LOCUS       NM_001384900            6772 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens semaphorin 3D (SEMA3D), transcript variant 2, mRNA.
ACCESSION   NM_001384900 XM_011515960
VERSION     NM_001384900.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6772)
  AUTHORS   Thielman,N.R.J., Funes,V., Davuluri,S., Ibanez,H.E., Sun,W.C.,
            Fu,J., Li,K., Muth,S., Pan,X., Fujiwara,K., Dwayne L Thomas,Ii.,
            Henderson,M., Teh,S.S., Zhu,Q., Thompson,E., Jaffee,E.M.,
            Kolodkin,A., Meng,F. and Zheng,L.
  TITLE     Semaphorin 3D promotes pancreatic ductal adenocarcinoma progression
            and metastasis through macrophage reprogramming
  JOURNAL   Sci Adv 10 (42), eadp0684 (2024)
   PUBMED   39413197
  REMARK    GeneRIF: Semaphorin 3D promotes pancreatic ductal adenocarcinoma
            progression and metastasis through macrophage reprogramming.
REFERENCE   2  (bases 1 to 6772)
  AUTHORS   Zhang,Y., Xi,Q., Zhong,M., Jiang,Y., Zhuang,Q., Ding,Z., Tan,S.,
            Wang,J., Liu,H., Zhang,Z., Zhou,B. and Wu,G.
  TITLE     Tumor-derived semaphorin 3D promoting cancer cachexia via
            regulating hypothalamic pro-opiomelanocortin neurons
  JOURNAL   FASEB J 37 (6), e22980 (2023)
   PUBMED   37219490
  REMARK    GeneRIF: Tumor-derived semaphorin 3D promoting cancer cachexia via
            regulating hypothalamic pro-opiomelanocortin neurons.
REFERENCE   3  (bases 1 to 6772)
  AUTHORS   Hai,R., You,Q., Wu,F., Qiu,G., Yang,Q., Shu,L., Xie,L. and Zhou,X.
  TITLE     Semaphorin 3D inhibits proliferation and migration of papillary
            thyroid carcinoma by regulating MAPK/ERK signaling pathway
  JOURNAL   Mol Biol Rep 49 (5), 3793-3802 (2022)
   PUBMED   35190928
  REMARK    GeneRIF: Semaphorin 3D inhibits proliferation and migration of
            papillary thyroid carcinoma by regulating MAPK/ERK signaling
            pathway.
REFERENCE   4  (bases 1 to 6772)
  AUTHORS   Yoshida,E., Terao,Y., Hayashi,N., Mogushi,K., Arakawa,A.,
            Tanaka,Y., Ito,Y., Ohmiya,H., Hayashizaki,Y., Takeda,S., Itoh,M.
            and Kawaji,H.
  TITLE     Promoter-level transcriptome in primary lesions of endometrial
            cancer identified biomarkers associated with lymph node metastasis
  JOURNAL   Sci Rep 7 (1), 14160 (2017)
   PUBMED   29074988
  REMARK    GeneRIF: SEMA3D mRNA is expressed mainly in the cytoplasm of the
            endometrial cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6772)
  AUTHORS   Wang,Z., Ding,M., Qian,N., Song,B., Yu,J., Tang,J. and Wang,J.
  TITLE     Decreased expression of semaphorin 3D is associated with genesis
            and development in colorectal cancer
  JOURNAL   World J Surg Oncol 15 (1), 67 (2017)
   PUBMED   28320475
  REMARK    GeneRIF: Low SEMA3D expression is associated with colorectal
            cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6772)
  AUTHORS   Fujii,T., Uchiyama,H., Yamamoto,N., Hori,H., Tatsumi,M.,
            Ishikawa,M., Arima,K., Higuchi,T. and Kunugi,H.
  TITLE     Possible association of the semaphorin 3D gene (SEMA3D) with
            schizophrenia
  JOURNAL   J Psychiatr Res 45 (1), 47-53 (2011)
   PUBMED   20684831
  REMARK    GeneRIF: This study provided strong evidence that SEMA3D confers
            susceptibility to schizophrenia, which could contribute to the
            neurodevelopmental impairments in the disorder.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6772)
  AUTHORS   Gregorio,S.P., Sallet,P.C., Do,K.A., Lin,E., Gattaz,W.F. and
            Dias-Neto,E.
