LOCUS       NM_006379               4874 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens semaphorin 3C (SEMA3C), transcript variant 2, mRNA.
ACCESSION   NM_006379
VERSION     NM_006379.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4874)
  AUTHORS   Peng,H., Yang,M., Feng,K., Lv,Q. and Zhang,Y.
  TITLE     Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote
            hepatocellular carcinoma progression
  JOURNAL   Signal Transduct Target Ther 9 (1), 169 (2024)
   PUBMED   38956074
  REMARK    GeneRIF: Semaphorin 3C (Sema3C) reshapes stromal microenvironment
            to promote hepatocellular carcinoma progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4874)
  AUTHORS   Tam,K.J., Liu,L., Hsing,M., Dalal,K., Thaper,D., McConeghy,B.,
            Yenki,P., Bhasin,S., Peacock,J.W., Wang,Y., Cherkasov,A.,
            Rennie,P.S., Gleave,M.E. and Ong,C.J.
  TITLE     Clinically-observed FOXA1 mutations upregulate SEMA3C through
            transcriptional derepression in prostate cancer
  JOURNAL   Sci Rep 14 (1), 7082 (2024)
   PUBMED   38528115
  REMARK    GeneRIF: Clinically-observed FOXA1 mutations upregulate SEMA3C
            through transcriptional derepression in prostate cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4874)
  AUTHORS   Yenki,P., Bhasin,S., Liu,L., Nabavi,N., Cheng,C.W., Tam,K.J.,
            Peacock,J.W., Adomat,H.H., Tombe,T., Fazli,L., Ivanova,L.,
            Dusek,C., Khosravi,S., Guns,E.S.T., Wang,Y., Buttyan,R.,
            Gleave,M.E. and Ong,C.J.
  TITLE     Semaphorin 3C promotes de novo steroidogenesis in prostate cancer
            cells
  JOURNAL   Endocr Relat Cancer 30 (12), e230010 (2023)
   PUBMED   37800655
  REMARK    GeneRIF: Semaphorin 3C promotes de novo steroidogenesis in prostate
            cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4874)
  AUTHORS   Hao,J., Han,X., Huang,H., Yu,X., Fang,J., Zhao,J., Prayson,R.A.,
            Bao,S. and Yu,J.S.
  TITLE     Sema3C signaling is an alternative activator of the canonical WNT
            pathway in glioblastoma
  JOURNAL   Nat Commun 14 (1), 2262 (2023)
   PUBMED   37080989
  REMARK    GeneRIF: Sema3C signaling is an alternative activator of the
            canonical WNT pathway in glioblastoma.
            Erratum:[Nat Commun. 2023 Sep 27;14(1):6018. doi:
            10.1038/s41467-023-41842-1.. PMID: 37758699]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4874)
  AUTHORS   Nasarre,P., Gemmill,R.M. and Drabkin,H.A.
  TITLE     The emerging role of class-3 semaphorins and their neuropilin
            receptors in oncology
  JOURNAL   Onco Targets Ther 7, 1663-1687 (2014)
   PUBMED   25285016
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4874)
  AUTHORS   Yamada,T., Endo,R., Gotoh,M. and Hirohashi,S.
  TITLE     Identification of semaphorin E as a non-MDR drug resistance gene of
            human cancers
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14713-14718 (1997)
   PUBMED   9405678
REFERENCE   7  (bases 1 to 4874)
  AUTHORS   Chen,H., Chedotal,A., He,Z., Goodman,C.S. and Tessier-Lavigne,M.
  TITLE     Neuropilin-2, a novel member of the neuropilin family, is a high
            affinity receptor for the semaphorins Sema E and Sema IV but not
            Sema III
  JOURNAL   Neuron 19 (3), 547-559 (1997)
   PUBMED   9331348
  REMARK    Erratum:[Neuron 1997 Sep;19(3):559]
REFERENCE   8  (bases 1 to 4874)
  AUTHORS   Mangasser-Stephan,K., Dooley,S., Welter,C., Mutschler,W. and
            Hanselmann,R.G.
  TITLE     Identification of human semaphorin E gene expression in rheumatoid
            synovial cells by mRNA differential display
  JOURNAL   Biochem Biophys Res Commun 234 (1), 153-156 (1997)
   PUBMED   9168980
REFERENCE   9  (bases 1 to 4874)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     Murine semaphorin D/collapsin is a member of a diverse gene family
            and creates domains inhibitory for axonal extension
  JOURNAL   Neuron 14 (5), 941-948 (1995)
   PUBMED   7748561
REFERENCE   10 (bases 1 to 4874)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB000220.1, AK304294.1,
            BC030690.1, CN334969.1, CN334967.1, AA853650.1 and BM473251.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006379.4.
