LOCUS       NM_006080               8113 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens semaphorin 3A (SEMA3A), mRNA.
ACCESSION   NM_006080
VERSION     NM_006080.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8113)
  AUTHORS   Yang,R., Yang,F., Wei,Y., Huang,B., Cao,T., Tan,H., Liu,D., Zou,Q.,
            Wen,J., Wen,L., Lu,X., Yu,C., Cai,H., Xie,X., Jiang,S., Yao,S. and
            Liang,Y.
  TITLE     Hypoxia-induced Semaphorin 3A promotes the development of
            endometriosis through regulating macrophage polarization
  JOURNAL   Int Immunopharmacol 138, 112559 (2024)
   PUBMED   38955028
  REMARK    GeneRIF: Hypoxia-induced Semaphorin 3A promotes the development of
            endometriosis through regulating macrophage polarization.
REFERENCE   2  (bases 1 to 8113)
  AUTHORS   Huang,P., Jiang,R.X., Wang,F., Qiao,W.W., Ji,Y.T., Meng,L.Y. and
            Bian,Z.
  TITLE     PIEZO1 Promotes Odontoblast-Mediated Reactionary Dentinogenesis via
            SEMA3A
  JOURNAL   J Dent Res 103 (9), 889-898 (2024)
   PUBMED   38910430
  REMARK    GeneRIF: PIEZO1 Promotes Odontoblast-Mediated Reactionary
            Dentinogenesis via SEMA3A.
REFERENCE   3  (bases 1 to 8113)
  AUTHORS   Yang,Y., Guan,W., Sheng,X.M. and Gu,H.J.
  TITLE     Role of Semaphorin 3A in common psychiatric illnesses such as
            schizophrenia, depression, and anxiety
  JOURNAL   Biochem Pharmacol 226, 116358 (2024)
   PUBMED   38857830
  REMARK    GeneRIF: Role of Semaphorin 3A in common psychiatric illnesses such
            as schizophrenia, depression, and anxiety.
            Review article
REFERENCE   4  (bases 1 to 8113)
  AUTHORS   Lupo,F., Pezzini,F., Pasini,D., Fiorini,E., Adamo,A., Veghini,L.,
            Bevere,M., Frusteri,C., Delfino,P., D'agosto,S., Andreani,S.,
            Piro,G., Malinova,A., Wang,T., De Sanctis,F., Lawlor,R.T.,
            Hwang,C.I., Carbone,C., Amelio,I., Bailey,P., Bronte,V.,
            Tuveson,D., Scarpa,A., Ugel,S. and Corbo,V.
  TITLE     Axon guidance cue SEMA3A promotes the aggressive phenotype of
            basal-like PDAC
  JOURNAL   Gut 73 (8), 1321-1335 (2024)
   PUBMED   38670629
  REMARK    GeneRIF: Axon guidance cue SEMA3A promotes the aggressive phenotype
            of basal-like PDAC.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8113)
  AUTHORS   Takahashi,T., Nakamura,F., Jin,Z., Kalb,R.G. and Strittmatter,S.M.
  TITLE     Semaphorins A and E act as antagonists of neuropilin-1 and agonists
            of neuropilin-2 receptors
  JOURNAL   Nat Neurosci 1 (6), 487-493 (1998)
   PUBMED   10196546
REFERENCE   6  (bases 1 to 8113)
  AUTHORS   Chen,H., Chedotal,A., He,Z., Goodman,C.S. and Tessier-Lavigne,M.
  TITLE     Neuropilin-2, a novel member of the neuropilin family, is a high
            affinity receptor for the semaphorins Sema E and Sema IV but not
            Sema III
  JOURNAL   Neuron 19 (3), 547-559 (1997)
   PUBMED   9331348
  REMARK    Erratum:[Neuron 1997 Sep;19(3):559]
REFERENCE   7  (bases 1 to 8113)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     Murine semaphorin D/collapsin is a member of a diverse gene family
            and creates domains inhibitory for axonal extension
  JOURNAL   Neuron 14 (5), 941-948 (1995)
   PUBMED   7748561
REFERENCE   8  (bases 1 to 8113)
  AUTHORS   Kolodkin,A.L., Matthes,D.J. and Goodman,C.S.