  TITLE     Polymorphisms in genes involved in neurodevelopment may be
            associated with altered brain morphology in schizophrenia:
            preliminary evidence
  JOURNAL   Psychiatry Res 165 (1-2), 1-9 (2009)
   PUBMED   19054571
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 6772)
  AUTHORS   Kigel,B., Varshavsky,A., Kessler,O. and Neufeld,G.
  TITLE     Successful inhibition of tumor development by specific class-3
            semaphorins is associated with expression of appropriate semaphorin
            receptors by tumor cells
  JOURNAL   PLoS One 3 (9), e3287 (2008)
   PUBMED   18818766
  REMARK    GeneRIF: Sema3D inhibits tumor development from MDA-MB-231 and
            MDA-MB-435 cancer cells. It inhibits tumor angiogenesis in all of
            the formed tumors.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6772)
  AUTHORS   Lallier,T.E.
  TITLE     Semaphorin profiling of periodontal fibroblasts and osteoblasts
  JOURNAL   J Dent Res 83 (9), 677-682 (2004)
   PUBMED   15329371
REFERENCE   10 (bases 1 to 6772)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006151.4 and AC004957.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 1, 2020 this sequence version replaced XM_011515960.1.
            
            Summary: This gene encodes a member of the semaphorin III family of
            secreted signaling proteins that are involved in axon guidance
            during neuronal development. The encoded protein contains an
            N-terminal Sema domain, an immunoglobulin like domain and a
            C-terminal basic domain. The protein encoded by this gene binds
            neuropilin and plays an important role in cardiovascular
            development. [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.3384259.1,
                                           SRR14038197.451407.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284136.11/ ENSP00000284136.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-379               AC006151.4         62736-63114         c
            380-511             AC006151.4         29666-29797         c
            512-702             AC004957.1         158286-158476       c
            703-863             AC004957.1         134350-134510       c
            864-926             AC004957.1         118062-118124       c
            927-1046            AC004957.1         109507-109626       c
            1047-1140           AC004957.1         104736-104829       c
            1141-1269           AC004957.1         101969-102097       c
            1270-1412           AC004957.1         92262-92404         c
            1413-1527           AC004957.1         78716-78830         c
            1528-1597           AC004957.1         77218-77287         c
            1598-1742           AC004957.1         73434-73578         c
            1743-1965           AC004957.1         58936-59158         c
            1966-2054           AC004957.1         56778-56866         c
            2055-2096           AC004957.1         54797-54838         c
            2097-2254           AC004957.1         51604-51761         c
            2255-2319           AC004957.1         49327-49391         c
            2320-2459           AC004957.1         43347-43486         c
            2460-6772           AC004957.1         32098-36410         c
FEATURES             Location/Qualifiers
     source          1..6772
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.11"
     gene            1..6772
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /note="semaphorin 3D"
                     /db_xref="GeneID:223117"
                     /db_xref="HGNC:HGNC:10726"
                     /db_xref="MIM:609907"
     exon            1..379
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     exon            380..511
