LOCUS       NM_016275               3437 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens selenoprotein T (SELENOT), mRNA.
ACCESSION   NM_016275
VERSION     NM_016275.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3437)
  AUTHORS   De Bartolo,A., Pasqua,T., Romeo,N., Rago,V., Perrotta,I.,
            Giordano,F., Granieri,M.C., Marrone,A., Mazza,R., Cerra,M.C.,
            Lefranc,B., Leprince,J., Anouar,Y., Angelone,T. and Rocca,C.
  TITLE     The redox-active defensive Selenoprotein T as a novel stress sensor
            protein playing a key role in the pathophysiology of heart failure
  JOURNAL   J Transl Med 22 (1), 375 (2024)
   PUBMED   38643121
  REMARK    GeneRIF: The redox-active defensive Selenoprotein T as a novel
            stress sensor protein playing a key role in the pathophysiology of
            heart failure.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3437)
  AUTHORS   Gladyshev,V.N., Arner,E.S., Berry,M.J., Brigelius-Flohe,R.,
            Bruford,E.A., Burk,R.F., Carlson,B.A., Castellano,S., Chavatte,L.,
            Conrad,M., Copeland,P.R., Diamond,A.M., Driscoll,D.M., Ferreiro,A.,
            Flohe,L., Green,F.R., Guigo,R., Handy,D.E., Hatfield,D.L.,
            Hesketh,J., Hoffmann,P.R., Holmgren,A., Hondal,R.J., Howard,M.T.,
            Huang,K., Kim,H.Y., Kim,I.Y., Kohrle,J., Krol,A., Kryukov,G.V.,
            Lee,B.J., Lee,B.C., Lei,X.G., Liu,Q., Lescure,A., Lobanov,A.V.,
            Loscalzo,J., Maiorino,M., Mariotti,M., Sandeep Prabhu,K.,
            Rayman,M.P., Rozovsky,S., Salinas,G., Schmidt,E.E., Schomburg,L.,
            Schweizer,U., Simonovic,M., Sunde,R.A., Tsuji,P.A., Tweedie,S.,
            Ursini,F., Whanger,P.D. and Zhang,Y.
  TITLE     Selenoprotein Gene Nomenclature
  JOURNAL   J Biol Chem 291 (46), 24036-24040 (2016)
   PUBMED   27645994
REFERENCE   3  (bases 1 to 3437)
  AUTHORS   Boukhzar,L., Hamieh,A., Cartier,D., Tanguy,Y., Alsharif,I.,
            Castex,M., Arabo,A., El Hajji,S., Bonnet,J.J., Errami,M.,
            Falluel-Morel,A., Chagraoui,A., Lihrmann,I. and Anouar,Y.
  TITLE     Selenoprotein T Exerts an Essential Oxidoreductase Activity That
            Protects Dopaminergic Neurons in Mouse Models of Parkinson's
            Disease
  JOURNAL   Antioxid Redox Signal 24 (11), 557-574 (2016)
   PUBMED   26866473
REFERENCE   4  (bases 1 to 3437)
  AUTHORS   Prevost,G., Arabo,A., Jian,L., Quelennec,E., Cartier,D., Hassan,S.,
            Falluel-Morel,A., Tanguy,Y., Gargani,S., Lihrmann,I.,
            Kerr-Conte,J., Lefebvre,H., Pattou,F. and Anouar,Y.
  TITLE     The PACAP-regulated gene selenoprotein T is abundantly expressed in
            mouse and human beta-cells and its targeted inactivation impairs
            glucose tolerance
  JOURNAL   Endocrinology 154 (10), 3796-3806 (2013)
   PUBMED   23913443
  REMARK    GeneRIF: Data suggest SELT is expressed in pancreatic beta- and
            delta-cells; inactivation of SELT in beta-cells leads to glucose
            intolerance via impaired glucose homeostasis and PACAP (pituitary
            adenylate cyclase-activating polypeptide) insulinotropic effect.