            
            Summary: This gene encodes a secreted glycoprotein that belongs to
            the semaphorin class 3 family of neuronal guidance cues. The
            encoded protein contains an N-terminal sema domain, integrin and
            immunoglobulin-like domains, and a C-terminal basic domain.
            Homodimerization and proteolytic cleavage of the C-terminal
            propeptide are necessary for the function of the encoded protein.
            It binds a neuropilin co-receptor before forming a heterotrimeric
            complex with an associated plexin. An increase in the expression of
            this gene correlates with an increase in cancer cell invasion and
            adhesion. Naturally occurring mutations in this gene are associated
            with Hirschsprung disease. [provided by RefSeq, May 2017].
            
            Transcript Variant: This variant (2) contains an alternate exon in
            the 5' UTR, lacks a portion of the 5' coding region, and initiates
            translation at a downstream start codon, compared to variant 1. The
            encoded isoform (2) has a shorter N-terminus, compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030690.1, AB000220.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265361.8/ ENSP00000265361.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1548              AB000220.1         301-1848
            1549-1673           AK304294.1         1420-1544
            1674-1998           BC030690.1         1777-2101
            1999-2527           CN334969.1         104-632
            2528-2999           BC030690.1         2631-3102
            3000-3277           CN334967.1         84-361
            3278-3395           AA853650.1         23-140              c
            3396-3449           BM473251.1         680-733
            3450-4085           AB000220.1         3755-4390
            4086-4311           BC030690.1         4193-4418
            4312-4641           AB000220.1         4616-4945
            4642-4874           BC030690.1         4749-4981
FEATURES             Location/Qualifiers
     source          1..4874
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.11"
     gene            1..4874
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /note="semaphorin 3C"
                     /db_xref="GeneID:10512"
                     /db_xref="HGNC:HGNC:10725"
                     /db_xref="MIM:602645"
     exon            1..224
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            225..365
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..2518
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; semaphorin E; sema E; sema domain,
                     immunoglobulin domain (Ig), short basic domain, secreted,
                     (semaphorin) 3C"
                     /codon_start=1
                     /product="semaphorin-3C isoform 2 precursor"
                     /protein_id="NP_006370.1"
                     /db_xref="CCDS:CCDS5596.1"
                     /db_xref="GeneID:10512"
                     /db_xref="HGNC:HGNC:10725"
                     /db_xref="MIM:602645"
                     /translation="MAFRTICVLVGVFICSICVKGSSQPQARVYLTFDELRETKTSEY
                     FSLSHHPLDYRILLMDEDQDRIYVGSKDHILSLNINNISQEALSVFWPASTIKVEECK
                     MAGKDPTHGCGNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRRSEDQVFMIDSKCE
                     SGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWL
                     SEPMFVDAHVIPDGTDPNDAKVYFFFKEKLTDNNRSTKQIHSMIARICPNDTGGLRSL
                     VNKWTTFLKARLVCSVTDEDGPETHFDELEDVFLLETDNPRTTLVYGIFTTSSSVFKG
                     SAVCVYHLSDIQTVFNGPFAHKEGPNHQLISYQGRIPYPRPGTCPGGAFTPNMRTTKE
                     FPDDVVTFIRNHPLMYNSIYPIHKRPLIVRIGTDYKYTKIAVDRVNAADGRYHVLFLG
                     TDRGTVQKVVVLPTNNSVSGELILEELEVFKNHAPITTMKISSKKQQLYVSSNEGVSQ
