LOCUS       NM_020163               4993 bp    mRNA    linear   PRI 30-OCT-2024
DEFINITION  Homo sapiens semaphorin 3G (SEMA3G), mRNA.
ACCESSION   NM_020163
VERSION     NM_020163.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4993)
  AUTHORS   Mirza,S.L., Upton,P.D., Hodgson,J., Graf,S., Morrell,N.W. and
            Dunmore,B.J.
  TITLE     SEMA3G regulates BMP9 inhibition of VEGF-mediated migration and
            network formation in pulmonary endothelial cells
  JOURNAL   Vascul Pharmacol 155, 107381 (2024)
   PUBMED   38795838
  REMARK    GeneRIF: SEMA3G regulates BMP9 inhibition of VEGF-mediated
            migration and network formation in pulmonary endothelial cells.
REFERENCE   2  (bases 1 to 4993)
  AUTHORS   Wang,H., Zhang,W., Ding,Z., Ke,H., Su,D., Wang,Q. and Xu,K.
  TITLE     SEMA3G functions as a novel prognostic biomarker associated with
            Wnt pathway in clear cell renal cell carcinoma
  JOURNAL   Cell Signal 111, 110868 (2023)
   PUBMED   37633476
  REMARK    GeneRIF: SEMA3G functions as a novel prognostic biomarker
            associated with Wnt pathway in clear cell renal cell carcinoma.
REFERENCE   3  (bases 1 to 4993)
  AUTHORS   Chen,D.Y., Sun,N.H., Chen,X., Gong,J.J., Yuan,S.T., Hu,Z.Z.,
            Lu,N.N., Korbelin,J., Fukunaga,K., Liu,Q.H., Lu,Y.M. and Han,F.
  TITLE     Endothelium-derived semaphorin 3G attenuates ischemic retinopathy
            by coordinating beta-catenin-dependent vascular remodeling
  JOURNAL   J Clin Invest 131 (4) (2021)
   PUBMED   33586674
  REMARK    GeneRIF: Endothelium-derived semaphorin 3G attenuates ischemic
            retinopathy by coordinating beta-catenin-dependent vascular
            remodeling.
REFERENCE   4  (bases 1 to 4993)
  AUTHORS   Gao,X., Yang,J. and Chen,Y.
  TITLE     Identification of a four immune-related genes signature based on an
            immunogenomic landscape analysis of clear cell renal cell carcinoma
  JOURNAL   J Cell Physiol 235 (12), 9834-9850 (2020)
   PUBMED   32452055
  REMARK    GeneRIF: Identification of a four immune-related genes signature
            based on an immunogenomic landscape analysis of clear cell renal
            cell carcinoma.
REFERENCE   5  (bases 1 to 4993)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4993)
  AUTHORS   Liu,W., Li,J., Liu,M., Zhang,H. and Wang,N.
  TITLE     PPAR-gamma promotes endothelial cell migration by inducing the
            expression of Sema3g
  JOURNAL   J Cell Biochem 116 (4), 514-523 (2015)
   PUBMED   25335934
  REMARK    GeneRIF: Results identify Sema3g as one of the downstream effectors
            of PPAR-gamma, which is centrally involved in regulating
            endothelial cell migration.
REFERENCE   7  (bases 1 to 4993)
  AUTHORS   Zhou,X., Ma,L., Li,J., Gu,J., Shi,Q. and Yu,R.
  TITLE     Effects of SEMA3G on migration and invasion of glioma cells
  JOURNAL   Oncol Rep 28 (1), 269-275 (2012)
   PUBMED   22562223
  REMARK    GeneRIF: overexpressed SEMA3G inhibited the migratory and invasive
            behavior of U251MG cancer cells
REFERENCE   8  (bases 1 to 4993)
  AUTHORS   Kutschera,S., Weber,H., Weick,A., De Smet,F., Genove,G.,
            Takemoto,M., Prahst,C., Riedel,M., Mikelis,C., Baulande,S.,
            Champseix,C., Kummerer,P., Conseiller,E., Multon,M.C., Heroult,M.,
            Bicknell,R., Carmeliet,P., Betsholtz,C. and Augustin,H.G.
  TITLE     Differential endothelial transcriptomics identifies semaphorin 3G
            as a vascular class 3 semaphorin
  JOURNAL   Arterioscler Thromb Vasc Biol 31 (1), 151-159 (2011)
   PUBMED   20947821
  REMARK    GeneRIF: Identify Sema3G as a primarily endothelial cell-expressed
            class 3 semaphorin that controls endothelial and smooth muscle cell
            functions in autocrine and paracrine manners.
