LOCUS       NM_003005               3157 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens selectin P (SELP), mRNA.
ACCESSION   NM_003005
VERSION     NM_003005.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3157)
  AUTHORS   Waggiallah,H.A., Eltayeb,M.M., Hjazi,A.M. and Elmosaad,Y.M.
  TITLE     High expression of angiotensin-converting enzyme 2 receptor
            (ACE-2), transmembrane protease serine (TMPRSS), and P-selectin in
            platelets lead to thrombosis formation in COVID-19 patients
  JOURNAL   Eur Rev Med Pharmacol Sci 28 (5), 1847-1856 (2024)
   PUBMED   38497867
  REMARK    GeneRIF: High expression of angiotensin-converting enzyme 2
            receptor (ACE-2), transmembrane protease serine (TMPRSS), and
            P-selectin in platelets lead to thrombosis formation in COVID-19
            patients.
REFERENCE   2  (bases 1 to 3157)
  AUTHORS   O'Dwyer,M., Kirkham-McCarthy,L., Cerreto,M., Foa,R. and Natoni,A.
  TITLE     PSGL-1 decorated with sialyl Lewisa/x promotes high affinity
            binding of myeloma cells to P-selectin but is dispensable for
            E-selectin engagement
  JOURNAL   Sci Rep 14 (1), 1756 (2024)
   PUBMED   38243063
  REMARK    GeneRIF: PSGL-1 decorated with sialyl Lewis[a/x] promotes high
            affinity binding of myeloma cells to P-selectin but is dispensable
            for E-selectin engagement.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3157)
  AUTHORS   Fu,L., Lei,C., Chen,Y., Xu,X., Wu,B., Dong,L., Ye,X., Zheng,L. and
            Gong,D.
  TITLE     Association of the rs3917647 polymorphism of the SELP gene with
            malnutrition in gastric cancer
  JOURNAL   Support Care Cancer 31 (12), 708 (2023)
   PUBMED   37978991
  REMARK    GeneRIF: Association of the rs3917647 polymorphism of the SELP gene
            with malnutrition in gastric cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3157)
  AUTHORS   Fan,H., Liu,Y., Zhang,X., Sun,J. and Lin,N.
  TITLE     Clinical significance of elevated soluble T-cell immunoglobulin and
            mucin domain 1 and soluble P-selectin in individuals with
            obstructive sleep apnea-hypopnea syndrome
  JOURNAL   Saudi Med J 44 (11), 1113-1119 (2023)
   PUBMED   37926453
  REMARK    GeneRIF: Clinical significance of elevated soluble T-cell
            immunoglobulin and mucin domain 1 and soluble P-selectin in
            individuals with obstructive sleep apnea-hypopnea syndrome.
REFERENCE   5  (bases 1 to 3157)
  AUTHORS   Takada,Y., Fujita,M. and Takada,Y.K.
  TITLE     Virtual Screening of Protein Data Bank via Docking Simulation
            Identified the Role of Integrins in Growth Factor Signaling, the
            Allosteric Activation of Integrins, and P-Selectin as a New
            Integrin Ligand
  JOURNAL   Cells 12 (18), 2265 (2023)
   PUBMED   37759488
  REMARK    GeneRIF: Virtual Screening of Protein Data Bank via Docking
            Simulation Identified the Role of Integrins in Growth Factor
            Signaling, the Allosteric Activation of Integrins, and P-Selectin
            as a New Integrin Ligand.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3157)
  AUTHORS   Israels,S.J., Gerrard,J.M., Jacques,Y.V., McNicol,A., Cham,B.,
            Nishibori,M. and Bainton,D.F.
  TITLE     Platelet dense granule membranes contain both granulophysin and
            P-selectin (GMP-140)
  JOURNAL   Blood 80 (1), 143-152 (1992)
   PUBMED   1377048
REFERENCE   7  (bases 1 to 3157)
  AUTHORS   Ryan,U.S. and Worthington,R.E.
  TITLE     Cell-cell contact mechanisms
  JOURNAL   Curr Opin Immunol 4 (1), 33-37 (1992)
   PUBMED   1375831
  REMARK    Review article
REFERENCE   8  (bases 1 to 3157)
  AUTHORS   Fukami,M.H.
  TITLE     Isolation of dense granules from human platelets
  JOURNAL   Methods Enzymol 215, 36-42 (1992)
   PUBMED   1435334
REFERENCE   9  (bases 1 to 3157)
  AUTHORS   Johnston,G.I., Bliss,G.A., Newman,P.J. and McEver,R.P.
