LOCUS       NM_182704               1667 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens selenoprotein V (SELENOV), transcript variant 1, mRNA.
ACCESSION   NM_182704
VERSION     NM_182704.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1667)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1667)
  AUTHORS   Varlamova,E.G., Goltyaev,M.V. and Kuznetsova,J.P.
  TITLE     [Effect of Sodium Selenite on Gene Expression of SELF, SELW, and
            TGR Selenoproteins in Adenocarcinoma Cells of the Human Prostate]
  JOURNAL   Mol Biol (Mosk) 52 (3), 519-526 (2018)
   PUBMED   29989584
  REMARK    GeneRIF: The SS concentrations that lead to a decrease in the
            viability of human prostate adenocarcinoma cells (line Du-145) have
            been selected, and the effect of sodium selenite on the expression
            of mRNA of the SELV, SELW, and TGR selenocysteine proteins in these
            cells has been analyzed.
REFERENCE   3  (bases 1 to 1667)
  AUTHORS   Gladyshev,V.N., Arner,E.S., Berry,M.J., Brigelius-Flohe,R.,
            Bruford,E.A., Burk,R.F., Carlson,B.A., Castellano,S., Chavatte,L.,
            Conrad,M., Copeland,P.R., Diamond,A.M., Driscoll,D.M., Ferreiro,A.,
            Flohe,L., Green,F.R., Guigo,R., Handy,D.E., Hatfield,D.L.,
            Hesketh,J., Hoffmann,P.R., Holmgren,A., Hondal,R.J., Howard,M.T.,
            Huang,K., Kim,H.Y., Kim,I.Y., Kohrle,J., Krol,A., Kryukov,G.V.,
            Lee,B.J., Lee,B.C., Lei,X.G., Liu,Q., Lescure,A., Lobanov,A.V.,
            Loscalzo,J., Maiorino,M., Mariotti,M., Sandeep Prabhu,K.,
            Rayman,M.P., Rozovsky,S., Salinas,G., Schmidt,E.E., Schomburg,L.,
            Schweizer,U., Simonovic,M., Sunde,R.A., Tsuji,P.A., Tweedie,S.,
            Ursini,F., Whanger,P.D. and Zhang,Y.
  TITLE     Selenoprotein Gene Nomenclature
  JOURNAL   J Biol Chem 291 (46), 24036-24040 (2016)
   PUBMED   27645994
REFERENCE   4  (bases 1 to 1667)
  AUTHORS   Mariotti,M., Ridge,P.G., Zhang,Y., Lobanov,A.V., Pringle,T.H.,
            Guigo,R., Hatfield,D.L. and Gladyshev,V.N.
  TITLE     Composition and evolution of the vertebrate and mammalian
            selenoproteomes
  JOURNAL   PLoS One 7 (3), e33066 (2012)
   PUBMED   22479358
REFERENCE   5  (bases 1 to 1667)
  AUTHORS   Kryukov,G.V., Castellano,S., Novoselov,S.V., Lobanov,A.V.,
            Zehtab,O., Guigo,R. and Gladyshev,V.N.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011500.7.
            
            On Aug 31, 2021 this sequence version replaced NM_182704.1.
            
            Summary: This gene encodes a selenoprotein containing a
            selenocysteine (Sec) residue, which is encoded by the UGA codon
            that normally signals translation termination. The 3' UTRs of
            selenoprotein mRNAs contain a conserved stem-loop structure, the
            Sec insertion sequence (SECIS) element, which is necessary for the
            recognition of UGA as a Sec codon rather than as a stop signal.
            This protein is specifically expressed in the testis. It belongs to
            the SelWTH family, which possesses a thioredoxin-like fold and a
            conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox
            function for this gene. Alternatively spliced transcript variants
            have been found for this gene.[provided by RefSeq, Apr 2017].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY324825.1, BC117331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145313
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000335426.9/
                                               ENSP00000333956.4
            protein contains selenocysteine :: PMID: 12775843
            RefSeq Select criteria          :: based on manual assertion,
                                               conservation, expression,
                                               longest protein
            stop codon readthrough          :: PMID: 12775843
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-883               AC011500.7         119963-120845
            884-908             AC011500.7         123432-123456
            909-962             AC011500.7         123564-123617
            963-1037            AC011500.7         123727-123801
            1038-1137           AC011500.7         123895-123994
            1138-1667           AC011500.7         124970-125499
FEATURES             Location/Qualifiers
     source          1..1667
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1667
                     /gene="SELENOV"
                     /gene_synonym="SELV"
                     /note="selenoprotein V"
                     /db_xref="GeneID:348303"
                     /db_xref="HGNC:HGNC:30399"
                     /db_xref="MIM:607919"
     exon            1..883
                     /gene="SELENOV"
