LOCUS       NM_005410               2056 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens selenoprotein P (SELENOP), transcript variant 1, mRNA.
ACCESSION   NM_005410
VERSION     NM_005410.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2056)
  AUTHORS   Czerwinska,K., Januszewska,L., Markiewicz-Gorka,I., Jaremkow,A.,
            Martynowicz,H., Pawlas,K., Mazur,G., Poreba,R. and Gac,P.
  TITLE     Selenoprotein P, peroxiredoxin-5, renalase, and total antioxidant
            status in patients with suspected obstructive sleep apnea
  JOURNAL   Sleep Breath 28 (1), 211-219 (2024)
   PUBMED   37495908
  REMARK    GeneRIF: Selenoprotein P, peroxiredoxin-5, renalase, and total
            antioxidant status in patients with suspected obstructive sleep
            apnea.
REFERENCE   2  (bases 1 to 2056)
  AUTHORS   Schottker,B., Holleczek,B., Hybsier,S., Kohrle,J., Schomburg,L. and
            Brenner,H.
  TITLE     Strong associations of serum selenoprotein P with all-cause
            mortality and mortality due to cancer, cardiovascular, respiratory
            and gastrointestinal diseases in older German adults
  JOURNAL   Eur J Epidemiol 39 (2), 121-136 (2024)
   PUBMED   38198038
  REMARK    GeneRIF: Strong associations of serum selenoprotein P with
            all-cause mortality and mortality due to cancer, cardiovascular,
            respiratory and gastrointestinal diseases in older German adults.
REFERENCE   3  (bases 1 to 2056)
  AUTHORS   Zheng,X., Toyama,T., Siu,S., Kaneko,T., Sugiura,H., Yamashita,S.,
            Shimoda,Y., Kanamori,M., Arisawa,K., Endo,H. and Saito,Y.
  TITLE     Selenoprotein P expression in glioblastoma as a regulator of
            ferroptosis sensitivity: preservation of GPX4 via the
            cycling-selenium storage
  JOURNAL   Sci Rep 14 (1), 682 (2024)
   PUBMED   38182643
  REMARK    GeneRIF: Selenoprotein P expression in glioblastoma as a regulator
            of ferroptosis sensitivity: preservation of GPX4 via the
            cycling-selenium storage.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2056)
  AUTHORS   Jujic,A., Molvin,J., Schomburg,L., Hartmann,O., Bergmann,A.,
            Melander,O. and Magnusson,M.
  TITLE     Selenoprotein P deficiency is associated with higher risk of
            incident heart failure
  JOURNAL   Free Radic Biol Med 207, 11-16 (2023)
   PUBMED   37423559
  REMARK    GeneRIF: Selenoprotein P deficiency is associated with higher risk
            of incident heart failure.
REFERENCE   5  (bases 1 to 2056)
  AUTHORS   Mariotti,M., Shetty,S., Baird,L., Wu,S., Loughran,G.,
            Copeland,P.R., Atkins,J.F. and Howard,M.T.
  TITLE     Multiple RNA structures affect translation initiation and UGA
            redefinition efficiency during synthesis of selenoprotein P
  JOURNAL   Nucleic Acids Res 45 (22), 13004-13015 (2017)
   PUBMED   29069514
  REMARK    GeneRIF: Results indicate a diversity of RNA elements conducting
            multiple occurrences of UGA redefinition to control the synthesis
            of full-length and truncated selenoprotein P (SELENOP) isoforms.
REFERENCE   6  (bases 1 to 2056)
  AUTHORS   Wu,S., Mariotti,M., Santesmasses,D., Hill,K.E., Baclaocos,J.,
            Aparicio-Prat,E., Li,S., Mackrill,J., Wu,Y., Howard,M.T.,
            Capecchi,M., Guigo,R., Burk,R.F. and Atkins,J.F.
  TITLE     Human selenoprotein P and S variant mRNAs with different numbers of
            SECIS elements and inferences from mutant mice of the roles of
            multiple SECIS elements
  JOURNAL   Open Biol 6 (11) (2016)
   PUBMED   27881738
  REMARK    GeneRIF: Study suggests the 3' UTR structural elements (SECIS) in
            Sepp1 functions with site specificity and further illustrates how
            mRNA processing may produce transcripts with altered coding
            potential to produce diversity in selenoprotein isoforms.
REFERENCE   7  (bases 1 to 2056)
  AUTHORS   Hill,K.E., Dasouki,M., Phillips,J.A. 3rd and Burk,R.F.
  TITLE     Human selenoprotein P gene maps to 5q31
  JOURNAL   Genomics 36 (3), 550-551 (1996)
   PUBMED   8884283
REFERENCE   8  (bases 1 to 2056)
  AUTHORS   Burk,R.F. and Hill,K.E.
  TITLE     Selenoprotein P. A selenium-rich extracellular glycoprotein
  JOURNAL   J Nutr 124 (10), 1891-1897 (1994)
   PUBMED   7931697
  REMARK    Review article
REFERENCE   9  (bases 1 to 2056)
  AUTHORS   Akesson,B., Bellew,T. and Burk,R.F.
