LOCUS       NM_004186               3607 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens semaphorin 3F (SEMA3F), transcript variant 1, mRNA.
ACCESSION   NM_004186
VERSION     NM_004186.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3607)
  AUTHORS   Moragas,N., Fernandez-Nogueira,P., Recalde-Percaz,L., Inman,J.L.,
            Lopez-Plana,A., Bergholtz,H., Noguera-Castells,A., Del Burgo,P.J.,
            Chen,X., Sorlie,T., Gascon,P., Bragado,P., Bissell,M., Carbo,N. and
            Fuster,G.
  TITLE     The SEMA3F-NRP1/NRP2 axis is a key factor in the acquisition of
            invasive traits in in situ breast ductal carcinoma
  JOURNAL   Breast Cancer Res 26 (1), 122 (2024)
   PUBMED   39138514
  REMARK    GeneRIF: The SEMA3F-NRP1/NRP2 axis is a key factor in the
            acquisition of invasive traits in in situ breast ductal carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3607)
  AUTHORS   Li,Q., Ma,N., Li,X., Yang,C., Zhang,W., Xiong,J., Zhu,L., Li,J.,
            Wen,Q., Gao,L., Yang,C., Rao,L., Gao,L., Zhang,X. and Rao,J.
  TITLE     Reverse effect of Semaphorin-3F on rituximab resistance in diffuse
            large B-cell lymphoma via the Hippo pathway
  JOURNAL   Chin Med J (Engl) 136 (12), 1448-1458 (2023)
   PUBMED   37114652
  REMARK    GeneRIF: Reverse effect of Semaphorin-3F on rituximab resistance in
            diffuse large B-cell lymphoma via the Hippo pathway.
REFERENCE   3  (bases 1 to 3607)
  AUTHORS   Duncan,B.W., Mohan,V., Wade,S.D., Truong,Y., Kampov-Polevoi,A.,
            Temple,B.R. and Maness,P.F.
  TITLE     Semaphorin3F Drives Dendritic Spine Pruning Through Rho-GTPase
            Signaling
  JOURNAL   Mol Neurobiol 58 (8), 3817-3834 (2021)
   PUBMED   33856648
  REMARK    GeneRIF: Semaphorin3F Drives Dendritic Spine Pruning Through
            Rho-GTPase Signaling.
REFERENCE   4  (bases 1 to 3607)
  AUTHORS   Halabi,R., Watterston,C., Hehr,C.L., Mori-Kreiner,R., Childs,S.J.
            and McFarlane,S.
  TITLE     Semaphorin 3fa Controls Ocular Vascularization From the Embryo
            Through to the Adult
  JOURNAL   Invest Ophthalmol Vis Sci 62 (2), 21 (2021)
   PUBMED   33595613
  REMARK    GeneRIF: Semaphorin 3fa Controls Ocular Vascularization From the
            Embryo Through to the Adult.
REFERENCE   5  (bases 1 to 3607)
  AUTHORS   Xie,Z., Li,T., Huang,B., Liu,S., Zhang,L. and Zhang,Q.
  TITLE     Semaphorin 3F Serves as a Tumor Suppressor in Esophageal Squamous
            Cell Carcinoma and is Associated With Lymph Node Metastasis in
            Disease Progression
  JOURNAL   Technol Cancer Res Treat 19, 1533033820928117 (2020)
   PUBMED   32441221
  REMARK    GeneRIF: Semaphorin 3F Serves as a Tumor Suppressor in Esophageal
            Squamous Cell Carcinoma and is Associated With Lymph Node
            Metastasis in Disease Progression.
REFERENCE   6  (bases 1 to 3607)
  AUTHORS   Sekido,Y., Bader,S., Latif,F., Chen,J.Y., Duh,F.M., Wei,M.H.,
            Albanesi,J.P., Lee,C.C., Lerman,M.I. and Minna,J.D.
  TITLE     Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung
            cancer deletion region and demonstrate distinct expression patterns
  JOURNAL   Proc Natl Acad Sci U S A 93 (9), 4120-4125 (1996)
   PUBMED   8633026
REFERENCE   7  (bases 1 to 3607)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   8  (bases 1 to 3607)
  AUTHORS   Goshima,Y., Nakamura,F., Strittmatter,P. and Strittmatter,S.M.
  TITLE     Collapsin-induced growth cone collapse mediated by an intracellular
            protein related to UNC-33
  JOURNAL   Nature 376 (6540), 509-514 (1995)
   PUBMED   7637782
REFERENCE   9  (bases 1 to 3607)
  AUTHORS   Kolodkin,A.L., Matthes,D.J. and Goodman,C.S.
  TITLE     The semaphorin genes encode a family of transmembrane and secreted
            growth cone guidance molecules
  JOURNAL   Cell 75 (7), 1389-1399 (1993)
   PUBMED   8269517
REFERENCE   10 (bases 1 to 3607)
  AUTHORS   Luo,Y., Raible,D. and Raper,J.A.