REFERENCE   5  (bases 1 to 3437)
  AUTHORS   Dikiy,A., Novoselov,S.V., Fomenko,D.E., Sengupta,A., Carlson,B.A.,
            Cerny,R.L., Ginalski,K., Grishin,N.V., Hatfield,D.L. and
            Gladyshev,V.N.
  TITLE     SelT, SelW, SelH, and Rdx12: genomics and molecular insights into
            the functions of selenoproteins of a novel thioredoxin-like family
  JOURNAL   Biochemistry 46 (23), 6871-6882 (2007)
   PUBMED   17503775
REFERENCE   6  (bases 1 to 3437)
  AUTHORS   Kryukov,G.V., Castellano,S., Novoselov,S.V., Lobanov,A.V.,
            Zehtab,O., Guigo,R. and Gladyshev,V.N.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
  REMARK    GeneRIF: The paper reported that the full-length SELT protein
            contains 182 amino acids.
REFERENCE   7  (bases 1 to 3437)
  AUTHORS   Kryukov,G.V., Kryukov,V.M. and Gladyshev,V.N.
  TITLE     New mammalian selenocysteine-containing proteins identified with an
            algorithm that searches for selenocysteine insertion sequence
            elements
  JOURNAL   J Biol Chem 274 (48), 33888-33897 (1999)
   PUBMED   10567350
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA997063.1, BC071699.1,
            BC026350.1, AK075006.1 and AI686634.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016275.4.
            
            Summary: This gene encodes a selenoprotein, containing a
            selenocysteine (Sec) residue at the active site. Sec is encoded by
            the UGA codon that normally signals translation termination. The 3'
            UTRs of selenoprotein mRNAs contain a conserved stem-loop
            structure, the Sec insertion sequence (SECIS) element, that is
            necessary for the recognition of UGA as a Sec codon rather than as
            a stop signal. This protein is localized in the endoplasmic
            reticulum. It belongs to the SelWTH family that possesses a
            thioredoxin-like fold and a conserved CxxU (C is cysteine, U is
            Sec) motif found in several redox active proteins. Studies in mice
            indicate a crucial role for this gene in the protection of
            dopaminergic neurons against oxidative stress in Parkinson's
            disease, and in the control of glucose homeostasis in pancreatic
            beta-cells. Pseudogenes of this locus have been identified on
            chromosomes 9 and 5. [provided by RefSeq, Sep 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.192592.1,
                                           SRR1660803.141169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000471696.6/
                                               ENSP00000418910.1
            protein contains selenocysteine :: PMID: 10567350
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                DA997063.1         59-146
            89-1382             BC071699.1         74-1367
            1383-1867           BC026350.1         1405-1889
            1868-3046           AK075006.1         1883-3061
            3047-3434           BC026350.1         3068-3455
            3435-3437           AI686634.1         33-35               c
FEATURES             Location/Qualifiers
     source          1..3437
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.1"
     gene            1..3437
                     /gene="SELENOT"
                     /gene_synonym="SELT"
                     /note="selenoprotein T"
                     /db_xref="GeneID:51714"
                     /db_xref="HGNC:HGNC:18136"
