LOCUS       NM_001371194            4562 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens semaphorin 4D (SEMA4D), transcript variant 3, mRNA.
ACCESSION   NM_001371194 XM_005251654
VERSION     NM_001371194.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4562)
  AUTHORS   Xuan,Z., Zhang,Y., Li,D., Wang,K., Huang,P. and Shi,J.
  TITLE     PLXNB1/SEMA4D signals mediate interactions between malignant
            epithelial and immune cells to promote colorectal cancer liver
            metastasis
  JOURNAL   J Cell Mol Med 28 (20), e70142 (2024)
   PUBMED   39443302
  REMARK    GeneRIF: PLXNB1/SEMA4D signals mediate interactions between
            malignant epithelial and immune cells to promote colorectal cancer
            liver metastasis.
REFERENCE   2  (bases 1 to 4562)
  AUTHORS   Ikhar,A.S., Kolte,R.A., Kolte,A.P., Rathi,P.R., Ghoderao,D.G. and
            Dahake,R.N.
  TITLE     Comparative evaluation of semaphorin-4D, peptidylarginine
            deiminase-2, and matrix metalloproteinase-8 levels of gingival
            crevicular fluid in periodontally healthy and Stage III
            periodontitis smoker and non-smoker patients before and after
            non-surgical periodontal therapy
  JOURNAL   J Periodontol 95 (6), 563-570 (2024)
   PUBMED   37846733
  REMARK    GeneRIF: Comparative evaluation of semaphorin-4D, peptidylarginine
            deiminase-2, and matrix metalloproteinase-8 levels of gingival
            crevicular fluid in periodontally healthy and Stage III
            periodontitis smoker and non-smoker patients before and after
            non-surgical periodontal therapy.
REFERENCE   3  (bases 1 to 4562)
  AUTHORS   Liu,H., Zhang,Y., Cao,J., Li,J., Liu,H., Dai,B., Jin,L., Liao,R.
            and Fu,L.
  TITLE     Sema4D as a biomarker for Predicting rheumatoid arthritis disease
            activity
  JOURNAL   Clin Rheumatol 43 (2), 645-655 (2024)
   PUBMED   38097864
  REMARK    GeneRIF: Sema4D as a biomarker for Predicting rheumatoid arthritis
            disease activity.
REFERENCE   4  (bases 1 to 4562)
  AUTHORS   Yang,C., Li,Y., Liu,Y., Xu,Z., Li,W., Cao,W., Jin,K. and Liu,Y.
  TITLE     Protection of Barrier Function in Cultured Human Corneal Epithelial
            Cells by Semaphorin 4D
  JOURNAL   Curr Eye Res 48 (10), 894-903 (2023)
   PUBMED   37395011
  REMARK    GeneRIF: Protection of Barrier Function in Cultured Human Corneal
            Epithelial Cells by Semaphorin 4D.
REFERENCE   5  (bases 1 to 4562)
  AUTHORS   Zeng,Y., Wang,L., Liu,L., Wang,M., Yan,L., Ye,L., Song,D. and
            Huang,D.
  TITLE     The Potential Immunomodulatory Roles of Semaphorin 4D in Human
            Periapical Lesions
  JOURNAL   J Endod 49 (1), 62-68 (2023)
   PUBMED   36257402
  REMARK    GeneRIF: The Potential Immunomodulatory Roles of Semaphorin 4D in
            Human Periapical Lesions.
REFERENCE   6  (bases 1 to 4562)
  AUTHORS   Tamagnone,L., Artigiani,S., Chen,H., He,Z., Ming,G.I., Song,H.,
            Chedotal,A., Winberg,M.L., Goodman,C.S., Poo,M., Tessier-Lavigne,M.
            and Comoglio,P.M.
  TITLE     Plexins are a large family of receptors for transmembrane,
            secreted, and GPI-anchored semaphorins in vertebrates
  JOURNAL   Cell 99 (1), 71-80 (1999)
   PUBMED   10520995
  REMARK    Erratum:[Cell 2001 Jan 26;104(2):following 320]
REFERENCE   7  (bases 1 to 4562)
  AUTHORS   Furuyama,T., Inagaki,S., Kosugi,A., Noda,S., Saitoh,S., Ogata,M.,
            Iwahashi,Y., Miyazaki,N., Hamaoka,T. and Tohyama,M.
  TITLE     Identification of a novel transmembrane semaphorin expressed on
            lymphocytes
  JOURNAL   J Biol Chem 271 (52), 33376-33381 (1996)
   PUBMED   8969198
REFERENCE   8  (bases 1 to 4562)
  AUTHORS   Herold,C., Elhabazi,A., Bismuth,G., Bensussan,A. and Boumsell,L.