  TITLE     The semaphorin genes encode a family of transmembrane and secreted
            growth cone guidance molecules
  JOURNAL   Cell 75 (7), 1389-1399 (1993)
   PUBMED   8269517
REFERENCE   9  (bases 1 to 8113)
  AUTHORS   Brugada,R., Campuzano,O., Sarquella-Brugada,G., Brugada,P.,
            Brugada,J. and Hong,K.
  TITLE     Brugada Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301690
REFERENCE   10 (bases 1 to 8113)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX491494.1, DR002146.1,
            L26081.1, BM723807.1, AC006322.2 and CR748125.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006080.2.
            
            Summary: This gene is a member of the semaphorin family and encodes
            a protein with an Ig-like C2-type (immunoglobulin-like) domain, a
            PSI domain and a Sema domain. This secreted protein can function as
            either a chemorepulsive agent, inhibiting axonal outgrowth, or as a
            chemoattractive agent, stimulating the growth of apical dendrites.
            In both cases, the protein is vital for normal neuronal pattern
            development. Increased expression of this protein is associated
            with schizophrenia and is seen in a variety of human tumor cell
            lines. Also, aberrant release of this protein is associated with
            the progression of Alzheimer's disease. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1441051.1, AK289954.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265362.9/ ENSP00000265362.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               BX491494.1         150-342
            194-789             DR002146.1         144-739
            790-2353            L26081.1           602-2165
            2354-2495           BM723807.1         430-571
            2496-2704           L26081.1           2308-2516
            2705-4999           AC006322.2         37834-40128
            5000-5547           CR748125.1         14-561              c
            5548-8113           AC006322.2         40677-43242
FEATURES             Location/Qualifiers
     source          1..8113
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.11"
     gene            1..8113
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /note="semaphorin 3A"
                     /db_xref="GeneID:10371"
                     /db_xref="HGNC:HGNC:10723"
                     /db_xref="MIM:603961"
     exon            1..315
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..2519
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /note="semaphorin L; semaphorin III; collapsin 1;
                     semaphorin D; sema domain, immunoglobulin domain (Ig),
                     short basic domain, secreted, (semaphorin) 3A"
                     /codon_start=1
                     /product="semaphorin-3A precursor"
                     /protein_id="NP_006071.1"
                     /db_xref="CCDS:CCDS5599.1"
                     /db_xref="GeneID:10371"
                     /db_xref="HGNC:HGNC:10723"
                     /db_xref="MIM:603961"
                     /translation="MGWLTRIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNN
                     VITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDE
