LOCUS       NM_080430                694 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens selenoprotein M (SELENOM), mRNA.
ACCESSION   NM_080430
VERSION     NM_080430.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 694)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 694)
  AUTHORS   Varlamova,E.G., Goltyaev,M.V. and Fesenko,E.E.
  TITLE     Protein Partners of Selenoprotein SELM and the Role of Selenium
            Compounds in Regulation of Its Expression in Human Cancer Cells
  JOURNAL   Dokl Biochem Biophys 488 (1), 300-303 (2019)
   PUBMED   31768845
  REMARK    GeneRIF: Methylseleninic acid in both cancer cell lines increased
            the SELM gene expression; the most pronounced effect was observed
            when fibrosarcoma cells were treated with 10 microM MSA (the
            expression of the hSelm gene increased almost 4 times).
REFERENCE   3  (bases 1 to 694)
  AUTHORS   Jiang,H., Shi,Q.Q., Ge,L.Y., Zhuang,Q.F., Xue,D., Xu,H.Y. and
            He,X.Z.
  TITLE     Selenoprotein M stimulates the proliferative and metastatic
            capacities of renal cell carcinoma through activating the
            PI3K/AKT/mTOR pathway
  JOURNAL   Cancer Med 8 (10), 4836-4844 (2019)
   PUBMED   31274247
  REMARK    GeneRIF: Selenoprotein M stimulates the proliferative and
            metastatic capacities of renal cell carcinoma through activating
            the PI3K/AKT/mTOR pathway.
REFERENCE   4  (bases 1 to 694)
  AUTHORS   Gladyshev,V.N., Arner,E.S., Berry,M.J., Brigelius-Flohe,R.,
            Bruford,E.A., Burk,R.F., Carlson,B.A., Castellano,S., Chavatte,L.,
            Conrad,M., Copeland,P.R., Diamond,A.M., Driscoll,D.M., Ferreiro,A.,
            Flohe,L., Green,F.R., Guigo,R., Handy,D.E., Hatfield,D.L.,
            Hesketh,J., Hoffmann,P.R., Holmgren,A., Hondal,R.J., Howard,M.T.,
            Huang,K., Kim,H.Y., Kim,I.Y., Kohrle,J., Krol,A., Kryukov,G.V.,
            Lee,B.J., Lee,B.C., Lei,X.G., Liu,Q., Lescure,A., Lobanov,A.V.,
            Loscalzo,J., Maiorino,M., Mariotti,M., Sandeep Prabhu,K.,
            Rayman,M.P., Rozovsky,S., Salinas,G., Schmidt,E.E., Schomburg,L.,
            Schweizer,U., Simonovic,M., Sunde,R.A., Tsuji,P.A., Tweedie,S.,
            Ursini,F., Whanger,P.D. and Zhang,Y.
  TITLE     Selenoprotein Gene Nomenclature
  JOURNAL   J Biol Chem 291 (46), 24036-24040 (2016)
   PUBMED   27645994
REFERENCE   5  (bases 1 to 694)
  AUTHORS   Guerriero,E., Accardo,M., Capone,F., Colonna,G., Castello,G. and
            Costantini,S.
  TITLE     Assessment of the Selenoprotein M (SELM) over-expression on human
            hepatocellular carcinoma tissues by immunohistochemistry
  JOURNAL   Eur J Histochem 58 (4), 2433 (2014)
   PUBMED   25578973
  REMARK    GeneRIF: results evidence for the first time an increase of SELM
            expression in HCC liver tissues, and its gradual expression raise
            associated with an increased malignancy grade.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 694)
  AUTHORS   Guariniello,S., Colonna,G., Raucci,R., Costantini,M., Di
            Bernardo,G., Bergantino,F., Castello,G. and Costantini,S.
  TITLE     Structure-function relationship and evolutionary history of the
            human selenoprotein M (SelM) found over-expressed in hepatocellular
            carcinoma
  JOURNAL   Biochim Biophys Acta 1844 (2), 447-456 (2014)
   PUBMED   24332979
  REMARK    GeneRIF: The aim of this study has been to analyze the
            structure-function relationships of SelM.
REFERENCE   7  (bases 1 to 694)
  AUTHORS   Qiao,X., Tian,J., Chen,P., Wang,C., Ni,J. and Liu,Q.
  TITLE     Galectin-1 is an interactive protein of selenoprotein M in the
            brain
  JOURNAL   Int J Mol Sci 14 (11), 22233-22245 (2013)
   PUBMED   24284396
  REMARK    GeneRIF: As Gal-1 plays important roles in preventing
            neurodegeneration and promoting neuroprotection in the brain, the
            interaction between SelM' and Gal-1 displays a new direction for
            studying the biological function of SelM in the human brain.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 694)
  AUTHORS   Korotkov,K.V., Novoselov,S.V., Hatfield,D.L. and Gladyshev,V.N.