REFERENCE   9  (bases 1 to 4993)
  AUTHORS   Karayan-Tapon,L., Wager,M., Guilhot,J., Levillain,P., Marquant,C.,
            Clarhaut,J., Potiron,V. and Roche,J.
  TITLE     Semaphorin, neuropilin and VEGF expression in glial tumours:
            SEMA3G, a prognostic marker?
  JOURNAL   Br J Cancer 99 (7), 1153-1160 (2008)
   PUBMED   18781179
  REMARK    GeneRIF: In gliomas, SEMA3B, SEMA3G and NRP2 expressions were
            related to prolonged survival
REFERENCE   10 (bases 1 to 4993)
  AUTHORS   Kigel,B., Varshavsky,A., Kessler,O. and Neufeld,G.
  TITLE     Successful inhibition of tumor development by specific class-3
            semaphorins is associated with expression of appropriate semaphorin
            receptors by tumor cells
  JOURNAL   PLoS One 3 (9), e3287 (2008)
   PUBMED   18818766
  REMARK    GeneRIF: Sema3G inhibits tumor progression from MDA-MB-435 but not
            from MDA-MB-231 cancer cells. It inhibits tumor angiogenesis in
            MDA-MB-231 cells.
            Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006208.3, CN428810.1,
            AB029496.1 and BQ017460.1.
            
            On May 17, 2019 this sequence version replaced NM_020163.2.
            
            Summary: The transcription of this gene is activated by PPAR-gamma,
            and the resulting protein product plays a role in endothelial cell
            migration. Expression of this gene also inhibits tumor cell
            migration and invasion. [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB029496.1, SRR1803615.101779.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000231721.7/ ENSP00000231721.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC006208.3         53526-53543         c
            19-76               CN428810.1         3-60
            77-4776             AB029496.1         1-4700
            4777-4780           BQ017460.1         234-237             c
            4781-4781           AC006208.3         41687-41687         c
            4782-4993           BQ017460.1         21-232              c
FEATURES             Location/Qualifiers
     source          1..4993
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..4993
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /note="semaphorin 3G"
                     /db_xref="GeneID:56920"
                     /db_xref="HGNC:HGNC:30400"
                     /db_xref="MIM:620997"
     exon            1..191
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..2425
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /note="semaphorin sem2; sema domain, immunoglobulin domain
                     (Ig), short basic domain, secreted, (semaphorin) 3G"
                     /codon_start=1
                     /product="semaphorin-3G precursor"
                     /protein_id="NP_064548.1"
                     /db_xref="CCDS:CCDS2856.1"
                     /db_xref="GeneID:56920"
                     /db_xref="HGNC:HGNC:30400"
                     /db_xref="MIM:620997"
                     /translation="MAPSAWAICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSAN
                     RSAIFLGPQGSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQR
                     EECVRKGRDPLTECANFVRVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEP
                     GSVESGRGRCPHEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQ
                     SLLHDPRFVMAARIPENSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGG
                     QRVLVNKWSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSA
                     VFQGFAVCVYHMADIWEVFNGPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGR
                     PFGSTKDYPDEVLQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGT
                     YDVIFLGTDSGSVLKVIALQAGGSAEPEEVVLEELQVFKVPTPITEMEISVKRQMLYV
                     GSRLGVAQLRLHQCETYGTACAECCLARDPYCAWDGASCTHYRPSLGKRRFRRQDIRH
                     GNPALQCLGQSQEEEAVGLVAATMVYGTEHNSTFLECLPKSPQAAVRWLLQRPGDEGP
                     DQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEHGFSQTVVRLALVVIVASQLDNL