                     /gene_synonym="SELV"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1115
                     /gene="SELENOV"
                     /gene_synonym="SELV"
                     /note="UGA stop codon recoded as selenocysteine; isoform 1
                     is encoded by transcript variant 1"
                     /codon_start=1
                     /transl_except=(pos:891..893,aa:Sec)
                     /product="selenoprotein V isoform 1"
                     /protein_id="NP_874363.1"
                     /db_xref="CCDS:CCDS54266.1"
                     /db_xref="GeneID:348303"
                     /db_xref="HGNC:HGNC:30399"
                     /db_xref="MIM:607919"
                     /translation="MNNQARTPAPSSARTSTSVRASTPTRTPTPLRTPTPVRTRTPIR
                     TLTPVLTPSPAGTSPLVLTPAPAQIPTLVPTPALARIPRLVPPPAPAWIPTPVPTPVP
                     VRNPTPVPTPARTLTPPVRVPAPAPAQLLAGIRAALPVLDSYLAPALPLDPPPEPAPE
                     LPLLPEEDPEPAPSLKLIPSVSSEAGPAPGPLPTRTPLAANSPGPTLDFTFRADPSAI
                     GLADPPIPSPVPSPILGTIPSAISLQNCTETFPSSSENFALDKRVLIRVTYCGLUSYS
                     LRYILLKKSLEQQFPNHLLFEEDRAAQATGEFEVFVNGRLVHSKKRGDGFVNESRLQK
                     IVSVIDEEIKKR"
     exon            884..908
                     /gene="SELENOV"
                     /gene_synonym="SELV"
                     /inference="alignment:Splign:2.1.0"
     exon            909..962
                     /gene="SELENOV"
                     /gene_synonym="SELV"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1037
                     /gene="SELENOV"
                     /gene_synonym="SELV"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1137
                     /gene="SELENOV"
                     /gene_synonym="SELV"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1667
                     /gene="SELENOV"
                     /gene_synonym="SELV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1138..1210
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="SELENOV"
                     /gene_synonym="SELV"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      1238..1243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SELENOV"
                     /gene_synonym="SELV"
                     /note="hexamer: AATACA"
     polyA_site      1256
                     /gene="SELENOV"
                     /gene_synonym="SELV"
                     /note="major polyA site"
     regulatory      1650..1655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SELENOV"
                     /gene_synonym="SELV"
                     /note="hexamer: AATAAA"
     polyA_site      1667
                     /gene="SELENOV"
                     /gene_synonym="SELV"
ORIGIN      
        1 agacgctctc cccgcccaaa gagggaaggc gggcgggact ccccaaccgg cttgccccgg
       61 tccccctggg ccccatgaat aaccaggcgc ggaccccagc cccctcctcg gcgcggactt
      121 caacctcagt ccgggcttct accccgaccc ggacaccgac tccactccgg accccgactc
      181 cggtccggac tcggaccccc atccggaccc tgactccagt cctgactccg tctccagccg
      241 ggacttcccc tctggtcctg actcctgctc cagcccagat tcccactctg gtccccactc
      301 ccgctctggc ccggatcccc cgtctggttc cgcctcctgc tccggcctgg atccctactc
      361 cggtgccgac tcccgttccc gtccggaacc caactccggt cccgactccg gctcggaccc
      421 tgactcctcc agtccgggtc ccagccccag ccccagccca gctcctggca gggattcggg
      481 ccgcgctccc cgtcttggac tcctacctgg ccccggccct acctttggat ccgcccccgg
      541 aacctgctcc ggagctgcct ttgttgcccg aggaggaccc tgagccggcg ccgagcctga
      601 agctcatccc gtcggtctcc agcgaggccg ggcccgcccc ggggcccctt cccacgcgca
      661 ccccgctggc cgcgaactca cccgggccca ccctggactt caccttcagg gcagacccgt
      721 cggccatcgg gctggcggat ccccccattc ccagtcctgt cccctcgccc atcctgggga
      781 ccatcccgtc ggccatctcc ttacagaatt gtacggaaac cttcccctcc tccagcgaga
      841 acttcgcgct ggacaagagg gtcctgattc gagtgaccta ctgtggcctc tgaagctata
      901 gccttcggta cattctactg aaaaagagcc tggagcagca atttccgaat cacctactct
      961 ttgaggagga cagagctgcc caggctacag gggagtttga ggtgtttgtg aacgggagac
     1021 tggtccattc caagaagagg ggtgatggct ttgtgaacga gtccaggctg cagaaaattg
     1081 tgagcgttat cgatgaggaa atcaagaaaa ggtagccggc aaggggtgga gctggaggag
     1141 tctcagctgg atgatgagaa gggctgaaat gttgccaagt caggtccttt tctgatggtg
     1201 gctggggctg gggtgagctc agggagggga agaggagaat acatgcagag tcagcacccc
     1261 tgtgtccagt ctgactgtgt ctgctgtcgc cacactcacc tctgaggtct gtggaagtca
     1321 cctgatattc tggccccagg ggtgggaggg aggggagctt ggaaggctag tcctgtagct
     1381 ccagtcctct gtctggcctc cactcctctt gctcctgagg gcagtttgtt tcttttgtgg
     1441 attcgtcatt tcccatgccc tggttccaga tacattttga aaaccttcca tcttattggc
     1501 attttctggg gttgtgaggg aaacggggat ggcagtcaga ctcaaacccg tgacactcca
     1561 aactcgatta tgctccaggg cccactttct aaacctgtaa gatctatgtt ccagcctgcg
     1621 caacatagtg agaccccaac tctacaaaaa ataaaaaatt agccagg
//