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     exon            512..702
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     CDS             552..2885
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /note="collapsin 2; sema domain, immunoglobulin domain
                     (Ig), short basic domain, secreted, (semaphorin) 3D"
                     /codon_start=1
                     /product="semaphorin-3D precursor"
                     /protein_id="NP_001371829.1"
                     /db_xref="CCDS:CCDS34676.1"
                     /db_xref="GeneID:223117"
                     /db_xref="HGNC:HGNC:10726"
                     /db_xref="MIM:609907"
                     /translation="MNANKDERLKARSQDFHLFPALMMLSMTMLFLPVTGTLKQNIPR
                     LKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNF
                     KKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDL
                     GVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRS
                     LGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDK
                     TILSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPGSDGADTYFDELQDIYLLPTR
                     DERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESADHRWVQYDGRIPY
                     PRPGTCPSKTYDPLIKSTRDFPDDVISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLT
                     QIVVDHVIAEDGQYDVMFLGTDIGTVLKVVSISKEKWNMEEVVLEELQIFKHSSIILN
                     MELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACADCCLARDPYCAWDGNACSRYAPTS
                     KRRARRQDVKYGDPITQCWDIEDSISHETADEKVIFGIEFNSTFLECIPKSQQATIKW
                     YIQRSGDEHREELKPDERIIKTEYGLLIRSLQKKDSGMYYCKAQEHTFIHTIVKLTLN
                     VIENEQMENTQRAEHEEGKVKDLLAESRLRYKDYIQILSSPNFSLDQYCEQMWHREKR
                     RQRNKGGPKWKHMQEMKKKRNRRHHRDLDELPRAVAT"
     exon            703..863
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     exon            864..926
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1046
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1140
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1269
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1412
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1527
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1597
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1742
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1965
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2054
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2096
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2254
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2319
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2459
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..6772
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6735..6740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /note="hexamer: AATAAA"
     polyA_site      6772
                     /gene="SEMA3D"
                     /gene_synonym="coll-2; Sema-Z2"
                     /note="major polyA site"
ORIGIN      
        1 agaaagactg agtctctccc aggacagctg ctgcggtcac accacaaact taaaagccgc
       61 cctcctgttt ggagcgtgcc tttcctcgcc accctctcct ccccaaagct ccagctggtg
      121 ccttgctctc cgcctgtcct agcgcggctc tcgggggagg cagcagcgcc ccctgcctcc
      181 cggcctggcc cctgcggccg cagcttcccg gctctgccag ggctgccggc ggctccgctt
      241 gctcagccag ggctgcggct cagaggaacg cgcgccggtg ccccgggttg ccgcgccgct
      301 ggacctcagc ctgcatcccg ttcccctctc cctgaaaagg caccaggaaa agagagaggg
      361 agagaagagt tcacagcagg tctttacact tggactagaa ctgtaacatc tgctgtcctg
      421 gttgccaggc ttttgaacat acactgttgg ttctcctgga tcttcacctt accaactgca
      481 gatcttggga ctcatcagcc tcaataatta tattaaatta acaccatttg aaagagaaca
      541 ttgttttcat catgaatgct aataaagatg aaagacttaa agccagaagc caagattttc
      601 acctttttcc tgctttgatg atgctaagca tgaccatgtt gtttcttcca gtcactggca