                     /db_xref="MIM:607912"
     exon            1..179
                     /gene="SELENOT"
                     /gene_synonym="SELT"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..630
                     /gene="SELENOT"
                     /gene_synonym="SELT"
                     /EC_number="1.8.1.9"
                     /note="UGA stop codon recoded as selenocysteine;
                     thioredoxin reductase-like enzyme; thioredoxin
                     reductase-like selenoprotein T"
                     /codon_start=1
                     /transl_except=(pos:187..189,aa:Sec)
                     /product="thioredoxin reductase-like selenoprotein T
                     precursor"
                     /protein_id="NP_057359.2"
                     /db_xref="CCDS:CCDS46936.1"
                     /db_xref="GeneID:51714"
                     /db_xref="HGNC:HGNC:18136"
                     /db_xref="MIM:607912"
                     /translation="MRLLLLLLVAASAMVRSEASANLGGVPSKRLKMQYATGPLLKFQ
                     ICVSUGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYRHIASFLSVFKLVLIGLIIV
                     GKDPFAFFGMQAPSIWQWGQENKVYACMMVFFLSNMIENQCMSTGAFEITLNDVPVWS
                     KLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS"
     exon            180..290
                     /gene="SELENOT"
                     /gene_synonym="SELT"
                     /inference="alignment:Splign:2.1.0"
     exon            291..417
                     /gene="SELENOT"
                     /gene_synonym="SELT"
                     /inference="alignment:Splign:2.1.0"
     exon            418..505
                     /gene="SELENOT"
                     /gene_synonym="SELT"
                     /inference="alignment:Splign:2.1.0"
     exon            506..659
                     /gene="SELENOT"
                     /gene_synonym="SELT"
                     /inference="alignment:Splign:2.1.0"
     exon            660..3437
                     /gene="SELENOT"
                     /gene_synonym="SELT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      687..761
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="SELENOT"
                     /gene_synonym="SELT"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      3417..3422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SELENOT"
                     /gene_synonym="SELT"
                     /note="hexamer: AATAAA"
     polyA_site      3437
                     /gene="SELENOT"
                     /gene_synonym="SELT"
                     /note="major polyA site"
ORIGIN      
        1 gcagtctgtc tgagggcggc cgaagtggct ggctcattta agatgaggct tctgctgctt
       61 ctcctagtgg cggcgtctgc gatggtccgg agcgaggcct cggccaatct gggcggcgtg
      121 cccagcaaga gattaaagat gcagtacgcc acggggccgc tgctcaagtt ccagatttgt
      181 gtttcctgag gttataggcg ggtgtttgag gagtacatgc gggttattag ccagcggtac
      241 ccagacatcc gcattgaagg agagaattac ctccctcaac caatatatag acacatagca
      301 tctttcctgt cagtcttcaa actagtatta ataggcttaa taattgttgg caaggatcct
      361 tttgctttct ttggcatgca agctcctagc atctggcagt ggggccaaga aaataaggtt
      421 tatgcatgta tgatggtttt cttcttgagc aacatgattg agaaccagtg tatgtcaaca
      481 ggtgcatttg agataacttt aaatgatgta cctgtgtggt ctaagctgga atctggtcac
      541 cttccatcca tgcaacaact tgttcaaatt cttgacaatg aaatgaagct caatgtgcat
      601 atggattcaa tcccacacca tcgatcatag caccacctat cagcactgaa aactcttttg