  TITLE     CD100 is associated with CD45 at the surface of human T
            lymphocytes. Role in T cell homotypic adhesion
  JOURNAL   J Immunol 157 (12), 5262-5268 (1996)
   PUBMED   8955171
REFERENCE   9  (bases 1 to 4562)
  AUTHORS   Hall,K.T., Boumsell,L., Schultze,J.L., Boussiotis,V.A.,
            Dorfman,D.M., Cardoso,A.A., Bensussan,A., Nadler,L.M. and
            Freeman,G.J.
  TITLE     Human CD100, a novel leukocyte semaphorin that promotes B-cell
            aggregation and differentiation
  JOURNAL   Proc Natl Acad Sci U S A 93 (21), 11780-11785 (1996)
   PUBMED   8876214
REFERENCE   10 (bases 1 to 4562)
  AUTHORS   Bougeret,C., Mansur,I.G., Dastot,H., Schmid,M., Mahouy,G.,
            Bensussan,A. and Boumsell,L.
  TITLE     Increased surface expression of a newly identified 150-kDa dimer
            early after human T lymphocyte activation
  JOURNAL   J Immunol 148 (2), 318-323 (1992)
   PUBMED   1530858
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590233.23 and AL929575.24.
            
            On Aug 27, 2019 this sequence version replaced NM_001371194.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648216.1, SRR14038197.1272012.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000422704.7/ ENSP00000388768.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AL590233.23        4286-4480
            196-261             AL590233.23        46446-46511
            262-610             AL590233.23        96700-97048
            611-756             AL590233.23        99383-99528
            757-819             AL590233.23        103061-103123
            820-918             AL590233.23        105564-105662
            919-1012            AL929575.24        50236-50329         c
            1013-1126           AL929575.24        49097-49210         c
            1127-1278           AL929575.24        47938-48089         c
            1279-1454           AL929575.24        45546-45721         c
            1455-1611           AL929575.24        45310-45466         c
            1612-1834           AL929575.24        44060-44282         c
            1835-1950           AL929575.24        43041-43156         c
            1951-2123           AL929575.24        37848-38020         c
            2124-2167           AL929575.24        37729-37772         c
            2168-4562           AL929575.24        33909-36303         c
FEATURES             Location/Qualifiers
     source          1..4562
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.2"
     gene            1..4562
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /note="semaphorin 4D"
                     /db_xref="GeneID:10507"
                     /db_xref="HGNC:HGNC:10732"
                     /db_xref="MIM:601866"
     exon            1..195
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            196..261
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            262..610
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /inference="alignment:Splign:2.1.0"
     CDS             505..3093
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; sema domain, immunoglobulin domain (Ig),
                     transmembrane domain (TM) and short cytoplasmic domain,
                     4D; sema domain, immunoglobulin domain (Ig), transmembrane
                     domain (TM) and short cytoplasmic domain, (semaphorin) 4D"
                     /codon_start=1
                     /product="semaphorin-4D isoform 1 precursor"
                     /protein_id="NP_001358123.1"
                     /db_xref="CCDS:CCDS6685.1"
                     /db_xref="GeneID:10507"
                     /db_xref="HGNC:HGNC:10732"
                     /db_xref="MIM:601866"
                     /translation="MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHE
                     PDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGK
                     SKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDP
                     AHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIR
