LOCUS       NM_018445               1218 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens selenoprotein S (SELENOS), transcript variant 1, mRNA.
ACCESSION   NM_018445
VERSION     NM_018445.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1218)
  AUTHORS   Ghelichkhani,F., Gonzalez,F.A., Kapitonova,M.A. and Rozovsky,S.
  TITLE     Selenoprotein S Interacts with the Replication and Transcription
            Complex of SARS-CoV-2 by Binding nsp7
  JOURNAL   J Mol Biol 435 (8), 168008 (2023)
   PUBMED   36773692
  REMARK    GeneRIF: Selenoprotein S Interacts with the Replication and
            Transcription Complex of SARS-CoV-2 by Binding nsp7.
REFERENCE   2  (bases 1 to 1218)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   3  (bases 1 to 1218)
  AUTHORS   Kherrour,W., Benbia,S., Hambaba,L. and Kalicanin,D.
  TITLE     Rs7537605 polymorphism in VAV3 gene and rs28665122 polymorphism in
            SEPS gene are not associated with Hashimoto's thyroiditis in
            North-East Algerian population
  JOURNAL   Afr Health Sci 22 (4), 252-260 (2022)
   PUBMED   37092056
  REMARK    GeneRIF: Rs7537605 polymorphism in VAV3 gene and rs28665122
            polymorphism in SEPS gene are not associated with Hashimoto's
            thyroiditis in North-East Algerian population.
REFERENCE   4  (bases 1 to 1218)
  AUTHORS   Mao,H., Zhao,Y., Lei,L., Hu,Y., Zhu,H., Wang,R., Ni,D., Liu,J.,
            Xu,L., Xia,H., Zhang,Z., Ma,M., Pan,Z., Zhou,Q. and Xie,Y.
  TITLE     Selenoprotein S regulates tumorigenesis of clear cell renal cell
            carcinoma through AKT/ GSK3beta/NF-kappaB signaling pathway
  JOURNAL   Gene 832, 146559 (2022)
   PUBMED   35569765
  REMARK    GeneRIF: Selenoprotein S regulates tumorigenesis of clear cell
            renal cell carcinoma through AKT/ GSK3beta/NF-kappaB signaling
            pathway.
REFERENCE   5  (bases 1 to 1218)
  AUTHORS   Bubenik,J.L., Miniard,A.C. and Driscoll,D.M.
  TITLE     Alternative transcripts and 3'UTR elements govern the incorporation
            of selenocysteine into selenoprotein S
  JOURNAL   PLoS One 8 (4), e62102 (2013)
   PUBMED   23614019
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1218)
  AUTHORS   Gao,Y., Feng,H.C., Walder,K., Bolton,K., Sunderland,T., Bishara,N.,
            Quick,M., Kantham,L. and Collier,G.R.
  TITLE     Regulation of the selenoprotein SelS by glucose deprivation and
            endoplasmic reticulum stress - SelS is a novel glucose-regulated
            protein
  JOURNAL   FEBS Lett 563 (1-3), 185-190 (2004)
   PUBMED   15063746
  REMARK    GeneRIF: SELS is regulated by glucose deprivation and endoplasmic
            reticulum stress.  It is a glucose-regulated protein.
REFERENCE   7  (bases 1 to 1218)
  AUTHORS   Kryukov,G.V., Castellano,S., Novoselov,S.V., Lobanov,A.V.,
            Zehtab,O., Guigo,R. and Gladyshev,V.N.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
REFERENCE   8  (bases 1 to 1218)
  AUTHORS   Gao,Y., Walder,K., Sunderland,T., Kantham,L., Feng,H.C., Quick,M.,
            Bishara,N., de Silva,A., Augert,G., Tenne-Brown,J. and Collier,G.R.
  TITLE     Elevation in Tanis expression alters glucose metabolism and insulin
            sensitivity in H4IIE cells
  JOURNAL   Diabetes 52 (4), 929-934 (2003)
   PUBMED   12663463
REFERENCE   9  (bases 1 to 1218)
  AUTHORS   Walder,K., Kantham,L., McMillan,J.S., Trevaskis,J., Kerr,L., De
            Silva,A., Sunderland,T., Godde,N., Gao,Y., Bishara,N., Windmill,K.,
            Tenne-Brown,J., Augert,G., Zimmet,P.Z. and Collier,G.R.
  TITLE     Tanis: a link between type 2 diabetes and inflammation?
  JOURNAL   Diabetes 51 (6), 1859-1866 (2002)
   PUBMED   12031974
REFERENCE   10 (bases 1 to 1218)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG829960.1, BC005840.2 and
            AK097011.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018445.5.
            
            Summary: This gene encodes a transmembrane protein that is
            localized in the endoplasmic reticulum (ER). It is involved in the
            degradation process of misfolded proteins in the ER, and may also
            have a role in inflammation control. This protein is a
            selenoprotein, containing the rare amino acid selenocysteine (Sec).