                     CKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENS
                     HFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDS
                     RWLNDPKFISAHLISESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGH
                     RSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNI
                     FKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDST
                     KDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMF
                     IGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTKQQQLYIGSTAG
                     VAQLPLHRCDIYGKACAECCLARDPYCAWDGSACSRYFPTAKRRTRRQDIRNGDPLTH
                     CSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEERKEEIRVD
                     DHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTLEVIDTEHLEELLHKDDD
                     GDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHT
                     PGNSNKWKHLQENKKGRNRRTHEFERAPRSV"
     exon            316..473
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            474..536
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            537..656
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            657..750
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            751..870
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1013
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1128
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1198
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1343
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1563
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1655
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1697
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1855
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1920
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2063
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..8113
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5527..5532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /note="hexamer: AATACA"
     polyA_site      5547
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
     regulatory      6151..6156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /note="hexamer: AAGAAA"
     polyA_site      6173
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
     regulatory      6882..6887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /note="hexamer: AATAAA"
     polyA_site      6903
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /note="major polyA site"
     regulatory      8093..8098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
                     /note="hexamer: AATACA"
     polyA_site      8113
                     /gene="SEMA3A"
                     /gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
                     SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
ORIGIN      
        1 gagggtttga agtttctgtg cttcagtgac tgttacagaa gaagaggtgt tagtgttgcc
       61 atgaggtctt gattgtctgc atttatgaat gaaactgacc taaatcacct gttacctcca
      121 gtttccagat tgtttgaact tctctggccg cacaatacag gaaggaagac taaagcagca
      181 aagggaccta cagcgtctgc agcatgggct ggttaactag gattgtctgt cttttctggg
      241 gagtattact tacagcaaga gcaaactatc agaatgggaa gaacaatgtg ccaaggctga