  TITLE     Structure of the human gene encoding granule membrane protein-140,
            a member of the selectin family of adhesion receptors for
            leukocytes
  JOURNAL   J Biol Chem 265 (34), 21381-21385 (1990)
   PUBMED   1701178
REFERENCE   10 (bases 1 to 3157)
  AUTHORS   Watson,M.L., Kingsmore,S.F., Johnston,G.I., Siegelman,M.H., Le
            Beau,M.M., Lemons,R.S., Bora,N.S., Howard,T.A., Weissman,I.L.,
            McEver,R.P. et al.
  TITLE     Genomic organization of the selectin family of leukocyte adhesion
            molecules on human and mouse chromosome 1
  JOURNAL   J Exp Med 172 (1), 263-272 (1990)
   PUBMED   1694218
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA994564.1, BC068533.1,
            M25322.1 and DA926598.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003005.3.
            
            Summary: This gene encodes a 140 kDa protein that is stored in the
            alpha-granules of platelets and Weibel-Palade bodies of endothelial
            cells. This protein redistributes to the plasma membrane during
            platelet activation and degranulation and mediates the interaction
            of activated endothelial cells or platelets with leukocytes. The
            membrane protein is a calcium-dependent receptor that binds to
            sialylated forms of Lewis blood group carbohydrate antigens on
            neutrophils and monocytes. Alternative splice variants may occur
            but are not well documented. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M25322.1, SRR1803616.158534.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263686.11/ ENSP00000263686.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-496               DA994564.1         43-538
            497-1623            BC068533.1         498-1624
            1624-1843           M25322.1           1612-1831
            1844-2401           DA926598.1         19-576
            2402-3112           M25322.1           2390-3100
            3113-3157           BC068533.1         3111-3155
FEATURES             Location/Qualifiers
     source          1..3157
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..3157
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /note="selectin P"
                     /db_xref="GeneID:6403"
                     /db_xref="HGNC:HGNC:10721"
                     /db_xref="MIM:173610"
     exon            1..53
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..2543
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /note="platelet alpha-granule membrane protein;
                     P-selectin; leukocyte-endothelial cell adhesion molecule
                     3; granulocyte membrane protein; GMP-140; granule membrane
                     protein 140; CD62 antigen-like family member P; platelet
                     activation dependent granule-external membrane protein;
                     selectin P (granule membrane protein 140kDa, antigen
                     CD62)"
                     /codon_start=1
                     /product="P-selectin precursor"
                     /protein_id="NP_002996.2"
                     /db_xref="CCDS:CCDS1282.1"
                     /db_xref="GeneID:6403"
                     /db_xref="HGNC:HGNC:10721"
                     /db_xref="MIM:173610"
                     /translation="MANCQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTY
                     HYSTKAYSWNISRKYCQNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRKNNKTWT
                     WVGTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALCYT
                     ASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPLG
                     NFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCL
                     HSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGT
                     MDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESP
                     VHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQD
                     LPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAI
                     PCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPM
                     CEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSA
                     TPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDS
                     TLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLL
                     NGSAQTACQENGHWSTTVPTCQAGPLTIQEALTYFGGAVASTIGLIMGGTLLALLRKR
                     FRQKDDGKCPLNPHSHLGTYGVFTNAAFDPSP"
     exon            54..144
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /inference="alignment:Splign:2.1.0"
     exon            145..531
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /inference="alignment:Splign:2.1.0"
     exon            532..639
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /inference="alignment:Splign:2.1.0"
     exon            640..825
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1011
