LOCUS       NM_017789               3652 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens semaphorin 4C (SEMA4C), mRNA.
ACCESSION   NM_017789
VERSION     NM_017789.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3652)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3652)
  AUTHORS   Liu,H., Ye,H. and Li,X.
  TITLE     Effect of microrna-138 on epithelial-Mesenchymal transition and
            invasion of breast cancer cells by targeting semaphorin 4C
  JOURNAL   Bioengineered 12 (2), 10117-10125 (2021)
   PUBMED   34747314
  REMARK    GeneRIF: Effect of microrna-138 on epithelial-Mesenchymal
            transition and invasion of breast cancer cells by targeting
            semaphorin 4C.
REFERENCE   3  (bases 1 to 3652)
  AUTHORS   Wang,Y., Liu,J., Li,J., Li,H., Li,X., Qiao,L., Yang,J., Fang,T.,
            Chen,S., Ma,J., Wan,J., Li,X., Zhang,L., Xia,Y., Wu,Y., Xu,T.,
            Shao,J., Feng,Y., Kamel,I.R., Yang,Q., Li,Z. and Gao,Q.
  TITLE     Serum semaphorin4C as an auxiliary diagnostic biomarker for breast
            cancer
  JOURNAL   Clin Transl Med 11 (8), e480 (2021)
   PUBMED   34459126
  REMARK    GeneRIF: Serum semaphorin4C as an auxiliary diagnostic biomarker
            for breast cancer.
REFERENCE   4  (bases 1 to 3652)
  AUTHORS   Hou,Y., Wang,W., Zeng,Z., Gan,W., Lv,S., Li,T., Yan,Z., Zhang,R.
            and Yang,M.
  TITLE     High SEMA4C expression promotes the epithelial-mesenchymal
            transition and predicts poor prognosis in colorectal carcinoma
  JOURNAL   Aging (Albany NY) 12 (21), 21992-22018 (2020)
   PUBMED   33177246
  REMARK    GeneRIF: High SEMA4C expression promotes the epithelial-mesenchymal
            transition and predicts poor prognosis in colorectal carcinoma.
REFERENCE   5  (bases 1 to 3652)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 3652)
  AUTHORS   Inagaki,S., Ohoka,Y., Sugimoto,H., Fujioka,S., Amazaki,M.,
            Kurinami,H., Miyazaki,N., Tohyama,M. and Furuyama,T.
  TITLE     Sema4c, a transmembrane semaphorin, interacts with a post-synaptic
            density protein, PSD-95
  JOURNAL   J Biol Chem 276 (12), 9174-9181 (2001)
   PUBMED   11134026
REFERENCE   7  (bases 1 to 3652)
  AUTHORS   Ohoka,Y., Hirotani,M., Sugimoto,H., Fujioka,S., Furuyama,T. and
            Inagaki,S.
  TITLE     Semaphorin 4C, a transmembrane semaphorin, [corrected] associates
            with a neurite-outgrowth-related protein, SFAP75
  JOURNAL   Biochem Biophys Res Commun 280 (1), 237-243 (2001)
   PUBMED   11162505
  REMARK    Erratum:[Biochem Biophys Res Commun 2001 Feb 16;281(1):266]
REFERENCE   8  (bases 1 to 3652)
  AUTHORS   Wang,L.H., Kalb,R.G. and Strittmatter,S.M.
  TITLE     A PDZ protein regulates the distribution of the transmembrane
            semaphorin, M-SemF
  JOURNAL   J Biol Chem 274 (20), 14137-14146 (1999)
   PUBMED   10318831
REFERENCE   9  (bases 1 to 3652)
  AUTHORS   Simmons,A.D., Puschel,A.W., McPherson,J.D., Overhauser,J. and
            Lovett,M.
  TITLE     Molecular cloning and mapping of human semaphorin F from the
            Cri-du-chat candidate interval
  JOURNAL   Biochem Biophys Res Commun 242 (3), 685-691 (1998)
   PUBMED   9464278
REFERENCE   10 (bases 1 to 3652)
  AUTHORS   Inagaki,S., Furuyama,T. and Iwahashi,Y.