      301 aattatccta caaagaaatg ttggaatcca acaatgtgat cactttcaat ggcttggcca
      361 acagctccag ttatcatacc ttccttttgg atgaggaacg gagtaggctg tatgttggag
      421 caaaggatca catattttca ttcgacctgg ttaatatcaa ggattttcaa aagattgtgt
      481 ggccagtatc ttacaccaga agagatgaat gcaagtgggc tggaaaagac atcctgaaag
      541 aatgtgctaa tttcatcaag gtacttaagg catataatca gactcacttg tacgcctgtg
      601 gaacgggggc ttttcatcca atttgcacct acattgaaat tggacatcat cctgaggaca
      661 atatttttaa gctggagaac tcacattttg aaaacggccg tgggaagagt ccatatgacc
      721 ctaagctgct gacagcatcc cttttaatag atggagaatt atactctgga actgcagctg
      781 attttatggg gcgagacttt gctatcttcc gaactcttgg gcaccaccac ccaatcagga
      841 cagagcagca tgattccagg tggctcaatg atccaaagtt cattagtgcc cacctcatct
      901 cagagagtga caatcctgaa gatgacaaag tatacttttt cttccgtgaa aatgcaatag
      961 atggagaaca ctctggaaaa gctactcacg ctagaatagg tcagatatgc aagaatgact
     1021 ttggagggca cagaagtctg gtgaataaat ggacaacatt cctcaaagct cgtctgattt
     1081 gctcagtgcc aggtccaaat ggcattgaca ctcattttga tgaactgcag gatgtattcc
     1141 taatgaactt taaagatcct aaaaatccag ttgtatatgg agtgtttacg acttccagta
     1201 acattttcaa gggatcagcc gtgtgtatgt atagcatgag tgatgtgaga agggtgttcc
     1261 ttggtccata tgcccacagg gatggaccca actatcaatg ggtgccttat caaggaagag
     1321 tcccctatcc acggccagga acttgtccca gcaaaacatt tggtggtttt gactctacaa
     1381 aggaccttcc tgatgatgtt ataacctttg caagaagtca tccagccatg tacaatccag
     1441 tgtttcctat gaacaatcgc ccaatagtga tcaaaacgga tgtaaattat caatttacac
     1501 aaattgtcgt agaccgagtg gatgcagaag atggacagta tgatgttatg tttatcggaa
     1561 cagatgttgg gaccgttctt aaagtagttt caattcctaa ggagacttgg tatgatttag
     1621 aagaggttct gctggaagaa atgacagttt ttcgggaacc gactgctatt tcagcaatgg
     1681 agctttccac taagcagcaa caactatata ttggttcaac ggctggggtt gcccagctcc
     1741 ctttacaccg gtgtgatatt tacgggaaag cgtgtgctga gtgttgcctc gcccgagacc
     1801 cttactgtgc ttgggatggt tctgcatgtt ctcgctattt tcccactgca aagagacgca
     1861 caagacgaca agatataaga aatggagacc cactgactca ctgttcagac ttacaccatg
     1921 ataatcacca tggccacagc cctgaagaga gaatcatcta tggtgtagag aatagtagca
     1981 catttttgga atgcagtccg aagtcgcaga gagcgctggt ctattggcaa ttccagaggc
     2041 gaaatgaaga gcgaaaagaa gagatcagag tggatgatca tatcatcagg acagatcaag
     2101 gccttctgct acgtagtcta caacagaagg attcaggcaa ttacctctgc catgcggtgg
     2161 aacatgggtt catacaaact cttcttaagg taaccctgga agtcattgac acagagcatt
     2221 tggaagaact tcttcataaa gatgatgatg gagatggctc taagaccaaa gaaatgtcca
     2281 atagcatgac acctagccag aaggtctggt acagagactt catgcagctc atcaaccacc
     2341 ccaatctcaa cacaatggat gagttctgtg aacaagtttg gaaaagggac cgaaaacaac
     2401 gtcggcaaag gccaggacat accccaggga acagtaacaa atggaagcac ttacaagaaa
     2461 ataagaaagg tagaaacagg aggacccacg aatttgagag ggcacccagg agtgtctgag
     2521 ctgcattacc tctagaaacc tcaaacaagt agaaacttgc ctagacaata actggaaaaa
     2581 caaatgcaat atacatgaac ttttttcatg gcattatgtg gatgtttaca atggtgggaa
     2641 attcagctga gttccaccaa ttataaatta aatccatgag taactttcct aataggcttt
     2701 ttttcctaat accaccacct aacagagaac acaggtgaat gcagatgttc actttagcag
     2761 acttaatgtt tcctatgaga tttcactgta caggtttgtc tttcttcttt gcctgagaaa
     2821 taaaaatgtc atttgccata ttgccatcta aaggagaaaa actgcatcag caaagccatt
     2881 gtattgaact aaaagtttaa aatgaactgc atggatttac taagctgatg aatattccaa
