LOCUS       NM_021237               1497 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens selenoprotein K (SELENOK), mRNA.
ACCESSION   NM_021237 NM_145281
VERSION     NM_021237.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1497)
  AUTHORS   Li,J., Zhao,L., Wu,Z., Huang,S., Wang,J., Chang,Y., Liu,L., Jin,H.,
            Lu,J., Huang,C., Xie,Q., Huang,H. and Su,Z.
  TITLE     SelK promotes glioblastoma cell proliferation by inhibiting
            beta-TrCP1 mediated ubiquitin-dependent degradation of CDK4
  JOURNAL   J Exp Clin Cancer Res 43 (1), 231 (2024)
   PUBMED   39155374
  REMARK    GeneRIF: SelK promotes glioblastoma cell proliferation by
            inhibiting beta-TrCP1 mediated ubiquitin-dependent degradation of
            CDK4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1497)
  AUTHORS   Ouyang,P., Cai,Z., Peng,J., Lin,S., Chen,X., Chen,C., Feng,Z.,
            Wang,L., Song,G. and Zhang,Z.
  TITLE     SELENOK-dependent CD36 palmitoylation regulates microglial
            functions and Abeta phagocytosis
  JOURNAL   Redox Biol 70, 103064 (2024)
   PUBMED   38320455
  REMARK    GeneRIF: SELENOK-dependent CD36 palmitoylation regulates microglial
            functions and Abeta phagocytosis.
REFERENCE   3  (bases 1 to 1497)
  AUTHORS   Jia,C., Xiang,Z., Zhang,P., Liu,L., Zhu,X., Yu,R., Liu,Z., Wang,S.,
            Liu,K., Wang,Z., Vasilev,K., Zhou,S., Geng,Z., Liu,X., Zhao,Y.,
            Gao,Y., Cheng,L. and Li,Y.
  TITLE     Selenium-SelK-GPX4 axis protects nucleus pulposus cells against
            mechanical overloading-induced ferroptosis and attenuates
            senescence of intervertebral disc
  JOURNAL   Cell Mol Life Sci 81 (1), 49 (2024)
   PUBMED   38252317
  REMARK    GeneRIF: Selenium-SelK-GPX4 axis protects nucleus pulposus cells
            against mechanical overloading-induced ferroptosis and attenuates
            senescence of intervertebral disc.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1497)
  AUTHORS   Lv,L., Chai,L., Wang,J., Wang,M., Qin,D., Song,H., Fu,Y., Zhao,C.,
            Jia,J., Zhao,W. and Jia,M.
  TITLE     Selenoprotein K enhances STING oligomerization to facilitate
            antiviral response
  JOURNAL   PLoS Pathog 19 (4), e1011314 (2023)
   PUBMED   37023217
  REMARK    GeneRIF: Selenoprotein K enhances STING oligomerization to
            facilitate antiviral response.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1497)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1497)
  AUTHORS   Casabonne,D., Reina,O., Benavente,Y., Becker,N., Maynadie,M.,
            Foretova,L., Cocco,P., Gonzalez-Neira,A., Nieters,A., Boffetta,P.,
            Middeldorp,J.M. and de Sanjose,S.
  TITLE     Single nucleotide polymorphisms of matrix metalloproteinase 9
            (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus
            in chronic lymphocytic leukemia: results from the European
            case-control study EpiLymph
  JOURNAL   Haematologica 96 (2), 323-327 (2011)
   PUBMED   21048031
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   7  (bases 1 to 1497)
  AUTHORS   Du,S., Zhou,J., Jia,Y. and Huang,K.
  TITLE     SelK is a novel ER stress-regulated protein and protects HepG2
            cells from ER stress agent-induced apoptosis
  JOURNAL   Arch Biochem Biophys 502 (2), 137-143 (2010)
   PUBMED   20692228
REFERENCE   8  (bases 1 to 1497)
  AUTHORS   Lu,C., Qiu,F., Zhou,H., Peng,Y., Hao,W., Xu,J., Yuan,J., Wang,S.,
            Qiang,B., Xu,C. and Peng,X.
  TITLE     Identification and characterization of selenoprotein K: an
            antioxidant in cardiomyocytes
  JOURNAL   FEBS Lett 580 (22), 5189-5197 (2006)
   PUBMED   16962588
  REMARK    GeneRIF: SelK is a novel antioxidant in cardiomyocytes and is
            related to the regulation of cellular redox balance.
REFERENCE   9  (bases 1 to 1497)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 1497)
  AUTHORS   Kryukov,G.V., Castellano,S., Novoselov,S.V., Lobanov,A.V.,
            Zehtab,O., Guigo,R. and Gladyshev,V.N.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM762385.1, BC013162.1,
            AJ712004.1 and AC012467.9.
            
            On Nov 23, 2018 this sequence version replaced NM_021237.4.
            
            Summary: The protein encoded by this gene belongs to the
            selenoprotein K family. It is a transmembrane protein that is
            localized in the endoplasmic reticulum (ER), and is involved in
            ER-associated degradation (ERAD) of misfolded, glycosylated
            proteins. It also has a role in the protection of cells from ER
            stress-induced apoptosis. Knockout studies in mice show the
            importance of this gene in promoting Ca(2+) flux in immune cells
            and mounting effective immune response. This protein is a
            selenoprotein, containing the rare amino acid selenocysteine (Sec).