                     KSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLK
                     ARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAE
                     EVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQ
                     FVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHK
                     AISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGT
                     CEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPDKSKGSYRQHFF
                     KHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQC
                     LSEERVKNKTVFQVVAKHVLEVKVVPKPVVAPTLSVVQTEGSRIATKVLVASTQGSSP
                     PTPAVQATSSGAITLPPKPAPTGTSCEPKIVINTVPQLHSEKTMYLKSSDNRLLMSLF
                     LFFFVLFLCLFFYNCYKGYLPRQCLKFRSALLIGKKKPKSDFCDREQSLKETLVEPGS
                     FSQQNGEHPKPALDTGYETEQDTITSKVPTDREDSQRIDDLSARDKPFDVKCELKFAD
                     SDADGD"
     exon            611..756
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            757..819
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            820..918
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1012
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1126
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1278
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1454
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1611
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1834
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1950
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2123
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2167
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..4562
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4386..4391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /note="hexamer: AATAAA"
     polyA_site      4406
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /note="major polyA site"
     regulatory      4537..4542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /note="hexamer: AATAAA"
     polyA_site      4562
                     /gene="SEMA4D"
                     /gene_synonym="A8; BB18; C9orf164; CD100; coll-4; COLL4;
                     GR3; M-sema-G; SEMAJ"
                     /note="major polyA site"
ORIGIN      
        1 gcactccgtc cccgcgccgg cctcagcgct ctcgcgcgcc gcagcatccc agccgccgct
       61 gccgccgccg ggcctccccg ccaccccctc cccggcccgg ccgcctcccg ccgctgccgc
      121 cgccgccgcc gccgccattc ctggcgcccg aactcgcccg gccgggagcc gccgcgggca
      181 ggacgcgcgc tgcagactct gctaacacca gatagtggaa agaaaccatg tgctgaaatg
      241 tttgacgaca ctgatggttt gcatttcttc tgaggccctg aagaagtatc aagtgggctt
      301 tgacattgcg gtggtgagag cgacccctcc tcacctggag aactgggaaa tgtggattct
      361 cagggaccgc gctgttcacg agctccaggc tgtgctgctg gccctggtcc tggggcgctg
      421 agccgcatct gcaatagcac acctgcccgg ccacctgctg ccgtgagcct ttgctgctga
      481 agcccctggg gtcgcctcta cctgatgagg atgtgcaccc ccattagggg gctgctcatg
      541 gcccttgcag tgatgtttgg gacagcgatg gcatttgcac ccataccccg gatcacctgg
      601 gagcacagag aggtgcacct ggtgcagttt catgagccag acatctacaa ctactcagcc
      661 ttgctgctga gcgaggacaa ggacaccttg tacataggtg cccgggaggc ggtcttcgct
      721 gtgaacgcac tcaacatctc cgagaagcag catgaggtgt attggaaggt ctcagaagac
      781 aaaaaagcaa aatgtgcaga aaaggggaaa tcaaaacaga cagagtgcct caactacatc
      841 cgggtgctgc agccactcag cgccacttcc ctttacgtgt gtgggaccaa cgcattccag
      901 ccggcctgtg accacctgaa cttaacatcc tttaagtttc tggggaaaaa tgaagatggc
      961 aaaggaagat gtccctttga cccagcacac agctacacat ccgtcatggt tgatggagaa
     1021 ctttattcgg ggacgtcgta taattttttg ggaagtgaac ccatcatctc ccgaaattct
     1081 tcccacagtc ctctgaggac agaatatgca atcccttggc tgaacgagcc tagtttcgtg
     1141 tttgctgacg tgatccgaaa aagcccagac agccccgacg gcgaggatga cagggtctac
     1201 ttcttcttca cggaggtgtc tgtggagtat gagtttgtgt tcagggtgct gatcccacgg
     1261 atagcaagag tgtgcaaggg ggaccagggc ggcctgagga ccttgcagaa gaaatggacc
     1321 tccttcctga aagcccgact catctgctcc cggccagaca gcggcttggt cttcaatgtg
