.0"
     exon            801..952
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1131
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1279
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1502
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1612
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1773
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1832
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..6075
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2981..2986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /note="hexamer: AATACA"
     polyA_site      3000
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
     regulatory      4270..4275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /note="hexamer: AATAAA"
     polyA_site      4291
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /note="major polyA site"
     regulatory      5374..5379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /note="hexamer: AACAAA"
     polyA_site      5400
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
     regulatory      6058..6063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
                     /note="hexamer: AATAAA"
     polyA_site      6075
                     /gene="SEMA4F"
                     /gene_synonym="M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM;
                     SEMAW"
ORIGIN      
        1 gtttcatccc tcagcctcag gctgagccgg accgagccga gaggacccga gtggggccga
       61 ggccagtagc cccggggccc tgagcagagg ccgtagcttg cgccgcaccc gcggccaggc
      121 ggagccaaag atgccggcct ctgctgcgcg gccccgcccg ggtcccgggc agcctacagc
      181 ctcgcccttc ccgctactgc tgctggcggt gctgagcggc ccggtatccg gccgcgtccc
      241 ccgctcggtg cccagaacct cgcttccaat ctctgaggct gactcctgtc tcacccggtt
      301 cgcagtccct cacacataca attactctgt tctccttgtg gatcctgcct cccacacact
      361 ttatgttggc gcccgggaca ccatcttcgc tttatccctg cccttctcag gggagagacc
      421 ccgcaggatt gactggatgg ttcctgaggc tcacagacag aactgtagga agaaaggcaa
      481 gaaagaggac gaatgtcaca attttgtcca gattctcgcc attgccaatg cctctcacct
      541 cctcacttgt ggcaccttcg cttttgatcc gaagtgcggg gttattgatg tgtccaggtt
      601 ccagcaggtt gaaagacttg agagtggccg ggggaaatgt ccttttgagc cagctcagcg
      661 gtcagcagct gtaatggctg ggggggtcct ctatgctgcc actgtgaaaa actacctggg
      721 gacggagcca attatcacca gagcagtggg tcgtgccgag gactggattc ggacagatac
      781 cttgccttcc tggctgaacg ccccagcctt tgtcgcagcc gtggccttga gcccagccga
      841 atggggggat gaagatggag acgacgaaat ctacttcttc tttacggaga cttcccgagc
      901 atttgactca tacgagcgca ttaaagtccc acgggtggcc cgtgtgtgtg cgggggacct
      961 cgggggccgg aagaccctcc agcagagatg gacgacgttt ttgaaagctg acctgctctg
     1021 tccagggcct gagcatggcc gggcctccag tgtcctgcag gatgttgctg tgcttcgacc
     1081 tgagcttggg gcagggactc ccatctttta tggcatcttt tcttcccagt gggagggggc
     1141 tactatctct gctgtctgtg ccttccgacc acaagacatt cggacagtgc tgaatggtcc
     1201 cttcagagaa ctaaaacatg actgcaacag aggactgcct gtcgtggaca atgatgtgcc
     1261 ccagcccaga cctggagagt gcatcaccaa caacatgaag ctccggcact ttggctcatc
