LOCUS       NM_003009                758 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens selenoprotein W (SELENOW), mRNA.
ACCESSION   NM_003009
VERSION     NM_003009.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 758)
  AUTHORS   Miao,Z., Wang,W., Miao,Z., Cao,Q. and Xu,S.
  TITLE     Role of Selenoprotein W in participating in the progression of
            non-alcoholic fatty liver disease
  JOURNAL   Redox Biol 71, 103114 (2024)
   PUBMED   38460355
  REMARK    GeneRIF: Role of Selenoprotein W in participating in the
            progression of non-alcoholic fatty liver disease.
REFERENCE   2  (bases 1 to 758)
  AUTHORS   Kim,H., Oh,J., Kim,M.K., Lee,K.H. and Jeong,D.
  TITLE     Selenoprotein W engages in overactive osteoclast differentiation in
            multiple myeloma
  JOURNAL   Mol Biol Rep 51 (1), 587 (2024)
   PUBMED   38683225
  REMARK    GeneRIF: Selenoprotein W engages in overactive osteoclast
            differentiation in multiple myeloma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 758)
  AUTHORS   Chen,P., Wang,C., Liu,Q., Tian,J. and Liu,Q.
  TITLE     Identification of FAM96B as a novel selenoprotein W binding partner
            in the brain
  JOURNAL   Biochem Biophys Res Commun 512 (1), 137-143 (2019)
   PUBMED   30876693
  REMARK    GeneRIF: We performed a yeast two-hybrid screen on a human fetal
            brain cDNA library and identified FAM96B as a novel binding partner
            of SelW. FRET analyses confirmed the interaction between SelW' and
            FAM96B.
REFERENCE   4  (bases 1 to 758)
  AUTHORS   Tan,L., Mai,D., Zhang,B., Jiang,X., Zhang,J., Bai,R., Ye,Y., Li,M.,
            Pan,L., Su,J., Zheng,Y., Liu,Z., Zuo,Z., Zhao,Q., Li,X., Huang,X.,
            Yang,J., Tan,W., Zheng,J. and Lin,D.
  TITLE     PIWI-interacting RNA-36712 restrains breast cancer progression and
            chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA
  JOURNAL   Mol Cancer 18 (1), 9 (2019)
   PUBMED   30636640
  REMARK    GeneRIF: Functional studies demonstrated that piRNA-36,712
            interacts with RNAs produced by SEPW1P, a retroprocessed pseudogene
            of SEPW1, and subsequently inhibits SEPW1 expression through
            competition of SEPW1 mRNA with SEPW1P RNA for microRNA-7 and
            microRNA-324.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 758)
  AUTHORS   Bellingham,J., Gregory-Evans,K., Fox,M.F. and Gregory-Evans,C.Y.
  TITLE     Gene structure and tissue expression of human selenoprotein W,
            SEPW1, and identification of a retroprocessed pseudogene, SEPW1P
  JOURNAL   Biochim Biophys Acta 1627 (2-3), 140-146 (2003)
   PUBMED   12818432
  REMARK    GeneRIF: The gene lacks canonical TATA and CAAT boxes, but has
            numerous Sp1 consensus binding sites upstream of multiple
            transcription start sites. SEPW1 is expressed in all of the 22
            tissues assayed, and shows highest expression in skeletal muscle
            and heart.
REFERENCE   6  (bases 1 to 758)
  AUTHORS   Kryukov,G.V., Castellano,S., Novoselov,S.V., Lobanov,A.V.,
            Zehtab,O., Guigo,R. and Gladyshev,V.N.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
REFERENCE   7  (bases 1 to 758)
  AUTHORS   Whanger,P.D.
  TITLE     Selenoprotein W: a review
  JOURNAL   Cell Mol Life Sci 57 (13-14), 1846-1852 (2000)
   PUBMED   11215511
  REMARK    Review article
REFERENCE   8  (bases 1 to 758)
  AUTHORS   Smith,J.S., Tachibana,I., Pohl,U., Lee,H.K., Thanarajasingam,U.,
            Portier,B.P., Ueki,K., Ramaswamy,S., Billings,S.J.,
            Mohrenweiser,H.W., Louis,D.N. and Jenkins,R.B.
  TITLE     A transcript map of the chromosome 19q-arm glioma tumor suppressor
            region
  JOURNAL   Genomics 64 (1), 44-50 (2000)
   PUBMED   10708517
REFERENCE   9  (bases 1 to 758)
  AUTHORS   Gu,Q.P., Beilstein,M.A., Vendeland,S.C., Lugade,A., Ream,W. and
            Whanger,P.D.
  TITLE     Conserved features of selenocysteine insertion sequence (SECIS)
            elements in selenoprotein W cDNAs from five species
  JOURNAL   Gene 193 (2), 187-196 (1997)
   PUBMED   9256076
REFERENCE   10 (bases 1 to 758)
  AUTHORS   Yeh,J.Y., Beilstein,M.A., Andrews,J.S. and Whanger,P.D.