            Sec is encoded by the UGA codon, which normally signals translation
            termination. The 3' UTRs of selenoprotein mRNAs contain a conserved
            stem-loop structure, designated the Sec insertion sequence (SECIS)
            element, that is necessary for the recognition of UGA as a Sec
            codon, rather than as a stop signal. Pseudogenes of this locus have
            been identified on chromosomes 6 and 19.[provided by RefSeq, Aug
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.239828.1,
                                           SRR3476690.138120.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2163105, SAMN03267775
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000495461.6/
                                               ENSP00000418813.1
            protein contains selenocysteine :: PMID: 12775843
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-491               BM762385.1         130-620
            492-715             BC013162.1         491-714
            716-938             AJ712004.1         199-421
            939-1497            AC012467.9         31121-31679
FEATURES             Location/Qualifiers
     source          1..1497
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..1497
                     /gene="SELENOK"
                     /gene_synonym="HSPC030; HSPC297; SELK"
                     /note="selenoprotein K"
                     /db_xref="GeneID:58515"
                     /db_xref="HGNC:HGNC:30394"
                     /db_xref="MIM:607916"
     exon            1..90
                     /gene="SELENOK"
                     /gene_synonym="HSPC030; HSPC297; SELK"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..356
                     /gene="SELENOK"
                     /gene_synonym="HSPC030; HSPC297; SELK"
                     /note="UGA stop codon recoded as selenocysteine"
                     /codon_start=1
                     /transl_except=(pos:345..347,aa:Sec)
                     /product="selenoprotein K"
                     /protein_id="NP_067060.2"
                     /db_xref="CCDS:CCDS54597.1"
                     /db_xref="GeneID:58515"
                     /db_xref="HGNC:HGNC:30394"
                     /db_xref="MIM:607916"
                     /translation="MVYISNGQVLDSRSQSPWRLSLITDFFWGIAEFVVLFFKTLLQQ
                     DVKKRRSYGNSSDSRYDDGRGPPGNPPRRMGRINHLRGPSPPPMAGGUGR"
     exon            91..181
                     /gene="SELENOK"
                     /gene_synonym="HSPC030; HSPC297; SELK"
                     /inference="alignment:Splign:2.1.0"
     exon            182..265
                     /gene="SELENOK"
                     /gene_synonym="HSPC030; HSPC297; SELK"
                     /inference="alignment:Splign:2.1.0"
     exon            266..352
                     /gene="SELENOK"
                     /gene_synonym="HSPC030; HSPC297; SELK"
                     /inference="alignment:Splign:2.1.0"
     exon            353..1497
                     /gene="SELENOK"
                     /gene_synonym="HSPC030; HSPC297; SELK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      475..562
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="SELENOK"
                     /gene_synonym="HSPC030; HSPC297; SELK"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      693..698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SELENOK"
                     /gene_synonym="HSPC030; HSPC297; SELK"
                     /note="hexamer: AATAAA"
     polyA_site      715
                     /gene="SELENOK"
                     /gene_synonym="HSPC030; HSPC297; SELK"
                     /note="major polyA site"
     regulatory      1471..1476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SELENOK"
                     /gene_synonym="HSPC030; HSPC297; SELK"
                     /note="hexamer: AATAAA"
     polyA_site      1497
                     /gene="SELENOK"
                     /gene_synonym="HSPC030; HSPC297; SELK"
                     /note="major polyA site"
ORIGIN      
        1 gagcagaggg agatacagaa accgacaggg gccaggcgcc cggtggctcc gaagcgggga
       61 agtgggacaa gatggtttac atctcgaacg gacaagtgtt ggacagccgg agtcagtctc
      121 catggagatt atctttgata acagatttct tctggggaat agctgagttt gtggttttgt
      181 ttttcaaaac tctgcttcag caagatgtga aaaaaagaag aagctatgga aactcatctg
      241 attccagata tgatgatgga agagggccac caggaaaccc tccccgaaga atgggtagaa
      301 tcaatcatct gcgtggccct agtccccctc caatggctgg tggatgagga aggtaaatgt
      361 ctgctctaag aagcagacaa ccggacatgc gcattcatag cagaaggaaa ccatcaagaa
      421 gtggaaggct gaccatgatg agcagtagat gaatgtgtat gtctaaacaa ggactgctct
      481 gtgtcctcac agatgaatga ggtcatgctg ggaattccct ctgcagggaa ctggcctgac
      541 tgacatgcag ttccataaat gcagatgttt gtctcattac ctttttgtat agtttattaa
      601 agtattaata tagttttaat aagtaaatat ttttaggttg cagaatggac tcctcatctt
      661 tatattcacg aaaaagcaat ctgaagaaaa caaataaaag cctgtgtatt tagcactgtt
      721 agtgtcacct tttcaacttc tgaaacactg ttcattgtta actttttctc atttataaat
      781 cactgtattt attttagtag tatgcatagc atatctgtgc tcttgaatta atttttatct
      841 ttaacatatt tgtctcatca atctttaata cactgtgtct aatttgctac caaatgtaat
      901 tatcagggta tttataaaac catagctaac aaaactgagc tacaaaatga aaatttacta
      961 aatagttttt aaaatcatgg acttcagcct ggcgcggtgg ctcatgcctg taatcccagc
     1021 actgtgggag gctgaggcgg gcagatcgcc taagttcacg agtttgagac cagcctgcag
     1081 catgacgaaa cctaaaataa caaaaattag ccaggcgtgg tagagtgcac ctgtaatccc
     1141 tgctactcag gaggcggagg caggagaatc gcttcaaccc gggaggcgga ggttgctgtg
     1201 agcatgccac tgcactcctg cctaggcaac agagtgagac cctgtctcaa aaaaataaat
     1261 aaaaccatgg gcttccatgc tatcttgaca aatttgcact ctatagcatc actcaaaata
     1321 ctgcctattg gctttaaact ccatctgaat actgataact ttcacattct ttcactagag
     1381 tggaagctct gagactagga attttgttgt ctttacccca gtcctttgaa tagtgactac
     1441 atgtaagata gtcatgtagt atttattgga aataaatatt tattggaaaa acgaaaa
//