  TITLE     Identification of a member of mouse semaphorin family
  JOURNAL   FEBS Lett 370 (3), 269-272 (1995)
   PUBMED   7656991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092636.3, BI518922.1, BC109104.1 and BC017476.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017789.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358842.1, BC109103.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305476.10/ ENSP00000306844.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC092636.3         123245-123326       c
            83-156              BI518922.1         1-74
            157-2873            BC109104.1         1-2717
            2874-3634           BC017476.1         2068-2828
            3635-3652           AC092636.3         112964-112981       c
FEATURES             Location/Qualifiers
     source          1..3652
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..3652
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /note="semaphorin 4C"
                     /db_xref="GeneID:54910"
                     /db_xref="HGNC:HGNC:10731"
                     /db_xref="MIM:604462"
     exon            1..205
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /inference="alignment:Splign:2.1.0"
     exon            206..351
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..2744
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /note="M-Sema F; sema domain, immunoglobulin domain (Ig),
                     transmembrane domain (TM) and short cytoplasmic domain,
                     (semaphorin) 4C"
                     /codon_start=1
                     /product="semaphorin-4C precursor"
                     /protein_id="NP_060259.4"
                     /db_xref="CCDS:CCDS2029.1"
                     /db_xref="GeneID:54910"
                     /db_xref="HGNC:HGNC:10731"
                     /db_xref="MIM:604462"
                     /translation="MAPHWAVWLLAARLWGLGIGAEVWWNLVPRKTVSSGELATVVRR
                     FSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQK
                     GKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCP
                     YDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKTEYLAFWLNEPHFVGS
                     AYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWT
                     TFLKARLACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQL
                     EEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILN
                     FVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIGTGDGWLLK
                     AVSLGPWVHLIEELQLFDQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKYRSCAD
                     CVLARDPYCAWSVNTSRCVAVGGHSGSLLIQHVMTSDTSGICNLRGSKKVRPTPKNIT
                     VVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLYDARLQALVVMAAQPRHAGA
                     YHCFSEEQGARLAAEGYLVAVVAGPSVTLEARAPLENLGLVWLAVVALGAVCLVLLLL
                     VLSLRRRLREELEKGAKATERTLVYPLELPKEPTSPPFRPCPEPDEKLWDPVGYYYSD
                     GSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGGGRNSNANGYVRLQLGGED
                     RGGLGHPLPELADELRRKLQQRQPLPDSNPEESSV"
     exon            352..500
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /inference="alignment:Splign:2.1.0"
     exon            501..563
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /inference="alignment:Splign:2.1.0"
     exon            564..662
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /inference="alignment:Splign:2.1.0"
     exon            663..759
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /inference="alignment:Splign:2.1.0"
     exon            760..876
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1028
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1204
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1349
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1572
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1685
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1843
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1914
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..3652
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3611..3616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /note="hexamer: AATAAA"
     regulatory      3625..3630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /note="hexamer: AATGAA"
     polyA_site      3631
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
                     /note="major polyA site"
     polyA_site      3652
                     /gene="SEMA4C"
                     /gene_synonym="M-SEMA-F; SEMACL1; SEMAF; SEMAI"
ORIGIN      
