LOCUS       NM_198925               3780 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens semaphorin 4B (SEMA4B), transcript variant 2, mRNA.
ACCESSION   NM_198925
VERSION     NM_198925.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3780)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   2  (bases 1 to 3780)
  AUTHORS   Wang,X., Jian,W., Luo,Q. and Fang,L.
  TITLE     CircSEMA4B inhibits the progression of breast cancer by encoding a
            novel protein SEMA4B-211aa and regulating AKT phosphorylation
  JOURNAL   Cell Death Dis 13 (9), 794 (2022)
   PUBMED   36115854
  REMARK    GeneRIF: CircSEMA4B inhibits the progression of breast cancer by
            encoding a novel protein SEMA4B-211aa and regulating AKT
            phosphorylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3780)
  AUTHORS   Jiang,J., Lu,Y., Zhang,F., Pan,T., Zhang,Z., Wan,Y., Ren,X. and
            Zhang,R.
  TITLE     Semaphorin 4B promotes tumor progression and associates with immune
            infiltrates in lung adenocarcinoma
  JOURNAL   BMC Cancer 22 (1), 632 (2022)
   PUBMED   35676688
  REMARK    GeneRIF: Semaphorin 4B promotes tumor progression and associates
            with immune infiltrates in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3780)
  AUTHORS   Chen,Z., Wang,C., Feng,X., Nie,L., Tang,M., Zhang,H., Xiong,Y.,
            Swisher,S.K., Srivastava,M. and Chen,J.
  TITLE     Interactomes of SARS-CoV-2 and human coronaviruses reveal host
            factors potentially affecting pathogenesis
  JOURNAL   EMBO J 40 (17), e107776 (2021)
   PUBMED   34232536
REFERENCE   5  (bases 1 to 3780)
  AUTHORS   Stukalov,A., Girault,V., Grass,V., Karayel,O., Bergant,V.,
            Urban,C., Haas,D.A., Huang,Y., Oubraham,L., Wang,A., Hamad,M.S.,
            Piras,A., Hansen,F.M., Tanzer,M.C., Paron,I., Zinzula,L.,
            Engleitner,T., Reinecke,M., Lavacca,T.M., Ehmann,R., Wolfel,R.,
            Jores,J., Kuster,B., Protzer,U., Rad,R., Ziebuhr,J., Thiel,V.,
            Scaturro,P., Mann,M. and Pichlmair,A.
  TITLE     Multilevel proteomics reveals host perturbations by SARS-CoV-2 and
            SARS-CoV
  JOURNAL   Nature 594 (7862), 246-252 (2021)
   PUBMED   33845483
REFERENCE   6  (bases 1 to 3780)
  AUTHORS   Liu,T., Qian,W.J., Gritsenko,M.A., Camp,D.G. 2nd, Monroe,M.E.,
            Moore,R.J. and Smith,R.D.
  TITLE     Human plasma N-glycoproteome analysis by immunoaffinity
            subtraction, hydrazide chemistry, and mass spectrometry
  JOURNAL   J Proteome Res 4 (6), 2070-2080 (2005)
   PUBMED   16335952
REFERENCE   7  (bases 1 to 3780)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   8  (bases 1 to 3780)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 3780)
  AUTHORS   Swiercz,J.M., Kuner,R., Behrens,J. and Offermanns,S.
  TITLE     Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA
            and growth cone morphology
  JOURNAL   Neuron 35 (1), 51-63 (2002)
   PUBMED   12123608
REFERENCE   10 (bases 1 to 3780)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     Murine semaphorin D/collapsin is a member of a diverse gene family
            and creates domains inhibitory for axonal extension
  JOURNAL   Neuron 14 (5), 941-948 (1995)
   PUBMED   7748561
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091167.19.