      661 ctttgaagca aaatattcca agactcaagc taacctacaa agacttgctg ctttcaaata
      721 gctgtattcc ctttttgggt tcatcagaag gactggattt tcaaactctt ctcttagatg
      781 aggaaagagg caggctgctc ttgggagcca aagaccacat ctttctactc agtctggttg
      841 acttaaacaa aaattttaag aagatttatt ggcctgctgc aaaggaacgg gtggaattat
      901 gtaaattagc tgggaaagat gccaatacag aatgtgcaaa tttcatcaga gtacttcagc
      961 cctataacaa aactcacata tatgtgtgtg gaactggagc atttcatcca atatgtgggt
     1021 atattgatct tggagtctac aaggaggata ttatattcaa actagacaca cataatttgg
     1081 agtctggcag actgaaatgt cctttcgatc ctcagcagcc ttttgcttca gtaatgacag
     1141 atgagtacct ctactctgga acagcttctg atttccttgg caaagatact gcattcactc
     1201 gatcccttgg gcctactcat gaccaccact acatcagaac tgacatttca gagcactact
     1261 ggctcaatgg agcaaaattt attggaactt tcttcatacc agacacctac aatccagatg
     1321 atgataaaat atatttcttc tttcgtgaat catctcaaga aggcagtacc tccgataaaa
     1381 ccatcctttc tcgagttgga agagtttgta agaatgatgt aggaggacaa cgcagcctga
     1441 taaacaagtg gacgactttt cttaaggcca gactgatttg ctcaattcct ggaagtgatg
     1501 gggcagatac ttactttgat gagcttcaag atatttattt actccccaca agagatgaaa
     1561 gaaatcctgt agtatatgga gtctttacta caaccagctc catcttcaaa ggctctgctg
     1621 tttgtgtgta tagcatggct gacatcagag cagtttttaa tggtccatat gctcataagg
     1681 aaagtgcaga ccatcgttgg gtgcagtatg atgggagaat tccttatcca cggcctggta
     1741 catgtccaag caaaacctat gacccactga ttaagtccac ccgagatttt ccagatgatg
     1801 tcatcagttt cataaagcgg cactctgtga tgtataagtc cgtataccca gttgcaggag
     1861 gaccaacgtt caagagaatc aatgtggatt acagactgac acagatagtg gtggatcatg
     1921 tcattgcaga agatggccag tacgatgtaa tgtttcttgg aacagacatt ggaactgtcc
     1981 tcaaagttgt cagcatttca aaggaaaagt ggaatatgga agaggtagtg ctggaggagt
     2041 tgcagatatt caagcactca tcaatcatct tgaacatgga attgtctctg aagcagcaac
     2101 aattgtacat tggttcccga gatggattgg ttcagctctc cttgcacaga tgcgacactt
     2161 atgggaaagc ttgcgcagac tgttgtcttg ccagagaccc ctactgtgcc tgggatggaa
     2221 atgcatgctc tcgatatgct cctacttcta aaaggagagc tagacgccaa gatgtaaaat
     2281 atggcgaccc aatcacccag tgctgggaca tcgaagacag cattagtcat gaaactgctg
     2341 atgaaaaggt gatttttggc attgaattta actcaacctt tctggaatgt atacctaaat
     2401 cccaacaagc aactattaaa tggtatatcc agaggtcagg ggatgagcat cgagaggagt
     2461 tgaagcccga tgaaagaatc atcaaaacgg aatatgggct actgattcga agtttgcaga
     2521 agaaggattc tgggatgtat tactgcaaag cccaggagca cactttcatc cacaccatag
     2581 tgaagctgac tttgaatgtc attgagaatg aacagatgga aaatacccag agggcagagc
     2641 atgaggaggg gaaggtcaag gatctattgg ctgagtcacg gttgagatac aaagactaca
     2701 tccaaatcct tagcagccca aacttcagcc tcgaccagta ctgcgaacag atgtggcaca
     2761 gggagaagcg gagacagaga aacaaggggg gcccaaagtg gaagcacatg caggaaatga
     2821 agaagaaacg aaatcgaaga catcacagag acctggatga gctccctaga gctgtagcca
     2881 cgtagttttc tacttaattt aaagaaaaga attccttacc tataaaaaca ttgccttctg
     2941 ttttgtatat cccttatagt aattcataaa tgcttcccat ggagttttgc taaggcacaa
     3001 gacaataatc tgaataagac aatatgtgat gaatataaga aagggcaaaa aattcatttg
     3061 aaccagtttt ccaagaacaa atcttgcaca agcaaagtat aagaattatc ctaaaaatag
     3121 ggggtttaca gttgtaaatg ttttatgttt tgagttttgg aatttattgt catgtaaata
     3181 gttgagctaa gcaagccccg aatttgatag tgtataaggt gctttattcc ctcgaatgtc
     3241 cattaagcat ggaatttacc atgcagttgt gctatgttct tatgaacaga tatatcattc
     3301 ctattgagaa ccagctacct tgtggtaggg aataagaggt cagacacaaa ttaagacaac
     3361 tcccattatc aacaggaact ttctcagtga gccattcact cctggagaat ggtataggaa
     3421 tttggagagg tgcattattt ctttctggcc actggggtta aatttagtgt actacaacat
     3481 tgatttactg aagggcacta atgtttcccc caggatttct attgactagt caggagtaac
     3541 aggttcacag agagaagttg gtgcttagtt atgtgttttt tagagtatat actaagctct
     3601 acagggacag aatgcttaat aaatacttta ataagatatg ggaaaatatt ttaataaaac
     3661 aaggaaaaca taatgatgta taatgcatcc tgatgggaag gcatgcagat gggatttgtt