  TITLE     Collapsin: a protein in brain that induces the collapse and
            paralysis of neuronal growth cones
  JOURNAL   Cell 75 (2), 217-227 (1993)
   PUBMED   8402908
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104450.2, BF058597.1,
            BC042914.1, AA378582.1 and CB240860.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004186.4.
            
            Summary: This gene encodes a member of the semaphorin III family of
            secreted signaling proteins that are involved in axon guidance
            during neuronal development. The encoded protein contains an
            N-terminal Sema domain, an immunoglobulin loop and a C-terminal
            basic domain. This gene is expressed by the endothelial cells where
            it was found to act in an autocrine fashion to induce apoptosis,
            inhibit cell proliferation and survival, and function as an
            anti-tumorigenic agent. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042914.1, U33920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000002829.8/ ENSP00000002829.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC104450.2         20714-20800         c
            88-91               BF058597.1         1-4
            92-1795             BC042914.1         1-1704
            1796-1812           AA378582.1         102-118
            1813-2731           BC042914.1         1722-2640
            2732-3249           BC042914.1         2645-3162
            3250-3607           CB240860.1         16-373              c
FEATURES             Location/Qualifiers
     source          1..3607
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3607
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /note="semaphorin 3F"
                     /db_xref="GeneID:6405"
                     /db_xref="HGNC:HGNC:10728"
                     /db_xref="MIM:601124"
     exon            1..241
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     exon            242..401
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..2647
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sema domain, immunoglobulin domain (Ig), short
                     basic domain, secreted, 3F; semaphorin III/F; semaphorin
                     IV; sema domain, immunoglobulin domain (Ig), short basic
                     domain, secreted, (semaphorin) 3F"
                     /codon_start=1
                     /product="semaphorin-3F isoform 1 precursor"
                     /protein_id="NP_004177.3"
                     /db_xref="CCDS:CCDS2811.1"
                     /db_xref="GeneID:6405"
                     /db_xref="HGNC:HGNC:10728"
                     /db_xref="MIM:601124"
                     /translation="MLVAGLLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGT
                     AHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIE
                     ECVLSGKDVNGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQ
                     AVRGRGSRATDGALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEEL
                     YAGVYIDFMGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLY
                     FFFRERSAEAPQSPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIET
                     HFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEG
                     PNYQWMPFSGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQR
                     RPLVVRTGAPYRLTTIAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQELEELML
                     EEVEVFKDPAPVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYC
                     AWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRGFNSNANKNAVESVQYGVAGSAAFL
                     ECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYSCTATE
                     NNFKHVVTRVQLHVLGRDAVHAALFPPLSMSAPPPPGAGPPTPPYQELAQLLAQPEVG
                     LIHQYCQGYWRHVPPSPREAPGAPRSPEPQDQKKPRNRRHHPPDT"
     exon            402..562
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     exon            563..625
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     exon            626..745
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     exon            746..838
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     exon            839..932
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1052
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1192
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1307
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1377
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1522
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1745
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1834
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1876
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2034
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2102
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2236