            Sec is encoded by the UGA codon, which normally signals translation
            termination. The 3' UTRs of selenoprotein mRNAs contain a conserved
            stem-loop structure, designated the Sec insertion sequence (SECIS)
            element, that is necessary for the recognition of UGA as a Sec
            codon, rather than as a stop signal. Two additional
            phylogenetically conserved stem-loop structures (Stem-loop 1 and
            Stem-loop 2) in the 3' UTR of this mRNA have been shown to function
            as modulators of Sec insertion. An alternatively spliced transcript
            variant, lacking the SECIS element and encoding a non-Sec
            containing shorter isoform, has been described for this gene
            (PMID:23614019). [provided by RefSeq, Jul 2017].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes a selenocysteine-containing longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.184257.1,
                                           SRR1803617.201092.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000526049.6/
                                               ENSP00000433541.1
            protein contains selenocysteine :: PMID: 12775843, 23614019
            RefSeq Select criteria          :: based on conservation,
                                               expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BG829960.1         36-77
            43-1214             BC005840.2         1-1172
            1215-1218           AK097011.1         2440-2443
FEATURES             Location/Qualifiers
     source          1..1218
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.3"
     gene            1..1218
                     /gene="SELENOS"
                     /gene_synonym="AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP"
                     /note="selenoprotein S"
                     /db_xref="GeneID:55829"
                     /db_xref="HGNC:HGNC:30396"
                     /db_xref="MIM:607918"
     exon            1..144
                     /gene="SELENOS"
                     /gene_synonym="AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..638
                     /gene="SELENOS"
                     /gene_synonym="AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP"
                     /note="UGA stop codon recoded as selenocysteine; isoform 1
                     is encoded by transcript variant 1; VCP-interacting
                     membrane protein; valosin-containing protein-interacting
                     membrane protein; VCP interacting membrane selenoprotein;
                     tanis"
                     /codon_start=1
                     /transl_except=(pos:630..632,aa:Sec)
                     /product="selenoprotein S isoform 1"
                     /protein_id="NP_060915.2"
                     /db_xref="CCDS:CCDS53979.1"
                     /db_xref="GeneID:55829"
                     /db_xref="HGNC:HGNC:30396"
                     /db_xref="MIM:607918"
                     /translation="MERQEESLSARPALETEGLRFLHTTVGSLLATYGWYIVFSCILL
                     YVVFQKLSARLRALRQRQLDRAAAAVEPDVVVKRQEALAAARLKMQEELNAQVEKHKE
                     KLKQLEEEKRRQKIEMWDSMQEGKSYKGNAKKPQEEDSPGPSTSSVLKRKSDRKPLRG
                     GGYNPLSGEGGGACSWRPGRRGPSSGGUG"
     exon            145..279
                     /gene="SELENOS"
                     /gene_synonym="AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP"
                     /inference="alignment:Splign:2.1.0"
     exon            280..386
                     /gene="SELENOS"
                     /gene_synonym="AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP"
                     /inference="alignment:Splign:2.1.0"
     exon            387..476
                     /gene="SELENOS"
                     /gene_synonym="AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP"
                     /inference="alignment:Splign:2.1.0"
     exon            477..552
                     /gene="SELENOS"
                     /gene_synonym="AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1218
                     /gene="SELENOS"
                     /gene_synonym="AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      641..674
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="SELENOS"
                     /gene_synonym="AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP"
                     /note="Stem-loop 1"
                     /function="promotes selenocysteine insertion"
     regulatory      986..1065
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="SELENOS"
                     /gene_synonym="AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      1073..1100
                     /regulatory_class="other"
                     /gene="SELENOS"
                     /gene_synonym="AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP"
                     /note="recoding_inhibitory_region; Stem-loop 2"
                     /function="inhibits selenocysteine insertion"
     regulatory      1193..1198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SELENOS"
                     /gene_synonym="AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP"
                     /note="hexamer: ATTAAA"
     polyA_site      1218
                     /gene="SELENOS"
                     /gene_synonym="AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP"
                     /note="major polyA site"
ORIGIN      
        1 aggagcgcac cggaagcgcc cggctggagg cgcggcggca gggctgggcg gcggcggcgg
       61 cggcggtcat ggaacgccaa gaggagtctc tgtccgcgcg gccggccctg gagaccgagg
      121 ggctgcgctt cctgcacacc acggtgggct ccctgctggc cacctatggc tggtacatcg
      181 tcttcagctg catccttctc tacgtggtct ttcagaagct ttccgcccgg ctaagagcct
      241 tgaggcagag gcagctggac cgagctgcgg ctgctgtgga acctgatgtt gttgttaaac
      301 gacaagaagc tttagcagct gctcgactga aaatgcaaga agaactaaat gcgcaagttg
      361 aaaagcataa ggaaaaactg aaacaacttg aagaagaaaa aaggagacag aagattgaaa
      421 tgtgggacag catgcaagaa ggaaaaagtt acaaaggaaa tgcaaagaag ccccaggagg
      481 aagacagtcc tgggccttcc acttcatctg tcctgaaacg gaaatcggac agaaagcctt
      541 tgcggggagg aggttataac ccgttgtctg gtgaaggagg cggagcttgc tcctggagac
      601 ctggacgcag aggcccgtca tctggcggat gaggctaaga atcttgttag tgtcactttt
      661 gacattagca agatgaaccc ttaaccctcg attcaattgc cttacgcacg cttttcacag
      721 tgactagcca aggggaggtg gggttgattt ctgttcctaa ctacacctgc atatgtcagg
      781 gctccagtca gcaaaaggta tagatgttgc ctctaggcat gaggtcattg gtcacattct
      841 acttggagac agtgattgca ttcattgatt tcatggttaa ttgctagttg gtaggtaaag
      901 gcctctagat gattagcaat cttgataaaa gaggcctagt aatgttcttt tgaggttaga
      961 aatccttgct gctaggacag tctctgtgac aggttgcgtt gaatgatgtc ttccttatca
     1021 atggtgagcc caccagtgag gattactgat gtggacagtt gatggggttt gtttctgtat
     1081 atttattttt atgtacagaa ctttgtaaaa acgaaactat ttaaaaaaca agaataacat
     1141 ttttagcatc tttattcaag gagatttatg gacttcaatt tgtctatcaa acattaaata
     1201 gctttttatt acaacctc
//