     2941 aacgtggttg gattcaagga tatattttgt ctaccggccc tcatgtttgt atgtacttga
     3001 ggagtaaaat gagtaaaatg atactgaatg aaatgttctg tggaaatatt aaaaaaaaaa
     3061 aaaaacataa gccatccatc atccagaaga aaaatggaat acactgatct actactgatg
     3121 tcttctttca gctttgatct aaagatgtat tttattaaaa ctataattta aatgtaccat
     3181 gaaaaatatg cagtaaaaat tagttgtttt ctaagctaga gtaggatttg tcttacaatt
     3241 attgtgctat gtagtttttg ttttaaaaat tccaatggtg tgctgctttc tttggacatt
     3301 ttattttcaa ttctataaga gggatagatg acattgttct agaaacacat atacatcatt
     3361 aagagtgaat ctctaaaacc aggatataaa ttatgcttta tttctctgag aaaatcaaac
     3421 aaatggaagc tgttcacacc tccccttctt taagcattat ctaaattaat ttttacttgc
     3481 ataatgttct tagaaaaaaa aacagaacat ttaagcagga aaaaaggaag aaacaagttg
     3541 atttttaagt gcattttact ataatgaatc aatgaaggga aaaggaactg catatttcat
     3601 gaaaataata agcattgtct taatatactg ttaatagaaa atgtgtctta attccgtgct
     3661 tgaatccctg catgatattt gagactaaga tctctcttat gattctacca agaattatat
     3721 ctgtgtcact taattttttt aaaagagaga gatcaataac tattcagagc aacatgttaa
     3781 aggcaaagtt tccaatcatt tacatctgta tcaggtgcct cttacctttc cttatttaag
     3841 acaattattt gtacaagaaa cacatgactc ttttcatatc aatgggaggg acttttctac
     3901 aaagtatttt ccaggatgca acccacattt aaacaatgta aaattctttg tttcctgcaa
     3961 caacttacaa aataaggtaa aagactaaaa ttcaagattt gcttccttca ttgtcctaag
     4021 acgattcgtt gagaatcact gactttgaga tatttaaaac tttcagcatt atactgtggt
     4081 ttcttttgca ctgcactcac ctattcagga ctcctccccc aggttcctca tcatgcacaa
     4141 aaatgcaaag aaaacatctt attagtaatt aatgaagcaa cattgaaatt ctaactctag
     4201 ctgtctttgg attctaatta actcagcatc aatttctcac ctcagactac agtgaatttt
     4261 tatttcctat cagctgaaat atttcacaga tggaagctca tgtttcagtt ttaatgactg
     4321 ccttgaataa acaagttgtt gccacttgtt tcaaacaaaa gcctaaaaat aatctacatt
     4381 caattttagg ctccattgac taatatggtg ttgcttttgg aagtactgta tatcctcaca
     4441 tggaagccaa attgttaaat tatttgaagg acacaccact gtacagaaag tagtgtttca
     4501 aatataaatc gaagaacaaa gagtgctcca aaaaataggt cattctttta ttttcataaa
     4561 gtatctaaac tgtactaaca ttcagtgttg tgtttcattc taaatttgca gctgaaataa
     4621 atttatttgc gatagcagaa atatcttatt attcatcctc agaaataaag gatttgaagg
     4681 gatagagatt atatgataaa tttatagaag actttcagaa tttgaatgca ttttgtttag
     4741 tgttatgaaa tgacaataga aaaaagtctc gacttcaatt aaaagttaca caaacaaaca
     4801 aatctacagg catgtcttta tataccatca ggtctaagtt ttcaaagaaa attgtagata
     4861 taacttgcag ataactcatt acagtcataa tctctgccca tgtgtattga gagggggcag
     4921 tttgcacgaa aaagaattat tggcccattt aataattcag ctttaaatag actttgtcat
     4981 atgcatgaat catcagagat gaaactgttt gagagactca tgtgacctta cgaaaattac
     5041 aacagcagtc ttaaagtatg aaaaagatgc atcacagcag agacattatg gcccagttga
     5101 tatcaaatgt aaaatgtaaa tgcatgtaaa tgcacacttc attttatgta ttatttagta
     5161 atttgcagtg gtatgtgttt aatatttttg ctacctacac attaggcaaa aaaaagatgt
     5221 aaataatttg ggagaaaaag aggaagaaca gtgtaaaata aaactttcta taagtactcc
     5281 atttcaatgt gttcaacatc atcctaaaag gcaagatttt cccacgcagg tgacaaggtg
     5341 gtttatgtac tatttaaggg cggaaggtgc gtgcccgttc aataagcatg ttttttgcca
     5401 ggtaggaaat atgttccata tctttactta tcattgcatt tcagatggga actagaaaaa
     5461 ctggagagaa aaatgtaatg aaactgctgc tgtaaattat tccttttagc atgtattcac