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1197
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1383
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1569
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1755
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1941
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2151
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2337
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2457
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2488
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2544
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..3157
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3137..3142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /note="hexamer: ATTAAA"
     polyA_site      3157
                     /gene="SELP"
                     /gene_synonym="CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM;
                     PSEL"
                     /note="major polyA site"
ORIGIN      
        1 agcagtctgg gttgggcaga aggcagaaaa ccagcagagt cacagaggag atggccaact
       61 gccaaatagc catcttgtac cagagattcc agagagtggt ctttggaatt tcccaactcc
      121 tttgcttcag tgccctgatc tctgaactaa caaaccagaa agaagtggca gcatggactt
      181 atcattacag cacaaaagca tactcatgga atatttcccg taaatactgc cagaatcgct
      241 acacagactt agtggccatc cagaataaaa atgaaattga ttacctcaat aaggtcctac
      301 cctactacag ctcctactac tggattggga tccgaaagaa caataagaca tggacatggg
      361 tgggaaccaa aaaggctctc accaacgagg ctgagaactg ggctgataat gaacctaaca
      421 acaaaaggaa caacgaggac tgcgtggaga tatacatcaa gagtccgtca gcccctggca
      481 agtggaatga tgagcactgc ttgaagaaaa agcacgcatt gtgttacaca gcctcctgcc
      541 aggacatgtc ctgcagcaaa caaggagagt gcctcgagac catcgggaac tacacctgct
      601 cctgttaccc tggattctat gggccagaat gtgaatacgt gagagagtgt ggagaacttg
      661 agctccctca acacgtgctc atgaactgca gccaccctct gggaaacttc tcttttaact
      721 cgcagtgcag cttccactgc actgacgggt accaagtaaa tgggcccagc aagctggaat
      781 gcttggcttc tggaatctgg acaaataagc ctccacagtg tttagctgcc cagtgcccac
      841 ccctgaagat tcctgaacga ggaaacatga cctgccttca ttctgcaaaa gcattccagc
      901 atcagtctag ctgcagcttc agttgtgaag agggatttgc attagttgga ccggaagtgg
      961 tgcaatgcac agcctcgggg gtatggacag ccccagcccc agtgtgtaaa gctgtgcagt
     1021 gtcagcacct ggaagccccc agtgaaggaa ccatggactg tgttcatccg ctcactgctt
     1081 ttgcctatgg ctccagctgt aaatttgagt gccagcccgg ctacagagtg aggggcttgg
     1141 acatgctccg ctgcattgac tctggacact ggtctgcacc cttgccaacc tgtgaggcta
     1201 tttcgtgtga gccgctggag agtcctgtcc acggaagcat ggattgctct ccatccttga
     1261 gagcgtttca gtatgacacc aactgtagct tccgctgtgc tgaaggtttc atgctgagag
     1321 gagccgatat agttcggtgt gataacttgg gacagtggac agcaccagcc ccagtctgtc
     1381 aagctttgca gtgccaggat ctcccagttc caaatgaggc ccgggtgaac tgctcccacc
     1441 ccttcggtgc ctttaggtac cagtcagtct gcagcttcac ctgcaatgaa ggcttgctcc
     1501 tggtgggagc aagtgtgcta cagtgcttgg ctactggaaa ctggaattct gttcctccag
     1561 aatgccaagc cattccctgc acacctttgc taagccctca gaatggaaca atgacctgtg
     1621 ttcaacctct tggaagttcc agttataaat ccacatgtca attcatctgt gacgagggat
     1681 attctttgtc tggaccagaa agattggatt gtactcgatc gggacgctgg acagactccc
     1741 caccaatgtg tgaagccatc aagtgcccag aactctttgc cccagagcag ggcagcctgg
     1801 attgttctga cactcgtgga gaattcaatg ttggctccac ctgccatttc tcttgtgaca
     1861 acggctttaa gctggagggg cccaataatg tggaatgcac aacttctgga agatggtcag
     1921 ctactccacc aacctgcaaa ggcatagcat cacttcctac tccaggggtg caatgtccag
     1981 ccctcaccac tcctgggcag ggaaccatgt actgtaggca tcatccggga acctttggtt
     2041 ttaataccac ttgttacttt ggctgcaacg ctggattcac actcatagga gacagcactc
     2101 tcagctgcag accttcagga caatggacag cagtaactcc agcatgcaga gctgtgaaat
     2161 gctcagaact acatgttaat aagccaatag cgatgaactg ctccaacctc tggggaaact
     2221 tcagttatgg atcaatctgc tctttccatt gtctagaggg ccagttactt aatggctctg
     2281 cacaaacagc atgccaagag aatggccact ggtcaactac cgtgccaacc tgccaagcag
     2341 gaccattgac tatccaggaa gccctgactt actttggtgg agcggtggct tctacgatag
     2401 gtctgataat gggtgggacg ctcctggctt tgctaagaaa gcgtttcaga caaaaagatg
     2461 atgggaaatg ccccttgaat cctcacagcc acctaggaac atatggagtt tttacaaacg
     2521 ctgcatttga cccgagtcct taaggtttcc ataaacaccc atgaatcaaa gacatggaat
     2581 taccttagat tagctctgga ccagcctgtt ggacccgctc tggaccaacc ctgtttcctg
     2641 agtttgggat tgtggtacaa tctcaaattc tcaacctacc accccttcct gtcccacctc
     2701 ttctcttcct gtaacacaag ccacagaagc caggagcaaa tgtttctgca gtagtctctg
     2761 tgctttgact cacctgttac ttgaaatacc agtgaaccaa agagactgga gcatctgact
     2821 cacaagaaga ccagactgtg gagaaataaa aatacctctt tattttttga ttgaaggaag
     2881 gttttctcca ctttgttgga aagcaggtgg catctctaat tggaagaaat tcctgtagca
     2941 tcttctggag tctccagtgg ttgctgttga tgaggcctct tggacctctg ctctgaggct
     3001 tccagagagt cctctggatg gcaccagagg ctgcagaagg ccaagaatca agctagaagg
     3061 ccacatgtca ccgtggacct tcctgccacc agtcactgtc cctcaaatga cccaaagacc
     3121 aatattcaaa tgcgtaatta aaagaatttt ccccaaa
//