                     FPPEPKPEEPPARGGLASTPPKAWYKDILQLIGFANLPRVDEYCERVWCRGTTECSGC
                     FRSRSRGKQARGKSWAGLELGKKMKSRVHAEHNRTPREVEAT"
     exon            192..352
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /inference="alignment:Splign:2.1.0"
     exon            353..415
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /inference="alignment:Splign:2.1.0"
     exon            416..535
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /inference="alignment:Splign:2.1.0"
     exon            536..626
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /inference="alignment:Splign:2.1.0"
     exon            627..743
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /inference="alignment:Splign:2.1.0"
     exon            744..889
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1004
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1074
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1219
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1451
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1543
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1585
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1814
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1954
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..4993
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4692..4697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /note="hexamer: ATTATA"
     polyA_site      4710
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /note="major polyA site"
     regulatory      4953..4958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /note="hexamer: ATTAAA"
     polyA_site      4975
                     /gene="SEMA3G"
                     /gene_synonym="sem2"
                     /note="major polyA site"
ORIGIN      
        1 aaactacaac cggcggccag cgggaccaga gggcggctct gcaggcaggc ggcagcggtg
       61 ccctcagttc cccagcatgg ccccctcggc ctgggccatt tgctggctgc tagggggcct
      121 cctgctccat gggggtagct ctggccccag ccccggcccc agtgtgcccc gcctgcggct
      181 ctcctaccga gacctcctgt ctgccaaccg ctctgccatc tttctgggcc cccagggctc
      241 cctgaacctc caggccatgt acctagatga gtaccgagac cgcctctttc tgggtggcct
      301 ggacgccctc tactctctgc ggctggacca ggcatggcca gatccccggg aggtcctgtg
      361 gccaccgcag ccaggacaga gggaggagtg tgttcgaaag ggaagagatc ctttgacaga
      421 gtgcgccaac ttcgtgcggg tgctacagcc tcacaaccgg acccacctgc tagcctgtgg
      481 cactggggcc ttccagccca cctgtgccct catcacagtt ggccaccgtg gggagcatgt
      541 gctccacctg gagcctggca gtgtggaaag tggccggggg cggtgccctc acgagcccag
      601 ccgtcccttt gccagcacct tcatagacgg ggagctgtac acgggtctca ctgctgactt
      661 cctggggcga gaggccatga tcttccgaag tggaggtcct cggccagctc tgcgttccga
      721 ctctgaccag agtctcttgc acgacccccg gtttgtgatg gccgcccgga tccctgagaa
      781 ctctgaccag gacaatgaca aggtgtactt cttcttctcg gagacggtcc cctcgcccga
      841 tggtggctcg aaccatgtca ctgtcagccg cgtgggccgc gtctgcgtga atgatgctgg
      901 gggccagcgg gtgctggtga acaaatggag cactttcctc aaggccaggc tggtctgctc
      961 ggtgcccggc cctggtggtg ccgagaccca ctttgaccag ctagaggatg tgttcctgct
     1021 gtggcccaag gccgggaaga gcctcgaggt gtacgcgctg ttcagcaccg tcagtgccgt
     1081 gttccagggc ttcgccgtct gtgtgtacca catggcagac atctgggagg ttttcaacgg
     1141 gccctttgcc caccgagatg ggcctcagca ccagtggggg ccctatgggg gcaaggtgcc
     1201 cttccctcgc cctggcgtgt gccccagcaa gatgaccgca cagccaggac ggccttttgg
     1261 cagcaccaag gactacccag atgaggtgct gcagtttgcc cgagcccacc ccctcatgtt
     1321 ctggcctgtg cggcctcgac atggccgccc tgtccttgtc aagacccacc tggcccagca
     1381 gctacaccag atcgtggtgg accgcgtgga ggcagaggat gggacctacg atgtcatttt
     1441 cctggggact gactcagggt ctgtgctcaa agtcatcgct ctccaggcag ggggctcagc
     1501 tgaacctgag gaagtggttc tggaggagct ccaggtgttt aaggtgccaa cacctatcac
     1561 cgaaatggag atctctgtca aaaggcaaat gctatacgtg ggctctcggc tgggtgtggc
     1621 ccagctgcgg ctgcaccaat gtgagactta cggcactgcc tgtgcagagt gctgcctggc
     1681 ccgggaccca tactgtgcct gggatggtgc ctcctgtacc cactaccgcc ccagccttgg
     1741 caagcgccgg ttccgccggc aggacatccg gcacggcaac cctgccctgc agtgcctggg
