LOCUS       NM_000655               2358 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens selectin L (SELL), transcript variant 1, mRNA.
ACCESSION   NM_000655
VERSION     NM_000655.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2358)
  AUTHORS   Hanson,C.H., Henry,B., Andhare,P., Lin,F.J., Pak,H., Turner,J.S.,
            Adams,L.J., Liu,T., Fremont,D.H., Ellebedy,A.H. and Laidlaw,B.J.
  TITLE     CD62L expression marks a functionally distinct subset of memory B
            cells
  JOURNAL   Cell Rep 42 (12), 113542 (2023)
   PUBMED   38060451
  REMARK    GeneRIF: CD62L expression marks a functionally distinct subset of
            memory B cells.
REFERENCE   2  (bases 1 to 2358)
  AUTHORS   He,J., Ni,Z. and Li,Z.
  TITLE     Intercellular adhesion molecule 1 and selectin l play crucial roles
            in ulcerative colitis
  JOURNAL   Medicine (Baltimore) 102 (49), e36552 (2023)
   PUBMED   38065859
  REMARK    GeneRIF: Intercellular adhesion molecule 1 and selectin l play
            crucial roles in ulcerative colitis.
REFERENCE   3  (bases 1 to 2358)
  AUTHORS   Khantham,C., Ruksiriwanich,W., Chaitep,T., Linsaenkart,P.,
            Muangsanguan,A., Guzman-Jimenez,A., Cervan-Martin,M.,
            Bossini-Castillo,L., Gonzalez-Munoz,S., Palomino-Morales,R.J.,
            Leetrakool,N., Shaengkhamnang,B., Chittasupho,C., Jantrawut,P.,
            Sommano,S.R., Phimolsiripol,Y. and Carmona,F.D.
  TITLE     Sex-specific association of SELL gene polymorphisms with pattern
            hair loss in the Thai population: A candidate gene association
            study and in silico functional characterization
  JOURNAL   J Dermatol Sci 109 (2), 102-105 (2023)
   PUBMED   36828746
  REMARK    GeneRIF: Sex-specific association of SELL gene polymorphisms with
            pattern hair loss in the Thai population: A candidate gene
            association study and in silico functional characterization.
REFERENCE   4  (bases 1 to 2358)
  AUTHORS   Song,H., Huang,X.F., Hu,S.Y., Lu,L.L. and Yang,X.Y.
  TITLE     The LINC00261/MiR105-5p/SELL axis is involved in dysfunction of B
            cell and is associated with overall survival in hepatocellular
            carcinoma
  JOURNAL   PeerJ 10, e12588 (2022)
   PUBMED   35702258
  REMARK    GeneRIF: The LINC00261/MiR105-5p/SELL axis is involved in
            dysfunction of B cell and is associated with overall survival in
            hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2358)
  AUTHORS   Rutkowska,E., Kwiecien,I., Klos,K., Rzepecki,P. and Chcialowski,A.
  TITLE     Intermediate Monocytes with PD-L1 and CD62L Expression as a
            Possible Player in Active SARS-CoV-2 Infection
  JOURNAL   Viruses 14 (4), 819 (2022)
   PUBMED   35458548
  REMARK    GeneRIF: Intermediate Monocytes with PD-L1 and CD62L Expression as
            a Possible Player in Active SARS-CoV-2 Infection.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2358)
  AUTHORS   Lasky,L.A., Singer,M.S., Dowbenko,D., Imai,Y., Henzel,W.J.,
            Grimley,C., Fennie,C., Gillett,N., Watson,S.R. and Rosen,S.D.
  TITLE     An endothelial ligand for L-selectin is a novel mucin-like molecule
  JOURNAL   Cell 69 (6), 927-938 (1992)
   PUBMED   1376638
REFERENCE   7  (bases 1 to 2358)
  AUTHORS   Ryan,U.S. and Worthington,R.E.
  TITLE     Cell-cell contact mechanisms
  JOURNAL   Curr Opin Immunol 4 (1), 33-37 (1992)
   PUBMED   1375831
  REMARK    Review article
REFERENCE   8  (bases 1 to 2358)
  AUTHORS   Bevilacqua,M., Butcher,E., Furie,B., Furie,B., Gallatin,M.,
            Gimbrone,M., Harlan,J., Kishimoto,K., Lasky,L., McEver,R. et al.
  TITLE     Selectins: a family of adhesion receptors
  JOURNAL   Cell 67 (2), 233 (1991)
   PUBMED   1717161
REFERENCE   9  (bases 1 to 2358)
  AUTHORS   Ord,D.C., Ernst,T.J., Zhou,L.J., Rambaldi,A., Spertini,O.,
            Griffin,J. and Tedder,T.F.