                     VSLHRCHIYGTACADCCLARDPYCAWDGHSCSRFYPTGKRRSRRQDVRHGNPLTQCRG
                     FNLKAYRNAAEIVQYGVKNNTTFLECAPKSPQASIKWLLQKDKDRRKEVKLNERIIAT
                     SQGLLIRSVQGSDQGLYHCIATENSFKQTIAKINFKVLDSEMVAVVTDKWSPWTWASS
                     VRALPFHPKDIMGAFSHSEMQMINQYCKDTRQQHQQGDESQKMRGDYGKLKALINSRK
                     SRNRRNQLPES"
     exon            366..526
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            527..589
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            590..709
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            710..800
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            801..920
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1063
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1178
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1248
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1393
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1616
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1705
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1747
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1905
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..1973
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2104
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..4874
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4852..4857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /note="hexamer: AATAAA"
     polyA_site      4874
                     /gene="SEMA3C"
                     /gene_synonym="SEMAE; SemE"
                     /note="major polyA site"
ORIGIN      
        1 actccgaggt gcttgattga gcgacgcgga gaagagctcc gggtgccgcg gcactgcagc
       61 gctgagattc ctttacaaag aaactcagag gaccgggaag aaagaatttc acctttgcga
      121 cgtgctagaa aataaggtcg tctgggaaaa ggactggaga cacaagcgca tccaaccccg
      181 gtagcaaact gatgactttt ccgtgctgat ttctttcaac ctcggtattt tcccttggat
      241 attaacttgc atatctgaag aaatggcatt ccggacaatt tgcgtgttgg ttggagtatt
      301 tatttgttct atctgtgtga aaggatcttc ccagccccaa gcaagagttt atttaacatt
      361 tgatgaactt cgagaaacca agacctctga atacttcagc ctttcccacc atcctttaga
      421 ctacaggatt ttattaatgg atgaagatca ggaccggata tatgtgggaa gcaaagatca
      481 cattctttcc ctgaatatta acaatataag tcaagaagct ttgagtgttt tctggccagc
      541 atctacaatc aaagttgaag aatgcaaaat ggctggcaaa gatcccacac acggctgtgg
      601 gaactttgtc cgtgtaattc agactttcaa tcgcacacat ttgtatgtct gtgggagtgg
      661 cgctttcagt cctgtctgta cttacttgaa cagagggagg agatcagagg accaagtttt
      721 catgattgac tccaagtgtg aatctggaaa aggacgctgc tctttcaacc ccaacgtgaa
      781 cacggtgtct gttatgatca atgaggagct tttctctgga atgtatatag atttcatggg
      841 gacagatgct gctatttttc gaagtttaac caagaggaat gcggtcagaa ctgatcaaca
      901 taattccaaa tggctaagtg aacctatgtt tgtagatgca catgtcatcc cagatggtac
      961 tgatccaaat gatgctaagg tgtacttctt cttcaaagaa aaactgactg acaataacag
     1021 gagcacgaaa cagattcatt ccatgattgc tcgaatatgt cctaatgaca ctggtggact
     1081 gcgtagcctt gtcaacaagt ggaccacttt cttaaaggcg aggctggtgt gctcggtaac
     1141 agatgaagac ggcccagaaa cacactttga tgaattagag gatgtgtttc tgctggaaac
     1201 tgataacccg aggacaacac tagtgtatgg catttttaca acatcaagct cagttttcaa
     1261 aggatcagcc gtgtgtgtgt atcatttatc tgatatacag actgtgttta atgggccttt
     1321 tgcccacaaa gaagggccca atcatcagct gatttcctat cagggcagaa ttccatatcc
     1381 tcgccctgga acttgtccag gaggagcatt tacacccaat atgcgaacca ccaaggagtt
     1441 cccagatgat gttgtcactt ttattcggaa ccatcctctc atgtacaatt ccatctaccc
     1501 aatccacaaa aggcctttga ttgttcgtat tggcactgac tacaagtata caaagatagc
     1561 tgtggatcga gtgaacgctg ctgatgggag ataccatgtc ctgtttctcg gaacagatcg
     1621 gggtactgtg caaaaagtgg ttgttcttcc tactaacaac tctgtcagtg gcgagctcat
     1681 tctggaggag ctggaagtct ttaagaatca tgctcctata acaacaatga aaatttcatc
     1741 taaaaagcaa cagttgtatg tgagttccaa tgaaggggtt tcccaggtat ctctgcaccg