     1801 ccagagccag gaagaagagg cagtgggact tgtggcagcc accatggtct acggcacgga
     1861 gcacaatagc accttcctgg agtgcctgcc caagtctccc caggctgctg tgcgctggct
     1921 cttgcagagg ccaggggatg aggggcctga ccaggtgaag acggacgagc gagtcttgca
     1981 cacggagcgg gggctgctgt tccgcaggct tagccgtttc gatgcgggca cctacacctg
     2041 caccactctg gagcatggct tctcccagac tgtggtccgc ctggctctgg tggtgattgt
     2101 ggcctcacag ctggacaacc tgttccctcc ggagccaaag ccagaggagc ccccagcccg
     2161 gggaggcctg gcttccaccc cacccaaggc ctggtacaag gacatcctgc agctcattgg
     2221 cttcgccaac ctgccccggg tggatgagta ctgtgagcgc gtgtggtgca ggggcaccac
     2281 ggaatgctca ggctgcttcc ggagccggag ccggggcaag caggccaggg gcaagagctg
     2341 ggcagggctg gagctaggca agaagatgaa gagccgggtg catgccgagc acaatcggac
     2401 gccccgggag gtggaggcca cgtagaaggg ggcagaggag gggtggtcag gatgggctgg
     2461 ggggcccact agcagccccc agcatctccc acccacccag ctagggcaga ggggtcagga
     2521 tgtctgtttg cctcttagag acaggtgtct ctgcccccac accgctactg gggtctaatg
     2581 gaggggctgg gttcttgaag cctgttccct gcccttctct gtgctcttag acccagctgg
     2641 agccagcacc ctctggctgc tggcagcccc aagggatctg ccatttgttc tcagagatgg
     2701 cctggcttcc gcaacacatt tccgggtgtg cccagaggca agagggttgg gtggttcttt
     2761 cccagcctac agaacaatgg ccattctgag tgaccctcag agtgggtgtg tgggtgcgtc
     2821 tagggggtat cccggtaggg ggcctgcagg gagccagagg gtggaaatgg cctctaagct
     2881 agcaccccgt aagaagagcc tacctgaccg acttggggag ggaacacaga ggtgttggga
     2941 aggtggagca acaatgcacc tcccctcctg tcgcgccgtg atatcttggt ggctccctgc
     3001 cactgcccac cgcctcttct ccatctgaga atcacggaga ggtgtagata atctagaggc
     3061 atagactgct agagccccca gggatctggg gtggtcaggg ctcaggcttc actttgtaaa
     3121 ccaggtgggg gcatctcaca gcctgacttc ccttccccag gccagggttg ctgggatgcc
     3181 tgcccctcct gagaggaccc cctccccatt gtcaggctct ccatgtccac gagcggggag
     3241 gggtgggttc tggggcattg ttgtcccttg tgtctgtgga ctagagatag ggtgggggag
     3301 ctggggaagg gtgcaggcgg gaagagtggg ctgtctttcc cagggtgatg caagcatgcc
     3361 gcagccctgg aggctgggaa tgtggaggct ctgtgagccc tgcagccctc agaatcaggg
     3421 ccagggatgc agaagattga gaggatatgg agatggatag agggcaggag acccttagga
     3481 tagattgtgg gacccaggca ggaacaggtg tccacaagaa ctcaggatgg catcagttag
     3541 ctcagaagcc acctggaaga cccagtgttt ccatctctgg aatctctgtt ttatgctaaa
     3601 tggatttagg aagactgttt ttcttttaag ggggaaacaa ggtagagaaa aggacgaaga
     3661 agtgtaagtc ccgctgattc tcgggggtaa ggctcggatg gcaaggacgc gttctgcctg
     3721 ggcatgtagg ggaggtgttt ttgccatcac cagtttctca ggctggggag cacagagggg
     3781 aggaggagga ctaaatgaaa agttgttccc agcctgcaca tgaacacatt catgacacac
     3841 aaaactggct ggaaggagat aagagcactg ggtttgagat tccctccatt aaaacaacca
     3901 agacaaagaa aggaggggaa aaaaagataa aaagcaagcc agggttccct gccctattga
     3961 aactcaaacc cagactgcct tgggttttat ctttccctta cccctggcac ctccagagaa
     4021 ctgggacctg aaatagtccc tccgttctcc cctttgacca tgtaataaat gaaccagaag
     4081 cactgagatt aacctatcaa cgccctgaga agccttccag cctgcggtgc tgtctgctgg
     4141 gaggtcagct ggtcaaggca gaggaggaga ggaggaaagg atgggggctg aagagcagaa
     4201 gggaggggag acagagggga ttaaagaggg gaggagagag tgcagagctc caggaaaggg
     4261 tatcagagct gcagccagct ctgccctcta ccctagggag gccagaaaga cacaaacagc
     4321 cctccgggcc tttacgctgg actctggctt ggcaggctcc aggcagggtc ctctgggaag
     4381 ttactctaga aaacgaaggg aggaggagca caagatcctc agcaacgaac acctgcactt
     4441 agaaaaagtg gacagcttct gccaaccaca ccctacccat ggtactgtat gctattaact
     4501 cctggaaacg ccccgtaaat gcgagttgtt tttgtatttg tgtgttgaga tgggccttgt
     4561 ggtttctctg tactcagagc acatttcttg taattactat tgttattttt attgtcatga
     4621 ctgcccctga gctctggtga gaaaagctga atttacaagg aaagggatga agttaatatt
     4681 tgcatcacat aattatatca ttactgtgta tctgtgtatt gtactaaatg gactgatgct
     4741 gcgcacatga gctgaaaatg aagagccctc ccatccattc catgagaaag aaggtcaccc
     4801 tgagtgactt ctgtttcatg atttcccaaa caggttttag agctggaaaa ggacttaaag
     4861 aaagagactg ggtggtgctt tctagaaagg aggaagatgg gtatcagggg aaggaaggag
     4921 ttagagggct ttgtacaaag ccgagattgc tcattaaatg aggaacatcc tggcctgtgg
     4981 gcttgtaaga ctg
//