      661 cattaaggga tcattgcaag agcagcgtga ctgacattat gaaggcctgt actgaagaca
      721 gcaagctgtt agtacagacc agatgctttc ttggcaggct cgttgtacct cttggaaaac
      781 ctcaatgcaa gatagtgttt cagtgctggc atattttgga attctgcaca ttcatggagt
      841 gcaataatac tgtatagctt tccccacctc ccacaaaatc acccagttaa tgtgtgtgtg
      901 tgtttttttt ttaaggtaaa cattactact tgtaactttt tttcttagtc atatttgaaa
      961 aagtagaaaa ttgagttaca atttgatttt ttttccaaag atgtctgtta aatctgttgt
     1021 gcttttatat gaatatttgt tttttatagt ttaaaattga tcctttggga atccagttga
     1081 agttcccaaa tactttataa gagtttatca gacatctcta atttggccat gtccagttta
     1141 tacagtttac aaaatatagc agatgcaaga ttatggggga aatcctatat tcagagtact
     1201 ctataaattt ttgtgtatgt gtgtatgtgc gtgtgattac cagagaacta ctaaaaaaac
     1261 caactgcttt ttaaatccta ttgtgtagtt aaagtgtcat gccttgacca atctaatgaa
     1321 ttgattaatt aactgggcct ttatacttaa ctaaataaaa aactaagcag atatgagtta
     1381 aatttaaaag tttcaattta ttgctcagtg tacctgttaa cattatattt aacaattgct
     1441 taaatttttg tttttgattt atggataatt tcttaagagt acacacttta gatacacaaa
     1501 taatcgttca tttaccatct ttaggatcat tgaaactcat ctcactaaag aaagttcact
     1561 tgaacctctt tatagcattg atactaggtg aacagaaatt acctgactaa taatttgtct
     1621 aacatcatat atcagaattt tattgtatat gatgaacaaa acttaaaatt ttttaaattt
     1681 aatttttaaa tactgtttca gagttctaaa aaggcagttt tttaaaaaac ttaagttgat
     1741 aaaaactgta agaataattt agcagaaata gaaccagaat gtagaagagt agtcatgtaa
     1801 cagcagtaat aacatacttc agcttccata taggaataga agtggtagag ccaaaagtga
     1861 tttaggaaaa gttataaggt acaggttgag tatccctttt ccaaaaatgc ttgggacaag
     1921 aagtatttca gatttcataa tttttttcaa agtttggaat atttgcatta tacttaccag
     1981 ttgggcatcc caaatctgaa atctgaaatg ttccatgagc atttcctttg agtgtcatgt
     2041 tggcactcaa aaaggttcaa cattgagtcc acttaacact taggtgttag aagacctaac
     2101 tttctgtaac aattaacctt atactttgtt tgtcatcgaa tatttgttga atgcatgtca
     2161 ggtaatggtc ttgattgtga tagcttcaag gtggaacata ctgtaatctc cagatgctag
     2221 gaagttagtc taataattca ctgcagaaaa ttgattaagt ggctgtcctt ttaattaaga
     2281 gtgtggagtc ataaacttaa gttcttcata tagtgacaag agtccttaga gattgttatt
     2341 caagttcctt agaaattgtt atttaggtat aatatcatct tgtctttgac tagagcttga
     2401 aaccttgtta tctgattgtg taccactcca aattccctgc cttctgcaag ttgaatgtct
     2461 tgctgaatgt gtctaggggt tcatcttcag taatcgacat tccactagtg ccatagttaa
     2521 cttcatgaca tgtagacatt caaaacttga gccttggatg ttcctgtgga cctgacagtt
     2581 aaaaatataa agaacctagg attcaattcc aactttctct gtttgccttg ggttgaataa
     2641 cttatctttt ggagaatagc tttaagtggc ttagacactg ataaaattca gctgtgttgt
     2701 tgacgctcat ctcttttgtc ttacgcttag ccatatttaa atcttgaatt taatagagtc
     2761 tagtgaaaaa aatgagtggg aagaatgaat ataaaagtaa taatataagg aaaaagggaa
     2821 agtaaactat ttagaatgta gttttgttat attcccagca tttcaatatt tattagttac
     2881 ttgtaaatta ctgtggctgt gtagtttata aatgtctgtg cactatatta attagaagac
     2941 catagaacat gccagcaggt tggctaatgc tatgggggtt tttaccacag ttgccattgt
     3001 ggaagaaatt atttggtaca ttaataaaaa aagttggtaa aacatggttt tatacctcag
     3061 tgtataagat gtgcaagaca aatatgctta tttccttttc tagaatataa gtgatattat
     3121 ttgcttatga cactaacact attaatgaca ggagtcaatc agcctttaca gctatcaaaa
     3181 tataatgaga tcccaatgat gattcttttt tactttgaat gttaattagt ttgggacttt
     3241 gattggctgg caaacatttt atcattgtca gaatttaatt tagatttcaa aaatagctta
     3301 caggatttta aacatggtgt ggtattctaa agcctttttt ttaaaaaaag agatcttttt
     3361 gagagaaaca aatgaggatt gtaaagtttg gggacttacc tctgtagcat tgtgaaaata
     3421 aactttgatt aagctga
//