  TITLE     Structure of the gene encoding the human leukocyte adhesion
            molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils
  JOURNAL   J Biol Chem 265 (14), 7760-7767 (1990)
   PUBMED   1692315
REFERENCE   10 (bases 1 to 2358)
  AUTHORS   Tedder,T.F., Isaacs,C.M., Ernst,T.J., Demetri,G.D., Adler,D.A. and
            Disteche,C.M.
  TITLE     Isolation and chromosomal localization of cDNAs encoding a novel
            human lymphocyte cell surface molecule, LAM-1. Homology with the
            mouse lymphocyte homing receptor and other human adhesion proteins
  JOURNAL   J Exp Med 170 (1), 123-133 (1989)
   PUBMED   2473156
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA671852.1, AJ246000.1,
            BQ004720.1 and BP393094.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 9, 2018 this sequence version replaced NM_000655.4.
            
            Summary: This gene encodes a cell surface adhesion molecule that
            belongs to a family of adhesion/homing receptors. The encoded
            protein contains a C-type lectin-like domain, a calcium-binding
            epidermal growth factor-like domain, and two short complement-like
            repeats. The gene product is required for binding and subsequent
            rolling of leucocytes on endothelial cells, facilitating their
            migration into secondary lymphoid organs and inflammation sites.
            Single-nucleotide polymorphisms in this gene have been associated
            with various diseases including immunoglobulin A nephropathy.
            Alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X16150.1, X17519.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000236147.6/
                                                ENSP00000236147.5
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                DA671852.1         14-60
            48-1616             AJ246000.1         1-1569
            1617-2163           BQ004720.1         212-758             c
            2164-2358           BP393094.1         304-498
FEATURES             Location/Qualifiers
     source          1..2358
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..2358
                     /gene="SELL"
                     /gene_synonym="CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL;
                     LYAM1; PLNHR; TQ1"
                     /note="selectin L"
                     /db_xref="GeneID:6402"
                     /db_xref="HGNC:HGNC:10720"
                     /db_xref="MIM:153240"
     exon            1..125
                     /gene="SELL"
                     /gene_synonym="CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL;
                     LYAM1; PLNHR; TQ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1241
                     /gene="SELL"
                     /gene_synonym="CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL;
                     LYAM1; PLNHR; TQ1"
                     /note="lymph node homing receptor; lymphocyte adhesion
                     molecule 1; pln homing receptor; CD62 antigen-like family
                     member L; gp90-MEL; leukocyte-endothelial cell adhesion
                     molecule 1; leukocyte surface antigen Leu-8"
                     /codon_start=1
                     /product="L-selectin precursor"
                     /protein_id="NP_000646.3"
                     /db_xref="CCDS:CCDS53427.2"
                     /db_xref="GeneID:6402"
                     /db_xref="HGNC:HGNC:10720"
                     /db_xref="MIM:153240"
                     /translation="MIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYS
                     EKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVG
                     TNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASC
                     QPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFS
                     FSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPL
                     ASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPL
                     FIPVAVMVTAFSGLAFIIWLARRLKKGKKSKRSMNDPY"
     exon            126..207
                     /gene="SELL"
                     /gene_synonym="CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL;
                     LYAM1; PLNHR; TQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..594
                     /gene="SELL"
                     /gene_synonym="CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL;
                     LYAM1; PLNHR; TQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            595..702
                     /gene="SELL"
                     /gene_synonym="CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL;