     1321 tctctccctg cctgaccgcg tactcacctt catccgggac cacccactca tggacaggcc
     1381 agtgtttcca gctgatggcc accccctgct ggtcactaca gatacagcct atctcagagt
     1441 cgtggcccac agggtgacca gcctctcagg gaaagagtat gatgtgctct acctggggac
     1501 agaggatgga cacctccacc gagcagtgcg gatcggagct cagctcagcg ttcttgaaga
     1561 tctggcctta ttcccagagc cacagccagt tgagaacatg aaattgtacc acagctggct
     1621 cctggttggc tcccgtactg aggtgacaca agtgaataca accaactgtg gccgtctcca
     1681 gagctgctca gagtgcatcc tggcccagga cccagtctgt gcctggagct tccggctgga
     1741 tgagtgtgtg gcccatgccg gggagcaccg agggttggtc caagacatag agtcagcaga
     1801 tgtctcctct ttgtgtccta aagagcctgg agaacgtcca gtagtgtttg aagttcccgt
     1861 ggctacagct gcgcatgtgg tcttgccatg ttctccaagc tcagcatggg catcctgtgt
     1921 gtggcaccag cccagtggag tgactgcact caccccccgg cgggatggac tggaggtggt
     1981 ggtgacccca ggggccatgg gcgcttatgc ctgtgaatgt caggagggtg gggcagccca
     2041 tgtggtagca gcttacagct tggtatgggg cagccagcga gatgctccga gccgggccca
     2101 cacagtgggg gcgggactgg ctggcttctt cttggggatt ctcgcagcat ccctgactct
     2161 cattctgatt ggtcggcgtc agcagcgacg gcgacagagg gaacttctgg ctagagacaa
     2221 ggtgggcctg gacctggggg ctccaccttc tgggaccaca agctacagcc aagaccctcc
     2281 ctccccctct cctgaagatg agcggttgcc gctggccctg gccaagaggg gcagtggctt
     2341 tggtggattc tcaccaccct tcctgcttga tccttgccca agcccagccc acattcggct
     2401 aactggggct cctctagcca catgtgatga aacatccatc tagagctggg caaatgacca
     2461 ctagtgtata agtgatcact ggaacggagt gaccactgag atgctggggg tcactgggcc
     2521 tggaagacca tcccagcctc tgagttctct ttgagtatga gtgattactt ggattttagt
     2581 atctgttctc tctgagcctg gatgggcttg gggccagacc tttgcctgat tcctgattcc
     2641 catgagaaat cagaactgct ttctgcagca aatcagggct tccccctaac atctgaactc
     2701 ctgtaaacct tcatccctgg ccccctatct tgggcccatt agttttgggg atggggcaca
     2761 gggcatagct atgactttgc tttctggttg gagcctggcc ggaaggaaga gccctggagg
     2821 tggttggggg caaatgtgcc ctgagtcctt ggggtggttc tgcttattct tcaagtttat
     2881 ctgaatctgt ggggagtgca tgatccccat gttgcaatat ggagtctctg ccctgagatc
     2941 ttccccatct cagttttcct tccatgaaag agtacgtgta aatacatagt gttcataaga
     3001 gacctggcca catgtgcatg aatgactggg ccgatgctta ggaatattta tgagggatgg
     3061 ggagggagac aattggaatg ggggcgttgc ctgcagaact ttagaccctg tagccataga
     3121 gggaatggcg ttcctttcta aaaggaactg aaacactgcc cctctcccca ttgccccaca
     3181 accttactct aaatttgagt agagaaaagc tcctaaagtg accttccggg tgggaagggc
     3241 agcagtacac atgaccccat ccttttcttt gtttttaccc cctggctgcc accactgcca
     3301 tgtcacagct gctttctctg gctggagtgt aggctgtacc ccatttcctt ggctcccatt
     3361 aaaaatcaac aacattctaa tgattaggga acaacagaag gggaacagtc ataggatata
     3421 cgagcagtat aaagatacgt ttgcaatcag tgactactca gggtgacacc cttgccctaa
     3481 agcaggagtc ccccctacct ggggtccatg gactccctga aattgtatgc aaaatgttgt
     3541 ttgtacatgt gtgtctgtat gtctctgtgg ggaggtttta tggcttttgt cagattttca
     3601 aggccttaac aaagttaaag gaccactgcc ctgaggttac tgcactgagg ccaagttagg
     3661 atggcatcac tctgtggcag ctctccctgg acttgccctg cctggaacag ggtgatttgc