     1381 ctgcgggatg tcttcgtgct caggtccccg ggcctgaagg tgcctgtgtt ctatgcactc
     1441 ttcaccccac agctgaacaa cgtggggctg tcggcagtgt gcgcctacaa cctgtccaca
     1501 gccgaggagg tcttctccca cgggaagtac atgcagagca ccacagtgga gcagtcccac
     1561 accaagtggg tgcgctataa tggcccggta cccaagccgc ggcctggagc gtgcatcgac
     1621 agcgaggcac gggccgccaa ctacaccagc tccttgaatt tgccagacaa gacgctgcag
     1681 ttcgttaaag accacccttt gatggatgac tcggtaaccc caatagacaa caggcccagg
     1741 ttaatcaaga aagatgtgaa ctacacccag atcgtggtgg accggaccca ggccctggat
     1801 gggactgtct atgatgtcat gtttgtcagc acagaccggg gagctctgca caaagccatc
     1861 agcctcgagc acgctgttca catcatcgag gagacccagc tcttccagga ctttgagcca
     1921 gtccagaccc tgctgctgtc ttcaaagaag ggcaacaggt ttgtctatgc tggctctaac
     1981 tcgggcgtgg tccaggcccc gctggccttc tgtgggaagc acggcacctg cgaggactgt
     2041 gtgctggcgc gggaccccta ctgcgcctgg agcccgccca cagcgacctg cgtggctctg
     2101 caccagaccg agagccccag caggggtttg attcaggaga tgagcggcga tgcttctgtg
     2161 tgcccggata aaagtaaagg aagttaccgg cagcattttt tcaagcacgg tggcacagcg
     2221 gaactgaaat gctcccaaaa atccaacctg gcccgggtct tttggaagtt ccagaatggc
     2281 gtgttgaagg ccgagagccc caagtacggt cttatgggca gaaaaaactt gctcatcttc
     2341 aacttgtcag aaggagacag tggggtgtac cagtgcctgt cagaggagag ggttaagaac
     2401 aaaacggtct tccaagtggt cgccaagcac gtcctggaag tgaaggtggt tccaaagccc
     2461 gtagtggccc ccaccttgtc agttgttcag acagaaggta gtaggattgc caccaaagtg
     2521 ttggtggcat ccacccaagg gtcttctccc ccaaccccag ccgtgcaggc cacctcctcc
     2581 ggggccatca cccttcctcc caagcctgcg cccaccggca catcctgcga accaaagatc
     2641 gtcatcaaca cggtccccca gctccactcg gagaaaacca tgtatcttaa gtccagcgac
     2701 aaccgcctcc tcatgtccct cttcctcttc ttctttgttc tcttcctctg cctctttttc
     2761 tacaactgct ataagggata cctgcccaga cagtgcttga aattccgctc ggccctacta
     2821 attgggaaga agaagcccaa gtcagatttc tgtgaccgtg agcagagcct gaaggagacg
     2881 ttagtagagc cagggagctt ctcccagcag aatggggagc accccaagcc agccctggac
     2941 accggctatg agaccgagca agacaccatc accagcaaag tccccacgga tagggaggac
     3001 tcacagagga tcgacgacct ttctgccagg gacaagccct ttgacgtcaa gtgtgagctg
     3061 aagttcgctg actcagacgc agatggagac tgaggccggc tgtgcatccc cgctggtgcc
     3121 tcggctgcga cgtgtccagg cgtggagagt tttgtgtttc tcctgttcag tatccgagtc
     3181 tcgtgcagtg ctgcgtaggt tagcccgcat cgtgcagaca acctcagtcc tcttgtctat
     3241 tttctcttgg gttgagcctg tgacttggtt tctctttgtc cttttggaaa aatgacaagc
     3301 attgcatccc agtcttgtgt tccgaagtca gtcggagtac ttgaagaagg cccacgggcg
     3361 gcacggagtt cctgagccct ttctgtagtg ggggaaaggt ggctggacct ctgttggctg
     3421 agaagagcat cccttcagct tcccctcccc gtagcagcca ctaaaagatt atttaattcc
     3481 agattggaaa tgacatttta gtttatcaga ttggtaactt atcgcctgtt gtccagattg
     3541 gcacgaacct tttcttccac ttaattattt ttttaggatt ttgctttgat tgtgtttatg
     3601 tcatgggtca ttttttttta gttacagaag cagttgtgtt aatatttaga agaagatgta
     3661 tatcttccag attttgttat atatttggca taaaatacgg cttacgttgc ttaagattct
     3721 cagggataaa cttccttttg ctaaatgcat tctttctgct tttagaaatg tagacataaa
     3781 cactccccgg agcccactca ccttttttct ttttcttttt ttttttttaa ctttattcct
     3841 tgagggaagc attgtttttg gagagatttt ctttctgtac ttcgttttac ttttcttttt
     3901 ttttaacttt tactctctcg aagaagagga ccttcccaca tccacgaggt gggttttgag
     3961 caagggaagg tagcctggat gagctgagtg gagccaggct ggcccagagc tgagatggga
     4021 gtgcggtaca atctggagcc cacagctgtc ggtcagaacc tcctgtgaga cagatggaac
     4081 cttcacaagg gcgcctttgg ttctctgaac atctcctttc tcttcttgct tcaattgctt
     4141 acccactgcc tgcccagact ttctatccag cctcactgag ctgcccacta ctggaaggga
     4201 actgggcctc ggtggccggg gccgcgagct gtgaccacag caccctcaag catacggcgc
     4261 tgttcctgcc actgtcctga agatgtgaat gggtggtacg atttcaacac tggttaattt
     4321 cacactccat ctccccgctt tgtaaatacc catcgggaag agactttttt tccatggtga
     4381 agagcaataa actctggatg tttgtgcgcg tgtgtggaca gtcttatctt ccagcatgat
     4441 aggatttgac cattttggtg taaacatttg tgttttataa gatttacctt gtttttattt
     4501 ttctactttg aattgtatac atttggaaag tacccaaata aatgagaagc ttctatcctt
     4561 ga
//