            
            On Mar 22, 2021 this sequence version replaced NM_198925.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY445887.1, AK026108.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000411539.7/ ENSP00000394720.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-406               AC091167.19        136938-137343       c
            407-570             AC091167.19        121071-121234       c
            571-633             AC091167.19        120844-120906       c
            634-732             AC091167.19        118782-118880       c
            733-844             AC091167.19        117580-117691       c
            845-958             AC091167.19        117193-117306       c
            959-1110            AC091167.19        116908-117059       c
            1111-1292           AC091167.19        114933-115114       c
            1293-1443           AC091167.19        114685-114835       c
            1444-1654           AC091167.19        113495-113705       c
            1655-1770           AC091167.19        113276-113391       c
            1771-1937           AC091167.19        112846-113012       c
            1938-2023           AC091167.19        111031-111116       c
            2024-3780           AC091167.19        109013-110769       c
FEATURES             Location/Qualifiers
     source          1..3780
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..3780
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /note="semaphorin 4B"
                     /db_xref="GeneID:10509"
                     /db_xref="HGNC:HGNC:10730"
                     /db_xref="MIM:617029"
     exon            1..406
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..2763
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; sema domain, immunoglobulin domain (Ig),
                     transmembrane domain (TM) and short cytoplasmic domain,
                     4B; sema domain, immunoglobulin domain (Ig), transmembrane
                     domain (TM) and short cytoplasmic domain, (semaphorin) 4B;
                     semaphorin-C"
                     /codon_start=1
                     /product="semaphorin-4B isoform 1 precursor"
                     /protein_id="NP_945119.1"
                     /db_xref="CCDS:CCDS45347.1"
                     /db_xref="GeneID:10509"
                     /db_xref="HGNC:HGNC:10730"
                     /db_xref="MIM:617029"
                     /translation="MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWAL
                     SPRISLPLGSEERPFLRFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPG
                     GEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTY
                     INMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAIS
                     RSQSLRPTKTESSLNWLQDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFEN
                     TIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQD
                     WRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVP
                     TPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQVRSRMLLLQPQARYQRVA
                     VHRVPGLHHTYDVLFLGTGDGRLHKAVSVGPRVHIIEELQIFSSGQPVQNLLLDTHRG
                     LLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWI
                     QDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQFQPNTVNTLACPLLSNLATRLWLR
                     NGAPVNASASCHVLPTGDLLLVGTQQLGEFQCWSLEEGFQQLVASYCPEVVEDGVADQ
                     TDEGGSVPVIISTSRVSAPAGGKASWGADRSYWKEFLVMCTLFVLAVLLPVLFLLYRH
                     RNSMKVFLKQGECASVHPKTCPVVLPPETRPLNGLGPPSTPLDHRGYQSLSDSPPGSR
                     VFTESEKRPLSIQDSFVEVSPVCPRPRVRLGSEIRDSVV"
     exon            407..570
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            571..633
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            634..732
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            733..844
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            845..958
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1110
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1292
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1443
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1654
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1770
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1937
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2023
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..3780
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3754..3759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /note="hexamer: AATAAA"
     polyA_site      3780
                     /gene="SEMA4B"
                     /gene_synonym="SEMAC; SemC"
                     /note="major polyA site"
ORIGIN      