     3721 tggaatggag ttaccactga gatgccaaag gttgctgggt ctggaagact gttgtggcct
     3781 ctcagttctc tttgagtctg actgactgtg gccagtccct ggactggtag ctgctggagg
     3841 ccttcttgtt tctccagtcc ctggaagctg agctctatgt gtatttgatg acattgtcag
     3901 ctcttaccaa acgtcaagac ctcttcctgc ttgaccactc gcacatggct ctaggcttct
     3961 cctgctgagt cctggtcttg gcctgtgaat gtgcctcgtt catccctggt gcttgagccc
     4021 ctcaagctcc agtcaatgat ccagtccttc ccctttgaag ttttctgctc tactttcctt
     4081 ggcagcagcc tgtgaactac tcaaaagagt ccccttgggt ttggaattat cagtggcttt
     4141 gccactagta aatgtgtgat cttcggcaag taacctaacc tagggacatc agtttactca
     4201 tctgcgaagt ggggataata aaacctacct cagggttgct tcaaggatta aatgagaaaa
     4261 tatgtcaaca ataaagacct gtctgtacca atagatgttg ttattgcaaa aatgggctta
     4321 ctatccataa ccatatagct taactatatg ataaccatga cattcgtagg ctgggcatgg
     4381 tggcttacgc ctgtaatccc agcactttgg gaggccaagg caggtggatc acaaggtcag
     4441 gagatcgaga ccattctggc taacacggtg aaaccccgtc tctactaaaa atacaaaaaa
     4501 ttagccgggc gtggtggcgg gggcctgtag tcccagctac tcgggaggct gaggcaggag
     4561 aatggcgtga acccgggagg tggagtttgc agtgagccaa gatcacgcca ctgcactcca
     4621 gcctgggcaa cagagcaaaa ctccgtctca aaaaaaaaaa aaaaagataa ccatgacact
     4681 cgcaatcata ttaagcctca ctcagtaaag gacagtcatt gtttcacaga tatcctgttc
     4741 tgggtcacct ctggacagct catagctgct ggtttctagg ttttaggagg cagatctatg
     4801 atttttgtaa tcctcagacc tgtctgacct tagtggcctg agatcccttt gtatagaatg
     4861 gaggaaggct gtgtgttctt tggtttaccc tcagcctatc tttcaacccc actcacttga
     4921 ggttgtggcc tagttcctct ttgggggagg gaggaaggtg gggagatgtc aaaggggact
     4981 gggcttcctg tggggagtgg gagagaagag tttttcaagg aggagagaga ccagggctct
     5041 tatactctgg gccactatct gcctgctcta atcacctagg gccaggcacc agacaactag
     5101 ggatggcctc tttaccccaa agcctgctga aattactcaa actagccaat cctaagtctg
     5161 cctaccctgc ctcagtcatt ccttccaatg gaaaccacaa taagcactct tgcccacgtt
     5221 ttccctgctc cctctgcatc ccaactgacc ctggtgcttc cccatgtggc ccctgtatag
     5281 tgtgctttgc ctcctgtttc tagggacctg tgagtatcag ctttctcgat gacagtcatt
     5341 tctgtgtcta tgtgtcttat tataccttat taaaacaaac ctgggtacat ttgtaagaca
     5401 gcagggattc tctgaagatt aatgattgag aaggatgatt ggacctgtct agtcagggag
     5461 gctgaggcct caggccttca ttaggcacgt tgcatgtctg tcaagtaagg gccactaatc
     5521 acctcacatg ggttcatctg aactttatgc cagcccaaaa cacgaggacg tgccacccat
     5581 cctcagcact ctcaagacac acttaagtgt gtttgatacg taagctccaa ttccttcctc
     5641 cataagaaga gagaaggcag aagtggcttt ccccgaggtg aggacgggga tgggagtttt
     5701 ttcttttgag tgatgtagac ctatgccctg cttccatgcc acttcctcag atgtgacaga
     5761 cctctgctgg gatggaatgt gtgtttgctg gagacagctg tggcatagag gattgtgaga
     5821 aagggtcccc atgcttggtg tggaaggagg gagctgctca ccctctgtat gggcttggat
     5881 gaggagcttc tcagcggcag tcataagaac cagaggattt tctgcccttt gctgggagcc
     5941 acatgagccc cctggattca tgtggaattc ttgggagagg gatgaccacc ctgaagatgg
     6001 ctgagatcaa atatctcatc agatgactgg atgcttagaa tcgggttaac ttgattaaat
     6061 aaataaatag aaata
//