     5521 ttgctaaata cacatttctt caaaatattt gaattcagat gtctttactg ttccctataa
     5581 catatggtgt taaggaacat aagctcataa aatgttgaga accagagtca ggttgctaca
     5641 taattagcta acagatttct tcattgtagt catctgtaaa ctgggttcta tatttatggt
     5701 gatgatgtga atttttatgc cctttaaatt aagtattgtt ctttttaatg tcatacctaa
     5761 aaaggaaatg tagggataaa tttttataat gtgtcatttt cataatcagt ttggttttat
     5821 tcaggatcca caaagatgtc agatgactgt tattgaaatt gcttatctta aaggtcacag
     5881 acaagcattt tattaatatg gagccactag tataatatgt taaaatcttt gttttattag
     5941 ctcattttaa aacacaattt ccattcaatt taatgaaact gtatcaggtt tcatggtttc
     6001 aaagacagac ttaaatagga ttcaacaccc ccgtatcgtg taataacatg ttaaactggt
     6061 ctaacaccaa ggacatctat acttttaact tgatttgtaa taattatttg aagtcaatgt
     6121 taatgtttgc aaatacatgt ttccataaag aagaaaacat tatttttcaa aaatctgtaa
     6181 aatctcatta gtttgtttga tctctaaaaa ttttcttaaa ctagttaatt aaatgaacat
     6241 aatttttcaa gttaataaat taagaaaata tctaaatgaa agagagaata aaatcagcat
     6301 atgtgacagc ccatatagta aggacagttt cgcaatcaac gtaaccaagg aaaacagctt
     6361 tgttatcatt tcaaacatgc aggcacacac aggcagaggc aaagctggaa ccaaaccaaa
     6421 caaaaagaag attttgaata ttaaaaaact gggcctctag acactttgcc ttttagaacc
     6481 agcttcctac acgttcaagt aaattccact gatagatctt gactatctac aatgtgctag
     6541 gtattatgtt aggtgatgag gacactaaag tgaataagac ataacccttg ttctcaaaga
     6601 gctcacaatg aaattaagga aacagagcga gatgacttat catcatctaa tccagcaagt
     6661 ctttcctaat cctcccatcc ctagttcaag ctagggacct tctctatgct aaacctgtgc
     6721 cttgtatata ccttttattg tcacactacc ccaatgtgtg atttatttgt ttatgtttcc
     6781 atctccattt ctagactgtg agctccttga gggcaggatt tgtatctaat tgatctctgt
     6841 ccccagtgtc tagcatgatg cctggcacaa agagggagcc caataaatca ctgttgaaaa
     6901 gaaccaagtt acgatatgac aattgccaaa tacaagctca caataagagc ggtatggatc
     6961 aaagaaaaaa aaaaggagga attaacttgt ggagagagat catggggtgc ttcagagaat
     7021 aagtgacttt ccagctgtga atcagtcaga tatgcctaga tgaagaaaca aaatggcaat
     7081 ctgagtagaa gaaataagga gaaaggagga gaggtgtgaa aaaaagtcct ttttctgaga
     7141 acaagcattc aaacagataa aacacaggtt tcataaagaa aagttaaatg tcccactact
     7201 atgagtcaaa atggtgcatt tgctttttcc tgggttttga tttattgccc tctgtttgta
     7261 ccccacattc gcatccttgg cacagactgt catatgtcac acattcagcc tcctacactt
     7321 ccaccccaca atctctttac cttccttctt aatgttcacc tcatttatct ttactcagct
     7381 aaagtcatag cactagacag tgttcccaca accgtcttca aactcatctg tatttcataa
     7441 tctctcctct agttcaaacc agcacaggtc agctgaaact ctgaattcta caaataaata
     7501 tttagaggaa gctaacttca tcagacactc ccctatgctc tcagttcaaa cgaaagtttc
     7561 tgttacattt cacctaccta cagccttacc tcactcagct agcattagac tactcagcaa
     7621 tgagttccaa cattgccttg ctaaaaagca aggtggctca caaacaagac ttcagcaaag
     7681 atagcattaa aatgtgaagt ctgcatttgt tcaaggcata ccttagatgg agtaattcat
     7741 ggccaagcaa tgctgcaggt gtggtcagca catgtagttg ataggcagac tcctattatt
     7801 ttaaacaaac aaaccaaaaa agttttttaa aaaatgagac ccaccttcat cttgaatatg
     7861 tcaaccccgc accaccgttg tattaatctg tcatgttttt ctcatataac aaaagaatgg
     7921 attttctttc ttttaatcta aacactatac ttgtatatac aatgtttatt tatataggac
     7981 ctaagcaaaa gtttttatag atgtgttcat gtcatcacaa ttcaggtaat gtgaaggctc
     8041 aacttccgtc ttctctcttt gtaaatctca ctgaagcatt agatctcaag taaatacatt
     8101 tgtaaaatat cca
//