     3721 agaagacaga aggaaagaca gccataaatt ctggctttgg ggaaaactca tatccccatg
     3781 aaaaggaaga acaatcacaa ataaagtgag agtaatgtaa tggagctctt ttcactaggg
     3841 tataagtagc tgccaatttg taattcatct gttaaaaaaa atctagatta taacaaactg
     3901 ctagcaaaat ctgaggaaac ataaattctt ctgaagaatc ataggaagag tagacatttt
     3961 atttataacc aatgatattt cagtatatat tttctctctt ttaaaaaata tttatcatac
     4021 tctgtatatt atttcttttt actgccttta ttctctcctg tatattggat tttgtgatta
     4081 tatttgagtg aataggagaa aacaatatat aacacacaga gaattaagaa aatgacattt
     4141 ctggggagtg gggatatata tttgttgaat aacagaacga gtgtaaaatt ttaacaacgg
     4201 aaagggttaa attaactctt tgacatcttc actcaacctt ttctcattgc tgagttaatc
     4261 tgttgtaatt gtagtattgt ttttgtaatt taacaataaa taagcctgct acatgtaaaa
     4321 agaaccaaac tcacaatatt aacataaaca tctttcatat tttgttagta ctttcaaatg
     4381 ttttcaattt gactttccct ctgaatatgc atggtgtgtt tcctgtctgt ttaagcagaa
     4441 ctcacctttc cttcttgtaa cacagaaccc ttagccttct tctgttttgc cttttcacgc
     4501 cctttatagt gtgaaatgaa aaattagtca cttcctcaca tggaaggcag cttttcagaa
     4561 aataacagac attgctcgtt tctcatgcat tctacatatc ttgaaagaaa agtctgtgag
     4621 aaaaccctgt gattagaggg caacttaatg caagatctgt ggctctatgt tgagagcatt
     4681 ctctctctgt tatttttatt ttatttgcat tgcttaccta tctcaaagta gtcaaactga
     4741 tatatgagat tgagtactcc cttttgatat tatactgatg aatatttgta ggtgtttcac
     4801 tataaggaac agctaaggaa taattttaat aaaagtgaac cagaacaaat cactcattta
     4861 aaaagtaatt cagaagaaca gtgtggcatg atcagacttc taattgaata gcgtaacaac
     4921 agtgtttgta attatagatt tgcttggaca aaatattcca ggaactcata gcgagctcaa
     4981 agcaattaag tgggaacatt tttaatttaa aaaaaatttc caaatatttg tgggtccgac
     5041 agtaatgatc aaaatatgaa tgactttgga aaatttacat gaagctcaag tgttaggatt
     5101 gacttatgaa aataaatttt atttctatcc aaatttgaat gtccaaacca ttttttagtt
     5161 acttctttct aatcctagtt attcagacaa aatttggaaa cttattttat gaccacatct
     5221 aatattctgg ctgctttgga tacaatactc ttgatttatg ataattagtt aaaatatatt
     5281 aaaaatatta ttagtaaaat aaaatttcac acaataaaaa acaacataga gtacacatat
     5341 ttatatgtat ttttaaagat aaagaatatc taaaatgtgt ttttttctta gctttttagt
     5401 tgtctagaac atttagagaa agagtatgaa tatattaaat ccacaaacac actatatact
     5461 tcctcaccac tgactatttt atcaaatttg ccttaaaata atgaaaaaga aaagtatagt
     5521 taatggtttc aaatatgcta agaaattgac tctgcggagg ggatcttaaa atgcctgttt
     5581 actcatgttt tcgtattttt cttgtctcta atacttttgt ctttgtctgc cttgtgtgtt
     5641 cttttctgaa tttcatttca gcaatttatg ctgctaaata gaatcccgca tgtctgcatt
     5701 catttacatt caacttattg taaattttga gattttattt agaaatgaat tgtctaatta
     5761 atttatgtag agtccttttt tccaaagagc tcaaaacact acatccacat tattgacttt
     5821 tggaaaccaa ccaaattact taagaaatgg aaaagtagtc acagagaaat ttagtaattt
     5881 gcaaaagcca caacagtagt ggaagaatta aaattcataa agtctcatca ttctgttggc
     5941 taaaataatg ctctttacaa tatgctggct acaaaatggt cttactcttg aattttgctt
     6001 ttggttcata ttttggttct tcatattcta gtatgttttg ttcctgctga attttacaga
     6061 ctcagctaaa caataagtta ttagtagtca cttgttttca ttatcataat tgaatttcca
     6121 agaacaactt gatatcattc agctgtccaa aaaataataa gagcattcat taaatactga
     6181 ttttcttaaa cttaaatgtt gtatttcata tttatttata taatacaaat ggaaatcaaa
     6241 actgaaatag cctcccttta gaatgtcaca tttttcttag aaaacatttt ggaattggtt
     6301 aaccttattg ggaatggata atttagaaac aaaccaaaaa aaaaaaaaga tatttgaagt
     6361 gtttttatag gagatgtatt tttatcatag taaatgatca caattttaaa taattcatct
     6421 tacaagtcag gtaaaataaa atcgattccc agattccata cattaggagt gcaaagacag
     6481 gatcatacac atgacttata cctctcattt aaatatttta tagtataaag tatttatgga
     6541 aagggtttga gatagatgat ttttgggaaa gggcaaaatg tgtcagatgc cctagttaat
     6601 catgtaattt aattctggta ttgtgagtgg ttagcaatca attttgaatt tataattctg
     6661 ctattttaaa agaaatgtag tcttgtagta tgaaataatt aaaaattgtt aaatgtatat
     6721 tttggttgta ttataataaa atgcaaacat gactgttcta tgattataaa aa
//