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..3607
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3583..3588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /note="hexamer: AATAAA"
     polyA_site      3607
                     /gene="SEMA3F"
                     /gene_synonym="SEMA-IV; SEMA4; SEMAK"
                     /note="major polyA site"
ORIGIN      
        1 gagcgcccct gagccttccc atggcccggg ctggggcccg ggccctcggc tgctgacgcg
       61 cccgaagccc gcggaaccgg ttaagccgcg gccgcggcgc cgatcccggc tgaggcgcag
      121 cggcgagagg tcgcgggcag ggccatggcc ccggggggcc gctagcgcgg accggcccaa
      181 cgggagccgc tccgtgccgc cgccgccgcc cgggcgccca ggccccgccg ctgcggaaga
      241 ggtttctaga gagtggagcc tgcttcctgg gccctaggcc cctcccacaa tgcttgtcgc
      301 cggtcttctt ctctgggctt ccctactgac cggggcctgg ccatccttcc ccacccagga
      361 ccacctcccg gccacgcccc gggtccggct ctcattcaaa gagctgaagg ccacaggcac
      421 cgcccacttc ttcaacttcc tgctcaacac aaccgactac cgaatcttgc tcaaggacga
      481 ggaccacgac cgcatgtacg tgggcagcaa ggactacgtg ctgtccctgg acctgcacga
      541 catcaaccgc gagcccctca ttatacactg ggcagcctcc ccacagcgca tcgaggaatg
      601 cgtgctctca ggcaaggatg tcaacggcga gtgtgggaac ttcgtcaggc tcatccagcc
      661 ctggaaccga acacacctgt atgtgtgcgg gacaggtgcc tacaacccca tgtgcaccta
      721 tgtgaaccgc ggacgccgcg cccaggccac accatggacc cagactcagg cggtcagagg
      781 ccgcggcagc agagccacgg atggtgccct ccgcccgatg cccacagccc cacgccagga
      841 ttacatcttc tacctggagc ctgagcgact cgagtcaggg aagggcaagt gtccgtacga
      901 tcccaagctg gacacagcat cggccctcat caatgaggag ctctatgctg gtgtgtacat
      961 cgattttatg ggcactgatg cagccatctt ccgcacactt ggaaagcaga cagccatgcg
     1021 cacggatcag tacaactccc ggtggctgaa cgacccgtcg ttcatccatg ctgagctcat
     1081 tcctgacagt gcggagcgca atgatgataa gctttacttc ttcttccgtg agcggtcggc
     1141 agaggcgccg cagagccccg cggtgtacgc ccgcatcggg cgcatttgcc tgaacgatga
     1201 cggtggtcac tgttgcctgg tcaacaagtg gagcacattc ctgaaggcgc ggctcgtctg
     1261 ctctgtcccg ggcgaggatg gcattgagac tcactttgat gagctccagg acgtgtttgt
     1321 ccagcagacc caggacgtga ggaaccctgt catttacgct gtctttacct cctctggctc
     1381 cgtgttccga ggctctgccg tgtgtgtcta ctccatggct gatattcgca tggtcttcaa
     1441 cgggcccttt gcccacaaag aggggcccaa ctaccagtgg atgcccttct cagggaagat
     1501 gccctaccca cggccgggca cgtgccctgg tggaaccttc acgccatcta tgaagtccac
     1561 caaggattat cctgatgagg tgatcaactt catgcgcagc cacccactca tgtaccaggc
     1621 cgtgtaccct ctgcagcggc ggcccctggt agtccgcaca ggtgctccct accgccttac
     1681 cactattgcc gtggaccagg tggatgcagc cgacgggcgc tatgaggtgc ttttcctggg
     1741 cacagaccgc gggacagtgc agaaggtcat tgtgctgccc aaggatgacc aggagttgga
     1801 ggagctcatg ctggaggagg tggaggtctt caaggatcca gcacccgtca agaccatgac
     1861 catctcttct aagaggcaac aactctacgt ggcgtcagcc gtgggtgtca cacacctgag
     1921 cctgcaccgc tgccaggcgt atggggctgc ctgtgctgac tgctgccttg cccgggaccc
     1981 ttactgtgcc tgggatggcc aggcctgctc ccgctataca gcatcctcca agaggcggag
     2041 ccgccggcag gacgtccggc acggaaaccc catcaggcag tgccgtgggt tcaactccaa
     2101 tgccaacaag aatgccgtgg agtctgtgca gtatggcgtg gccggcagcg cagccttcct
     2161 tgagtgccag ccccgctcgc cccaagccac tgttaagtgg ctgttccagc gagatcctgg
     2221 tgaccggcgc cgagagattc gtgcagagga ccgcttcctg cgcacagagc agggcttgtt
     2281 gctccgtgca ctgcagctca gcgatcgtgg cctctactcc tgcacagcca ctgagaacaa
     2341 ctttaagcac gtcgtcacac gagtgcagct gcatgtactg ggccgggacg ccgtccatgc
     2401 tgccctcttc ccaccactgt ccatgagcgc cccgccaccc ccaggcgcag gccccccaac
     2461 gcctccttac caggagttag cccagctgct ggcccagcca gaagtgggcc tcatccacca
     2521 gtactgccag ggttactggc gccatgtgcc ccccagcccc agggaggctc caggggcacc
     2581 ccggtctcct gagccccagg accagaaaaa gccccggaac cgccggcacc accctccgga
     2641 cacatgaggc cagctgcctg tgcctgccat gggccagcct agcccttgtc ccttttaata
     2701 taaaagatat atatatatat atatatatat aaaatatcta tattctatac acaccctgcc
     2761 cctgcaaaga cagtatttat tggtgggttg aatatagcct gcctcagtgg cagcatcctc
     2821 caaaacttag acccatgctg gtcagagacg gcagaaaaca gagcctgcct aaccaggccc
     2881 agccagttgg tggggccagg ccaggaccac acagtcccca gactcagctg gaagtctacc
     2941 tgctggacag cctccgccaa gatctacagg acaaagggag ggagcaagcc ctactcggat
     3001 ggggcacgga ctgtccacct tttctgatgt gtgttgtcag cctgtgctgt ggcatagaca
     3061 tggatgcgag gaccactttg gagactgggg tggcctcaag agcacacaga gaagggaaga
     3121 aggggccatc acaggatgcc agcccctgcc tgggttgggg gcactcagcc acgaccagcc
     3181 ccttcctggg tatttattct ctatttattg gggataggag aagaggcatc ctgcctgggt
     3241 gggacagcct cttcagcccc ttctcccctc cccgcctggc cagggcaggg ccaccccact
     3301 ctacctcctt agctttccct gtgccacttt gactcagagg ctgggagcat agcagagggg
     3361 ccaggcccag gcagagctga cgggaggccc cagctctgag gggagggggt ccgtggtaga
     3421 ggcctggggc cggtagaggc tccccagggc tcccttatgt ccaccacttc aggggatggg
     3481 tgtggatgta attagctctg gggggcagtt gggtagatgg gtgggggctc ctggtggcct
     3541 tctgctgccc aggccacagc cgcctttggg ttccatcttg ctaataaaca ctggctctgg
     3601 gactaga
//