                     LYAM1; PLNHR; TQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..888
                     /gene="SELL"
                     /gene_synonym="CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL;
                     LYAM1; PLNHR; TQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1074
                     /gene="SELL"
                     /gene_synonym="CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL;
                     LYAM1; PLNHR; TQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1203
                     /gene="SELL"
                     /gene_synonym="CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL;
                     LYAM1; PLNHR; TQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1222
                     /gene="SELL"
                     /gene_synonym="CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL;
                     LYAM1; PLNHR; TQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..2358
                     /gene="SELL"
                     /gene_synonym="CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL;
                     LYAM1; PLNHR; TQ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2333..2338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SELL"
                     /gene_synonym="CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL;
                     LYAM1; PLNHR; TQ1"
                     /note="hexamer: AATAAA"
     polyA_site      2358
                     /gene="SELL"
                     /gene_synonym="CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL;
                     LYAM1; PLNHR; TQ1"
                     /note="major polyA site"
ORIGIN      
        1 gacattcagt gcagtctacc tgcagcacag cacactccct ttgggcaagg acctgagacc
       61 cttgtgctaa gtcaagaggc tcaatgggct gcagaagaac tagagaagga ccaagcaaag
      121 ccatgatatt tccatggaaa tgtcagagca cccagaggga cttatggaac atcttcaagt
      181 tgtgggggtg gacaatgctc tgttgtgatt tcctggcaca tcatggaacc gactgctgga
      241 cttaccatta ttctgaaaaa cccatgaact ggcaaagggc tagaagattc tgccgagaca
      301 attacacaga tttagttgcc atacaaaaca aggcggaaat tgagtatctg gagaagactc
      361 tgcctttcag tcgttcttac tactggatag gaatccggaa gataggagga atatggacgt
      421 gggtgggaac caacaaatct cttactgaag aagcagagaa ctggggagat ggtgagccca
      481 acaacaagaa gaacaaggag gactgcgtgg agatctatat caagagaaac aaagatgcag
      541 gcaaatggaa cgatgacgcc tgccacaaac taaaggcagc cctctgttac acagcttctt
      601 gccagccctg gtcatgcagt ggccatggag aatgtgtaga aatcatcaat aattacacct
      661 gcaactgtga tgtggggtac tatgggcccc agtgtcagtt tgtgattcag tgtgagcctt
      721 tggaggcccc agagctgggt accatggact gtactcaccc tttgggaaac ttcagcttca
      781 gctcacagtg tgccttcagc tgctctgaag gaacaaactt aactgggatt gaagaaacca
      841 cctgtggacc atttggaaac tggtcatctc cagaaccaac ctgtcaagtg attcagtgtg
      901 agcctctatc agcaccagat ttggggatca tgaactgtag ccatcccctg gccagcttca
      961 gctttacctc tgcatgtacc ttcatctgct cagaaggaac tgagttaatt gggaagaaga
     1021 aaaccatttg tgaatcatct ggaatctggt caaatcctag tccaatatgt caaaaattgg
     1081 acaaaagttt ctcaatgatt aaggagggtg attataaccc cctcttcatt ccagtggcag
     1141 tcatggttac tgcattctct gggttggcat ttatcatttg gctggcaagg agattaaaaa
     1201 aaggcaagaa atccaagaga agtatgaatg acccatatta aatcgccctt ggtgaaagaa
     1261 aattcttgga atactaaaaa tcatgagatc ctttaaatcc ttccatgaaa cgttttgtgt
     1321 ggtggcacct cctacgtcaa acatgaagtg tgtttccttc agtgcatctg ggaagatttc
     1381 tacctgacca acagttcctt cagcttccat ttcgcccctc atttatccct caacccccag
     1441 cccacaggtg tttatacagc tcagcttttt gtcttttctg aggagaaaca aataagacca
     1501 taaagggaaa ggattcatgt ggaatataaa gatggctgac tttgctcttt cttgactctt
     1561 gttttcagtt tcaattcagt gctgtacttg atgacagaca cttctaaatg aagtgcaaat
     1621 ttgatacata tgtgaatatg gactcagttt tcttgcagat caaatttcac gtcgtcttct
     1681 gtatactgtg gaggtacact cttatagaaa gttcaaaaag tctacgctct cctttctttc
     1741 taactccagt gaagtaatgg ggtcctgctc aagttgaaag agtcctattt gcactgtagc
     1801 ctcgccgtct gtgaattgga ccatcctatt taactggctt cagcctcccc accttcttca
     1861 gccacctctc tttttcagtt ggctgacttc cacacctagc atctcatgag tgccaagcaa
     1921 aaggagagaa gagagaaata gcctgcgctg ttttttagtt tgggggtttt gctgtttcct
     1981 tttatgagac ccattcctat ttcttatagt caatgtttct tttatcacga tattattagt
     2041 aagaaaacat cactgaaatg ctagctgcaa gtgacatctc tttgatgtca tatggaagag
     2101 ttaaaacagg tggagaaatt ccttgattca caatgaaatg ctctcctttc ccctgccccc
     2161 agacctttta tccacttacc tagattctac atattcttta aatttcatct caggcctccc
     2221 tcaaccccac cacttctttt ataactagtc ctttactaat ccaacccatg atgagctcct
     2281 cttcctggct tcttactgaa aggttaccct gtaacatgca attttgcatt tgaataaagc
     2341 ctgcttttta agtgttaa
//