        1 ggagaaagag ccggcgcccg ccgtggtggc gcggggagcc cgagcctagg ggcgcggagc
       61 cgggcgggga cggaggggcg gtggcagaga ggccgcggag ggctggcggg cgagcgcggg
      121 caggcggcga cgcgggggca ggggtggacg gcggtcagag ccgaacgcga gggcggcgcc
      181 cggggactgg agctgcgcgc aataggacag ctggcctgaa gctcagagcc ggggcgtgcg
      241 ccatggcccc acactgggct gtctggctgc tggcagcaag gctgtggggc ctgggcattg
      301 gggctgaggt gtggtggaac cttgtgccgc gtaagacagt gtcttctggg gagctggcca
      361 cggtagtacg gcggttctcc cagaccggca tccaggactt cctgacactg acgctgacgg
      421 agcccactgg gcttctgtac gtgggcgccc gagaggccct gtttgccttc agcatggagg
      481 ccctggagct gcaaggagcg atctcctggg aggcccccgt ggagaagaag actgagtgta
      541 tccagaaagg gaagaacaac cagaccgagt gcttcaactt catccgcttc ctgcagccct
      601 acaatgcctc ccacctgtac gtctgtggca cctacgcctt ccagcccaag tgcacctacg
      661 tcaacatgct caccttcact ttggagcatg gagagtttga agatgggaag ggcaagtgtc
      721 cctatgaccc agctaagggc catgctggcc ttcttgtgga tggtgagctg tactcggcca
      781 cactcaacaa cttcctgggc acggaaccca ttatcctgcg taacatgggg ccccaccact
      841 ccatgaagac agagtacctg gccttttggc tcaacgaacc tcactttgta ggctctgcct
      901 atgtacctga gagtgtgggc agcttcacgg gggacgacga caaggtctac ttcttcttca
      961 gggagcgggc agtggagtcc gactgctatg ccgagcaggt ggtggctcgt gtggcccgtg
     1021 tctgcaaggg cgatatgggg ggcgcacgga ccctgcagag gaagtggacc acgttcctga
     1081 aggcgcggct ggcatgctct gccccgaact ggcagctcta cttcaaccag ctgcaggcga
     1141 tgcacaccct gcaggacacc tcctggcaca acaccacctt ctttggggtt tttcaagcac
     1201 agtggggtga catgtacctg tcggccatct gtgagtacca gttggaagag atccagcggg
     1261 tgtttgaggg cccctataag gagtaccatg aggaagccca gaagtgggac cgctacactg
     1321 accctgtacc cagccctcgg cctggctcgt gcattaacaa ctggcatcgg cgccacggct
     1381 acaccagctc cctggagcta cccgacaaca tcctcaactt cgtcaagaag cacccgctga
     1441 tggaggagca ggtggggcct cggtggagcc gccccctgct cgtgaagaag ggcaccaact
     1501 tcacccacct ggtggccgac cgggttacag gacttgatgg agccacctat acagtgctgt
     1561 tcattggcac aggagacggc tggctgctca aggctgtgag cctggggccc tgggttcacc
     1621 tgattgagga gctgcagctg tttgaccagg agcccatgag aagcctggtg ctatctcaga
     1681 gcaagaagct gctctttgcc ggctcccgct ctcagctggt gcagctgccc gtggccgact
     1741 gcatgaagta tcgctcctgt gcagactgtg tcctcgcccg ggacccctat tgcgcctgga
     1801 gcgtcaacac cagccgctgt gtggccgtgg gtggccactc tggatctcta ctgatccagc
     1861 atgtgatgac ctcggacact tcaggcatct gcaacctccg tggcagtaag aaagtcaggc
     1921 ccactcccaa aaacatcacg gtggtggcgg gcacagacct ggtgctgccc tgccacctct
     1981 cctccaactt ggcccatgcc cgctggacct ttgggggccg ggacctgcct gcggaacagc
     2041 ccgggtcctt cctctacgat gcccggctcc aggccctggt tgtgatggct gcccagcccc
     2101 gccatgccgg ggcctaccac tgcttttcag aggagcaggg ggcgcggctg gctgctgaag
     2161 gctaccttgt ggctgtcgtg gcaggcccgt cggtgacctt ggaggcccgg gcccccctgg
     2221 aaaacctggg gctggtgtgg ctggcggtgg tggccctggg ggctgtgtgc ctggtgctgc
     2281 tgctgctggt gctgtcattg cgccggcggc tgcgggaaga gctggagaaa ggggccaagg
     2341 ctactgagag gaccttggtg taccccctgg agctgcccaa ggagcccacc agtcccccct
     2401 tccggccctg tcctgaacca gatgagaaac tttgggatcc tgtcggttac tactattcag
     2461 atggctccct taagatagta cctgggcatg cccggtgcca gcccggtggg gggccccctt
     2521 cgccacctcc aggcatccca ggccagcctc tgccttctcc aactcggctt cacctggggg
     2581 gtgggcggaa ctcaaatgcc aatggttacg tgcgcttaca actaggaggg gaggaccggg
     2641 gagggctcgg gcaccccctg cctgagctcg cggatgaact gagacgcaaa ctgcagcaac
     2701 gccagccact gcccgactcc aaccccgagg agtcatcagt atgaggggaa cccccaccgc
     2761 gtcggcggga agcgtgggag gtgtagctcc tacttttgca caggcaccag ctacctcagg
     2821 gacatggcac gggcacctgc tctgtctggg acagatactg cccagcaccc acccggccat
     2881 gaggacctgc tctgctcagc acgggcactg ccacttggtg tggctcacca gggcaccagc
     2941 ctcgcagaag gcatcttcct cctctctgtg aatcacagac acgcgggacc ccagccgcca
     3001 aaacttttca aggcagaagt ttcaagatgt gtgtttgtct gtatttgcac atgtgtttgt
     3061 gtgtgtgtgt atgtgtgtgt gcacgcgcgt gcgcgcttgt ggcatagcct tcctgtttct
     3121 gtcaagtctt cccttggcct gggtcctcct ggtgagtcat tggagctatg aaggggaagg
     3181 ggtcgtatca ctttgtctct cctaccccca ctgccccgag tgtcgggcag cgatgtacat
     3241 atggaggtgg ggtggacagg gtgctgtgcc ccttcagagg gagtgcaggg cttggggtgg
     3301 gcctagtcct gctcctaggg ctgtgaatgt tttcagggtg gggggaggga gatggagcct
     3361 cctgtgtgtt tggggggaag ggtgggtggg gcctcccact tggccccggg gttcagtggt
     3421 attttatact tgccttcttc ctgtacaggg ctgggaaagg ctgtgtgagg ggagagaagg
     3481 gagagggtgg gcctgctgtg gacaatggca tactctcttc cagccctagg aggagggctc
     3541 ctaacagtgt aacttattgt gtccccgcgt atttatttgt tgtaaatatt tgagtatttt
     3601 tatattgaca aataaaatgg agaaaatgaa acgattgctc tgatggggct aa
//