  TITLE     Mammalian selenoprotein in which selenocysteine (Sec) incorporation
            is supported by a new form of Sec insertion sequence element
  JOURNAL   Mol Cell Biol 22 (5), 1402-1411 (2002)
   PUBMED   11839807
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY137180.1 and BC068004.1.
            
            On Nov 23, 2018 this sequence version replaced NM_080430.3.
            
            Summary: The protein encoded by this gene belongs to the
            selenoprotein M/SEP15 family. The exact function of this protein is
            not known. It is localized in the perinuclear region, is highly
            expressed in the brain, and may be involved in neurodegenerative
            disorders. Transgenic mice with targeted deletion of this gene
            exhibit increased weight gain, suggesting a role for this gene in
            the regulation of body weight and energy metabolism. This protein
            is a selenoprotein, containing the rare amino acid selenocysteine
            (Sec). Sec is encoded by the UGA codon, which normally signals
            translation termination. The 3' UTRs of selenoprotein mRNAs contain
            a conserved stem-loop structure, designated the Sec insertion
            sequence (SECIS) element, that is necessary for the recognition of
            UGA as a Sec codon, rather than as a stop signal. [provided by
            RefSeq, Dec 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.109510.1,
                                           SRR5189667.377161.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162946, SAMEA2467150
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000400299.6/
                                               ENSP00000383155.2
            protein contains selenocysteine :: PMID: 11839807
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                HY137180.1         20-32
            14-694              BC068004.1         1-681
FEATURES             Location/Qualifiers
     source          1..694
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..694
                     /gene="SELENOM"
                     /gene_synonym="SELM; SEPM"
                     /note="selenoprotein M"
                     /db_xref="GeneID:140606"
                     /db_xref="HGNC:HGNC:30397"
                     /db_xref="MIM:610918"
     exon            1..192
                     /gene="SELENOM"
                     /gene_synonym="SELM; SEPM"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..501
                     /gene="SELENOM"
                     /gene_synonym="SELM; SEPM"
                     /note="UGA stop codon recoded as selenocysteine;
                     selenoprotein SelM"
                     /codon_start=1
                     /transl_except=(pos:205..207,aa:Sec)
                     /product="selenoprotein M precursor"
                     /protein_id="NP_536355.1"
                     /db_xref="CCDS:CCDS43003.1"
                     /db_xref="GeneID:140606"
                     /db_xref="HGNC:HGNC:30397"
                     /db_xref="MIM:610918"
                     /translation="MSLLLPPLALLLLLAALVAPATAATAYRPDWNRLSGLTRARVET
                     CGGUQLNRLKEVKAFVTQDIPFYHNLVMKHLPGADPELVLLGRRYEELERIPLSEMTR
                     EEINALVQELGFYRKAAPDAQVPPEYVWAPAKPPEETSDHADL"
     exon            193..228
                     /gene="SELENOM"
                     /gene_synonym="SELM; SEPM"
                     /inference="alignment:Splign:2.1.0"
     exon            229..263
                     /gene="SELENOM"
                     /gene_synonym="SELM; SEPM"
                     /inference="alignment:Splign:2.1.0"
     exon            264..342
                     /gene="SELENOM"
                     /gene_synonym="SELM; SEPM"
                     /inference="alignment:Splign:2.1.0"
     exon            343..694
                     /gene="SELENOM"
                     /gene_synonym="SELM; SEPM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      537..617
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="SELENOM"
                     /gene_synonym="SELM; SEPM"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      673..678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SELENOM"
                     /gene_synonym="SELM; SEPM"
                     /note="hexamer: ACTAAA"
     polyA_site      694
                     /gene="SELENOM"
                     /gene_synonym="SELM; SEPM"
                     /note="major polyA site"
ORIGIN      
        1 agacgtggcg cagcgactcg gaggttcgcc tccagcttgc gcatcatctg cggccgggtc
       61 ccgatgagcc tcctgttgcc tccgctggcg ctgctgctgc ttctcgcggc gcttgtggcc
      121 ccagccacag ccgccactgc ctaccggccg gactggaacc gtctgagcgg cctaacccgc
      181 gcccgggtag agacctgcgg gggatgacag ctgaaccgcc taaaggaggt gaaggctttc
      241 gtcacgcagg acattccatt ctatcacaac ctggtgatga aacacctccc tggggccgac
      301 cctgagctcg tgctgctggg ccgccgctac gaggaactag agcgcatccc actcagtgaa
      361 atgacccgcg aagagatcaa tgcgctagtg caggagctcg gcttctaccg caaggcggcg
      421 cccgacgcgc aggtgccccc cgagtacgtg tgggcgcccg cgaagccccc agaggaaact
      481 tcggaccacg ctgacctgta ggtccggggg cgcggcggag ctgggaccta cctgcctgag
      541 tcctggagac agaatgaagc gctcagcatc ccgggaatac ttctcttgct gagagccgat
      601 gcccgtcccc gggccagcag ggatggggtt ggggaggttc tcccaacccc actttcttcc
      661 ttccccagct ccactaaatt ccctcctgcc ttaa
//