  TITLE     Tissue distribution and influence of selenium status on levels of
            selenoprotein W
  JOURNAL   FASEB J 9 (5), 392-396 (1995)
   PUBMED   7896009
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR991097.1, BC039597.1 and
            AC008745.7.
            
            On Nov 23, 2018 this sequence version replaced NM_003009.3.
            
            Summary: This gene encodes a selenoprotein containing a
            selenocysteine (Sec) residue, which is encoded by the UGA codon
            that normally signals translation termination. The 3' UTRs of
            selenoprotein mRNAs contain a conserved stem-loop structure, the
            Sec insertion sequence (SECIS) element that is necessary for the
            recognition of UGA as a Sec codon rather than as a stop signal.
            This protein is highly expressed in skeletal muscle, heart and
            brain. It belongs to the SelWTH family, which possesses a
            thioredoxin-like fold and a conserved CxxU (C is cysteine, U is
            Sec) motif, suggesting a redox function for this gene. Studies in
            mouse show that this selenoprotein is involved in muscle growth and
            differentiation, and in the protection of neurons from oxidative
            stress during neuronal development. A retroprocessed pseudogene of
            this locus has been identified on chromosome 1. [provided by
            RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.162141.1,
                                           SRR5189652.186262.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: community standard
                                                (PMID:9256076)
            MANE Ensembl match               :: ENST00000601048.6/
                                                ENSP00000473185.1
            protein contains selenocysteine  :: PMID: 12818432
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                CR991097.1         49-62
            15-757              BC039597.1         1-743
            758-758             AC008745.7         64896-64896
FEATURES             Location/Qualifiers
     source          1..758
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..758
                     /gene="SELENOW"
                     /gene_synonym="selW; SEPW1"
                     /note="selenoprotein W"
                     /db_xref="GeneID:6415"
                     /db_xref="HGNC:HGNC:10752"
                     /db_xref="MIM:603235"
     exon            1..112
                     /gene="SELENOW"
                     /gene_synonym="selW; SEPW1"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..347
                     /gene="SELENOW"
                     /gene_synonym="selW; SEPW1"
                     /note="UGA stop codon recoded as selenocysteine;
                     selenoprotein W, 1"
                     /codon_start=1
                     /transl_except=(pos:120..122,aa:Sec)
                     /product="selenoprotein W"
                     /protein_id="NP_003000.1"
                     /db_xref="CCDS:CCDS59402.1"
                     /db_xref="GeneID:6415"
                     /db_xref="HGNC:HGNC:10752"
                     /db_xref="MIM:603235"
                     /translation="MALAVRVVYCGAUGYKSKYLQLKKKLEDEFPGRLDICGEGTPQA
                     TGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAALAQG"
     exon            113..137
                     /gene="SELENOW"
                     /gene_synonym="selW; SEPW1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..191
                     /gene="SELENOW"
                     /gene_synonym="selW; SEPW1"
                     /inference="alignment:Splign:2.1.0"
     exon            192..266
                     /gene="SELENOW"
                     /gene_synonym="selW; SEPW1"
                     /inference="alignment:Splign:2.1.0"
     exon            267..365
                     /gene="SELENOW"
                     /gene_synonym="selW; SEPW1"
                     /inference="alignment:Splign:2.1.0"
     exon            366..758
                     /gene="SELENOW"
                     /gene_synonym="selW; SEPW1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      380..468
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="SELENOW"
                     /gene_synonym="selW; SEPW1"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      736..741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SELENOW"
                     /gene_synonym="selW; SEPW1"
                     /note="hexamer: AATAAA"
     polyA_site      758
                     /gene="SELENOW"
                     /gene_synonym="selW; SEPW1"
                     /note="major polyA site"
ORIGIN      
        1 actcgcgcag acctagcgcg tccaggtggg aggttagtgt ggcccgggcg tccgctcctc
       61 agcggatgtg gcagccccga gccatggctc tcgccgtccg agtcgtttat tgtggcgctt
      121 gaggctacaa gtccaagtat cttcagctca agaagaagtt agaagatgag ttccccggcc
      181 gcctggacat ctgcggcgag ggaactcccc aggccaccgg gttctttgaa gtgatggtag
      241 ccgggaagtt gattcactct aagaagaaag gcgatggcta cgtggacaca gaaagcaagt
      301 ttctgaagtt ggtggccgcc atcaaagccg ccttggctca gggctaatgc gccctgaagg
      361 cagagtccag ggaccttgac ccagcccctc tcagcagacg cttcatgata ggaaggactg
      421 aaaagtcttg tggacacctg gtctttccct gatgttctcg tggctgctgt tgggggcaga
      481 gattgacgcc cccggtcttt gcctctgagc gggagagtct gtgtgtatgt gtcttccccg
      541 gaatccacac caccccaccc tcctcctgtc ccgtggtttc atcatatctc tttgcatacc
      601 ccatgtcttc cccagttgtc ccctggagtt tggggggaca tcccgcctca ggcatccttc
      661 tcaaggggaa gccaagagag gcatcaggat gggtgggttt ctgattgtgg caacgtttgc
      721 aaccgttcac gattcaataa atattggatg aatttaac
//