        1 gcttgcgggt gagctctgcc caagccgagg ctgcggggcc ggcgccggcg ggaggactgc
       61 ggtgccccgc ggaggggctg agtttgccag ggcccacttg accctgtttc ccacctcccg
      121 ccccccaggt ccggaggcgg gggcccccgg ggcgactcgg gggcggaccg cggggcggag
      181 ctgccgcccg tgagtccggc cgagccacct gagcccgagc cgcgggacac cgtcgctcct
      241 gctctccgaa tgctgcgcac cgcgatgggc ctgaggagct ggctcgccgc cccatggggc
      301 gcgctgccgc ctcggccacc gctgctgctg ctcctgctgc tgctgctcct gctgcagccg
      361 ccgcctccga cctgggcgct cagcccccgg atcagcctgc ctctgggctc tgaagagcgg
      421 ccattcctca gattcgaagc tgaacacatc tccaactaca cagcccttct gctgagcagg
      481 gatggcagga ccctgtacgt gggtgctcga gaggccctct ttgcactcag tagcaacctc
      541 agcttcctgc caggcgggga gtaccaggag ctgctttggg gtgcagacgc agagaagaaa
      601 cagcagtgca gcttcaaggg caaggaccca cagcgcgact gtcaaaacta catcaagatc
      661 ctcctgccgc tcagcggcag tcacctgttc acctgtggca cagcagcctt cagccccatg
      721 tgtacctaca tcaacatgga gaacttcacc ctggcaaggg acgagaaggg gaatgtcctc
      781 ctggaagatg gcaagggccg ttgtcccttc gacccgaatt tcaagtccac tgccctggtg
      841 gttgatggcg agctctacac tggaacagtc agcagcttcc aagggaatga cccggccatc
      901 tcgcggagcc aaagccttcg ccccaccaag accgagagct ccctcaactg gctgcaagac
      961 ccagcttttg tggcctcagc ctacattcct gagagcctgg gcagcttgca aggcgatgat
     1021 gacaagatct actttttctt cagcgagact ggccaggaat ttgagttctt tgagaacacc
     1081 attgtgtccc gcattgcccg catctgcaag ggcgatgagg gtggagagcg ggtgctacag
     1141 cagcgctgga cctccttcct caaggcccag ctgctgtgct cacggcccga cgatggcttc
     1201 cccttcaacg tgctgcagga tgtcttcacg ctgagcccca gcccccagga ctggcgtgac
     1261 acccttttct atggggtctt cacttcccag tggcacaggg gaactacaga aggctctgcc
     1321 gtctgtgtct tcacaatgaa ggatgtgcag agagtcttca gcggcctcta caaggaggtg
     1381 aaccgtgaga cacagcagtg gtacaccgtg acccacccgg tgcccacacc ccggcctgga
     1441 gcgtgcatca ccaacagtgc ccgggaaagg aagatcaact catccctgca gctcccagac
     1501 cgcgtgctga acttcctcaa ggaccacttc ctgatggacg ggcaggtccg aagccgcatg
     1561 ctgctgctgc agccccaggc tcgctaccag cgcgtggctg tacaccgcgt ccctggcctg
     1621 caccacacct acgatgtcct cttcctgggc actggtgacg gccggctcca caaggcagtg
     1681 agcgtgggcc cccgggtgca catcattgag gagctgcaga tcttctcatc gggacagccc
     1741 gtgcagaatc tgctcctgga cacccacagg gggctgctgt atgcggcctc acactcgggc
     1801 gtagtccagg tgcccatggc caactgcagc ctgtacagga gctgtgggga ctgcctcctc
     1861 gcccgggacc cctactgtgc ttggagcggc tccagctgca agcacgtcag cctctaccag
     1921 cctcagctgg ccaccaggcc gtggatccag gacatcgagg gagccagcgc caaggacctt
     1981 tgcagcgcgt cttcggttgt gtccccgtct tttgtaccaa caggggagaa gccatgtgag
     2041 caagtccagt tccagcccaa cacagtgaac actttggcct gcccgctcct ctccaacctg
     2101 gcgacccgac tctggctacg caacggggcc cccgtcaatg cctcggcctc ctgccacgtg
     2161 ctacccactg gggacctgct gctggtgggc acccaacagc tgggggagtt ccagtgctgg
     2221 tcactagagg agggcttcca gcagctggta gccagctact gcccagaggt ggtggaggac
     2281 ggggtggcag accaaacaga tgagggtggc agtgtacccg tcattatcag cacatcgcgt
     2341 gtgagtgcac cagctggtgg caaggccagc tggggtgcag acaggtccta ctggaaggag
     2401 ttcctggtga tgtgcacgct ctttgtgctg gccgtgctgc tcccagtttt attcttgctc
     2461 taccggcacc ggaacagcat gaaagtcttc ctgaagcagg gggaatgtgc cagcgtgcac
     2521 cccaagacct gccctgtggt gctgccccct gagacccgcc cactcaacgg cctagggccc
     2581 cctagcaccc cgctcgatca ccgagggtac cagtccctgt cagacagccc cccggggtcc
     2641 cgagtcttca ctgagtcaga gaagaggcca ctcagcatcc aagacagctt cgtggaggta
     2701 tccccagtgt gcccccggcc ccgggtccgc cttggctcgg agatccgtga ctctgtggtg
     2761 tgagagctga cttccagagg acgctgccct ggcttcaggg gctgtgaatg ctcggagagg
     2821 gtcaactgga cctcccctcc gctctgctct tcgtggaaca cgaccgtggt gcccggccct
     2881 tgggagcctt ggggccagct ggcctgctgc tctccagtca agtagcgaag ctcctaccac
     2941 ccagacaccc aaacagccgt ggccccagag gtcctggcca aatatggggg cctgcctagg
     3001 ttggtggaac agtgctcctt atgtaaactg agccctttgt ttaaaaaaca attccaaatg
     3061 tgaaactaga atgagaggga agagatagca tggcatgcag cacacacggc tgctccagtt
     3121 catggcctcc caggggtgct ggggatgcat ccaaagtggt tgtctgagac agagttggaa
     3181 accctcacca actggcctct tcaccttcca cattatcccg ctgccaccgg ctgccctgtc
     3241 tcactgcaga ttcaggacca gcttgggctg cgtgcgttct gccttgccag tcagccgagg
     3301 atgtagttgt tgctgccgtc gtcccaccac ctcagggacc agagggctag gttggcactg
     3361 cggccctcac caggtcctgg gctcggaccc aactcctgga cctttccagc ctgtatcagg
     3421 ctgtggccac acgagaggac agcgcgagct caggagagat ttcgtgacaa tgtacgcctt
     3481 tccctcagaa ttcagggaag agactgtcgc ctgccttcct ccgttgttgc gtgagaaccc
     3541 gtgtgcccct tcccaccata tccaccctcg ctccatcttt gaactcaaac acgaggaact
     3601 aactgcaccc tggtcctctc cccagtcccc agttcaccct ccatccctca ccttcctcca
     3661 ctctaaggga tatcaacact gcccagcaca ggggccctga atttatgtgg tttttataca
     3721 ttttttaata agatgcactt tatgtcattt tttaataaag tctgaagaat tactgtttaa
//