  TITLE     Purification of selenoprotein P from human plasma
  JOURNAL   Biochim Biophys Acta 1204 (2), 243-249 (1994)
   PUBMED   8142465
REFERENCE   10 (bases 1 to 2056)
  AUTHORS   Hill,K.E., Lloyd,R.S. and Burk,R.F.
  TITLE     Conserved nucleotide sequences in the open reading frame and 3'
            untranslated region of selenoprotein P mRNA
  JOURNAL   Proc Natl Acad Sci U S A 90 (2), 537-541 (1993)
   PUBMED   8421687
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA288385.1, BC040075.1 and
            HM005482.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005410.3.
            
            Summary: This gene encodes a selenoprotein that is predominantly
            expressed in the liver and secreted into the plasma. This
            selenoprotein is unique in that it contains multiple selenocysteine
            (Sec) residues per polypeptide (10 in human), and accounts for most
            of the selenium in plasma. It has been implicated as an
            extracellular antioxidant, and in the transport of selenium to
            extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2).
            Mice lacking this gene exhibit neurological dysfunction, suggesting
            its importance in normal brain function. Sec is encoded by the UGA
            codon, which normally signals translation termination. The 3' UTRs
            of selenoprotein mRNAs contain a conserved stem-loop structure,
            designated the Sec insertion sequence (SECIS) element, that is
            necessary for the recognition of UGA as a Sec codon, rather than as
            a stop signal. The mRNA for this selenoprotein contains two SECIS
            elements. The use of alternative polyadenylation sites, one located
            in between the two SECIS elements, results in two populations of
            mRNAs containing either both (predominant) or just the upstream
            SECIS element (PMID:27881738). Alternatively spliced transcript
            variants have also been found for this gene. [provided by RefSeq,
            Oct 2018].
            
            Transcript Variant: This variant (1, also known as Sepp1a)
            represents the predominant transcript and encodes isoform 1.
            Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833145.1, SRR1660809.204172.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000514985.6/
                                               ENSP00000420939.1
            protein contains selenocysteine :: PMID: 8421687
            RefSeq Select criteria          :: based on conservation,
                                               expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DA288385.1         185-204
            21-1458             BC040075.1         1-1438
            1459-2056           HM005482.1         1518-2115
FEATURES             Location/Qualifiers
     source          1..2056
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p12"
     gene            1..2056
                     /gene="SELENOP"
                     /gene_synonym="SELP; SeP; SEPP; SEPP1"
                     /note="selenoprotein P"
                     /db_xref="GeneID:6414"
                     /db_xref="HGNC:HGNC:10751"
                     /db_xref="MIM:601484"
     exon            1..57
                     /gene="SELENOP"
                     /gene_synonym="SELP; SeP; SEPP; SEPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            58..273
                     /gene="SELENOP"
                     /gene_synonym="SELP; SeP; SEPP; SEPP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1216
                     /gene="SELENOP"
                     /gene_synonym="SELP; SeP; SEPP; SEPP1"
                     /note="UGA stop codons recoded as selenocysteine; isoform
                     1 precursor is encoded by transcript variant 1;
                     selenoprotein P, plasma, 1"
                     /codon_start=1
                     /transl_except=(pos:245..247,aa:Sec)
                     /transl_except=(pos:968..970,aa:Sec)
                     /transl_except=(pos:1022..1024,aa:Sec)
                     /transl_except=(pos:1058..1060,aa:Sec)
                     /transl_except=(pos:1103..1105,aa:Sec)
                     /transl_except=(pos:1124..1126,aa:Sec)
                     /transl_except=(pos:1169..1171,aa:Sec)
                     /transl_except=(pos:1175..1177,aa:Sec)
                     /transl_except=(pos:1196..1198,aa:Sec)
                     /transl_except=(pos:1202..1204,aa:Sec)
                     /product="selenoprotein P isoform 1 precursor"