     1801 ctgccacatc tatggtacag cctgtgctga ctgctgcctg gcgcgggacc cttattgcgc
     1861 ctgggatggc cattcctgtt ccagattcta cccaactggg aaacggagga gccgaagaca
     1921 agatgtgaga catggaaacc cactgactca atgcagagga tttaatctaa aagcatacag
     1981 aaatgcagct gaaattgtcc agtatggagt aaaaaataac accacttttc tggagtgtgc
     2041 ccccaagtct ccgcaggcat ctatcaagtg gctgttacag aaagacaaag acaggaggaa
     2101 agaggttaag ctgaatgaac gaataatagc cacttcacag ggactcctga tccgctctgt
     2161 tcagggttct gaccaaggac tttatcactg cattgctaca gaaaatagtt tcaagcagac
     2221 catagccaag atcaacttca aagttttaga ttcagaaatg gtggctgttg tgacggacaa
     2281 atggtcccca tggacctggg ccagctctgt gagggcttta cccttccacc cgaaggacat
     2341 catgggggca ttcagccact cagaaatgca gatgattaac caatattgca aagacactcg
     2401 gcagcaacat cagcagggag atgaatcaca gaaaatgaga ggggactatg gcaagttaaa
     2461 ggccctcatc aatagtcgga aaagtagaaa caggaggaat cagttgccag agtcataata
     2521 ttttcttatg tgggtcttat gcttccatta acaaatgctc tgtcttcaat gatcaaattt
     2581 tgagcaaaga aacttgtgct ttaccaaggg gaattactga aaaaggtgat tactcctgaa
     2641 gtgagtttta cacgaactga aatgagcatg cattttcttg tatgatagtg actagcacta
     2701 gacatgtcat ggtcctcatg gtgcatataa atatatttaa cttaacccag attttattta
     2761 tatctttatt caccttttct tcaaaatcga tatggtggct gcaaaactag aattgttgca
     2821 tccctcaatt gaatgagggc catatccctg tggtattcct ttcctgcttt ggggctttag
     2881 aattctaatt gtcagtgatt ttgtatatga aaacaagttc caaatccaca gcttttacgt
     2941 agtaaaagtc ataaatgcat atgacagaat ggctatcaaa agaaatagaa aaggaagaca
     3001 gcatttaaag ttgtataaaa acatgagtta ttcataaaga gaaaatgatg agtttttatg
     3061 gttccaatga aatatgttgg ggttttttta agattgtaaa aataatcagt tactggtatc
     3121 tgtcactgac ctttgtttcc ttattcagga agataaaaat cagtaaccta ccccatgaag
     3181 atatttggtg ggagttatat cagtgaagca gtttggttta tattcttatg ttatcacctt
     3241 ccaaacaaaa gcacttactt tttttggaag ttatttattt tagactcaaa gaatataatc
     3301 tggcactact cagttattac tgtttgttct cttattccct agtctgtgtg gcaaattaaa
     3361 caatataaga aggaaaaatt tgaagtatta gacttctaaa taaggtgtga aatcatcaaa
     3421 aagaaaaatc aaagtagaaa ctactaattt tttaagagga atttataaca aatatggcta
     3481 gttttcaact tcagtactca aattcaatga ttcttccttt tattaaaacc agtctcagat
     3541 atcatactga tttttaagtc aacactatat attttatgat cttttcagtg tgatggcaag
     3601 gtgcttgtta tgtctagaaa gtaagaaaac aatatgagga gacattctgt ctttcaaaag
     3661 gtaatggtac atacgttcac tggtctctaa gtgtaaaagt agtaaatttt gtgatgaata
     3721 aaataattat ctcctaattg tatgttagaa taattttatt agaataattt catactgaaa
     3781 ttattttctc caaataaaaa ttagatggaa aaatgtgaaa aaaattattc atgctctcat
     3841 atatatttta aaaacactac ttttgctttt ttatttacct tttaagacat tttcatgctt
     3901 ccaggtaaaa acagatattg taccatgtac ctaatccaaa tatcatataa acattttatt
     3961 tatagttaat aatctatgat gaaggtaatt aaagtagatt atggcctttt taagtattgc
     4021 agtctaaaac ttcaaaaact aaaatcattg tcaaaattaa tatgattatt aatcagaata
     4081 tcagaatatg attcactatt taaactatga taaattatga taatatatga ggaggcctcg
     4141 ctatagcaaa aatagttaaa atgctgacat aacaccaaac ttcatttttt aaaaaatctg
     4201 ttgttccaaa tgtgtataat tttaaagtaa tttctaaagc agtttattat aatggtttgc
     4261 ctgcttaaaa ggtataatta aacttctttt ctcttctaca ttgacacaca gaaatgtgtc
     4321 aatgtaaagc caaaaccatc ttctgtgttt atggccaatc tattctcaaa gttaaaagta
     4381 aaattgtttc agagtcacag ttccctttat ttcacataag cccaaactga tagacagtaa
     4441 cggtgtttag ttttatacta tatttgtgct atttaattct ttctattttc acaattatta
     4501 aattgtgtac actttcatta cttttaaaaa tgtagaaatt cttcatgaac ataactctgc
     4561 tgaatgtaaa agaaaatttt ttttcaaaaa tgctgttaat gtatactact ggtggttgat
     4621 tggttttatt ttatgtagct tgacaattca gtgacttaat atctattcca tttgtattgt
     4681 acataaaatt ttctagaaat acactttttt ccaaagtgta agtttgtgaa tagattttag
     4741 catgatgaaa ctgtcataat ggtgaatgtt caatctgtgt aagaaaacaa actaaatgta
     4801 gttgtcacac taaaatttaa ttggatattg atgaaatcat tggcctggca aaataaaaca
     4861 tgttgaattc ccca
//