                     /protein_id="NP_005401.3"
                     /db_xref="CCDS:CCDS43311.1"
                     /db_xref="GeneID:6414"
                     /db_xref="HGNC:HGNC:10751"
                     /db_xref="MIM:601484"
                     /translation="MWRSLGLALALCLLPSGGTESQDQSSLCKQPPAWSIRDQDPMLN
                     SNGSVTVVALLQASUYLCILQASKLEDLRVKLKKEGYSNISYIVVNHQGISSRLKYTH
                     LKNKVSEHIPVYQQEENQTDVWTLLNGSKDDFLIYDRCGRLVYHLGLPFSFLTFPYVE
                     EAIKIAYCEKKCGNCSLTTLKDEDFCKRVSLATVDKTVETPSPHYHHEHHHNHGHQHL
                     GSSELSENQQPGAPNAPTHPAPPGLHHHHKHKGQHRQGHPENRDMPASEDLQDLQKKL
                     CRKRCINQLLCKLPTDSELAPRSUCCHCRHLIFEKTGSAITUQCKENLPSLCSUQGLR
                     AEENITESCQURLPPAAUQISQQLIPTEASASURUKNQAKKUEUPSN"
     exon            274..486
                     /gene="SELENOP"
                     /gene_synonym="SELP; SeP; SEPP; SEPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..604
                     /gene="SELENOP"
                     /gene_synonym="SELP; SeP; SEPP; SEPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..2056
                     /gene="SELENOP"
                     /gene_synonym="SELP; SeP; SEPP; SEPP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1468..1550
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="SELENOP"
                     /gene_synonym="SELP; SeP; SEPP; SEPP1"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      1909..1974
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="SELENOP"
                     /gene_synonym="SELP; SeP; SEPP; SEPP1"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      2037..2042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SELENOP"
                     /gene_synonym="SELP; SeP; SEPP; SEPP1"
                     /note="hexamer: AATAAA"
     polyA_site      2056
                     /gene="SELENOP"
                     /gene_synonym="SELP; SeP; SEPP; SEPP1"
                     /note="major polyA site"
ORIGIN      
        1 gtggagctgc cagagtaaag caaagagaaa ggaagcaggc ccgttggaag tggttgtgac
       61 aaccccagca atgtggagaa gcctggggct tgccctggct ctctgtctcc tcccatcggg
      121 aggaacagag agccaggacc aaagctcctt atgtaagcaa cccccagcct ggagcataag
      181 agatcaagat ccaatgctaa actccaatgg ttcagtgact gtggttgctc ttcttcaagc
      241 cagctgatac ctgtgcatac tgcaggcatc taaattagaa gacctgcgag taaaactgaa
      301 gaaagaagga tattctaata tttcttatat tgttgttaat catcaaggaa tctcttctcg
      361 attaaaatac acacatctta agaataaggt ttcagagcat attcctgttt atcaacaaga
      421 agaaaaccaa acagatgtct ggactctttt aaatggaagc aaagatgact tcctcatata
      481 tgatagatgt ggccgtcttg tatatcatct tggtttgcct ttttccttcc taactttccc
      541 atatgtagaa gaagccatta agattgctta ctgtgaaaag aaatgtggaa actgctctct
      601 cacgactctc aaagatgaag acttttgtaa acgtgtatct ttggctactg tggataaaac
      661 agttgaaact ccatcgcctc attaccatca tgagcatcat cacaatcatg gacatcagca
      721 ccttggcagc agtgagcttt cagagaatca gcaaccagga gcaccaaatg ctcctactca
      781 tcctgctcct ccaggccttc atcaccacca taagcacaag ggtcagcata ggcagggtca
      841 cccagagaac cgagatatgc cagcaagtga agatttacaa gatttacaaa agaagctctg
      901 tcgaaagaga tgtataaatc aattactctg taaattgccc acagattcag agttggctcc
      961 taggagctga tgctgccatt gtcgacatct gatatttgaa aaaacagggt ctgcaatcac
     1021 ctgacagtgt aaagaaaacc tcccatcttt atgtagctga cagggacttc gggcagagga
     1081 gaacataact gaatcttgtc agtgacgttt gcctccagct gcctgacaaa taagtcagca
     1141 gcttataccc acagaagcca gtgccagttg acgctgaaag aatcaggcaa aaaagtgaga
     1201 atgaccttca aactaaatat ttaaaatagg acatactccc caatttagtc tagacacaat
     1261 ttcatttcca gcatttttat aaactaccaa attagtgaac caaaaataga aattagattt
     1321 gtgcaaacat ggagaaatct actgaattgg cttccagatt ttaaatttta tgtcatagaa
     1381 atattgactc aaaccatatt ttttatgatg gagcaactga aaggtgattg cagcttttgg
     1441 ttaatatgtc tttttttttc tttttccagt gttctatttg ctttaatgag aatagaaacg
     1501 taaactatga cctaggggtt tctgttggat aattagcagt ttagaatgga ggaagaacaa
     1561 caaagacatg ctttccattt ttttctttac ttatctctca aaacaatatt actttgtctt
     1621 ttcaatcttc tacttttaac taataaaata agtggatttt gtattttaag atccagaaat
     1681 acttaacacg tgaatatttt gctaaaaaag catatataac tattttaaat atccatttat
     1741 cttttgtata tctaagactc atcctgattt ttactatcac acatgaataa agcctttgta
     1801 tctttctttc tctaatgttg tatcatactc ttctaaaact tgagtggctg tcttaaaaga
     1861 tataagggga aagataatat tgtctgtctc tatattgctt agtaagtatt tccatagtca
     1921 atgatggttt aataggtaaa ccaaacccta taaacctgac ctcctttatg gttaatacta
     1981 ttaagcaaga atgcagtaca gaattggata cagtacggat ttgtccaaat aaattcaata
     2041 aaaaccttaa agctga
//
